Vault-13

SPYRE THERAPEUTICS INC SYRE

COM NEW · Common Stock · CUSIP 00773J202

Business enterprise in United States of America

131 institutional holders +0 vs Q1 2025
63,619,40463.6m shares reported held*
105.3% of all shares outstanding*
$952.5mreported value*
18 new 63 added 26 reduced 17 sold out net bought ≈ $22.5m (+1.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($207.4k this quarter). Holder counts are more reliable. Shares outstanding: 60.4m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.97. Options: 3 managers hold calls ($1.0m notional), 3 hold puts ($602.8k).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 23: 28Q4 23: 55Q1 24: 103Q2 24: 109Q3 24: 121Q4 24: 133Q1 25: 131Q2 25: 131131Q3 23Q1 24Q3 24Q1 25Q2 25
Numbers
QuarterHolders
Q3 202328
Q4 202355
Q1 2024103
Q2 2024109
Q3 2024121
Q4 2024133
Q1 2025131
Q2 2025131

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 23: 44 bought or addedQ4 23: 7 cut or sold outQ4 23Q1 24: 72 bought or addedQ1 24: 21 cut or sold outQ2 24: 74 bought or addedQ2 24: 40 cut or sold outQ2 24Q3 24: 71 bought or addedQ3 24: 40 cut or sold outQ4 24: 87 bought or addedQ4 24: 42 cut or sold outQ4 24Q1 25: 71 bought or addedQ1 25: 54 cut or sold outQ2 25: 81 bought or addedQ2 25: 43 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q4 2023447
Q1 20247221
Q2 20247440
Q3 20247140
Q4 20248742
Q1 20257154
Q2 20258143

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5mQ3 24 calls: $17.6kQ3 24 puts: $38.2kQ3 24P/C 2.17Q4 24 calls: $160.6kQ4 24 puts: $79.2kQ4 24P/C 0.49Q1 25 calls: $827.2kQ1 25 puts: $1.0mQ1 25P/C 1.22Q2 25 calls: $1.0mQ2 25 puts: $602.8kQ2 25P/C 0.57
Numbers
QuarterCallsPutsP/C
Q3 2024$17.6k$38.2k2.17
Q4 2024$160.6k$79.2k0.49
Q1 2025$827.2k$1.0m1.22
Q2 2025$1.0m$602.8k0.57

Biggest buyers

TANG CAPITAL MANAGEMENT LLC Added +1,150,000+1.1m
PRICE T ROWE ASSOCIATES INC /MD/ Added +681,939+681.9k
BAKER BROS. ADVISORS LP New +626,703+626.7k
BlackRock, Inc. Added +434,622+434.6k
MORGAN STANLEY Added +335,577+335.6k
GOLDMAN SACHS GROUP INC Added +326,348+326.3k
Capitolis Liquid Global Markets LLC New +183,000+183.0k
VANGUARD GROUP INC Added +168,319+168.3k
GEODE CAPITAL MANAGEMENT, LLC Added +167,669+167.7k
BNP PARIBAS FINANCIAL MARKETS Added +167,487+167.5k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -1,028,410-1.0m
PERCEPTIVE ADVISORS LLC Reduced -783,827-783.8k
Driehaus Capital Management LLC Reduced -631,722-631.7k
Paradigm Biocapital Advisors LP Reduced -256,760-256.8k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -193,000-193.0k
STEMPOINT CAPITAL LP Sold out -136,139-136.1k
CITADEL ADVISORS LLC Sold out -130,884-130.9k
SOROS FUND MANAGEMENT LLC Sold out -125,000-125.0k
STATE STREET CORP Reduced -101,824-101.8k
UBS Group AG Reduced -89,380-89.4k

Biggest calls

Caption Management, LLC New $1.0m70.0k shares
SIMPLEX TRADING, LLC Reduced $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC New $598.8k40.0k shares
SIMPLEX TRADING, LLC New $4.0k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-10-09 10.0% no change 10.2m≈ $860.2m 2026-10-09
BlackRock, Inc. 13G · institution filed 2025-07-16 6.6% 4.0m≈ $351.8m 2025-07-16
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-10-01 5.1% new 4.5m≈ $395.7m 2026-10-01

Fell to 5% or below in the last year: PERCEPTIVE ADVISORS LLC (4.9%, 2026-08-14), RTW INVESTMENTS, LP (4.8%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27), TANG CAPITAL MANAGEMENT LLC (2.4%, 2026-02-17)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q3 23: 0 buyingQ3 23: 0 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 0 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 1 sellingQ4 24: 0 buyingQ4 24: 1 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20230—0——
Q4 20230—0——
Q1 20240—0——
Q2 20240—0——
Q3 20240—1$522.0k—
Q4 20240—1$257.2k$257.2k
Q1 20250—0——
Q2 20250—0——

None reported in Q2 2025.

