PROTHENA CORP PLC PRTA
SHS · Common Stock · CUSIP G72800108
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($810.7k this quarter). Holder counts are more reliable. Shares outstanding: 51.3m as of 2026-07-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.84. Options: 6 managers hold calls ($8.8m notional), 5 hold puts ($5.3m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 183 |
| Q4 2022 | 201 |
| Q1 2023 | 192 |
| Q2 2023 | 197 |
| Q3 2023 | 188 |
| Q4 2023 | 188 |
| Q1 2024 | 170 |
| Q2 2024 | 161 |
| Q3 2024 | 166 |
| Q4 2024 | 172 |
| Q1 2025 | 162 |
| Q2 2025 | 190 |
| Q3 2025 | 187 |
| Q4 2025 | 182 |
| Q1 2026 | 185 |
| Q2 2026 | 188 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 68 | 65 |
| Q4 2024 | 86 | 67 |
| Q1 2025 | 57 | 82 |
| Q2 2025 | 104 | 64 |
| Q3 2025 | 89 | 93 |
| Q4 2025 | 86 | 81 |
| Q1 2026 | 92 | 74 |
| Q2 2026 | 84 | 80 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $7.5m | $15.1m | 2.01 |
| Q4 2025 | $6.7m | $8.0m | 1.19 |
| Q1 2026 | $3.6m | $2.5m | 0.69 |
| Q2 2026 | $8.8m | $5.3m | 0.60 |
Biggest buyers
| ACADIAN ASSET MANAGEMENT LLC | Added | +463.1k |
| STATE STREET CORP | Added | +454.9k |
| Man Group plc | Added | +296.5k |
| MACKENZIE FINANCIAL CORP | New | +239.9k |
| BlackRock, Inc. | Added | +223.8k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +205.3k |
| Qube Research & Technologies Ltd | Added | +176.6k |
| GOLDMAN SACHS GROUP INC | Added | +160.8k |
| DIADEMA PARTNERS LP | New | +149.5k |
| MARSHALL WACE, LLP | Added | +146.3k |
Biggest sellers
| ARMISTICE CAPITAL, LLC | Sold out | -439.4k |
| Point72 Asset Management, L.P. | Sold out | -399.8k |
| FMR LLC | Reduced | -352.0k |
| Walleye Capital LLC | Sold out | -277.2k |
| MORGAN STANLEY | Reduced | -235.1k |
| Nuveen, LLC | Reduced | -202.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -185.4k |
| MONIMUS CAPITAL MANAGEMENT, LP | Reduced | -156.6k |
| D. E. Shaw & Co., Inc. | Reduced | -151.9k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -108.8k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.1m420.9k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $1.5m149.9k shares |
| CITADEL ADVISORS LLC | Added | $1.1m116.9k shares |
| JANE STREET GROUP, LLC | Added | $1.0m103.6k shares |
| SIMPLEX TRADING, LLC | Added | $988.8k101.0k shares |
| GROUP ONE TRADING LLC | Reduced | $56.8k5.8k shares |
Biggest puts
| GROUP ONE TRADING LLC | Added | $2.2m220.4k shares |
| CITADEL ADVISORS LLC | Added | $1.4m142.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $646.1k66.0k shares |
| SIMPLEX TRADING, LLC | Added | $595.2k60.8k shares |
| JANE STREET GROUP, LLC | Added | $465.0k47.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution filed 2026-08-06 | 13.8% |
| SCULLY WILLIAM P 13G · passive investor +0.5 pts · filed 2026-05-11 | 10.3% |
| Fennell Todd W. 13G · passive investor +0.4 pts · filed 2026-08-19 | 10.2% |
| Rubric Capital Management LP 13G · institution +2.5 pts · filed 2026-05-15 | 9.3% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-29 | 6.9% |
Fell to 5% or below in the last year: ADAR1 Capital Management, LLC (2.7%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 2 | $135.9k | $135.9k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-29 | SCULLY WILLIAM P 10% owner · By Spouse | Bought | $1.4m162.0k shares |
| 2026-09-28 | SCULLY WILLIAM P 10% owner · By Manatee Equity Fund LLC | Bought | $890.1k103.5k shares |
| 2026-09-18 | SCULLY WILLIAM P 10% owner | Bought | $843.0k100.0k shares |
| 2026-09-02 | SCULLY WILLIAM P 10% owner | Bought | $255.7k27.0k shares |
| 2026-08-20 | SCULLY WILLIAM P 10% owner | Bought | $439.5k50.0k shares |
| 2026-08-07 | SCULLY WILLIAM P 10% owner | Bought | $293.1k34.0k shares |
| 2026-08-07 | SCULLY WILLIAM P 10% owner | Bought | $30.2k3.5k shares |
| 2026-07-29 | Isaacs Michael John General Counsel & Company Sec. | Sold plan | $71.0k8.4k shares |
| 2026-07-29 | Kingston Anne Evans Chief Strategy Officer | Sold plan | $64.9k7.7k shares |
| 2026-06-16 | SCULLY WILLIAM P 10% owner | Bought | $158.0k20.0k shares |
| 2026-06-11 | SCULLY WILLIAM P 10% owner | Bought | $1.0m125.0k shares |
| 2026-06-04 | SCULLY WILLIAM P 10% owner | Bought | $465.5k50.0k shares |
| 2026-06-02 | SCULLY WILLIAM P 10% owner | Bought | $471.5k50.0k shares |
| 2026-05-22 | SCULLY WILLIAM P 10% owner | Bought | $981.0k100.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 7.2m $70.5m | Reduced -352.0k |
| Rubric Capital Management LP 0.45% of their portfolio | 5.0m $49.0m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 4.9m $47.7m | Added +223.8k |
| STATE STREET CORP 0.00% of their portfolio | 2.4m $23.4m | Added +454.9k |
| ACADIAN ASSET MANAGEMENT LLC 0.02% of their portfolio | 2.0m $19.7m | Added +463.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.7m $16.2m | Added +205.3k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 1.6m $15.8m | Reduced -151.9k |
| ADAR1 Capital Management, LLC 0.72% of their portfolio | 1.6m $15.2m | Reduced -26.9k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 1.3m $12.4m | Added +59.0k |
| Palo Alto Investors LP 1.55% of their portfolio | 1.1m $11.2m | Reduced -65.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.1m $11.0m | Added +27.7k |
| FEDERATED HERMES, INC. 0.02% of their portfolio | 1.1m $10.6m | Added +24.6k |
| MORGAN STANLEY 0.00% of their portfolio | 995.3k $9.7m | Reduced -235.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 979.7k $9.6m | Added +160.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.03% of their portfolio | 966.0k $9.5m | Reduced -6.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 905.7k $8.9m | Added +123.0k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 791.2k $7.7m | Added +176.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 697.6k $6.8m | Added +90.1k |
| Man Group plc 0.01% of their portfolio | 678.1k $6.6m | Added +296.5k |
| Mariner, LLC 0.01% of their portfolio | 625.1k $6.1m | Added +62.0k |
| Nuveen, LLC 0.00% of their portfolio | 557.2k $5.5m | Reduced -202.2k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 479.9k $4.7m | Reduced -4.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 457.1k $4.5m | Added +87.6k |
| Birchview Capital, LP 2.06% of their portfolio | 449.0k $4.4m | Unchanged |
| Rangeley Capital, LLC 3.80% of their portfolio | 417.3k $4.1m | Reduced -32.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 355.9k $3.5m | Reduced -769 |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 338.8k $3.3m | Reduced -96.8k |
| MONIMUS CAPITAL MANAGEMENT, LP 0.82% of their portfolio | 329.1k $3.2m | Reduced -156.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 315.8k $3.1m | Reduced -108.8k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 302.6k $3.0m | Added +98.6k |
| Penbrook Management LLC 1.70% of their portfolio | 271.7k $2.7m | Unchanged |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 259.1k $2.5m | Added +4.5k |
| UBS Group AG 0.00% of their portfolio | 241.4k $2.4m | Reduced -87.1k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 239.9k $2.3m | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 224.0k $2.2m | Reduced -6.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 208.2k $2.0m | Reduced -185.4k |
| Focused Wealth Management, Inc 0.18% of their portfolio | 207.4k $2.0m | Added +42 |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 191.7k $1.9m | Added +35.1k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 190.8k $1.9m | Added +146.3k |
| Quantinno Capital Management LP 0.00% of their portfolio | 158.3k $1.6m | Added +14.0k |
| DIADEMA PARTNERS LP 0.52% of their portfolio | 149.5k $1.5m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 133.9k $1.3m | Reduced -2.4k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 127.0k $1.2m | Reduced -5.1k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 125.6k $1.2m | Added +48.8k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 121.9k $1.2m | Added +21.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 109.3k $1.1m | Added +13.6k |
| Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio | 90.8k $888.9k | Added +2.3k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 90.6k $887.4k | Added +11.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 87.2k $853.8k | Reduced -2.0k |
