CRISPR THERAPEUTICS AG CRSP
NAMEN AKT · Common Stock · CUSIP H17182108
Company in Basel, Switzerland
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersZug, Switzerland
- Founded2013
- Websitecrisprtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($95.2m this quarter). Holder counts are more reliable. Shares outstanding: 96.7m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $54.52. Options: 21 managers hold calls ($92.8m notional), 19 hold puts ($95.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 437 |
| Q4 2022 | 398 |
| Q1 2023 | 381 |
| Q2 2023 | 419 |
| Q3 2023 | 409 |
| Q4 2023 | 473 |
| Q1 2024 | 484 |
| Q2 2024 | 450 |
| Q3 2024 | 417 |
| Q4 2024 | 405 |
| Q1 2025 | 399 |
| Q2 2025 | 436 |
| Q3 2025 | 441 |
| Q4 2025 | 482 |
| Q1 2026 | 495 |
| Q2 2026 | 525 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 171 | 203 |
| Q4 2024 | 154 | 191 |
| Q1 2025 | 176 | 159 |
| Q2 2025 | 219 | 162 |
| Q3 2025 | 216 | 177 |
| Q4 2025 | 220 | 180 |
| Q1 2026 | 243 | 174 |
| Q2 2026 | 230 | 189 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $317.2m | $294.6m | 0.93 |
| Q4 2025 | $237.0m | $185.1m | 0.78 |
| Q1 2026 | $127.0m | $105.1m | 0.83 |
| Q2 2026 | $92.8m | $95.6m | 1.03 |
Biggest buyers
| D. E. Shaw & Co., Inc. | New | +893.8k |
| BlackRock, Inc. | Added | +668.9k |
| TWO SIGMA INVESTMENTS, LP | Added | +505.6k |
| STATE STREET CORP | Added | +339.2k |
| Logos Global Management LP | New | +300.0k |
| MORGAN STANLEY | Added | +211.8k |
| BANK OF AMERICA CORP /DE/ | Added | +172.0k |
| Jump Financial, LLC | Added | +170.5k |
| Life Cycle Investment Partners Ltd | New | +143.7k |
| Squarepoint Ops LLC | Added | +133.2k |
Biggest sellers
| ARK Investment Management LLC | Reduced | -1.9m |
| LOOMIS SAYLES & CO L P | Sold out | -968.1k |
| T. Rowe Price Investment Management, Inc. | Reduced | -899.6k |
| Orbis Allan Gray Ltd | Reduced | -656.9k |
| UBS Group AG | Reduced | -445.0k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -218.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -166.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -156.2k |
| GOLDMAN SACHS GROUP INC | Reduced | -141.8k |
| Amova Asset Management Americas, Inc. | Reduced | -133.8k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $17.8m325.7k shares |
| IMC-Chicago, LLC | Reduced | $16.7m305.8k shares |
| CITADEL ADVISORS LLC | Reduced | $14.0m256.2k shares |
| JANE STREET GROUP, LLC | Reduced | $12.6m230.4k shares |
| D. E. Shaw & Co., Inc. | Reduced | $5.9m108.2k shares |
| PEAK6 LLC | Reduced | $3.8m70.3k shares |
| MILLENNIUM MANAGEMENT LLC | New | $3.1m57.7k shares |
| Walleye Trading LLC | Added | $3.0m55.1k shares |
| Caption Management, LLC | Added | $3.0m55.0k shares |
| CITIGROUP INC | Reduced | $2.8m51.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $18.5m338.4k shares |
| CITADEL ADVISORS LLC | Reduced | $15.8m290.1k shares |
| IMC-Chicago, LLC | Added | $13.8m253.8k shares |
| PEAK6 LLC | Reduced | $11.6m213.3k shares |
| GROUP ONE TRADING LLC | Reduced | $6.6m120.2k shares |
| SFE Investment Counsel | New | $6.2m16.7k shares |
| JANE STREET GROUP, LLC | Reduced | $5.9m107.3k shares |
| Walleye Trading LLC | Added | $3.5m64.7k shares |
| CITIGROUP INC | New | $2.8m51.0k shares |
| WOLVERINE ASSET MANAGEMENT LLC | New | $2.7m50.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARK Investment Management LLC 13G · institution +1.0 pts · filed 2026-04-30 | 11.8% |
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-07-27 | 8.3% |
| ORBIS INVESTMENT MANAGEMENT LTD 13G · institution -0.7 pts · filed 2026-08-14 | 5.6% |
| Capital World Investors 13G · institution new · filed 2026-05-14 | 5.1% |
Fell to 5% or below in the last year: Capital International Investors (1.2%, 2026-02-05)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 2 | $2.7m | $2.5m |
| Q1 2025 | 1 | $313.9k | 4 | $4.4m | $2.0m |
| Q2 2025 | 1 | $49.7k | 1 | $141.3k | — |
| Q3 2025 | 2 | $52.6m | 1 | $760.7k | — |
| Q4 2025 | 0 | — | 3 | $4.4m | $559.5k |
| Q1 2026 | 0 | — | 4 | $12.3m | $9.1m |
| Q2 2026 | 0 | — | 1 | $210.6k | — |
| Q3 2026 | 0 | — | 2 | $1.4m | $626.5k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-22 | KASINGER JAMES R. General Counsel and Secretary | Sold plan | $626.5k10.4k shares |
| 2026-09-17 | Behbahani Ali Director | Sold | $780.9k13.7k shares |
| 2026-05-29 | Patel Naimish Chief Medical Officer | Sold | $210.6k3.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 3.35% of their portfolio | 9.5m $516.0m | Reduced -1.9m |
| BlackRock, Inc. 0.01% of their portfolio | 8.3m $455.4m | Added +668.9k |
| Orbis Allan Gray Ltd 1.02% of their portfolio | 5.4m $297.2m | Reduced -656.9k |
| Capital World Investors 0.03% of their portfolio | 4.7m $259.0m | Added +24.5k |
| STATE STREET CORP 0.01% of their portfolio | 4.3m $235.7m | Added +339.2k |
| GSK plc 29.17% of their portfolio | 3.2m $175.7m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.5m $136.9m | Added +132.8k |
| T. Rowe Price Investment Management, Inc. 0.07% of their portfolio | 2.1m $112.0m | Reduced -899.6k |
| SR One Capital Management, LP 10.70% of their portfolio | 2.0m $111.2m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.08% of their portfolio | 2.0m $108.5m | Added +505.6k |
| FMR LLC 0.00% of their portfolio | 1.9m $104.1m | Reduced -46.2k |
| Sumitomo Mitsui Trust Group, Inc. 0.05% of their portfolio | 1.7m $93.8m | Reduced -133.1k |
| Amova Asset Management Americas, Inc. 1.21% of their portfolio | 1.7m $93.8m | Reduced -133.8k |
| EcoR1 Capital, LLC 3.76% of their portfolio | 1.4m $75.8m | Unchanged |
| UBS Group AG 0.01% of their portfolio | 1.3m $71.9m | Reduced -445.0k |
| Capital International Investors 0.01% of their portfolio | 1.3m $69.2m | Added +81.6k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.2m $64.5m | Added +39.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.2m $63.0m | Added +172.0k |
| NEA Management Company, LLC 3.64% of their portfolio | 1.1m $57.7m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.1m $57.7m | Added +18.5k |
| D. E. Shaw & Co., Inc. 0.03% of their portfolio | 893.8k $48.7m | New |
| MORGAN STANLEY 0.00% of their portfolio | 879.9k $48.0m | Added +211.8k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 863.1k $47.1m | Added +60.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 648.7k $35.4m | Added +101.9k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 570.0k $31.1m | Added +27.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 465.8k $25.4m | Reduced -50.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 431.7k $24.6m | Reduced -26.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 427.2k $23.3m | Reduced -166.2k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 382.0k $20.8m | Added +4.9k |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 1.33% of their portfolio | 382.0k $20.8m | Reduced -18.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 326.8k $17.8m | Added +15.4k |
| Logos Global Management LP 0.70% of their portfolio | 300.0k $16.4m | New |
| Squarepoint Ops LLC 0.03% of their portfolio | 286.8k $15.6m | Added +133.2k |
| Jump Financial, LLC 0.14% of their portfolio | 278.0k $15.2m | Added +170.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 275.4k $15.0m | Reduced -218.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 272.4k $14.9m | Reduced -141.8k |
| NORGES BANK 0.00% of their portfolio | 270.8k $14.8m | Not comparable |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 263.2k $14.4m | Reduced -17.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 250.6k $13.7m | Reduced -36.2k |
| Vestmark Advisory Solutions, Inc. 0.12% of their portfolio | 242.3k $13.2m | Reduced -14.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 232.0k $12.7m | Added +11.7k |
| Nuveen, LLC 0.00% of their portfolio | 203.1k $11.1m | Added +12.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 173.0k $9.4m | Added +9.3k |
| Marex Group Ltd 0.07% of their portfolio | 170.6k $9.3m | Added +36.5k |
| Swiss National Bank 0.00% of their portfolio | 169.2k $9.2m | Reduced -500 |
| Susquehanna Portfolio Strategies, LLC 0.14% of their portfolio | 164.0k $8.9m | Added +58.7k |
| Legal & General Group Plc 0.00% of their portfolio | 163.8k $8.9m | Added +88.2k |
| LPL Financial LLC 0.00% of their portfolio | 153.6k $8.4m | Added +1.5k |
| Versant Venture Management, LLC 4.99% of their portfolio | 148.8k $8.1m | Unchanged |