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.01% of their portfolio BOSTON, MA 9,053,0349.1m $135.5m $135.5m 0.01% Added +14.5k +14,481
2 Fairmount Funds Management LLC 7.79% of their portfolio WEST CONSHOHOCKEN, PA 4,018,1014.0m $60.2m $60.2m 7.79% Unchanged
3 BlackRock, Inc. 0.00% of their portfolio New York, NY 4,007,2964.0m $60.0m $60.0m 0.00% Added +434.6k +434,622
4 RTW INVESTMENTS, LP 0.77% of their portfolio NEW YORK, NY 3,621,9963.6m $54.2m $54.2m 0.77% Unchanged
5 TANG CAPITAL MANAGEMENT LLC 2.42% of their portfolio SAN DIEGO, CA 3,200,0003.2m $47.9m $47.9m 2.42% Added +1.1m +1,150,000
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,066,5863.1m $45.9m $45.9m 0.00% Added +168.3k +168,319
7 Venrock Adviser, LLC 3.01% of their portfolio NEW YORK, NY 2,685,4482.7m $40.2m $40.2m 3.01% Unchanged
8 BRAIDWELL LP 1.32% of their portfolio STAMFORD, CT 2,578,4042.6m $38.6m $38.6m 1.32% Unchanged
9 Capital International Investors 0.01% of their portfolio Los Angeles, CA 2,392,5412.4m $35.8m $35.8m 0.01% Unchanged
10 Driehaus Capital Management LLC 0.25% of their portfolio Chicago, IL 2,085,5902.1m $31.2m $31.2m 0.25% Reduced -631.7k -631,722
11 Commodore Capital LP 2.10% of their portfolio NEW YORK, NY 1,988,0842.0m $29.8m $29.8m 2.10% Unchanged
12 Paradigm Biocapital Advisors LP 1.20% of their portfolio NEW YORK, NY 1,870,4451.9m $28.0m $28.0m 1.20% Reduced -256.8k -256,760
13 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,595,2911.6m $23.9m $23.9m 0.00% Reduced -101.8k -101,824
14 PERCEPTIVE ADVISORS LLC 0.86% of their portfolio NEW YORK, NY 1,529,4451.5m $22.9m $22.9m 0.86% Reduced -783.8k -783,827
15 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 1,513,4781.5m $22.7m $22.7m 0.00% Reduced -80.2k -80,200
16 Jefferies Financial Group Inc. 0.34% of their portfolio NEW YORK, NY 1,388,8541.4m $20.8m $20.8m 0.34% Added +140.0k +140,000
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,227,2321.2m $18.4m $18.4m 0.00% Added +167.7k +167,669
18 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 1,079,4431.1m $16.2m $16.2m 0.02% Added +10.6k +10,551
19 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 930,481930.5k $13.9m $13.9m 0.00% Added +681.9k +681,939
20 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 795,275795.3k $11.9m $11.9m 0.00% Added +34.6k +34,647
21 Polar Capital Holdings Plc 0.06% of their portfolio London, X0 745,000745.0k $11.2m $11.2m 0.06% Reduced -80.0k -80,000
22 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 671,044671.0k $10.0m $10.0m 0.00% Added +335.6k +335,577
23 BAKER BROS. ADVISORS LP 0.09% of their portfolio NEW YORK, NY 626,703626.7k $9.4m $9.4m 0.09% New
24 DEERFIELD MANAGEMENT COMPANY, L.P. 0.17% of their portfolio New York, NY 613,665613.7k $9.2m $9.2m 0.17% Added +163.7k +163,665
25 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 610,200610.2k $9.1m $9.1m 0.02% Reduced -193.0k -193,000
26 Affinity Asset Advisors, LLC 1.34% of their portfolio NEW YORK, NY 606,678606.7k $9.1m $9.1m 1.34% Added +125.0k +125,000
27 EMERALD ADVISERS, LLC 0.31% of their portfolio LEOLA, PA 565,863565.9k $8.5m $8.5m 0.31% Added +18.0k +18,036
28 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 523,416523.4k $7.8m $7.8m 0.00% Added +326.3k +326,348
29 Blackstone Inc. 0.03% of their portfolio NEW YORK, NY 489,248489.2k $7.3m $7.3m 0.03% Unchanged
30 Woodline Partners LP 0.04% of their portfolio San Francisco, CA 465,152465.2k $7.0m $7.0m 0.04% Added +344 +344
31 UBS Group AG 0.00% of their portfolio ZURICH, V8 462,863462.9k $6.9m $6.9m 0.00% Reduced -89.4k -89,380
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 436,947436.9k $6.5m $6.5m 0.00% Added +57.1k +57,072
