UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($49.9k this quarter). Holder counts are more reliable. Shares outstanding: 54.9m as of 2025-07-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $13.94. Options: 25 managers hold calls ($82.8m notional), 14 hold puts ($19.2m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
| Q3 2023 | 161 |
| Q4 2023 | 144 |
| Q1 2024 | 133 |
| Q2 2024 | 118 |
| Q3 2024 | 132 |
| Q4 2024 | 139 |
| Q1 2025 | 142 |
| Q2 2025 | 144 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 90 | 90 |
| Q4 2023 | 69 | 98 |
| Q1 2024 | 69 | 63 |
| Q2 2024 | 52 | 70 |
| Q3 2024 | 66 | 55 |
| Q4 2024 | 62 | 75 |
| Q1 2025 | 77 | 57 |
| Q2 2025 | 74 | 79 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $5.0m | $3.3m | 0.66 |
| Q4 2024 | $51.5m | $13.2m | 0.26 |
| Q1 2025 | $22.9m | $5.6m | 0.25 |
| Q2 2025 | $82.8m | $19.2m | 0.23 |
Biggest buyers
| Jefferies Financial Group Inc. | New | +2.1m |
| JPMORGAN CHASE & CO | Added | +1.5m |
| Avoro Capital Advisors LLC | Added | +1.4m |
| Sofinnova Investments, Inc. | Added | +1.0m |
| RTW INVESTMENTS, LP | Added | +892.8k |
| ROYAL BANK OF CANADA | Added | +733.9k |
| Aberdeen Group plc | Added | +535.2k |
| Balyasny Asset Management L.P. | Added | +512.0k |
| Bank of New York Mellon Corp | New | +348.3k |
| MORGAN STANLEY | Added | +304.8k |
Biggest sellers
| Vestal Point Capital, LP | Reduced | -1.1m |
| Nantahala Capital Management, LLC | Reduced | -704.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Sold out | -501.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP | Reduced | -496.8k |
| PFM Health Sciences, LP | Reduced | -425.6k |
| Catalio Capital Management, LP | Reduced | -412.9k |
| LORD, ABBETT & CO. LLC | Sold out | -400.8k |
| FRANKLIN RESOURCES INC | Reduced | -382.2k |
| Assenagon Asset Management S.A. | Sold out | -334.9k |
| Invesco Ltd. | Reduced | -318.5k |
Biggest calls
| Caption Management, LLC | Added | $20.8m1.5m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $16.8m1.2m shares |
| Ikarian Capital, LLC | Added | $11.2m800.0k shares |
| GROUP ONE TRADING LLC | Added | $6.7m481.1k shares |
| SIMPLEX TRADING, LLC | Added | $4.8m342.7k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Added | $3.9m279.0k shares |
| PEAK6 LLC | Added | $3.1m225.8k shares |
| BARCLAYS PLC | Added | $2.3m161.9k shares |
| EcoR1 Capital, LLC | Unchanged | $1.9m135.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.8m126.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $7.6m542.3k shares |
| Caption Management, LLC | New | $4.8m346.5k shares |
| CITADEL ADVISORS LLC | Added | $1.8m131.4k shares |
| BARCLAYS PLC | New | $1.4m100.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.0m73.3k shares |
| GROUP ONE TRADING LLC | Added | $1.0m72.3k shares |
| 683 Capital Management, LLC | New | $522.8k37.5k shares |
| JANE STREET GROUP, LLC | New | $377.8k27.1k shares |
| WOLVERINE TRADING, LLC | New | $273.0k19.7k shares |
| NOMURA HOLDINGS INC | New | $185.4k13.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17), Vestal Point Capital, LP (0.4%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 2 | $215.3k | $171.7k |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 3 | $339.8k | — |
| Q2 2024 | 0 | — | 12 | $138.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2025 | 0 | — | 4 | $1.0m | — |
| Q2 2025 | 0 | — | 9 | $169.8k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-27 | Abi-Saab Walid Chief Medical Officer | Sold | $20.4k1.5k shares |
| 2025-06-20 | Gut Robert Director | Sold | $48.2k3.3k shares |
| 2025-06-20 | Balachandran Madhavan Director | Sold | $30.5k2.1k shares |
| 2025-06-20 | Kaye Jack Director | Sold | $30.5k2.1k shares |
| 2025-06-20 | POST LEONARD E Director | Sold | $30.5k2.1k shares |
| 2025-06-20 | Springhorn Jeremy P. Director | Sold | $30.5k2.1k shares |
| 2025-06-20 | Jacques Rachelle Suzanne Director | Sold | $30.5k2.1k shares |
| 2025-06-20 | Meek David D. Director | Sold | $30.5k2.1k shares |
