ZENTALIS PHARMACEUTICALS INC ZNTL
COM · Common Stock · CUSIP 98943L107
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 71.7m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.83. Options: 5 managers hold calls ($2.9m notional), 3 hold puts ($139.2k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 120 |
| Q4 2022 | 105 |
| Q1 2023 | 110 |
| Q2 2023 | 134 |
| Q3 2023 | 137 |
| Q4 2023 | 120 |
| Q1 2024 | 142 |
| Q2 2024 | 145 |
| Q3 2024 | 136 |
| Q4 2024 | 142 |
| Q1 2025 | 133 |
| Q2 2025 | 118 |
| Q3 2025 | 99 |
| Q4 2025 | 86 |
| Q1 2026 | 102 |
| Q2 2026 | 114 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 69 | 73 |
| Q4 2024 | 82 | 56 |
| Q1 2025 | 59 | 75 |
| Q2 2025 | 54 | 81 |
| Q3 2025 | 41 | 56 |
| Q4 2025 | 34 | 49 |
| Q1 2026 | 53 | 38 |
| Q2 2026 | 63 | 51 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $65.1k | $112.0k | 1.72 |
| Q4 2025 | $27.1k | $0 | 0.00 |
| Q1 2026 | $971.3k | $138.3k | 0.14 |
| Q2 2026 | $2.9m | $139.2k | 0.05 |
Biggest buyers
| BlackRock, Inc. | Added | +2.5m |
| ORBIMED ADVISORS LLC | New | +1.4m |
| Soleus Capital Management, L.P. | New | +950.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +663.1k |
| STATE STREET CORP | Added | +637.7k |
| CITADEL ADVISORS LLC | Added | +566.3k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +525.0k |
| ADAR1 Capital Management, LLC | Added | +508.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +447.9k |
| DIMENSIONAL FUND ADVISORS LP | Added | +270.8k |
Biggest sellers
| D. E. Shaw & Co., Inc. | Reduced | -937.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -625.5k |
| Almitas Capital LLC | Sold out | -610.1k |
| JANE STREET GROUP, LLC | Reduced | -475.9k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -459.0k |
| BARCLAYS PLC | Reduced | -432.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -356.1k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -329.1k |
| Woodline Partners LP | Sold out | -266.0k |
| GSA CAPITAL PARTNERS LLP | Reduced | -246.1k |
Biggest calls
| Squadron Capital Management LLC | Added | $2.1m426.0k shares |
| JANE STREET GROUP, LLC | New | $481.1k99.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $200.3k41.3k shares |
| CITADEL ADVISORS LLC | Added | $128.5k26.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $9.7k2.0k shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $62.6k12.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $61.1k12.6k shares |
| SIMPLEX TRADING, LLC | Added | $15.5k3.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| WALTERS GROUP 13G · passive investor -0.9 pts · filed 2026-08-19 | 18.8% |
| Walters William T 13G · passive investor +0.8 pts · filed 2025-01-31 | 9.9% |
| 5AM Opportunities II (GP), LLC 13G · passive investor new · filed 2025-12-30 | 6.4% |
| Squadron Capital Management LLC 13G · passive investor new · filed 2026-03-03 | 5.1% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.1%, 2026-10-27), BARCLAYS PLC (3.2%, 2026-08-13), Matrix Capital Management Company, LP (0.0%, 2026-01-02)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $5.1k | $5.1k |
| Q1 2025 | 4 | $223.1k | 3 | $65.4k | — |
| Q2 2025 | 1 | $29.4k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 3 | $134.7k | $105.4k |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-14 | WALTERS GROUP +2 10% owner | Bought | $15.2m4.3m shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| 5AM Venture Management, LLC 6.65% of their portfolio | 3.9m $19.1m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 3.8m $18.2m | Added +2.5m |
| Squadron Capital Management LLC 6.14% of their portfolio | 3.7m $17.9m | Added +69.0k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 3.0m $14.7m | Added +68.4k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.8m $13.8m | Added +525.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.02% of their portfolio | 2.7m $13.0m | Reduced -166.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 2.3m $11.1m | Added +566.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.6m $7.8m | Reduced -329.1k |
| Opaleye Management Inc. 0.62% of their portfolio | 1.4m $6.9m | Unchanged |
| ORBIMED ADVISORS LLC 0.13% of their portfolio | 1.4m $6.7m | New |
| Decheng Capital LLC 0.88% of their portfolio | 1.3m $6.4m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $6.2m | Added +663.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $5.4m | Reduced -17.6k |
| Ishara Investments LP 3.65% of their portfolio | 1.0m $5.0m | Reduced -205.0k |
| PRIMECAP MANAGEMENT CO/CA/ 0.00% of their portfolio | 957.4k $4.6m | Unchanged |
| Pfizer Inc 2.26% of their portfolio | 953.8k $3.9m | Unchanged |
| Soleus Capital Management, L.P. 0.16% of their portfolio | 950.0k $4.6m | New |
| STATE STREET CORP 0.00% of their portfolio | 887.4k $4.3m | Added +637.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 808.5k $3.9m | Added +447.9k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 758.0k $3.7m | Reduced -34.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 664.3k $3.2m | Reduced -625.5k |
| ADAR1 Capital Management, LLC 0.15% of their portfolio | 652.8k $3.2m | Added +508.1k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 591.5k $2.9m | Added +198.8k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 574.8k $2.8m | Reduced -62.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 546.6k $2.7m | Reduced -937.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 542.9k $2.6m | Added +270.8k |
| MORGAN STANLEY 0.00% of their portfolio | 471.2k $2.3m | Added +121.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 388.3k $1.9m | Added +270.1k |