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 418,503418.5k $6.3m $6.3m 0.00% Added +35.9k +35,867
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 396,351396.4k $5.9m $5.9m 0.00% Reduced -30.7k -30,724
35 Siren, L.L.C. 0.29% of their portfolio New York, NY 368,598368.6k $5.5m $5.5m 0.29% Unchanged
36 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 354,116354.1k $5.3m $5.3m 0.00% Added +102.3k +102,270
37 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 350,774350.8k $5.3m $5.3m 0.00% Unchanged
38 EMERALD MUTUAL FUND ADVISERS TRUST 0.30% of their portfolio LEOLA, PA 329,430329.4k $4.9m $4.9m 0.30% Reduced -60.0k -59,992
39 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 278,920278.9k $4.2m $4.2m 0.02% Added +21.5k +21,488
40 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 246,030246.0k $3.7m $3.7m 0.02% Unchanged
41 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 223,320223.3k $3.3m $3.3m 0.00% Added +167.5k +167,487
42 Deep Track Capital, LP 0.11% of their portfolio GREENWICH, CT 219,015219.0k $3.3m $3.3m 0.11% Unchanged
43 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 216,646216.6k $3.2m $3.2m 0.00% Added +2.0k +2,040
44 Capitolis Liquid Global Markets LLC 0.02% of their portfolio NEW YORK, NY 183,000183.0k $2.7m $2.7m 0.02% New
45 ARMISTICE CAPITAL, LLC 0.10% of their portfolio NEW YORK, NY 172,000172.0k $2.6m $2.6m 0.10% Reduced -28.0k -28,000
46 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 135,068135.1k $2.0m $2.0m 0.00% Reduced -5.1k -5,061
47 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 132,150132.2k $2.0m $2.0m 0.00% Added +17.9k +17,910
48 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 129,558129.6k $2.0m $2.0m 0.00% Added +21.1k +21,054
49 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 113,968114.0k $1.7m $1.7m 0.00% Added +91.6k +91,600
50 HighVista Strategies LLC 0.62% of their portfolio BOSTON, MA 112,805112.8k $1.7m $1.7m 0.62% Added +17.6k +17,646
51 Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio FRANKFURT AM MAIN, 2M 109,284109.3k $1.6m $1.6m 0.00% Reduced -11.0k -11,037
52 MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio DENVER, CO 106,142106.1k $1.6m $1.6m 0.00% New
53 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 85,70285.7k $1.3m $1.3m 0.00% Added +33.6k +33,564
54 ExodusPoint Capital Management, LP 0.02% of their portfolio NEW YORK, NY 82,97783.0k $1.2m $1.2m 0.02% Added +67.9k +67,922
55 B Group, Inc. 1.03% of their portfolio DALLAS, TX 80,00080.0k $1.2m $1.2m 1.03% Added +10.0k +10,000
56 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 79,89679.9k $1.2m $1.2m 0.00% Added +26.0k +25,995
57 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 73,16873.2k $1.1m $1.1m 0.00% Added +17.1k +17,145
58 Foresite Capital Management VI LLC 0.59% of their portfolio WEST HOLLYWOOD, CA 70,00070.0k $1.0m $1.0m 0.59% New
59 Swiss National Bank 0.00% of their portfolio ZURICH, V8 68,60068.6k $1.0m $1.0m 0.00% Unchanged
60 Verition Fund Management LLC 0.01% of their portfolio GREENWICH, CT 65,04265.0k $973.7k $973.7k 0.01% New
61 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 59,81659.8k $895.4k $895.4k 0.00% Added +1.1k +1,120
62 F/m Investments LLC 0.03% of their portfolio WASHINGTON, DC 52,54652.5k $786.6k $786.6k 0.03% Added +702 +702
63 Rafferty Asset Management, LLC 0.00% of their portfolio New York, NY 50,95751.0k $762.8k $762.8k 0.00% Reduced -19.4k -19,366
64 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 47,27947.3k $707.8k $707.8k 0.00% Added +5.7k +5,723
65 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 36,23036.2k $542.4k $542.4k 0.00% Unchanged
66 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 35,04635.0k $524.6k $524.6k 0.00% Added +145 +145
