Vault-13

CRESCENT BIOPHARMA INC. CBIO

COM · Common Stock · CUSIP G2545C104

31 institutional holders
10,751,78010.8m shares reported held*
77.4% of all shares outstanding*
$173.5mreported value*

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 13.9m as of 2025-07-25, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $16.14. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).

Biggest buyers

FMR LLC New +1,414,190+1.4m
Fairmount Funds Management LLC New +1,387,866+1.4m
Venrock Adviser, LLC New +1,387,864+1.4m
BVF INC/IL New +1,387,863+1.4m
Paradigm Biocapital Advisors LP New +642,721+642.7k
Logos Global Management LP New +553,686+553.7k
Commodore Capital LP New +453,686+453.7k
PERCEPTIVE ADVISORS LLC New +453,686+453.7k
Deep Track Capital, LP New +453,686+453.7k
Boxer Capital Management, LLC New +453,686+453.7k

Biggest sellers

None

Biggest calls

Biggest puts

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Fairmount Funds Management LLC 13D · may seek influence -2.0 pts · filed 2026-07-20
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Fund II purchased the Ordinary Shares and Pre-funded Warrants referenced in Item 3 for investment purposes. Lock-Up Agreement In connection with the Company's underwritten public offering of Ordinary Shares and Pre-Funded Warrants that closed on July 16, 2026, the Reporting Persons entered into a customary lock-up letter agreement (the "Lock-Up Agreement") with Jefferies LLC and TD Securities (USA) LLC acting as the Representatives (collectively, the "Representatives") of the underwiters party to to an underwriting agreement with the Company. Pursuant to the Lock-Up Agreement, the Reporting Persons agreed to refrain from selling shares of the Company's securities without the consent of the Representatives, and other… Full filing
16.5% -2.0 pts 6.6m≈ $118.8m 2026-07-20
FMR LLC 13G · institution filed 2026-02-05 15.0% 4.1m≈ $74.4m 2026-02-05
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2025-08-14 10.0% 1.4m≈ $25.0m 2025-08-14
Venrock Healthcare Capital Partners III, L.P. 13G · passive investor filed 2026-02-17 9.5% 2.7m≈ $48.0m 2026-02-17
ForGrowth III PA B.V. 13G · passive investor new · filed 2025-12-11 6.1% new 1.7m≈ $30.2m 2025-12-11
BlackRock, Inc. 13G · institution new · filed 2026-10-27 5.6% new 2.1m≈ $37.4m 2026-10-27
Vestal Point Capital, LP 13G · institution new · filed 2026-02-17 5.4% new 1.5m≈ $27.0m 2026-02-17

Fell to 5% or below in the last year: TANG CAPITAL MANAGEMENT LLC (4.2%, 2026-05-15)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q3 23: 1 buyingQ3 23: 0 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 0 buyingQ1 24: 0 sellingQ2 24: 2 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 0 buyingQ4 24: 0 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20231$90.3k0——
Q4 20230—0——
Q1 20240—0——
Q2 20242$82.9k0——
Q3 20240—0——
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——

None reported in Q2 2025.

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.00% of their portfolio BOSTON, MA 1,414,1901.4m $22.8m $22.8m 0.00% New
2 Fairmount Funds Management LLC 2.90% of their portfolio WEST CONSHOHOCKEN, PA 1,387,8661.4m $22.4m $22.4m 2.90% New
3 Venrock Adviser, LLC 1.68% of their portfolio NEW YORK, NY 1,387,8641.4m $22.4m $22.4m 1.68% New
4 BVF INC/IL 0.80% of their portfolio San Francisco, CA 1,387,8631.4m $22.4m $22.4m 0.80% New
5 Paradigm Biocapital Advisors LP 0.44% of their portfolio NEW YORK, NY 642,721642.7k $10.4m $10.4m 0.44% New
6 Logos Global Management LP 1.19% of their portfolio San Francisco, CA 553,686553.7k $8.9m $8.9m 1.19% New
7 PERCEPTIVE ADVISORS LLC 0.27% of their portfolio NEW YORK, NY 453,686453.7k $7.3m $7.3m 0.27% New
8 Commodore Capital LP 0.52% of their portfolio NEW YORK, NY 453,686453.7k $7.3m $7.3m 0.52% New
9 Deep Track Capital, LP 0.24% of their portfolio GREENWICH, CT 453,686453.7k $7.3m $7.3m 0.24% New
10 Boxer Capital Management, LLC 3.69% of their portfolio San Diego, CA 453,686453.7k $7.3m $7.3m 3.69% New
11 Frazier Life Sciences Management, L.P. 0.29% of their portfolio PALO ALTO, CA 453,685453.7k $7.3m $7.3m 0.29% New
12 Soleus Capital Management, L.P. 0.45% of their portfolio GREENWICH, CT 400,000400.0k $6.5m $6.5m 0.45% New
13 Driehaus Capital Management LLC 0.04% of their portfolio Chicago, IL 302,457302.5k $4.9m $4.9m 0.04% New
14 Affinity Asset Advisors, LLC 0.67% of their portfolio NEW YORK, NY 280,031280.0k $4.5m $4.5m 0.67% New
15 BRAIDWELL LP 0.14% of their portfolio STAMFORD, CT 261,504261.5k $4.2m $4.2m 0.14% New
16 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 179,886179.9k $2.9m $2.9m 0.00% New
17 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 100,912100.9k $1.6m $1.6m 0.00% New
18 Blackstone Inc. 0.01% of their portfolio NEW YORK, NY 75,61475.6k $1.2m $1.2m 0.01% New
19 TANG CAPITAL MANAGEMENT LLC 0.04% of their portfolio SAN DIEGO, CA 50,15250.2k $809.5k $809.5k 0.04% New
20 Jefferies Financial Group Inc. 0.01% of their portfolio NEW YORK, NY 27,09627.1k $437.3k $437.3k 0.01% New
21 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 15,39415.4k $248.5k $248.5k 0.00% New
22 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 9,2319.2k $149.0k $149.0k 0.00% New
23 BlackRock, Inc. 0.00% of their portfolio New York, NY 6,0516.1k $97.7k $97.7k 0.00% New
24 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 286286 $4.6k $4.6k 0.00% New
25 UBS Group AG 0.00% of their portfolio ZURICH, V8 223223 $3.6k $3.6k 0.00% New
26 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 162162 $2.6k $2.6k 0.00% New
27 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 6868 $1.1k $1.1k 0.00% New
28 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 5050 $807 $807 0.00% New
29 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4040 $0 $0 0.00% New
30 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 44 $65 $65 0.00% New
31 CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio BIRMINGHAM, AL 00 $0 $0 — New