| 2025-06-16 | Potts Jeannette Chief Legal Officer | Sold | $70.7k4.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 1.02% of their portfolio | 5.2m $71.9m | Added +892.8k |
| EcoR1 Capital, LLC 3.30% of their portfolio | 4.0m $55.6m | Unchanged |
| Vestal Point Capital, LP 2.72% of their portfolio | 3.7m $51.6m | Reduced -1.1m |
| Avoro Capital Advisors LLC 0.88% of their portfolio | 3.6m $50.5m | Added +1.4m |
| Aberdeen Group plc 0.07% of their portfolio | 2.8m $38.3m | Added +535.2k |
| Jefferies Financial Group Inc. 0.48% of their portfolio | 2.1m $29.2m | New |
| Nantahala Capital Management, LLC 2.02% of their portfolio | 2.1m $28.6m | Reduced -704.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.8m $25.2m | Added +1.5m |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.6m $22.4m | Reduced -382.2k |
| Sofinnova Investments, Inc. 1.48% of their portfolio | 1.6m $21.7m | Added +1.0m |
| Integral Health Asset Management, LLC 1.76% of their portfolio | 1.4m $18.8m | Added +100.0k |
| BlackRock, Inc. 0.00% of their portfolio | 1.3m $18.6m | Reduced -103.3k |
| 683 Capital Management, LLC 1.82% of their portfolio | 1.3m $17.9m | Reduced -265.0k |
| FMR LLC 0.00% of their portfolio | 1.2m $16.5m | Reduced -16.6k |
| STATE STREET CORP 0.00% of their portfolio | 1.1m $15.9m | Reduced -86.8k |
| VANGUARD GROUP INC 0.00% of their portfolio | 972.7k $13.6m | Added +27.2k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 941.0k $13.1m | Added +24.5k |
| MORGAN STANLEY 0.00% of their portfolio | 908.3k $12.7m | Added +304.8k |
| Boxer Capital Management, LLC 6.31% of their portfolio | 899.5k $12.5m | Added +149.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 783.2k $10.9m | Added +733.9k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 761.9k $10.6m | Added +212.2k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 706.2k $9.8m | Unchanged |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 693.3k $9.7m | Reduced -496.8k |
| TWO SIGMA ADVISERS, LP 0.02% of their portfolio | 659.7k $9.2m | Reduced -8.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 603.2k $8.4m | Reduced -7.8k |
| STEMPOINT CAPITAL LP 2.57% of their portfolio | 572.6k $8.0m | Reduced -158.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 555.9k $7.7m | Reduced -229.5k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 537.0k $7.5m | Added +512.0k |
| Pale Fire Capital SE 0.77% of their portfolio | 529.8k $7.4m | Added +67.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 503.7k $7.0m | Added +22.2k |
| Privium Fund Management B.V. 1.35% of their portfolio | 447.5k $6.3m | Reduced -131.7k |
| Parkman Healthcare Partners LLC 0.72% of their portfolio | 443.4k $6.2m | Added +239.6k |
| Catalio Capital Management, LP 1.22% of their portfolio | 417.4k $5.8m | Reduced -412.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 356.5k $5.0m | Added +96.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 348.3k $4.9m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 292.9k $4.1m | Added +12.9k |
| UBS Group AG 0.00% of their portfolio | 263.7k $3.7m | Added +36.8k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 223.0k $3.1m | Added +163.7k |
| Avidity Partners Management LP 0.58% of their portfolio | 207.0k $2.9m | Reduced -129.2k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.58% of their portfolio | 202.6k $2.8m | Reduced -835 |
| Caption Management, LLC 0.23% of their portfolio | 176.9k $2.5m | Added +156.6k |
| Squarepoint Ops LLC 0.01% of their portfolio | 176.0k $2.5m | Reduced -2.3k |
| Woodline Partners LP 0.01% of their portfolio | 175.8k $2.5m | Unchanged |
| MOORE CAPITAL MANAGEMENT, LP 0.05% of their portfolio | 175.0k $2.4m | Added +25.0k |
| PFM Health Sciences, LP 0.21% of their portfolio | 174.3k $2.4m | Reduced -425.6k |
| Invesco Ltd. 0.00% of their portfolio | 166.8k $2.3m | Reduced -318.5k |
| Hudson Bay Capital Management LP 0.01% of their portfolio | 148.2k $2.1m | Reduced -3.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 141.8k $2.0m | Reduced -239.0k |
| JENNISON ASSOCIATES LLC 0.00% of their portfolio | 140.1k $2.0m | New |