67 Legal & General Group Plc 0.00% of their portfolio London, X0 34,96935.0k $523.5k $523.5k 0.00% Reduced -2.9k -2,875
68 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 34,68034.7k $519.2k $519.2k 0.00% Added +9.5k +9,473
69 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 34,40934.4k $515.1k $515.1k 0.00% Added +4.4k +4,374
70 ADAR1 Capital Management, LLC 0.08% of their portfolio AUSTIN, TX 34,05134.1k $509.7k $509.7k 0.08% Added +19.0k +19,018
71 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 33,93833.9k $508.1k $508.1k 0.00% Added +5.5k +5,455
72 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 33,20133.2k $497.0k $497.0k 0.00% Added +603 +603
73 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 30,93630.9k $463.1k $463.1k 0.00% New
74 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 30,04630.0k $449.8k $449.8k 0.00% Reduced -42.0k -41,965
75 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 29,91829.9k $447.9k $447.9k 0.00% Added +6.2k +6,185
76 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 29,81229.8k $446.9k $446.9k 0.00% Added +2.8k +2,794
77 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 29,26129.3k $438.0k $438.0k 0.00% Reduced -54.2k -54,203
78 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.00% of their portfolio FRANKFORT, KY 25,79925.8k $386.0k $386.0k 0.00% Unchanged
79 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 24,94524.9k $373.4k $373.4k 0.00% Added +4.5k +4,517
80 Assenagon Asset Management S.A. 0.00% of their portfolio SENNINGERBERG, N4 22,13622.1k $331.4k $331.4k 0.00% Reduced -590 -590
81 NATIXIS 0.00% of their portfolio PARIS, I0 20,04020.0k $354.9k $354.9k 0.00% New
82 Waverly Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 19,45319.5k $291.2k $291.2k 0.00% Added +23 +23
83 NBW CAPITAL LLC 0.06% of their portfolio BOSTON, MA 19,43019.4k $290.9k $290.9k 0.06% Unchanged
84 Global Endowment Management, LP 0.04% of their portfolio CHARLOTTE, NC 18,18418.2k $272.2k $272.2k 0.04% Unchanged
85 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 17,97318.0k $269.1k $269.1k 0.00% New
86 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 16,94816.9k $252.0k $252.0k 0.00% Added +14.8k +14,776
87 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 16,56516.6k $248.0k $248.0k 0.00% Added +6.3k +6,300
88 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 13,58913.6k $203.4k $203.4k 0.00% Reduced -7.1k -7,107
89 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 13,00013.0k $194.5k $194.5k 0.00% Reduced -1.0m -1,028,410
90 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 12,87312.9k $192.7k $192.7k 0.00% New
91 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 12,47912.5k $186.8k $186.8k 0.00% Added +1.1k +1,101
92 China Universal Asset Management Co., Ltd. 0.02% of their portfolio SHANGHAI, F4 12,12212.1k $181.5k $181.5k 0.02% Added +35 +35
93 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 11,52511.5k $172.5k $172.5k 0.00% Added +2.8k +2,758
94 PROFUND ADVISORS LLC 0.01% of their portfolio BETHESDA, MD 11,04311.0k $165.3k $165.3k 0.01% Reduced -3.6k -3,619
95 Man Group plc 0.00% of their portfolio LONDON, X0 10,84310.8k $162.3k $162.3k 0.00% New
96 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 10,51210.5k $157.4k $157.4k 0.00% Added +495 +495
97 KLP KAPITALFORVALTNING AS 0.00% of their portfolio OSLO, Q8 7,8007.8k $116.8k $116.8k 0.00% Unchanged
98 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 5,7695.8k $86.4k $86.4k 0.00% Added +3.7k +3,725
99 Virtus Investment Advisers, LLC 0.03% of their portfolio HARTFORD, CT 5,3105.3k $79.5k $79.5k 0.03% Reduced -1.6k -1,551
100 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 5,0915.1k $76.2k $76.2k 0.00% Added +1.0k +1,045