| GSA CAPITAL PARTNERS LLP 0.11% of their portfolio | 374.3k $1.8m | Reduced -246.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 372.6k $1.8m | Reduced -90.1k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 336.9k $1.6m | Added +32.5k |
| Seven Fleet Capital Management LP 0.24% of their portfolio | 317.6k $1.5m | Added +207.6k |
| FMR LLC 0.00% of their portfolio | 310.3k $1.5m | Added +26.3k |
| UBS Group AG 0.00% of their portfolio | 297.4k $1.4m | Added +141.7k |
| XTX Topco Ltd 0.02% of their portfolio | 289.7k $1.4m | Reduced -32.8k |
| Creative Planning 0.00% of their portfolio | 285.0k $1.4m | Unchanged |
| SEI INVESTMENTS CO 0.00% of their portfolio | 256.1k $1.2m | Added +64.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 215.1k $1.0m | Reduced -356.1k |
| Peapod Lane Capital LLC 0.66% of their portfolio | 202.9k $983.9k | Reduced -164.0k |
| CDC Financial, Inc. 0.66% of their portfolio | 177.8k $862.1k | Reduced -106.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 171.9k $833.8k | Added +120.8k |
| Invesco Ltd. 0.00% of their portfolio | 161.7k $784.0k | Added +35.9k |
| Stonepine Capital Management, LLC 0.60% of their portfolio | 161.6k $783.7k | Reduced -107.5k |
| BARCLAYS PLC 0.00% of their portfolio | 158.9k $770.5k | Reduced -432.4k |
| Informed Momentum Co LLC 0.05% of their portfolio | 126.9k $615.3k | New |
| Quarry LP 0.10% of their portfolio | 125.1k $606.8k | Reduced -24.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 122.1k $592.0k | New |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 112.1k $543.8k | New |
| BARR E S & CO 0.03% of their portfolio | 110.0k $533.5k | Unchanged |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 98.6k $478.3k | Added +33.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 97.8k $474.1k | Added +49.2k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 78.9k $382.7k | Reduced -19.6k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 77.3k $374.9k | Unchanged |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 75.0k $363.6k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 68.8k $335.8k | Reduced -9.9k |
| Nuveen, LLC 0.00% of their portfolio | 66.7k $323.4k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 61.4k $297.9k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 55.8k $270.4k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 48.8k $236.7k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 41.9k $203.2k | Added +41.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 41.0k $200.0k | New |
| Verdad Advisers, LP 0.18% of their portfolio | 39.6k $192.1k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 37.6k $182.4k | Added +4.3k |
| Private Advisor Group, LLC 0.00% of their portfolio | 36.5k $176.9k | Added +5.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 30.1k $146.0k | New |
| RBF Capital, LLC 0.01% of their portfolio | 30.0k $145.5k | Reduced -20.0k |
| Regency Capital Management Inc.\DE 0.06% of their portfolio | 29.5k $143.1k | Unchanged |
| Marquette Asset Management, LLC 0.02% of their portfolio | 29.0k $140.5k | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.00% of their portfolio | 26.0k $125.9k | New |
| TORONTO DOMINION BANK 0.00% of their portfolio | 23.6k $114.3k | New |
| CITIGROUP INC 0.00% of their portfolio | 23.1k $112.1k | Reduced -54.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 23.0k $111.7k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 22.8k $110.5k | Reduced -110 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 22.4k $103.4k | Reduced -90.7k |
| Graham Capital Management, L.P. 0.00% of their portfolio | 22.4k $108.4k | Reduced -70.1k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 21.7k $105.4k | Unchanged |
| Carson Advisory Inc. 0.05% of their portfolio | 21.2k $102.7k | Reduced -2.1k |
| Sivia Capital Partners, LLC 0.01% of their portfolio | 20.0k $97.0k | Unchanged |
| State of Wyoming 0.01% of their portfolio | 18.8k $91.0k | Reduced -9.7k |
| Jump Financial, LLC 0.00% of their portfolio | 17.8k $86.4k | New |
| EVERGREEN CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 17.4k $84.5k | Added +514 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 17.1k $40.0k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 15.5k $75.2k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 14.8k $71.6k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 14.4k $69.8k | Reduced -475.9k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 14.3k $69.3k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 13.8k $67.1k | Reduced -6.6k |
| Scientech Research LLC 0.05% of their portfolio | 13.6k $66.0k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 13.5k $65.4k | Reduced -17.2k |
| OPPENHEIMER & CO INC 0.00% of their portfolio | 12.7k $61.4k | New |
| Spark Investment Management LLC 0.12% of their portfolio | 12.5k $60.6k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 12.5k $60.5k | Reduced -459.0k |
| nVerses Capital, LLC 0.08% of their portfolio | 11.0k $53.1k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 10.5k $50.7k | New |
| Cornerstone Wealth Management, LLC 0.00% of their portfolio | 10.2k $49.4k | Unchanged |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 10.1k $49.0k | Reduced -12.4k |
| Legal & General Group Plc 0.00% of their portfolio | 4.8k $23.5k | New |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 4.8k $23.4k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 4.5k $22.0k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 4.0k $19.4k | New |