UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($29.3k this quarter). Holder counts are more reliable. Shares outstanding: 54.1m as of 2025-02-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.65. Options: 18 managers hold calls ($51.5m notional), 9 hold puts ($13.2m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
| Q3 2023 | 161 |
| Q4 2023 | 144 |
| Q1 2024 | 133 |
| Q2 2024 | 118 |
| Q3 2024 | 132 |
| Q4 2024 | 139 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 81 | 90 |
| Q2 2023 | 92 | 91 |
| Q3 2023 | 90 | 90 |
| Q4 2023 | 69 | 98 |
| Q1 2024 | 69 | 63 |
| Q2 2024 | 52 | 70 |
| Q3 2024 | 66 | 55 |
| Q4 2024 | 62 | 75 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $5.5m | $7.3m | 1.33 |
| Q2 2024 | $7.8m | $3.1m | 0.40 |
| Q3 2024 | $5.0m | $3.3m | 0.66 |
| Q4 2024 | $51.5m | $13.2m | 0.26 |
Biggest buyers
| EcoR1 Capital, LLC | New | +3.4m |
| Avoro Capital Advisors LLC | New | +2.2m |
| RTW INVESTMENTS, LP | Added | +893.6k |
| Point72 Asset Management, L.P. | Added | +794.5k |
| Integral Health Asset Management, LLC | Added | +700.0k |
| FMR LLC | Added | +616.1k |
| Schonfeld Strategic Advisors LLC | New | +536.4k |
| Invesco Ltd. | Added | +502.7k |
| FRANKLIN RESOURCES INC | Added | +494.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +326.7k |
Biggest sellers
| Boxer Capital, LLC | Sold out | -2.2m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.7m |
| Vestal Point Capital, LP | Reduced | -1.7m |
| SCHRODER INVESTMENT MANAGEMENT GROUP | Reduced | -634.6k |
| Hudson Bay Capital Management LP | Reduced | -460.5k |
| Avidity Partners Management LP | Reduced | -451.6k |
| D. E. Shaw & Co., Inc. | Reduced | -443.7k |
| DEUTSCHE BANK AG\ | Sold out | -420.7k |
| Aberdeen Group plc | Reduced | -419.7k |
| MARSHALL WACE, LLP | Reduced | -396.2k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $7.3m411.3k shares |
| EcoR1 Capital, LLC | New | $6.8m385.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.8m383.7k shares |
| GROUP ONE TRADING LLC | Added | $6.7m378.2k shares |
| CITADEL ADVISORS LLC | Added | $5.6m317.4k shares |
| Caption Management, LLC | Added | $3.9m222.0k shares |
| Nantahala Capital Management, LLC | Unchanged | $3.5m201.0k shares |
| SIMPLEX TRADING, LLC | Added | $3.5m200.4k shares |
| DIADEMA PARTNERS LP | First filing | $1.8m100.0k shares |
| WOLVERINE TRADING, LLC | Added | $1.4m81.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $4.5m253.6k shares |
| CITADEL ADVISORS LLC | Added | $3.4m189.8k shares |
| SIMPLEX TRADING, LLC | Added | $1.9m108.6k shares |
| GROUP ONE TRADING LLC | Added | $1.8m100.0k shares |
| JANE STREET GROUP, LLC | New | $695.8k39.4k shares |
| WOLVERINE TRADING, LLC | New | $442.6k25.7k shares |
| CITIGROUP INC | Reduced | $436.2k24.7k shares |
| Walleye Trading LLC | New | $63.6k3.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 13 | $1.4m | — |
| Q2 2023 | 0 | — | 10 | $448.1k | — |
| Q3 2023 | 0 | — | 2 | $215.3k | $171.7k |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 3 | $339.8k | — |
| Q2 2024 | 0 | — | 12 | $138.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 2 | $1.5m | $1.5m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-10 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $1.5m100.0k shares |
| 2024-12-09 | Kapusta Matthew C CEO, Managing Director, director | Sold | $26.1k3.4k shares |
| 2024-12-09 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $13.6k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| EcoR1 Capital, LLC 2.40% of their portfolio | 3.4m $60.0m | New |
| Vestal Point Capital, LP 3.17% of their portfolio | 3.0m $53.4m | Reduced -1.7m |
| Nantahala Capital Management, LLC 3.03% of their portfolio | 2.5m $43.3m | Reduced -327.6k |
| Avoro Capital Advisors LLC 0.54% of their portfolio | 2.2m $38.4m | New |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 2.0m $35.1m | Added +494.7k |
