UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($380.1k this quarter). Holder counts are more reliable. Shares outstanding: 63.1m as of 2026-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $16.27. Options: 43 managers hold calls ($282.9m notional), 17 hold puts ($42.8m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
| Q3 2023 | 161 |
| Q4 2023 | 144 |
| Q1 2024 | 133 |
| Q2 2024 | 118 |
| Q3 2024 | 132 |
| Q4 2024 | 139 |
| Q1 2025 | 142 |
| Q2 2025 | 144 |
| Q3 2025 | 219 |
| Q4 2025 | 226 |
| Q1 2026 | 213 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 52 | 70 |
| Q3 2024 | 66 | 55 |
| Q4 2024 | 62 | 75 |
| Q1 2025 | 77 | 57 |
| Q2 2025 | 74 | 79 |
| Q3 2025 | 145 | 78 |
| Q4 2025 | 135 | 124 |
| Q1 2026 | 112 | 113 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $82.8m | $19.2m | 0.23 |
| Q3 2025 | $291.9m | $281.4m | 0.96 |
| Q4 2025 | $232.6m | $63.7m | 0.27 |
| Q1 2026 | $282.9m | $42.8m | 0.15 |
Biggest buyers
| Aberdeen Group plc | Added | +1.6m |
| ORBIMED ADVISORS LLC | Added | +1.4m |
| Two Seas Capital LP | New | +1.3m |
| TWO SIGMA INVESTMENTS, LP | Added | +1.2m |
| Siren, L.L.C. | New | +1.0m |
| Balyasny Asset Management L.P. | Added | +828.6k |
| SG Americas Securities, LLC | Added | +712.3k |
| JANE STREET GROUP, LLC | New | +636.0k |
| Kalehua Capital Management LLC | New | +502.8k |
| MAK CAPITAL ONE LLC | New | +441.2k |
Biggest sellers
| FMR LLC | Reduced | -4.5m |
| MONTANOVA CAPITAL, LLC | Sold out | -1.2m |
| RTW INVESTMENTS, LP | Reduced | -1.1m |
| TWO SIGMA ADVISERS, LP | Sold out | -1.1m |
| Artia Global Partners LP | Sold out | -1.0m |
| STATE STREET CORP | Reduced | -970.5k |
| Logos Global Management LP | Sold out | -675.0k |
| Tyro Capital Management LLC | Sold out | -663.9k |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -498.2k |
| Nantahala Capital Management, LLC | Reduced | -462.2k |
Biggest calls
| Nantahala Capital Management, LLC | New | $42.5m2.6m shares |
| CITIGROUP INC | Added | $36.3m2.2m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $34.0m2.1m shares |
| Caption Management, LLC | Added | $31.6m1.9m shares |
| 683 Capital Management, LLC | Added | $20.5m1.3m shares |
| GROUP ONE TRADING LLC | Added | $17.0m1.0m shares |
| CITADEL ADVISORS LLC | Added | $15.6m956.0k shares |
| SIMPLEX TRADING, LLC | Added | $10.7m657.1k shares |
| NOMURA HOLDINGS INC | Added | $8.4m515.0k shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | $8.2m500.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $9.2m561.5k shares |
| CITADEL ADVISORS LLC | Reduced | $7.7m470.5k shares |
| DIADEMA PARTNERS LP | Reduced | $4.9m299.0k shares |
| Caption Management, LLC | Added | $4.8m291.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.9m239.3k shares |
| JANE STREET GROUP, LLC | Added | $2.7m162.8k shares |
| BARCLAYS PLC | Unchanged | $2.7m162.5k shares |
| GROUP ONE TRADING LLC | Added | $2.6m160.3k shares |
| IMC-Chicago, LLC | Reduced | $1.1m68.7k shares |
| CITIGROUP INC | Added | $989.2k60.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17), Vestal Point Capital, LP (0.4%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 12 | $138.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2025 | 0 | — | 4 | $1.0m | — |
| Q2 2025 | 0 | — | 9 | $169.8k | — |
| Q3 2025 | 0 | — | 2 | $10.3m | $10.3m |
| Q4 2025 | 0 | — | 2 | $2.0m | $2.0m |
| Q1 2026 | 0 | — | 6 | $2.1m | $804.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-04 | Kapusta Matthew C CEO, Managing Director, director | Sold | $132.1k14.6k shares |
| 2026-03-04 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $108.7k12.0k shares |
| 2026-03-04 | Potts Jeannette Chief Legal Officer | Sold | $30.9k3.4k shares |
| 2026-03-04 | Abi-Saab Walid Chief Medical Officer | Sold | $7.3k808 shares |
| 2026-03-02 | Kapusta Matthew C CEO, Managing Director, director | Sold | $342.6k34.4k shares |
| 2026-03-02 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $124.7k12.5k shares |
| 2026-03-02 | Potts Jeannette Chief Legal Officer | Sold | $85.4k8.6k shares |
| 2026-03-02 | Abi-Saab Walid Chief Medical Officer | Sold | $16.5k1.7k shares |
| 2026-02-25 | Kapusta Matthew C CEO, Managing Director, director | Sold | $295.3k12.4k shares |
| 2026-02-25 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $148.3k6.2k shares |
| 2026-01-12 | Gut Robert Director | Sold plan | $630.5k25.6k shares |
| 2026-01-09 | Kaye Jack Director | Sold plan | $174.3k6.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| Avoro Capital Advisors LLC 0.96% of their portfolio | 6.0m $97.4m | Reduced -190.4k |
| Aberdeen Group plc 0.14% of their portfolio | 5.3m $86.8m | Added +1.6m |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.8m $41.8m | Reduced -97.2k |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 2.7m $43.8m | Added +1.2m |
| RTW INVESTMENTS, LP 0.42% of their portfolio | 2.6m $42.3m | Reduced -1.1m |
| STATE STREET CORP 0.00% of their portfolio | 2.3m $37.0m | Reduced -970.5k |
| ORBIMED ADVISORS LLC 0.76% of their portfolio | 2.1m $34.9m | Added +1.4m |
| FMR LLC 0.00% of their portfolio | 1.7m $28.5m | Reduced -4.5m |
| BlackRock, Inc. 0.00% of their portfolio | 1.7m $28.3m | Reduced -241.5k |
| MPM BIOIMPACT LLC 1.73% of their portfolio | 1.4m $22.4m | Reduced -12.4k |
| Two Seas Capital LP 0.98% of their portfolio | 1.3m $21.3m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.3m $20.7m | Added +95.6k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 1.2m $20.2m | Reduced -137.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 1.0m $16.4m | Reduced -215.6k |
| Siren, L.L.C. 0.45% of their portfolio | 1.0m $16.4m | New |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 964.3k $15.8m | Added +828.6k |
| Integral Health Asset Management, LLC 0.78% of their portfolio | 900.0k $14.7m | Unchanged |
| Fiera Capital Corp 0.05% of their portfolio | 816.9k $13.4m | Added +48.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 804.6k $13.2m | Added +28.5k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 792.8k $13.0m | Reduced -10.8k |
| SG Americas Securities, LLC 0.01% of their portfolio | 776.6k $12.7m | Added +712.3k |
| MAVERICK CAPITAL LTD 0.13% of their portfolio | 697.6k $11.4m | Added +35.8k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 694.7k $11.4m | First filing |
| Boxer Capital Management, LLC 1.42% of their portfolio | 662.0k $10.8m | Added +372.0k |
| Whitefort Capital Management, LP 3.27% of their portfolio | 657.6k $10.8m | Added +198.6k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 636.0k $10.4m | New |
| First Turn Management, LLC 1.12% of their portfolio | 615.5k $10.1m | Added +293.8k |
| Voss Capital, LP 0.57% of their portfolio | 605.0k $9.9m | Added +395.0k |
| CITIGROUP INC 0.01% of their portfolio | 531.9k $8.7m | Added +347.1k |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 0.72% of their portfolio | 521.7k $8.5m | Unchanged |
| READYSTATE ASSET MANAGEMENT LP 0.48% of their portfolio | 504.7k $8.3m | Added +143.1k |
| Kalehua Capital Management LLC 3.16% of their portfolio | 502.8k $8.2m | New |
| 683 Capital Management, LLC 0.76% of their portfolio | 500.0k $8.2m | Added +115.0k |
| Catalio Capital Management, LP 1.68% of their portfolio | 491.1k $8.0m | Added +202.8k |
| UBS Group AG 0.00% of their portfolio | 487.8k $8.0m | Reduced -3.6k |
| Privium Fund Management B.V. 1.66% of their portfolio | 486.5k $8.0m | Added +70.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 480.9k $7.9m | Reduced -265.7k |
| MAK CAPITAL ONE LLC 1.19% of their portfolio | 441.2k $7.2m | New |
| ExodusPoint Capital Management, LP 0.07% of their portfolio | 436.5k $7.1m | Added +362.7k |
| Massar Capital Management, LP 1.39% of their portfolio | 426.0k $7.0m | Added +385.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 404.6k $6.6m | Reduced -64.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 375.9k $6.1m | Added +13.0k |
| MORGAN STANLEY 0.00% of their portfolio | 366.1k $6.0m | Reduced -350.8k |
| Vestal Point Capital, LP 0.16% of their portfolio | 359.0k $5.9m | New |
| Squarepoint Ops LLC 0.01% of their portfolio | 346.0k $5.7m | Added +170.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 332.5k $5.4m | First filing |
| Caption Management, LLC 0.24% of their portfolio | 303.2k $5.0m | Added +126.0k |
| Engineers Gate Manager LP 0.06% of their portfolio | 299.8k $4.9m | Added +256.4k |
| Militia Capital Management LLC 0.35% of their portfolio | 282.6k $4.6m | First filing |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 258.2k $4.2m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 246.9k $4.0m | Reduced -82.7k |
| Nantahala Capital Management, LLC 0.24% of their portfolio | 237.1k $3.9m | Reduced -462.2k |
| SIMPLEX TRADING, LLC 0.12% of their portfolio | 231.8k $3.8m | Added +121.1k |
| Parkman Healthcare Partners LLC 0.35% of their portfolio | 206.8k $3.4m | Reduced -50.5k |
| GROUP ONE TRADING LLC 0.10% of their portfolio | 179.0k $2.9m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 170.0k $2.8m | Added +1.1k |
| BARCLAYS PLC 0.00% of their portfolio | 167.7k $2.7m | Reduced -42.1k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 160.7k $2.6m | Added +28.8k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 158.5k $2.6m | Added +33.0k |
| STEMPOINT CAPITAL LP 0.25% of their portfolio | 156.1k $2.6m | Added +112.6k |
| FLAX POND CAPITAL, LLC 2.00% of their portfolio | 152.0k $2.5m | Added +5.5k |
| Creek Drive Management Group LLC 1.54% of their portfolio | 150.0k $2.5m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 147.5k $2.4m | Unchanged |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 146.7k $2.4m | Reduced -460.2k |
| Susquehanna Portfolio Strategies, LLC 0.03% of their portfolio | 139.0k $2.3m | Added +110.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 122.7k $2.0m | Added +101.6k |
| MOORE CAPITAL MANAGEMENT, LP 0.07% of their portfolio | 122.2k $2.0m | Added +47.2k |
| Tejara Capital Ltd 0.66% of their portfolio | 122.1k $2.0m | Added +80.1k |
| K2 PRINCIPAL FUND, L.P. 0.20% of their portfolio | 118.6k $1.9m | New |
| NAN FUNG TRINITY (HK) LTD 0.21% of their portfolio | 115.5k $1.9m | Unchanged |
| Y-Intercept (Hong Kong) Ltd 0.04% of their portfolio | 114.0k $1.9m | Added +68.2k |
| Pekin Hardy Strauss, Inc. 0.19% of their portfolio | 112.6k $1.8m | Added +83.3k |
| Brevan Howard Capital Management LP 0.02% of their portfolio | 108.6k $1.8m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 107.9k $1.8m | Added +22.2k |
| Propel Bio Management, LLC 1.08% of their portfolio | 104.8k $1.7m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 103.4k $1.7m | Added +33.2k |
| Birchview Capital, LP 0.94% of their portfolio | 100.7k $1.6m | Added +69.9k |
| Irenic Capital Management LP 0.15% of their portfolio | 100.0k $1.6m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 96.6k $1.6m | Reduced -3.0k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio | 91.6k $1.5m | Added +61.2k |
| Ikarian Capital, LLC 0.21% of their portfolio | 91.1k $1.5m | Unchanged |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 90.3k $1.5m | Reduced -74.7k |
| Walleye Capital LLC 0.01% of their portfolio | 88.5k $1.4m | Added +9.5k |
| Newtyn Management, LLC 0.15% of their portfolio | 87.7k $1.4m | New |
| Clearline Capital LP 0.11% of their portfolio | 83.7k $1.4m | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 82.6k $1.4m | Added +2.4k |
| Marex Group Ltd 0.01% of their portfolio | 80.0k $1.3m | Reduced -6.0k |
| Swiss National Bank 0.00% of their portfolio | 79.0k $1.3m | Unchanged |
| Cinctive Capital Management LP 0.08% of their portfolio | 77.3k $1.3m | New |
| ADAR1 Capital Management, LLC 0.07% of their portfolio | 76.2k $1.2m | Reduced -158.9k |
| Senvest Management, LLC 0.04% of their portfolio | 72.3k $1.2m | Added +22.3k |
| Hennion & Walsh Asset Management, Inc. 0.04% of their portfolio | 68.5k $1.1m | Added +808 |
| Shay Capital LLC 0.16% of their portfolio | 67.5k $1.1m | Added +26.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 57.1k $934.1k | Reduced -13.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 55.0k $810.4k | Unchanged |
| DCF Advisers, LLC 0.30% of their portfolio | 49.0k $801.1k | New |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 48.8k $798.3k | Reduced -73.7k |
| Havemeyer Place LP 0.09% of their portfolio | 48.5k $792.4k | Added +18.8k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 47.1k $769.8k | Added +1.1k |
| IMC-Chicago, LLC 0.01% of their portfolio | 45.1k $737.1k | New |