ENTERA BIO LTD ENTX
SHS · Common Stock · CUSIP M40527109
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 173.1m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.77. Options: 1 managers hold calls ($4.8k notional), 2 hold puts ($18.9k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 10 |
| Q4 2022 | 13 |
| Q1 2023 | 10 |
| Q2 2023 | 13 |
| Q3 2023 | 13 |
| Q4 2023 | 11 |
| Q1 2024 | 16 |
| Q2 2024 | 16 |
| Q3 2024 | 18 |
| Q4 2024 | 15 |
| Q1 2025 | 19 |
| Q2 2025 | 20 |
| Q3 2025 | 22 |
| Q4 2025 | 22 |
| Q1 2026 | 26 |
| Q2 2026 | 27 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 6 | 4 |
| Q4 2024 | 7 | 7 |
| Q1 2025 | 8 | 3 |
| Q2 2025 | 9 | 6 |
| Q3 2025 | 9 | 8 |
| Q4 2025 | 9 | 8 |
| Q1 2026 | 13 | 11 |
| Q2 2026 | 15 | 12 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $40.9k | $0 | 0.00 |
| Q4 2025 | $14.7k | $0 | 0.00 |
| Q1 2026 | $0 | $0 | — |
| Q2 2026 | $4.8k | $18.9k | 3.96 |
Biggest buyers
| BVF INC/IL | New | +2.4m |
| Siren, L.L.C. | New | +736.5k |
| PNC Financial Services Group, Inc. | Added | +263.0k |
| HRT FINANCIAL LP | Added | +57.0k |
| TWO SIGMA SECURITIES, LLC | New | +48.6k |
| HighTower Advisors, LLC | Added | +37.7k |
| Virtu Financial LLC | New | +36.9k |
| JPMORGAN CHASE & CO | Added | +33.7k |
| SIMPLEX TRADING, LLC | New | +15.7k |
| SG Americas Securities, LLC | New | +13.9k |
Biggest sellers
| CITADEL ADVISORS LLC | Reduced | -206.8k |
| MARSHALL WACE, LLP | Sold out | -195.8k |
| NORTHERN TRUST CORP | Sold out | -146.9k |
| XTX Topco Ltd | Reduced | -111.1k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -104.6k |
| JANE STREET GROUP, LLC | Reduced | -15.6k |
| Seven Fleet Capital Management LP | Reduced | -14.2k |
| Parkman Healthcare Partners LLC | Reduced | -14.2k |
| Point72 Asset Management, L.P. | Sold out | -12.4k |
| BANK OF AMERICA CORP /DE/ | Sold out | -12.0k |
Biggest calls
| SIMPLEX TRADING, LLC | New | $4.8k2.7k shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $17.9k10.1k shares |
| SIMPLEX TRADING, LLC | New | $1.1k600 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BIOTECHNOLOGY VALUE FUND L P
13D · may seek influence
new · filed 2026-08-04
Stated purposeThe Reporting Persons purchased the securities reported owned herein based on the Reporting Persons' belief that such securities, when purchased, were undervalued and represented an attractive investment opportunity. Depending upon overall market conditions, other investment opportunities available to the Reporting Persons, and the availability of Shares at prices that would make the purchase or sale of Shares desirable, the Reporting Persons may endeavor to increase or decrease their position in the Issuer through, among other things, the purchase or sale of Shares on the open market or in private transactions or otherwise, on such terms and at such times as the Reporting Persons may deem advisable. April Securities Purchase Agreement and Registration Rights Agreement On April 1, 2026, … Full filing |
10.0% |
| OPKO HEALTH, INC. 13G · passive investor new · filed 2025-04-02 | 8.1% |
| TCG Crossover GP III, LLC 13G · passive investor new · filed 2026-08-04 | 7.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-08-04 | 6.9% |
Fell to 5% or below in the last year: Longitude Capital Partners V, LLC (4.6%, 2026-08-04), Seven Fleet Capital Management LP (4.1%, 2026-08-04), Point72 Asset Management, L.P. (2.6%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $19.9k | 0 | — | — |
| Q1 2026 | 4 | $121.0k | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Knoll Capital Management, LLC 5.81% of their portfolio | 5.9m $10.4m | Unchanged |
| BVF INC/IL 0.11% of their portfolio | 2.4m $4.3m | New |
| Siren, L.L.C. 0.03% of their portfolio | 736.5k $1.3m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 368.8k $652.9k | Reduced -104.6k |
| Parkman Healthcare Partners LLC 0.05% of their portfolio | 274.5k $485.9k | Reduced -14.2k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 273.0k $483.3k | Added +263.0k |
| Seven Fleet Capital Management LP 0.06% of their portfolio | 191.4k $338.7k | Reduced -14.2k |
| HighTower Advisors, LLC 0.00% of their portfolio | 74.6k $132.9k | Added +37.7k |
| HRT FINANCIAL LP 0.00% of their portfolio | 72.5k $128.0k | Added +57.0k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 58.9k $104.2k | Added +3.6k |
| TWO SIGMA SECURITIES, LLC 0.01% of their portfolio | 48.6k $86.0k | New |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC 0.00% of their portfolio | 47.3k $83.8k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 40.9k $67.5k | Added +33.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 38.8k $68.7k | Reduced -206.8k |
| Virtu Financial LLC 0.00% of their portfolio | 36.9k $65.0k | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 29.9k $52.9k | Added +8.8k |
| DIADEMA PARTNERS LP 0.01% of their portfolio | 23.3k $41.2k | Unchanged |
| XTX Topco Ltd 0.00% of their portfolio | 20.6k $36.4k | Reduced -111.1k |
| Gem Investment Advisors, LLC 0.02% of their portfolio | 19.1k $33.9k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 17.3k $30.7k | Reduced -15.6k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 15.7k $27.8k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 13.9k $25.0k | New |
| UBS Group AG 0.00% of their portfolio | 12.7k $22.5k | Added +9.5k |
| Persistent Asset Partners Ltd 0.00% of their portfolio | 5.9k $10.4k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 500 $885 | Added +100 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 400 $708 | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 51 $90 | Unchanged |