| XTX Topco Ltd 0.01% of their portfolio | 85.7k $839.2k | Reduced -6.6k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 82.7k $809.7k | Added +14.8k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 82.0k $803.0k | Added +70.9k |
| MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio | 78.8k $771.5k | Added +9.7k |
| Trexquant Investment LP 0.00% of their portfolio | 76.7k $751.2k | Added +52.2k |
| DCF Advisers, LLC 0.19% of their portfolio | 73.2k $717.1k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 71.5k $699.8k | Added +21.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 70.3k $688.5k | New |
| Duncan Williams Asset Management, LLC 0.16% of their portfolio | 70.3k $688.1k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 69.2k $672.8k | Reduced -390 |
| Campbell & CO Investment Adviser LLC 0.04% of their portfolio | 68.3k $669.1k | Reduced -74.2k |
| Creative Planning 0.00% of their portfolio | 62.6k $613.0k | Reduced -10.4k |
| PINNACLE ASSOCIATES LTD 0.01% of their portfolio | 57.9k $567.0k | Reduced -2.7k |
| CITIGROUP INC 0.00% of their portfolio | 57.8k $566.1k | Added +49.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 55.9k $547.2k | Added +529 |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 50.4k $492.9k | Added +38.0k |
| EDGEWOOD MANAGEMENT LLC 0.01% of their portfolio | 50.0k $489.5k | Unchanged |
| Quinn Opportunity Partners LLC 0.02% of their portfolio | 50.0k $489.5k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 49.6k $492.2k | Reduced -15.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 49.5k $484.8k | Added +22.2k |
| Seven Fleet Capital Management LP 0.07% of their portfolio | 43.3k $423.9k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 43.3k $423.6k | Added +3.3k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 42.2k $412.7k | Unchanged |
| Engineers Gate Manager LP 0.01% of their portfolio | 41.3k $404.0k | New |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 40.4k $395.5k | Reduced -12.9k |
| Virtus Investment Advisers, LLC 0.09% of their portfolio | 39.7k $388.3k | Added +13.3k |
| SHELTON CAPITAL MANAGEMENT 0.01% of their portfolio | 39.5k $386.4k | New |
| Persistent Asset Partners Ltd 0.12% of their portfolio | 38.1k $373.0k | New |
| BARCLAYS PLC 0.00% of their portfolio | 37.6k $368.3k | Reduced -3.2k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 30.9k $302.3k | Added +13.6k |
| WINTON GROUP Ltd 0.01% of their portfolio | 30.5k $298.6k | Reduced -4.2k |
| RBF Capital, LLC 0.01% of their portfolio | 29.2k $285.9k | Unchanged |
| GREAT LAKES ADVISORS, LLC 0.00% of their portfolio | 28.7k $281.3k | Reduced -860 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 28.4k $277.9k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 26.6k $265.4k | Added +653 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 25.9k $253.5k | Added +6.4k |
| Aquatic Capital Management LLC 0.01% of their portfolio | 25.4k $248.9k | New |
| Covestor Ltd 0.14% of their portfolio | 25.2k $246.0k | Reduced -7.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 25.2k $247.3k | Added +535 |
| Purkiss Capital Advisors LLC 0.09% of their portfolio | 25.1k $245.6k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 24.4k $239.3k | Reduced -26 |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 24.0k $235.0k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 22.9k $224.3k | New |
| MOGY JOEL R INVESTMENT COUNSEL INC 0.01% of their portfolio | 20.8k $203.1k | Unchanged |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 20.6k $201.4k | Reduced -3.4k |
| Savant Capital, LLC 0.00% of their portfolio | 19.5k $190.2k | Added +9.4k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 19.4k $194.7k | Added +21 |
| Foundation Wealth Management, LLC 0.11% of their portfolio | 19.2k $188.3k | Unchanged |
| Graham Capital Management, L.P. 0.00% of their portfolio | 18.5k $181.1k | Added +5.7k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 18.2k $178.7k | Unchanged |
| STRS OHIO 0.00% of their portfolio | 17.9k $175.2k | Added +3.2k |