XERIS BIOPHARMA HOLDINGS INC XERS
COM · Common Stock · CUSIP 98422E103 · ISIN US98422E1038
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersChicago, IL
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($124.7k this quarter). Holder counts are more reliable. Shares outstanding: 182.3m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.92. Options: 7 managers hold calls ($8.6m notional), 7 hold puts ($4.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 101 |
| Q4 2022 | 98 |
| Q1 2023 | 93 |
| Q2 2023 | 106 |
| Q3 2023 | 112 |
| Q4 2023 | 121 |
| Q1 2024 | 143 |
| Q2 2024 | 136 |
| Q3 2024 | 145 |
| Q4 2024 | 163 |
| Q1 2025 | 200 |
| Q2 2025 | 202 |
| Q3 2025 | 231 |
| Q4 2025 | 226 |
| Q1 2026 | 238 |
| Q2 2026 | 240 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 69 | 49 |
| Q4 2024 | 81 | 45 |
| Q1 2025 | 125 | 56 |
| Q2 2025 | 101 | 83 |
| Q3 2025 | 135 | 87 |
| Q4 2025 | 109 | 117 |
| Q1 2026 | 139 | 88 |
| Q2 2026 | 138 | 93 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $3.9m | $782.2k | 0.20 |
| Q4 2025 | $4.8m | $433.3k | 0.09 |
| Q1 2026 | $5.2m | $3.4m | 0.65 |
| Q2 2026 | $8.6m | $4.6m | 0.53 |
Biggest buyers
| BlackRock, Inc. | Added | +1.6m |
| Nuveen, LLC | Added | +1.5m |
| DIMENSIONAL FUND ADVISORS LP | New | +1.1m |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Added | +839.1k |
| Walleye Capital LLC | New | +611.3k |
| ALGERT GLOBAL LLC | Added | +586.0k |
| FEDERATED HERMES, INC. | Added | +577.6k |
| BANK OF AMERICA CORP /DE/ | Added | +522.7k |
| FIRST TRUST ADVISORS LP | New | +485.0k |
| PERCEPTIVE ADVISORS LLC | New | +467.0k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -2.1m |
| Voss Capital, LP | Sold out | -1.4m |
| Qube Research & Technologies Ltd | Reduced | -1.2m |
| CenterBook Partners LP | Reduced | -968.1k |
| Driehaus Capital Management LLC | Sold out | -902.7k |
| JANE STREET GROUP, LLC | Reduced | -663.7k |
| Trexquant Investment LP | Reduced | -494.1k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -385.5k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Sold out | -370.1k |
| UBS Group AG | Reduced | -345.5k |
Biggest calls
| Caption Management, LLC | Reduced | $2.2m280.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.1m265.2k shares |
| Stonepine Capital Management, LLC | Unchanged | $2.1m280.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m159.1k shares |
| CITADEL ADVISORS LLC | Added | $397.6k50.2k shares |
| IMC-Chicago, LLC | Added | $338.2k42.7k shares |
| GROUP ONE TRADING LLC | Added | $227.3k28.7k shares |
Biggest puts
| Caption Management, LLC | Unchanged | $3.5m443.5k shares |
| CITADEL ADVISORS LLC | Added | $457.8k57.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $391.2k49.4k shares |
| IMC-Chicago, LLC | New | $110.1k13.9k shares |
| JANE STREET GROUP, LLC | Reduced | $99.8k12.6k shares |
| GROUP ONE TRADING LLC | Reduced | $20.6k2.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.6k200 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 1 | $217.2k | — |
| Q2 2025 | 1 | $109.5k | 0 | — | — |
| Q3 2025 | 0 | — | 4 | $1.6m | $119.7k |
| Q4 2025 | 0 | — | 4 | $1.5m | $346.5k |
| Q1 2026 | 0 | — | 4 | $708.5k | $407.9k |
| Q2 2026 | 0 | — | 5 | $706.7k | $706.7k |
| Q3 2026 | 0 | — | 3 | $2.1m | $2.1m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-28 | McCulloch Kevin Officer | Sold plan | $250.0k25.0k shares |
| 2026-09-01 | Hecht Beth Officer | Sold plan | $141.5k16.7k shares |
| 2026-09-01 | McCulloch Kevin Officer | Sold plan | $127.3k15.0k shares |
| 2026-09-01 | Pieper Steven Officer | Sold plan | $42.5k5.0k shares |
| 2026-08-12 | Pieper Steven Officer | Sold plan | $42.5k5.0k shares |
| 2026-08-03 | Hecht Beth Officer | Sold plan | $133.5k16.7k shares |
| 2026-08-03 | McCulloch Kevin Officer | Sold plan | $120.3k15.0k shares |
| 2026-07-07 | Pieper Steven Officer | Sold plan | $235.2k27.6k shares |
| 2026-07-06 | Pieper Steven Officer | Sold plan | $147.9k17.4k shares |
