UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($445.4k this quarter). Holder counts are more reliable. Shares outstanding: 62.3m as of 2025-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $23.93. Options: 31 managers hold calls ($232.6m notional), 20 hold puts ($63.7m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
| Q3 2023 | 161 |
| Q4 2023 | 144 |
| Q1 2024 | 133 |
| Q2 2024 | 118 |
| Q3 2024 | 132 |
| Q4 2024 | 139 |
| Q1 2025 | 142 |
| Q2 2025 | 144 |
| Q3 2025 | 219 |
| Q4 2025 | 226 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 69 | 63 |
| Q2 2024 | 52 | 70 |
| Q3 2024 | 66 | 55 |
| Q4 2024 | 62 | 75 |
| Q1 2025 | 77 | 57 |
| Q2 2025 | 74 | 79 |
| Q3 2025 | 145 | 78 |
| Q4 2025 | 135 | 124 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $22.9m | $5.6m | 0.25 |
| Q2 2025 | $82.8m | $19.2m | 0.23 |
| Q3 2025 | $291.9m | $281.4m | 0.96 |
| Q4 2025 | $232.6m | $63.7m | 0.27 |
Biggest buyers
| STATE STREET CORP | Added | +1.8m |
| Avoro Capital Advisors LLC | Added | +1.7m |
| MPM BIOIMPACT LLC | New | +1.4m |
| MONTANOVA CAPITAL, LLC | New | +1.2m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +992.8k |
| Fiera Capital Corp | New | +768.5k |
| Aberdeen Group plc | Added | +738.9k |
| TWO SIGMA ADVISERS, LP | Added | +700.9k |
| Tyro Capital Management LLC | New | +663.9k |
| MAVERICK CAPITAL LTD | New | +661.8k |
Biggest sellers
| EcoR1 Capital, LLC | Sold out | -4.0m |
| FRANKLIN RESOURCES INC | Reduced | -1.2m |
| FRED ALGER MANAGEMENT, LLC | Reduced | -945.5k |
| Eversept Partners, LP | Reduced | -814.6k |
| RTW INVESTMENTS, LP | Reduced | -713.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -704.5k |
| 683 Capital Management, LLC | Reduced | -685.0k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -551.0k |
| Boxer Capital Management, LLC | Reduced | -510.0k |
| Deep Track Capital, LP | Sold out | -483.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $53.9m2.3m shares |
| GROUP ONE TRADING LLC | Added | $20.2m845.8k shares |
| CITADEL ADVISORS LLC | Added | $19.4m812.4k shares |
| Affinity Asset Advisors, LLC | New | $19.1m800.0k shares |
| 683 Capital Management, LLC | New | $17.9m750.1k shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | $17.2m720.8k shares |
| Caption Management, LLC | Added | $15.2m635.0k shares |
| SIMPLEX TRADING, LLC | Added | $11.4m475.3k shares |
| PEAK6 LLC | Added | $8.6m359.0k shares |
| JANE STREET GROUP, LLC | Reduced | $8.5m354.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $11.9m498.8k shares |
| CITADEL ADVISORS LLC | Reduced | $11.6m483.2k shares |
| DIADEMA PARTNERS LP | Added | $7.2m301.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $7.1m295.8k shares |
| Caption Management, LLC | Reduced | $5.2m217.4k shares |
| BARCLAYS PLC | Reduced | $3.9m162.5k shares |
| HRT FINANCIAL LP | New | $3.7m156.0k shares |
| GROUP ONE TRADING LLC | Reduced | $2.6m110.7k shares |
| IMC-Chicago, LLC | New | $2.6m106.9k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $2.4m102.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 3 | $339.8k | — |
| Q2 2024 | 0 | — | 12 | $138.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2025 | 0 | — | 4 | $1.0m | — |
| Q2 2025 | 0 | — | 9 | $169.8k | — |
| Q3 2025 | 0 | — | 2 | $10.3m | $10.3m |
| Q4 2025 | 0 | — | 2 | $2.0m | $2.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-11-06 | Gut Robert Director | Sold plan | $856.9k31.4k shares |
| 2025-11-04 | Kaye Jack Director | Sold plan | $1.2m38.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 6.2m $149.3m | Added +181.4k |
| Avoro Capital Advisors LLC 1.45% of their portfolio | 6.2m $147.2m | Added +1.7m |
| RTW INVESTMENTS, LP 0.89% of their portfolio | 3.7m $88.8m | Reduced -713.5k |
| Aberdeen Group plc 0.14% of their portfolio | 3.7m $88.0m | Added +738.9k |
| STATE STREET CORP 0.00% of their portfolio | 3.2m $77.3m | Added +1.8m |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.9m $70.2m | Added +635.9k |
| BlackRock, Inc. 0.00% of their portfolio | 2.0m $47.3m | Added +528.9k |
| TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio | 1.5m $34.7m | Added +553.7k |
| MPM BIOIMPACT LLC 3.78% of their portfolio | 1.4m $33.1m | New |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 1.4m $32.8m | Added +371.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.04% of their portfolio | 1.2m $29.2m | Added +992.8k |
| MONTANOVA CAPITAL, LLC 0.73% of their portfolio | 1.2m $29.1m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.2m $27.9m | Added +505.4k |
| TWO SIGMA ADVISERS, LP 0.05% of their portfolio | 1.1m $26.6m | Added +700.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.1m $25.2m | Reduced -73.7k |
| Artia Global Partners LP 3.94% of their portfolio | 1.0m $24.5m | Added +364.7k |
| Integral Health Asset Management, LLC 1.09% of their portfolio | 900.0k $21.5m | Added +300.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 803.6k $19.2m | Added +612.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 776.1k $18.6m | Added +54.4k |
| Fiera Capital Corp 0.06% of their portfolio | 768.5k $18.4m | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 746.6k $17.9m | Reduced -1.2m |
| ORBIMED ADVISORS LLC 0.36% of their portfolio | 737.4k $17.6m | Added +278.9k |
| MORGAN STANLEY 0.00% of their portfolio | 716.9k $17.2m | Added +395.4k |
| Nantahala Capital Management, LLC 1.00% of their portfolio | 699.3k $16.7m | Reduced -308.2k |
| Logos Global Management LP 1.08% of their portfolio | 675.0k $16.2m | Added +375.0k |
| Tyro Capital Management LLC 4.94% of their portfolio | 663.9k $15.9m | New |
| MAVERICK CAPITAL LTD 0.17% of their portfolio | 661.8k $15.8m | New |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 606.9k $14.5m | New |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 1.11% of their portfolio | 521.7k $12.5m | Unchanged |
| EVENTIDE ASSET MANAGEMENT, LLC 0.19% of their portfolio | 498.2k $11.9m | New |
| UBS Group AG 0.00% of their portfolio | 491.5k $11.8m | Added +286.5k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 469.3k $11.2m | Added +39.6k |
| Whitefort Capital Management, LP 3.32% of their portfolio | 459.0k $11.0m | New |
| Privium Fund Management B.V. 1.83% of their portfolio | 416.3k $10.0m | Added +30.3k |
| 683 Capital Management, LLC 0.77% of their portfolio | 384.9k $9.2m | Reduced -685.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 362.9k $8.7m | Added +5.2k |
| READYSTATE ASSET MANAGEMENT LP 0.38% of their portfolio | 361.6k $8.7m | New |
| FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio | 344.9k $8.3m | Reduced -945.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 329.5k $7.9m | Added +34.4k |
| First Turn Management, LLC 0.88% of their portfolio | 321.7k $7.7m | New |
| HRT FINANCIAL LP 0.03% of their portfolio | 310.1k $7.4m | New |
| Jump Financial, LLC 0.09% of their portfolio | 306.1k $7.3m | Added +302.3k |
| Boxer Capital Management, LLC 1.52% of their portfolio | 290.0k $6.9m | Reduced -510.0k |
| Catalio Capital Management, LP 1.22% of their portfolio | 288.3k $6.9m | Added +5.4k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 258.2k $6.2m | First filing |
| Parkman Healthcare Partners LLC 0.59% of their portfolio | 257.4k $6.2m | Reduced -88.0k |
| ADAR1 Capital Management, LLC 0.42% of their portfolio | 235.2k $5.6m | Added +101.8k |
| Freshford Capital Management, LLC 2.20% of their portfolio | 229.6k $5.5m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 221.3k $5.3m | Reduced -164.3k |
| Voss Capital, LP 0.27% of their portfolio | 210.0k $5.0m | Added +85.0k |
| BARCLAYS PLC 0.00% of their portfolio | 209.8k $5.0m | Added +94.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 208.6k $5.0m | Reduced -704.5k |