| Affinity Asset Advisors, LLC 0.28% of their portfolio | 135.0k $1.9m | Reduced -265.0k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 134.9k $1.9m | Added +92.8k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 132.7k $1.8m | Reduced -133.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 125.7k $1.8m | Added +26.8k |
| Voss Capital, LP 0.12% of their portfolio | 125.0k $1.7m | New |
| Ikarian Capital, LLC 0.55% of their portfolio | 120.0k $1.7m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 110.6k $1.5m | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 106.5k $1.5m | Reduced -197.1k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 105.9k $1.5m | Reduced -24.1k |
| Shay Capital LLC 0.32% of their portfolio | 99.4k $1.4m | Added +17.5k |
| Birchview Capital, LP 1.37% of their portfolio | 98.7k $1.4m | Added +10.0k |
| SG Americas Securities, LLC 0.01% of their portfolio | 94.8k $1.3m | New |
| Verition Fund Management LLC 0.01% of their portfolio | 92.6k $1.3m | Reduced -3.9k |
| BARCLAYS PLC 0.00% of their portfolio | 89.0k $1.2m | Added +21.3k |
| Diamond Hill Capital Management, LLC (Investment Advisor) 0.01% of their portfolio | 82.7k $1.2m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 77.5k $1.1m | New |
| SummitTX Capital, L.P. 0.05% of their portfolio | 77.5k $1.1m | New |
| Monaco Asset Management SAM 0.37% of their portfolio | 70.0k $975.8k | Reduced -5.0k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 68.8k $959.2k | Reduced -13.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 67.3k $937.6k | Reduced -30.9k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 67.0k $933.7k | Added +11.2k |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 64.3k $895.0k | Added +16.7k |
| GROUP ONE TRADING LLC 0.03% of their portfolio | 63.7k $887.7k | Added +60.1k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 63.5k $884.8k | Reduced -51.4k |
| Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio | 62.5k $871.8k | New |
| Main Management ETF Advisors, LLC 0.03% of their portfolio | 56.4k $786.0k | Added +912 |
| SECTORAL ASSET MANAGEMENT INC 0.51% of their portfolio | 55.5k $773.0k | Reduced -2.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 50.4k $703.0k | Added +13.0k |
| Centiva Capital, LP 0.05% of their portfolio | 50.0k $697.0k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 48.3k $673.1k | Added +6.9k |
| Militia Capital Partners, LP 0.15% of their portfolio | 44.4k $618.9k | New |
| Headlands Technologies LLC 0.07% of their portfolio | 42.4k $591.7k | Added +31.9k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 40.3k $561.6k | Reduced -1.9k |
| Massar Capital Management, LP 0.42% of their portfolio | 40.0k $557.6k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 38.7k $539.6k | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 38.5k $537.2k | Unchanged |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 37.2k $518.5k | Reduced -33.8k |
| Legal & General Group Plc 0.00% of their portfolio | 35.6k $496.6k | New |
| Aquatic Capital Management LLC 0.01% of their portfolio | 35.3k $491.6k | Added +24.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 33.6k $468.6k | Reduced -4.2k |
| Hennion & Walsh Asset Management, Inc. 0.02% of their portfolio | 30.4k $423.3k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 28.4k $396.0k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 27.9k $389.0k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 27.5k $383.8k | New |
| DNB Asset Management AS 0.00% of their portfolio | 25.2k $350.7k | Reduced -161 |
| CITIGROUP INC 0.00% of their portfolio | 20.5k $285.5k | Reduced -73.7k |
| Virtu Financial LLC 0.01% of their portfolio | 19.9k $277.0k | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 19.8k $276.1k | Added +17.3k |
| Bellevue Group AG 0.01% of their portfolio | 19.6k $273.4k | Reduced -2.9k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 19.3k $269.6k | New |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 16.9k $235.6k | New |