CRESCENT BIOPHARMA INC. CBIO
COM · Common Stock · CUSIP G2545C104
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 13.9m as of 2025-07-25, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $16.14. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).
Biggest buyers
| FMR LLC | New | +1.4m |
| Fairmount Funds Management LLC | New | +1.4m |
| Venrock Adviser, LLC | New | +1.4m |
| BVF INC/IL | New | +1.4m |
| Paradigm Biocapital Advisors LP | New | +642.7k |
| Logos Global Management LP | New | +553.7k |
| Commodore Capital LP | New | +453.7k |
| PERCEPTIVE ADVISORS LLC | New | +453.7k |
| Deep Track Capital, LP | New | +453.7k |
| Boxer Capital Management, LLC | New | +453.7k |
Biggest sellers
| None |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Fairmount Funds Management LLC
13D · may seek influence
-2.0 pts · filed 2026-07-20
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Fund II purchased the Ordinary Shares and Pre-funded Warrants referenced in Item 3 for investment purposes. Lock-Up Agreement In connection with the Company's underwritten public offering of Ordinary Shares and Pre-Funded Warrants that closed on July 16, 2026, the Reporting Persons entered into a customary lock-up letter agreement (the "Lock-Up Agreement") with Jefferies LLC and TD Securities (USA) LLC acting as the Representatives (collectively, the "Representatives") of the underwiters party to to an underwriting agreement with the Company. Pursuant to the Lock-Up Agreement, the Reporting Persons agreed to refrain from selling shares of the Company's securities without the consent of the Representatives, and other… Full filing |
16.5% |
| FMR LLC 13G · institution filed 2026-02-05 | 15.0% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2025-08-14 | 10.0% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor filed 2026-02-17 | 9.5% |
| ForGrowth III PA B.V. 13G · passive investor new · filed 2025-12-11 | 6.1% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.6% |
| Vestal Point Capital, LP 13G · institution new · filed 2026-02-17 | 5.4% |
Fell to 5% or below in the last year: TANG CAPITAL MANAGEMENT LLC (4.2%, 2026-05-15)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 1 | $90.3k | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 2 | $82.9k | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 1.4m $22.8m | New |
| Fairmount Funds Management LLC 2.90% of their portfolio | 1.4m $22.4m | New |
| Venrock Adviser, LLC 1.68% of their portfolio | 1.4m $22.4m | New |
| BVF INC/IL 0.80% of their portfolio | 1.4m $22.4m | New |
| Paradigm Biocapital Advisors LP 0.44% of their portfolio | 642.7k $10.4m | New |
| Logos Global Management LP 1.19% of their portfolio | 553.7k $8.9m | New |
| PERCEPTIVE ADVISORS LLC 0.27% of their portfolio | 453.7k $7.3m | New |
| Commodore Capital LP 0.52% of their portfolio | 453.7k $7.3m | New |
| Deep Track Capital, LP 0.24% of their portfolio | 453.7k $7.3m | New |
| Boxer Capital Management, LLC 3.69% of their portfolio | 453.7k $7.3m | New |
| Frazier Life Sciences Management, L.P. 0.29% of their portfolio | 453.7k $7.3m | New |
| Soleus Capital Management, L.P. 0.45% of their portfolio | 400.0k $6.5m | New |
| Driehaus Capital Management LLC 0.04% of their portfolio | 302.5k $4.9m | New |
| Affinity Asset Advisors, LLC 0.67% of their portfolio | 280.0k $4.5m | New |
| BRAIDWELL LP 0.14% of their portfolio | 261.5k $4.2m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 179.9k $2.9m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 100.9k $1.6m | New |
| Blackstone Inc. 0.01% of their portfolio | 75.6k $1.2m | New |
| TANG CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 50.2k $809.5k | New |
| Jefferies Financial Group Inc. 0.01% of their portfolio | 27.1k $437.3k | New |
| MORGAN STANLEY 0.00% of their portfolio | 15.4k $248.5k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 9.2k $149.0k | New |
| BlackRock, Inc. 0.00% of their portfolio | 6.1k $97.7k | New |
| BARCLAYS PLC 0.00% of their portfolio | 286 $4.6k | New |
| UBS Group AG 0.00% of their portfolio | 223 $3.6k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 162 $2.6k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 68 $1.1k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 50 $807 | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 40 $0 | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 4 $65 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | New |