| Point72 Asset Management, L.P. 0.09% of their portfolio | 1.8m $31.3m | Added +794.5k |
| 683 Capital Management, LLC 2.65% of their portfolio | 1.5m $26.9m | Reduced -325.0k |
| Aberdeen Group plc 0.05% of their portfolio | 1.5m $26.7m | Reduced -419.7k |
| BlackRock, Inc. 0.00% of their portfolio | 1.4m $25.0m | Reduced -147.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.1m $19.5m | Reduced -128.3k |
| Integral Health Asset Management, LLC 1.72% of their portfolio | 1.1m $19.4m | Added +700.0k |
| FMR LLC 0.00% of their portfolio | 966.6k $17.1m | Added +616.1k |
| RTW INVESTMENTS, LP 0.24% of their portfolio | 903.6k $16.0m | Added +893.6k |
| Catalio Capital Management, LP 3.48% of their portfolio | 902.0k $15.9m | First filing |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 878.9k $15.5m | Added +74.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 834.1k $14.4m | Reduced -634.6k |
| TWO SIGMA ADVISERS, LP 0.03% of their portfolio | 756.9k $13.4m | Added +10.4k |
| Boxer Capital Management, LLC 1.13% of their portfolio | 750.0k $13.2m | First filing |
| Privium Fund Management B.V. 2.97% of their portfolio | 742.2k $13.1m | Reduced -2.8k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 729.4k $12.9m | Reduced -396.2k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 706.2k $12.5m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 697.3k $12.3m | Reduced -3.4k |
| Invesco Ltd. 0.00% of their portfolio | 613.6k $10.8m | Added +502.7k |
| Pale Fire Capital SE 2.40% of their portfolio | 580.7k $10.3m | Added +244.2k |
| Schonfeld Strategic Advisors LLC 0.06% of their portfolio | 536.4k $9.5m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 531.8k $9.4m | Reduced -334.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 520.6k $9.2m | Added +12.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 486.8k $8.6m | Added +326.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 468.4k $8.3m | Added +41.2k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 464.5k $8.2m | Reduced -1.7m |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 453.8k $8.0m | Reduced -337.3k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 359.2k $6.3m | Added +125.7k |
| LORD, ABBETT & CO. LLC 0.02% of their portfolio | 314.4k $5.6m | New |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 299.8k $5.3m | Reduced -443.7k |
| PFM Health Sciences, LP 0.38% of their portfolio | 283.2k $5.0m | Added +161.5k |
| Parkman Healthcare Partners LLC 0.65% of their portfolio | 275.0k $4.9m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 270.0k $4.8m | Reduced -7.3k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 257.8k $4.6m | Reduced -184.3k |
| Avidity Partners Management LP 0.39% of their portfolio | 222.0k $3.9m | Reduced -451.6k |
| Jump Financial, LLC 0.08% of their portfolio | 211.8k $3.7m | Added +139.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 203.9k $3.6m | Added +25.3k |
| STATE STREET CORP 0.00% of their portfolio | 192.5k $3.4m | Added +17.6k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.08% of their portfolio | 192.2k $3.4m | Reduced -6.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 177.2k $3.1m | New |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 175.0k $3.1m | Reduced -460.5k |
| MOORE CAPITAL MANAGEMENT, LP 0.05% of their portfolio | 150.0k $2.6m | Added +50.0k |
| UBS Group AG 0.00% of their portfolio | 143.8k $2.5m | Added +138.9k |
| Trexquant Investment LP 0.03% of their portfolio | 143.1k $2.5m | New |
| Woodline Partners LP 0.02% of their portfolio | 140.6k $2.5m | New |
| Monaco Asset Management SAM 1.07% of their portfolio | 136.7k $2.4m | New |
| GROUP ONE TRADING LLC 0.08% of their portfolio | 130.8k $2.3m | Reduced -23.1k |
| Walleye Capital LLC 0.02% of their portfolio | 130.4k $2.3m | Added +40.3k |
| Campbell & CO Investment Adviser LLC 0.17% of their portfolio | 123.2k $2.2m | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 110.5k $2.0m | First filing |
| SANDERS MORRIS HARRIS LLC 0.27% of their portfolio | 102.1k $1.8m | Added +34.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.39% of their portfolio | 100.0k $1.8m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 95.6k $1.7m | Added +1.9k |
| STEMPOINT CAPITAL LP 0.40% of their portfolio | 90.0k $1.6m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 82.3k $1.5m | Reduced -1.3k |
| Marex Group Ltd 0.02% of their portfolio | 80.0k $1.4m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 79.3k $1.4m | Reduced -243.8k |
| SIMPLEX TRADING, LLC 0.04% of their portfolio | 77.6k $1.4m | Added +36.6k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 73.6k $1.3m | Reduced -197.8k |
| SECTORAL ASSET MANAGEMENT INC 0.84% of their portfolio | 71.5k $1.3m | Reduced -81.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 71.0k $1.3m | Added +4.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 69.1k $1.2m | Reduced -182.4k |
| Quinn Opportunity Partners LLC 0.09% of their portfolio | 69.0k $1.2m | Added +45.0k |
| Diamond Hill Capital Management, LLC (Investment Advisor) 0.01% of their portfolio | 67.3k $1.2m | Reduced -9.3k |
| Shay Capital LLC 0.25% of their portfolio | 56.8k $1.0m | Reduced -18.4k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 56.2k $991.9k | Reduced -4.8k |
| J. Goldman & Co LP 0.03% of their portfolio | 51.1k $902.6k | Reduced -182.3k |
| Sonic GP LLC 1.95% of their portfolio | 50.0k $883.0k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 49.1k $866.3k | Reduced -69.0k |
| Sigma Planning Corp 0.03% of their portfolio | 46.7k $825.5k | Reduced -1.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 41.4k $731.3k | Reduced -41.1k |
| Birchview Capital, LP 0.29% of their portfolio | 40.0k $706.4k | Unchanged |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 38.5k $680.5k | First filing |
| PDT Partners, LLC 0.05% of their portfolio | 31.1k $549.2k | Reduced -26.1k |
| WOLVERINE TRADING, LLC 0.01% of their portfolio | 30.7k $529.1k | Added +20.4k |
| Y-Intercept (Hong Kong) Ltd 0.03% of their portfolio | 28.3k $500.1k | Reduced -29.0k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 24.8k $437.7k | Added +1.4k |
| Palumbo Wealth Management LLC 0.16% of their portfolio | 24.7k $437.1k | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 23.7k $417.8k | Reduced -50.8k |
| Lighthouse Investment Partners, LLC 0.02% of their portfolio | 22.5k $397.4k | New |
| Bellevue Group AG 0.01% of their portfolio | 22.5k $397.4k | New |
| DNB Asset Management AS 0.00% of their portfolio | 22.0k $389.0k | Reduced -5.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 21.7k $382.7k | Reduced -62.7k |
| Headlands Technologies LLC 0.03% of their portfolio | 18.4k $325.8k | New |
| PEAK6 LLC 0.01% of their portfolio | 18.2k $321.2k | First filing |
| OPPENHEIMER & CO INC 0.00% of their portfolio | 18.1k $319.6k | New |
| Clear Harbor Asset Management, LLC 0.02% of their portfolio | 17.0k $300.2k | Reduced -2.5k |
| Rangeley Capital, LLC 0.28% of their portfolio | 16.7k $294.9k | First filing |
| XTX Topco Ltd 0.02% of their portfolio | 16.3k $287.5k | New |
| Total Clarity Wealth Management, Inc. 0.09% of their portfolio | 15.3k $271.1k | Reduced -1.1k |
| Squarepoint Ops LLC 0.00% of their portfolio | 14.6k $257.6k | Reduced -9.4k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 14.0k $246.4k | Added +816 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 12.3k $217.1k | Added +1.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 12.0k $212.0k | Reduced -104.5k |
| China Universal Asset Management Co., Ltd. 0.02% of their portfolio | 11.1k $195.4k | Added +969 |
| Corient Private Wealth LP 0.00% of their portfolio | 10.6k $187.7k | Unchanged |