| 2026-07-01 | McCulloch Kevin Officer | Sold plan | $722.7k90.0k shares |
| 2026-07-01 | Hecht Beth Officer | Sold plan | $133.8k16.7k shares |
| 2026-06-04 | HALKUFF DAWN Director | Sold plan | $121.8k20.0k shares |
| 2026-06-04 | BORMANN-KENNEDY BARBARA-JEAN ANNE Director | Sold plan | $97.4k16.0k shares |
| 2026-06-04 | JOHNSON JOHN Director | Sold plan | $91.3k15.0k shares |
| 2026-06-03 | PERSKY MARLA Director | Sold plan | $91.5k15.5k shares |
| 2026-06-01 | Hecht Beth Officer | Sold plan | $101.0k16.7k shares |
| 2026-05-01 | Hecht Beth Officer | Sold plan | $103.8k16.7k shares |
| 2026-04-01 | Hecht Beth Officer | Sold plan | $99.8k16.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 14.5m $115.0m | Added +1.6m |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 7.8m $61.8m | Added +15.9k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 7.3m $58.1m | Added +359.3k |
| STATE STREET CORP 0.00% of their portfolio | 4.8m $38.2m | Added +163.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.7m $37.4m | Added +427.6k |
| Nuveen, LLC 0.01% of their portfolio | 4.4m $34.7m | Added +1.5m |
| Rosalind Advisors, Inc. 8.65% of their portfolio | 2.9m $23.0m | Reduced -322.7k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 2.9m $22.9m | Reduced -1.2m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 2.6m $20.8m | Reduced -39.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 2.4m $18.7m | Added +193.7k |
| MORGAN STANLEY 0.00% of their portfolio | 2.3m $18.5m | Reduced -235.6k |
| Legal & General Group Plc 0.00% of their portfolio | 2.0m $15.9m | Added +104.5k |
| ARMISTICE CAPITAL, LLC 0.43% of their portfolio | 2.0m $15.5m | Added +48.9k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 1.9m $14.9m | Reduced -38.7k |
| Parkman Healthcare Partners LLC 1.47% of their portfolio | 1.8m $14.3m | Added +86.4k |
| ALGERT GLOBAL LLC 0.16% of their portfolio | 1.7m $13.8m | Added +586.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.6m $12.7m | Added +153.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.6m $12.6m | Reduced -19.6k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.5m $12.2m | Added +146.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.5m $11.8m | Added +132.7k |
| FEDERATED HERMES, INC. 0.02% of their portfolio | 1.4m $11.4m | Added +577.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.4m $11.1m | Added +522.7k |
| UBS Group AG 0.00% of their portfolio | 1.3m $10.3m | Reduced -345.5k |
| Ishara Investments LP 7.16% of their portfolio | 1.2m $9.7m | Added +205.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.2m $9.7m | Added +90.5k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.17% of their portfolio | 1.2m $9.6m | Reduced -31.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.1m $8.5m | New |
| Knott David M Jr 4.44% of their portfolio | 1.1m $8.4m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.1m $8.2m | Added +445.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 972.9k $7.7m | Added +839.1k |
| Granahan Investment Management, LLC 0.25% of their portfolio | 898.8k $7.1m | Reduced -23.1k |
| NORGES BANK 0.00% of their portfolio | 797.2k $6.3m | Not comparable |
| ESSEX INVESTMENT MANAGEMENT CO LLC 0.74% of their portfolio | 715.6k $5.7m | Reduced -32.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 687.6k $5.4m | Added +19.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 685.6k $5.4m | Added +60.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 664.6k $5.3m | Reduced -17.1k |
| FMR LLC 0.00% of their portfolio | 644.1k $5.1m | Added +131.0k |
| Walleye Capital LLC 0.02% of their portfolio | 611.3k $4.8m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 529.4k $4.2m | Reduced -93.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 488.4k $3.9m | Added +62.2k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 485.0k $3.8m | New |
| IHT Wealth Management, LLC 0.08% of their portfolio | 481.9k $3.8m | