Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

118 institutional holders -13 vs Q1 2025
123,300,524123.3m shares reported held*
$1.6bnreported value*
18 new 45 added 35 reduced 32 sold out net sold ≈ $18.0m (-1.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $13.14. Options: 10 managers hold calls ($8.5m notional), 6 hold puts ($2.0m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131Q2 25: 118118Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131
Q2 2025118

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q3 23: 21 bought or addedQ3 23: 12 cut or sold outQ4 23: 28 bought or addedQ4 23: 12 cut or sold outQ4 23Q1 24: 45 bought or addedQ1 24: 13 cut or sold outQ2 24: 44 bought or addedQ2 24: 26 cut or sold outQ2 24Q3 24: 74 bought or addedQ3 24: 24 cut or sold outQ4 24: 52 bought or addedQ4 24: 52 cut or sold outQ4 24Q1 25: 74 bought or addedQ1 25: 51 cut or sold outQ2 25: 63 bought or addedQ2 25: 67 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20232112
Q4 20232812
Q1 20244513
Q2 20244426
Q3 20247424
Q4 20245252
Q1 20257451
Q2 20256367

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ3 24 calls: $98.5kQ3 24 puts: $848.5kQ3 24P/C 8.61Q4 24 calls: $117.2kQ4 24 puts: $3.7mQ4 24P/C 31.44Q1 25 calls: $2.4mQ1 25 puts: $11.7mQ1 25P/C 4.94Q2 25 calls: $8.5mQ2 25 puts: $2.0mQ2 25P/C 0.24
Numbers
QuarterCallsPutsP/C
Q3 2024$98.5k$848.5k8.61
Q4 2024$117.2k$3.7m31.44
Q1 2025$2.4m$11.7m4.94
Q2 2025$8.5m$2.0m0.24

Biggest buyers

RTW INVESTMENTS, LP Added +1,479,836+1.5m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,449,000+1.4m
Balyasny Asset Management L.P. New +1,221,610+1.2m
MILLENNIUM MANAGEMENT LLC Added +1,048,699+1.0m
Polar Capital Holdings Plc New +1,000,000+1.0m
Avoro Capital Advisors LLC Added +950,000+950.0k
Commodore Capital LP Added +930,711+930.7k
STEMPOINT CAPITAL LP Added +672,337+672.3k
JANUS HENDERSON GROUP PLC Added +610,282+610.3k
PRICE T ROWE ASSOCIATES INC /MD/ Added +565,648+565.6k

Biggest sellers

Holocene Advisors, LP Sold out -2,255,679-2.3m
PERCEPTIVE ADVISORS LLC Reduced -1,893,460-1.9m
T. Rowe Price Investment Management, Inc. Reduced -1,752,847-1.8m
BAKER BROS. ADVISORS LP Sold out -1,227,178-1.2m
MORGAN STANLEY Reduced -1,143,996-1.1m
SUSQUEHANNA INTERNATIONAL GROUP, LLP Sold out -899,505-899.5k
CITADEL ADVISORS LLC Sold out -706,331-706.3k
Affinity Asset Advisors, LLC Reduced -646,500-646.5k
Driehaus Capital Management LLC Reduced -584,754-584.8k
First Light Asset Management, LLC Reduced -580,713-580.7k

Biggest calls

Ikarian Capital, LLC New $2.6m200.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.5m192.1k shares
BOOTHBAY FUND MANAGEMENT, LLC New $950.0k72.3k shares
MILLENNIUM MANAGEMENT LLC New $830.4k63.2k shares
UBS Group AG New $595.2k45.3k shares
CITADEL ADVISORS LLC Added $466.5k35.5k shares
Caption Management, LLC Added $388.9k29.6k shares
GROUP ONE TRADING LLC Added $86.7k6.6k shares
SIMPLEX TRADING, LLC Added $68.0k5.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $906.7k69.0k shares
CITADEL ADVISORS LLC Added $525.6k40.0k shares
GOLDMAN SACHS GROUP INC Added $486.2k37.0k shares
GROUP ONE TRADING LLC New $65.7k5.0k shares
SIMPLEX TRADING, LLC Added $38.0k2.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 61.40% of their portfolio ST. HELIER, Y9 19,963,15720.0m $262.3m $262.3m 61.40% Unchanged
2 Index Venture Life Associates VI Ltd 100.00% of their portfolio ST. HELIER, Y9 9,961,78910.0m $130.9m $130.9m 100.00% Unchanged
3 GENERAL ATLANTIC, L.P. 3.51% of their portfolio New York, NY 9,681,8189.7m $127.2m $127.2m 3.51% Unchanged
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.19% of their portfolio Boston, MA 8,403,0008.4m $110.4m $110.4m 0.19% Added +1.4m +1,449,000
5 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 6,532,7686.5m $85.8m $85.8m 0.04% Added +610.3k +610,282
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 5,907,9925.9m $77.6m $77.6m 0.01% Added +565.6k +565,648
7 Avoro Capital Advisors LLC 1.15% of their portfolio NEW YORK, NY 5,000,0005.0m $65.7m $65.7m 1.15% Added +950.0k +950,000
8 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.27% of their portfolio SAN FRANCISCO, CA 4,529,3184.5m $59.5m $59.5m 0.27% Added +195.0k +195,000
9 First Light Asset Management, LLC 7.31% of their portfolio Edina, MN 4,293,4114.3m $56.4m $56.4m 7.31% Reduced -580.7k -580,713
10 FMR LLC 0.00% of their portfolio BOSTON, MA 3,826,1943.8m $50.3m $50.3m 0.00% Unchanged
11 Siren, L.L.C. 2.35% of their portfolio New York, NY 3,460,0293.5m $45.5m $45.5m 2.35% Added +500.0k +500,000
12 Commodore Capital LP 3.06% of their portfolio NEW YORK, NY 3,298,2893.3m $43.3m $43.3m 3.06% Added +930.7k +930,711
13 TCG Crossover Management, LLC 4.34% of their portfolio PALO ALTO, CA 2,890,8162.9m $38.0m $38.0m 4.34% Unchanged
14 Point72 Asset Management, L.P. 0.08% of their portfolio STAMFORD, CT 2,591,5962.6m $34.1m $34.1m 0.08% Added +305.2k +305,163
15 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,543,5392.5m $33.4m $33.4m 0.01% Added +1.5k +1,540
16 Cormorant Asset Management, LP 2.04% of their portfolio BOSTON, MA 2,086,6002.1m $27.4m $27.4m 2.04% Reduced -175.0k -175,000
17 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,793,4711.8m $23.6m $23.6m 0.00% Reduced -1.1m -1,143,996
18 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 1,657,8871.7m $21.8m $21.8m 0.02% Added +1.0m +1,048,699
19 RTW INVESTMENTS, LP 0.29% of their portfolio NEW YORK, NY 1,529,8361.5m $20.1m $20.1m 0.29% Added +1.5m +1,479,836
20 STEMPOINT CAPITAL LP 5.35% of their portfolio NEW YORK, NY 1,265,6721.3m $16.6m $16.6m 5.35% Added +672.3k +672,337
21 Foresite Capital Management VI LLC 9.26% of their portfolio WEST HOLLYWOOD, CA 1,253,3791.3m $16.5m $16.5m 9.26% Unchanged
22 Balyasny Asset Management L.P. 0.04% of their portfolio Chicago, IL 1,221,6101.2m $16.1m $16.1m 0.04% New
23 PERCEPTIVE ADVISORS LLC 0.57% of their portfolio NEW YORK, NY 1,146,9351.1m $15.1m $15.1m 0.57% Reduced -1.9m -1,893,460
24 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,130,7081.1m $14.9m $14.9m 0.01% Added +38.0k +37,954
25 Octagon Capital Advisors LP 2.97% of their portfolio NEW YORK, NY 1,030,0001.0m $13.5m $13.5m 2.97% Reduced -395.0k -395,000
26 Polar Capital Holdings Plc 0.07% of their portfolio London, X0 1,000,0001.0m $13.1m $13.1m 0.07% New
27 Affinity Asset Advisors, LLC 1.75% of their portfolio NEW YORK, NY 900,162900.2k $11.8m $11.8m 1.75% Reduced -646.5k -646,500
28 5AM Venture Management, LLC 4.20% of their portfolio SAN FRANCISCO, CA 830,945830.9k $10.9m $10.9m 4.20% Unchanged
29 Saturn V Capital Management LP 4.22% of their portfolio AUSTIN, TX 793,327793.3k $10.4m $10.4m 4.22% Added +344.6k +344,635
30 Tanager Wealth Management LLP 0.93% of their portfolio Goring On Thames, X0 598,044598.0k $7.9m $7.9m 0.93% Reduced -98.1k -98,052
31 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 559,744559.7k $7.4m $7.4m 0.01% Added +121.6k +121,611
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 559,283559.3k $7.3m $7.3m 0.00% Added +157.5k +157,519
33 Nantahala Capital Management, LLC 0.52% of their portfolio NEW CANAAN, CT 554,803554.8k $7.3m $7.3m 0.52% Unchanged
34 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 553,292553.3k $7.3m $7.3m 0.01% Reduced -34.8k -34,830
35 Driehaus Capital Management LLC 0.05% of their portfolio Chicago, IL 510,779510.8k $6.7m $6.7m 0.05% Reduced -584.8k -584,754
36 Deep Track Capital, LP 0.21% of their portfolio GREENWICH, CT 500,000500.0k $6.6m $6.6m 0.21% New
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 428,434428.4k $5.6m $5.6m 0.00% Added +260.7k +260,702
38 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 416,823416.8k $5.5m $5.5m 0.00% New
39 Woodline Partners LP 0.03% of their portfolio San Francisco, CA 400,278400.3k $5.3m $5.3m 0.03% Unchanged
40 ARMISTICE CAPITAL, LLC 0.20% of their portfolio NEW YORK, NY 400,000400.0k $5.3m $5.3m 0.20% Reduced -68.0k -68,000
41 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 384,900384.9k $5.1m $5.1m 0.01% Added +206.9k +206,900
42 BlackRock, Inc. 0.00% of their portfolio New York, NY 381,125381.1k $5.0m $5.0m 0.00% Reduced -18.8k -18,841
43 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 347,599347.6k $4.6m $4.6m 0.03% New
44 PFM Health Sciences, LP 0.39% of their portfolio SAN FRANCISCO, CA 344,972345.0k $4.5m $4.5m 0.39% Reduced -225.6k -225,574
45 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 343,318343.3k $4.5m $4.5m 0.01% Added +207.3k +207,291
46 Blue Owl Capital Holdings LP 1.40% of their portfolio New York, NY 330,600330.6k $4.3m $4.3m 1.40% Added +15.6k +15,600
47 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 317,574317.6k $4.2m $4.2m 0.00% Added +14.9k +14,928
48 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 307,880307.9k $4.0m $4.0m 0.01% Added +278.4k +278,446
49 ADAR1 Capital Management, LLC 0.63% of their portfolio AUSTIN, TX 296,766296.8k $3.9m $3.9m 0.63% Added +80.6k +80,600
50 Ally Bridge Group (NY) LLC 3.38% of their portfolio NEW YORK, NY 293,986294.0k $3.9m $3.9m 3.38% Added +50.9k +50,900
51 PLATINUM INVESTMENT MANAGEMENT LTD 0.25% of their portfolio SYDNEY AUSTRALIA 2000, C3 290,836290.8k $3.8m $3.8m 0.25% Added +22.9k +22,949
52 Cubist Systematic Strategies, LLC 0.04% of their portfolio STAMFORD, CT 276,452276.5k $3.6m $3.6m 0.04% New
53 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.00% of their portfolio FRANKFURT AM MAIN, 2M 257,418257.4k $3.4m $3.4m 0.00% Unchanged
54 HighMark Wealth Management LLC 1.52% of their portfolio ST. PAUL, MN 237,285237.3k $3.1m $3.1m 1.52% Added +1.5k +1,500
55 GREAT POINT PARTNERS LLC 1.92% of their portfolio Greenwich, CT 225,000225.0k $3.0m $3.0m 1.92% Added +75.3k +75,298
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 209,750209.8k $2.8m $2.8m 0.00% Added +136.3k +136,267
57 Exome Asset Management LLC 1.86% of their portfolio NEW YORK, NY 166,944166.9k $2.2m $2.2m 1.86% Added +24.2k +24,200
58 Windmill Hill Asset Management Ltd 0.59% of their portfolio WADDESDON, X0 163,768163.8k $2.2m $2.2m 0.59% Added +45.9k +45,855
59 Trexquant Investment LP 0.02% of their portfolio STAMFORD, CT 151,352151.4k $2.0m $2.0m 0.02% Reduced -112.6k -112,642
60 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 149,451149.5k $2.0m $2.0m 0.00% Added +10.7k +10,684
61 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 140,965141.0k $1.9m $1.9m 0.00% Reduced -86.6k -86,633
62 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 135,798135.8k $1.8m $1.8m 0.00% Reduced -71.2k -71,230
63 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 131,351131.4k $1.7m $1.7m 0.00% Added +57.6k +57,633
64 FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 123,756123.8k $1.6m $1.6m 0.01% Reduced -22.6k -22,642
65 Aberdeen Group plc 0.00% of their portfolio EDINBURGH, X0 119,389119.4k $1.6m $1.6m 0.00% Added +28.5k +28,506
66 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 118,163118.2k $1.6m $1.6m 0.01% Reduced -159.4k -159,407
67 Bollard Group LLC 0.03% of their portfolio BOSTON, MA 100,362100.4k $1.3m $1.3m 0.03% New
68 Legal & General Group Plc 0.00% of their portfolio London, X0 98,25698.3k $1.3m $1.3m 0.00% Added +22.2k +22,205
69 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 94,36594.4k $1.2m $1.2m 0.00% Reduced -56.9k -56,931
70 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 87,43587.4k $1.1m $1.1m 0.00% Added +27.0k +26,994
71 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 72,14472.1k $948.0k $948.0k 0.00% Added +56.8k +56,844
72 OMERS ADMINISTRATION Corp 0.01% of their portfolio TORONTO, A6 55,20055.2k $725.3k $725.3k 0.01% New
73 Allostery Investments LP 8.79% of their portfolio Stamford, CT 52,50052.5k $689.9k $689.9k 8.79% Reduced -330.0k -330,024
74 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 50,85150.9k $668.2k $668.2k 0.01% Reduced -55.1k -55,074
75 PRELUDE CAPITAL MANAGEMENT, LLC 0.06% of their portfolio NEW YORK, NY 50,10050.1k $658.3k $658.3k 0.06% Added +14.3k +14,300
76 TANG CAPITAL MANAGEMENT LLC 0.03% of their portfolio SAN DIEGO, CA 50,00050.0k $657.0k $657.0k 0.03% Unchanged
77 Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio HONG KONG, K3 46,66546.7k $613.2k $613.2k 0.01% New
78 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 45,91245.9k $603.3k $603.3k 0.00% Reduced -732 -732
79 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 41,90041.9k $550.6k $550.6k 0.02% Unchanged
80 HighVista Strategies LLC 0.20% of their portfolio BOSTON, MA 40,68440.7k $534.6k $534.6k 0.20% Added +1.7k +1,664
81 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 39,76039.8k $522.4k $522.4k 0.00% Reduced -3.1k -3,102
82 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio JUPITER, FL 39,37939.4k $517.4k $517.4k 0.00% New
83 Meridian Wealth Partners, LLC 0.07% of their portfolio EXTON, PA 38,10138.1k $500.6k $500.6k 0.07% New
84 XTX Topco Ltd 0.02% of their portfolio LONDON, X0 35,89835.9k $471.7k $471.7k 0.02% Reduced -5.2k -5,159
85 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 34,97235.0k $459.5k $459.5k 0.00% Added +33.9k +33,854
86 J. Goldman & Co LP 0.01% of their portfolio NEW YORK, NY 33,18433.2k $436.0k $436.0k 0.01% Reduced -103.5k -103,490
87 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,67029.7k $389.9k $389.9k 0.00% Reduced -29.7k -29,670
88 Coastal Bridge Advisors, LLC 0.02% of their portfolio WESTPORT, CT 19,65319.7k $258.2k $258.2k 0.02% New
89 China Universal Asset Management Co., Ltd. 0.02% of their portfolio SHANGHAI, F4 19,18119.2k $252.0k $252.0k 0.02% Added +870 +870
90 Campbell & CO Investment Adviser LLC 0.01% of their portfolio BALTIMORE, MD 16,61916.6k $218.4k $218.4k 0.01% New
91 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 16,50016.5k $216.8k $216.8k 0.00% Unchanged
92 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 15,76415.8k $207.1k $207.1k 0.00% New
93 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 14,99615.0k $196.0k $196.0k 0.00% Added +8.2k +8,241
94 Atria Investments, Inc 0.00% of their portfolio Charlotte, NC 13,92913.9k $183.0k $183.0k 0.00% Added +382 +382
95 OneAscent Financial Services LLC 0.01% of their portfolio BIRMINGHAM, AL 12,32412.3k $162.0k $162.0k 0.01% Reduced -892 -892
96 Engineers Gate Manager LP 0.00% of their portfolio NEW YORK, NY 11,35611.4k $149.2k $149.2k 0.00% Reduced -734 -734
97 Quarry LP 0.03% of their portfolio NEW YORK, NY 8,9999.0k $118.2k $118.2k 0.03% New
98 Virtus Investment Advisers, LLC 0.03% of their portfolio HARTFORD, CT 7,8107.8k $102.6k $102.6k 0.03% Reduced -1.9k -1,923
99 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 7,5197.5k $98.8k $98.8k 0.00% Reduced -30.7k -30,655
100 SILVERARC CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 5,0005.0k $65.7k $65.7k 0.01% Reduced -227.8k -227,758