| Life Cycle Investment Partners Ltd 0.04% of their portfolio | 143.7k $7.8m | New |
| TD Asset Management Inc 0.01% of their portfolio | 142.6k $7.8m | Reduced -15.8k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 142.2k $8.0m | Reduced -11.8k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 139.5k $7.6m | Added +19.0k |
| HRT FINANCIAL LP 0.02% of their portfolio | 134.7k $7.3m | Added +64.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 128.6k $7.0m | Added +23.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 122.7k $6.7m | Added +27.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 121.5k $6.6m | Added +6.7k |
| KBC Group NV 0.01% of their portfolio | 116.8k $6.4m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 114.3k $5.4m | Added +18.0k |
| CITIGROUP INC 0.00% of their portfolio | 114.3k $6.2m | Added +92.3k |
| Private Advisor Group, LLC 0.03% of their portfolio | 111.1k $6.1m | Added +4.5k |
| EverSource Wealth Advisors, LLC 0.20% of their portfolio | 110.7k $6.0m | Added +21.0k |
| CONGRESS ASSET MANAGEMENT CO 0.04% of their portfolio | 109.5k $6.0m | Added +1.1k |
| Campbell & CO Investment Adviser LLC 0.31% of their portfolio | 107.5k $5.9m | New |
| California Public Employees Retirement System 0.00% of their portfolio | 102.7k $5.6m | Reduced -13.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 101.9k $5.6m | Added +18.5k |
| Rockefeller Capital Management L.P. 0.01% of their portfolio | 101.6k $5.5m | Added +28.3k |
| CAPITAL INTERNATIONAL SARL 0.08% of their portfolio | 101.2k $5.5m | Reduced -1.0k |
| Affinity Asset Advisors, LLC 0.27% of their portfolio | 100.0k $5.5m | Reduced -50.0k |
| CLOUGH CAPITAL PARTNERS L P 0.44% of their portfolio | 98.3k $5.4m | Added +73.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 98.2k $5.4m | Reduced -3.1k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.01% of their portfolio | 94.8k $5.2m | Added +8.8k |
| Slow Capital, Inc. 0.59% of their portfolio | 92.9k $5.1m | Added +1.7k |
| Cambridge Investment Research Advisors, Inc. 0.01% of their portfolio | 92.4k $5.0m | Added +54.4k |
| Concurrent Investment Advisors, LLC 0.04% of their portfolio | 90.5k $4.9m | Added +28.1k |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 89.2k $4.9m | Reduced -6.5k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 86.5k $4.7m | Added +9.7k |
| CREDIT AGRICOLE S A 0.01% of their portfolio | 85.9k $4.7m | New |
| GROUP ONE TRADING LLC 0.13% of their portfolio | 85.0k $4.6m | Reduced -11.0k |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. 0.28% of their portfolio | 83.9k $4.6m | Reduced -8.6k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.02% of their portfolio | 82.5k $4.5m | New |
| OSAIC HOLDINGS, INC. 0.01% of their portfolio | 79.5k $4.3m | Added +19.4k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 78.0k $4.3m | New |
| Trexquant Investment LP 0.03% of their portfolio | 77.5k $4.2m | Reduced -49.7k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.01% of their portfolio | 76.9k $4.2m | Reduced -1.6k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 76.3k $4.2m | Added +28.8k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 73.8k $4.1m | Added +10.2k |
| Man Group plc 0.01% of their portfolio | 73.2k $4.0m | Reduced -16.9k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 70.1k $3.8m | Reduced -12.1k |
| Shah Wealth Advisors, LLC 0.87% of their portfolio | 69.1k $3.8m | First filing |
| ALGERT GLOBAL LLC 0.04% of their portfolio | 65.9k $3.6m | Reduced -30.9k |
| Invesco Ltd. 0.00% of their portfolio | 65.0k $3.5m | Added +872 |
| Curi Capital, LLC 0.05% of their portfolio | 59.0k $3.2m | Added +9.3k |
| CAPITAL INTERNATIONAL LTD /CA/ 0.10% of their portfolio | 56.1k $3.1m | Unchanged |
| NOMURA HOLDINGS INC 0.01% of their portfolio | 56.0k $3.1m | Added +50.8k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 55.8k $3.0m | Reduced -34.5k |
| Green Alpha Advisors, LLC 2.04% of their portfolio | 55.8k $3.0m | Reduced -1.2k |
| BENJAMIN EDWARDS INC 0.03% of their portfolio | 54.5k $3.0m | Reduced -1.0k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 54.2k $3.0m | Added +4.6k |
| Quantinno Capital Management LP 0.00% of their portfolio | 52.6k $2.9m | Added +4.6k |