ENLIVEN THERAPEUTICS INC ELVN
COM · Common Stock · CUSIP 29337E102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBurlingame, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Shares outstanding: 73.3m as of 2026-07-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $50.62. Options: 4 managers hold calls ($9.3m notional), 5 hold puts ($7.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 45 |
| Q2 2023 | 64 |
| Q3 2023 | 62 |
| Q4 2023 | 63 |
| Q1 2024 | 75 |
| Q2 2024 | 95 |
| Q3 2024 | 104 |
| Q4 2024 | 116 |
| Q1 2025 | 124 |
| Q2 2025 | 127 |
| Q3 2025 | 135 |
| Q4 2025 | 128 |
| Q1 2026 | 172 |
| Q2 2026 | 213 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 59 | 33 |
| Q4 2024 | 61 | 36 |
| Q1 2025 | 63 | 46 |
| Q2 2025 | 79 | 43 |
| Q3 2025 | 79 | 42 |
| Q4 2025 | 63 | 70 |
| Q1 2026 | 121 | 50 |
| Q2 2026 | 144 | 67 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $1.4m | — |
| Q4 2025 | $107.8k | $765.4k | 7.10 |
| Q1 2026 | $48.3m | $16.1m | 0.33 |
| Q2 2026 | $9.3m | $7.0m | 0.75 |
Biggest buyers
| FMR LLC | Added | +3.2m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +2.8m |
| Polar Capital Holdings Plc | Added | +1.4m |
| First Light Asset Management, LLC | Added | +1.2m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +1.1m |
| Siren, L.L.C. | Added | +1.0m |
| SAMLYN CAPITAL, LLC | New | +912.6k |
| Tri Locum Partners LP | New | +866.7k |
| Vestal Point Capital, LP | Added | +750.0k |
| BlackRock, Inc. | Added | +675.0k |
Biggest sellers
| Venrock Adviser, LLC | Reduced | -1.2m |
| ORBIMED ADVISORS LLC | Reduced | -1.2m |
| Bellevue Group AG | Reduced | -830.9k |
| Jones Hill Capital LP | Reduced | -543.2k |
| STEMPOINT CAPITAL LP | Reduced | -380.0k |
| Caption Management, LLC | Sold out | -370.0k |
| Capricorn Fund Managers Ltd | Sold out | -369.4k |
| Rock Springs Capital Management LP | Reduced | -361.9k |
| NOVO HOLDINGS A/S | Reduced | -280.0k |
| Avidity Partners Management LP | Reduced | -250.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.9m96.4k shares |
| Caption Management, LLC | Reduced | $2.5m50.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.9m37.6k shares |
| SIMPLEX TRADING, LLC | New | $10.2k200 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $3.7m72.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m26.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.1m20.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $893.2k17.6k shares |
| GROUP ONE TRADING LLC | New | $20.3k400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +1.7 pts · filed 2026-08-06 | 15.0% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.4 pts · filed 2026-06-24
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
9.5% |
| Polar Capital Holdings Plc 13G · institution no change · filed 2026-06-22 | 8.5% |
| Commodore Capital LP 13G · passive investor -2.2 pts · filed 2026-05-15 | 7.7% |
| BlackRock, Inc. 13G · institution +2.0 pts · filed 2026-10-27 | 7.1% |
| Vestal Point Capital, LP 13G · institution -1.1 pts · filed 2026-05-15 | 5.4% |
Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (2.8%, 2026-05-15), Fairmount Funds Management LLC (3.1%, 2026-05-15)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 7 | $4.3m | $4.3m |
| Q1 2025 | 0 | — | 4 | $1.8m | $1.6m |
| Q2 2025 | 0 | — | 4 | $2.1m | $2.1m |
| Q3 2025 | 0 | — | 4 | $1.9m | $1.9m |
| Q4 2025 | 0 | — | 3 | $1.6m | $1.6m |
| Q1 2026 | 0 | — | 5 | $10.1m | $9.8m |
| Q2 2026 | 0 | — | 3 | $1.3m | $1.3m |
| Q3 2026 | 0 | — | 4 | $11.8m | $11.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-17 | Hohl Benjamin CHIEF FINANCIAL OFFICER | Sold plan | $303.0k6.0k shares |
| 2026-09-17 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $251.8k5.0k shares |
| 2026-08-17 | Hohl Benjamin CHIEF FINANCIAL OFFICER | Sold plan | $352.5k6.0k shares |
| 2026-08-17 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $292.9k5.0k shares |
| 2026-08-04 | Derynck Mika K Director | Sold plan | $9.6m158.8k shares |
| 2026-07-17 | Hohl Benjamin CHIEF FINANCIAL OFFICER | Sold plan | $316.8k6.0k shares |
| 2026-07-17 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $263.4k5.0k shares |
| 2026-07-06 | Kunkel Lori Anne Director | Sold plan | $504.9k10.0k shares |
| 2026-06-22 | ORBIMED ADVISORS LLC +2 10% owner · See Footnotes | Sold | $39.0m860.1k shares |
| 2026-06-17 | Hohl Benjamin CHIEF FINANCIAL OFFICER | Sold plan | $263.6k6.0k shares |
| 2026-06-17 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $219.0k5.0k shares |
| 2026-06-15 | ORBIMED ADVISORS LLC +2 10% owner · See Footnotes | Sold | $12.7m281.4k shares |
| 2026-06-05 | Kunkel Lori Anne Director | Sold plan | $345.4k10.0k shares |
| 2026-05-18 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $199.0k5.0k shares |
| 2026-04-17 | Collins Helen Louise CHIEF MEDICAL OFFICER | Sold plan | $238.4k5.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.02% of their portfolio | 10.0m $508.8m | Added +3.2m |
| ORBIMED ADVISORS LLC 6.51% of their portfolio | 6.8m $343.9m | Reduced -1.2m |
| Polar Capital Holdings Plc 0.92% of their portfolio | 6.4m $326.4m | Added +1.4m |
| BlackRock, Inc. 0.00% of their portfolio | 4.4m $221.3m | Added +675.0k |
| Vestal Point Capital, LP 4.74% of their portfolio | 4.0m $203.0m | Added +750.0k |
| Commodore Capital LP 9.90% of their portfolio | 3.3m $166.2m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 2.9m $147.4m | Added +2.8m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.6m $130.4m | Added +400.8k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 2.1m $105.0m | Added +325.1k |
| Fairmount Funds Management LLC 6.22% of their portfolio | 1.9m $94.2m | Unchanged |
| Siren, L.L.C. 1.83% of their portfolio | 1.8m $90.1m | Added +1.0m |
| Bellevue Group AG 1.59% of their portfolio | 1.5m $75.6m | Reduced -830.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $71.4m | Added +340.8k |
| First Light Asset Management, LLC 4.20% of their portfolio | 1.4m $69.1m | Added +1.2m |
| STATE STREET CORP 0.00% of their portfolio | 1.2m $61.6m | Added +122.5k |
| Pictet Asset Management Holding SA 0.06% of their portfolio | 1.2m $59.0m | Added +232.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.08% of their portfolio | 1.1m $55.0m | New |
| NOVO HOLDINGS A/S 2.95% of their portfolio | 1.0m $50.8m | Reduced -280.0k |
| First Turn Management, LLC 5.18% of their portfolio | 954.4k $48.4m | Added +330.5k |
| SAMLYN CAPITAL, LLC 0.77% of their portfolio | 912.6k $46.3m | New |
| Candriam S.C.A. 0.21% of their portfolio | 905.7k $45.9m | Added +311.6k |
| BAKER BROS. ADVISORS LP 0.23% of their portfolio | 905.2k $45.9m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 896.2k $35.1m | Added +124.3k |
| Tri Locum Partners LP 5.41% of their portfolio | 866.7k $44.0m | New |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 671.4k $34.1m | Reduced -10.3k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 613.1k $31.1m | New |
| Balyasny Asset Management L.P. 0.06% of their portfolio | 607.2k $30.8m | Added +297.2k |
| Jupiter Topco LLC 0.01% of their portfolio | 604.1k $30.6m | First filing |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 566.2k $28.7m | Added +504.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 562.8k $28.6m | Added +231.8k |
| Avidity Partners Management LP 4.47% of their portfolio | 550.0k $27.9m | Reduced -250.0k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 532.3k $27.0m | New |
| Venrock Adviser, LLC 0.81% of their portfolio | 526.3k $26.7m | Reduced -1.2m |
| MORGAN STANLEY 0.00% of their portfolio | 509.9k $25.9m | Reduced -8.6k |
| Affinity Asset Advisors, LLC 1.24% of their portfolio | 500.0k $25.4m | Reduced -86.9k |
| SILVERARC CAPITAL MANAGEMENT, LLC 2.76% of their portfolio | 489.4k $24.8m | New |
| Logos Global Management LP 1.02% of their portfolio | 465.0k $23.6m | Reduced -75.0k |
| Rock Springs Capital Management LP 1.15% of their portfolio | 464.6k $23.6m | Reduced -361.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 440.9k $22.4m | Added +68.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 424.4k $21.5m | Added +63.9k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 411.4k $20.9m | Added +66.0k |
| Nicholas Investment Partners, LP 1.12% of their portfolio | 391.5k $19.9m | Added +208.8k |
| ADAR1 Capital Management, LLC 0.92% of their portfolio | 387.7k $19.7m | Added +58.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 383.5k $19.5m | Added +70.7k |
| Nuveen, LLC 0.00% of their portfolio | 374.2k $19.0m | Added +268.3k |
| Seven Fleet Capital Management LP 3.06% of their portfolio | 365.4k $18.5m | Added +106.1k |
| Woodline Partners LP 0.05% of their portfolio | 347.1k $17.6m | Added +45.5k |
| STEMPOINT CAPITAL LP 3.05% of their portfolio | 346.9k $17.6m | Reduced -380.0k |
| UBS Group AG 0.00% of their portfolio | 342.1k $17.4m | Added +58.6k |
| LORD, ABBETT & CO. LLC 0.05% of their portfolio | 330.8k $16.8m | New |
| Spruce Street Capital LP 3.28% of their portfolio | 329.0k $16.7m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 322.2k $16.3m | Reduced -151.0k |
| Longaeva Partners L.P. 0.46% of their portfolio | 312.6k $15.9m | Added +199.5k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 309.2k $15.7m | Added +39 |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 305.7k $15.5m | Added +112.2k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 300.9k $15.3m | New |
| TimesSquare Capital Management, LLC 0.20% of their portfolio | 261.3k $13.3m | Added +216.3k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 251.2k $12.7m | Added +90.6k |
| Deep Track Capital, LP 0.17% of their portfolio | 225.0k $11.4m | New |
| Blackstone Inc. 0.04% of their portfolio | 215.7k $10.9m | Not comparable |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 214.3k $10.9m | Added +152.7k |
| Patient Square Capital LP 1.67% of their portfolio | 212.5k $10.8m | Added +12.5k |
| Soleus Capital Management, L.P. 0.29% of their portfolio | 165.7k $8.4m | Reduced -65.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio | 160.9k $8.2m | Reduced -30.4k |
| Squadron Capital Management LLC 2.78% of their portfolio | 160.0k $8.1m | New |
| Cormorant Asset Management, LP 0.39% of their portfolio | 150.0k $7.6m | New |
| Integral Health Asset Management, LLC 0.31% of their portfolio | 150.0k $7.6m | New |
| HighVista Strategies LLC 1.60% of their portfolio | 137.9k $7.0m | Added +64.8k |
| Eversept Partners, LP 0.38% of their portfolio | 136.6k $6.9m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 133.1k $6.8m | Reduced -17.0k |
| Ikarian Capital, LLC 1.05% of their portfolio | 126.5k $6.4m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 118.9k $6.0m | Reduced -1.2k |
| Invesco Ltd. 0.00% of their portfolio | 113.0k $5.7m | Added +51.2k |
| SPHERA FUNDS MANAGEMENT LTD. 0.82% of their portfolio | 112.8k $5.7m | Reduced -40.5k |
| J. Goldman & Co LP 0.20% of their portfolio | 112.1k $5.7m | Added +83.5k |
| TD Asset Management Inc 0.00% of their portfolio | 109.7k $5.6m | Added +101.1k |
| Cinctive Capital Management LP 0.22% of their portfolio | 107.7k $5.5m | Reduced -5.7k |
| Exome Asset Management LLC 3.14% of their portfolio | 100.2k $5.1m | Reduced -119.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 98.0k $5.0m | Added +52.9k |
| Swiss National Bank 0.00% of their portfolio | 94.6k $4.8m | Added +30.3k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 91.9k $4.7m | Added +88.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 80.1k $4.1m | Added +12.6k |
| DV EQUITIES, LLC 0.56% of their portfolio | 76.2k $3.9m | First filing |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 75.3k $3.8m | Added +51.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 74.5k $3.8m | Added +60.0k |
| Artia Global Partners LP 0.70% of their portfolio | 72.1k $3.7m | Added +51.2k |
| ALGERT GLOBAL LLC 0.04% of their portfolio | 72.1k $3.7m | New |
| Informed Momentum Co LLC 0.32% of their portfolio | 70.4k $3.6m | Reduced -12.4k |
| GREAT POINT PARTNERS LLC 0.84% of their portfolio | 70.0k $3.6m | New |
| SEVEN GRAND MANAGERS, LLC 0.14% of their portfolio | 70.0k $3.6m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 67.2k $3.4m | Added +28.5k |
| Legato Capital Management LLC 0.27% of their portfolio | 64.8k $3.3m | Added +33.6k |
| Tidal Investments LLC 0.01% of their portfolio | 60.7k $3.1m | Added +13.2k |
| Tema ETFs LLC 0.10% of their portfolio | 60.7k $3.1m | First filing |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 57.2k $2.9m | Added +7.1k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 55.9k $2.8m | Reduced -163.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 53.3k $2.7m | Added +21.4k |
| Atom Investors LP 0.23% of their portfolio | 50.1k $2.5m | New |
| Jones Hill Capital LP 0.54% of their portfolio | 49.9k $2.5m | Reduced -543.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 45.7k $2.3m | Added +36.1k |