XILIO THERAPEUTICS INC XLO
COM · Common Stock · CUSIP 98422T209
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $9.58.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2026 | 23 |
| Q2 2026 | 25 |
Biggest buyers
| ORBIMED ADVISORS LLC | New | +592.3k |
| Stonepine Capital Management, LLC | Added | +161.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +111.5k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +54.9k |
| CITADEL ADVISORS LLC | New | +25.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | New | +17.5k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +14.6k |
| TWO SIGMA INVESTMENTS, LP | New | +14.5k |
| PRELUDE CAPITAL MANAGEMENT, LLC | New | +11.6k |
| BlackRock, Inc. | New | +8.8k |
Biggest sellers
| Caligan Partners LP | Sold out | -112.1k |
| AJU IB Investment Co., Ltd. | Sold out | -47.7k |
| FMR LLC | Sold out | -36.6k |
| Ghisallo Capital Management LLC | Sold out | -13.8k |
| VANGUARD FIDUCIARY TRUST CO | Reduced | -5.9k |
| UBS Group AG | Reduced | -4.0k |
| GSA CAPITAL PARTNERS LLP | Reduced | -3.4k |
| MORGAN STANLEY | Reduced | -539 |
| JPMORGAN CHASE & CO | Sold out | -240 |
| Vanguard Global Advisers, LLC | Sold out | -210 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ORBIMED ADVISORS LLC 13G · institution new · filed 2026-05-15 | 10.0% |
| Bain Capital Life Sciences Fund II, L.P. 13G · passive investor filed 2026-05-15 | 10.0% |
| STEMPOINT CAPITAL LP 13G · institution filed 2026-08-14 | 9.5% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 2 | $8.6k | $8.6k |
| Q2 2025 | 2 | $73.0k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 1 | $43.9k | 2 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Bain Capital Life Sciences Investors, LLC 0.38% of their portfolio | 664.0k $6.4m | Unchanged |
| ORBIMED ADVISORS LLC 0.11% of their portfolio | 592.3k $5.7m | New |
| Frazier Life Sciences Management, L.P. 0.09% of their portfolio | 422.5k $4.0m | Unchanged |
| Stonepine Capital Management, LLC 1.65% of their portfolio | 226.0k $2.2m | Added +161.8k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 178.5k $1.7m | Added +54.9k |
| Sio Capital Management, LLC 0.25% of their portfolio | 152.5k $1.5m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 111.5k $1.1m | New |
| Merck & Co., Inc. 0.19% of their portfolio | 106.0k $1.0m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 64.2k $614.6k | Added +14.6k |
| MORGAN STANLEY 0.00% of their portfolio | 57.0k $545.6k | Reduced -539 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 39.1k $374.2k | Added +1.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 25.9k $248.6k | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 22.6k $216.5k | Reduced -5.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 17.5k $168.1k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 14.5k $139.3k | New |
| Velan Capital Investment Management LP 0.08% of their portfolio | 14.3k $136.8k | Unchanged |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 13.6k $130.0k | Reduced -3.4k |
| STATE STREET CORP 0.00% of their portfolio | 13.3k $127.5k | Unchanged |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 11.6k $111.1k | New |
| BlackRock, Inc. 0.00% of their portfolio | 8.8k $83.9k | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 714 $6.8k | New |
| BARCLAYS PLC 0.00% of their portfolio | 115 $1.1k | New |
| Key Financial Inc 0.00% of their portfolio | 59 $565 | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 29 $262 | New |
| UBS Group AG 0.00% of their portfolio | 14 $134 | Reduced -4.0k |