| Eagle Health Investments LP 1.08% of their portfolio | 205.2k $4.9m | New |
| CITIGROUP INC 0.00% of their portfolio | 184.8k $4.4m | Added +173.2k |
| Caption Management, LLC 0.19% of their portfolio | 177.3k $4.2m | Reduced -281.0k |
| Sofinnova Investments, Inc. 0.18% of their portfolio | 176.5k $4.2m | Added +39.7k |
| Squarepoint Ops LLC 0.01% of their portfolio | 176.0k $4.2m | Reduced -5.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 168.8k $4.0m | Added +16.4k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 164.9k $3.9m | Added +82.1k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 151.1k $3.6m | Added +111.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 147.5k $3.5m | New |
| FLAX POND CAPITAL, LLC 2.61% of their portfolio | 146.5k $3.5m | First filing |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 135.6k $3.2m | Reduced -197.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 132.0k $3.2m | Added +99.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.44% of their portfolio | 126.0k $3.0m | Reduced -329.0k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 125.5k $3.0m | Added +121.2k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 122.5k $2.9m | Reduced -65.7k |
| NAN FUNG TRINITY (HK) LTD 0.22% of their portfolio | 115.5k $2.8m | New |
| SIMPLEX TRADING, LLC 0.07% of their portfolio | 110.7k $2.6m | Added +42.7k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 99.6k $2.4m | Added +88.0k |
| Ikarian Capital, LLC 0.28% of their portfolio | 91.1k $2.2m | Added +32.5k |
| Jefferies Financial Group Inc. 0.02% of their portfolio | 90.5k $2.2m | Unchanged |
| Deeter Investments LLP 0.46% of their portfolio | 89.1k $2.1m | First filing |
| Marex Group Ltd 0.02% of their portfolio | 86.0k $2.1m | Reduced -866 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 85.6k $2.0m | Reduced -125.8k |
| Clearline Capital LP 0.15% of their portfolio | 83.7k $2.0m | New |
| CAPITAL FUND MANAGEMENT S.A. 0.02% of their portfolio | 83.0k $2.0m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 80.2k $1.9m | New |
| Rhenman & Partners Asset Management AB 0.18% of their portfolio | 79.4k $1.9m | New |
| Swiss National Bank 0.00% of their portfolio | 79.0k $1.9m | Added +2.7k |
| Walleye Capital LLC 0.01% of their portfolio | 79.0k $1.9m | Reduced -23.9k |
| Atom Investors LP 0.15% of their portfolio | 78.2k $1.9m | Added +30.9k |
| MOORE CAPITAL MANAGEMENT, LP 0.04% of their portfolio | 75.0k $1.8m | New |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 74.0k $1.8m | Added +45.3k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 73.8k $1.8m | New |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 72.2k $1.7m | Added +49.3k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 70.8k $1.7m | Reduced -88.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 70.2k $1.7m | Added +59.4k |
| Hennion & Walsh Asset Management, Inc. 0.06% of their portfolio | 67.7k $1.6m | Added +16.1k |
| SG Americas Securities, LLC 0.00% of their portfolio | 64.3k $1.5m | Added +53.7k |
| Eversept Partners, LP 0.08% of their portfolio | 62.8k $1.5m | Reduced -814.6k |
| PROFUND ADVISORS LLC 0.04% of their portfolio | 59.5k $1.4m | Added +42.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 55.0k $1.3m | New |
| Senvest Management, LLC 0.04% of their portfolio | 50.0k $1.2m | New |
| Affinity Asset Advisors, LLC 0.09% of their portfolio | 50.0k $1.2m | Reduced -250.0k |
| WINTON GROUP Ltd 0.04% of their portfolio | 48.2k $1.2m | Added +7.2k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 46.0k $1.1m | Reduced -12.3k |
| Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio | 45.8k $1.1m | Added +23.1k |
| DIADEMA PARTNERS LP 0.64% of their portfolio | 45.0k $1.1m | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 44.2k $1.1m | Added +7.0k |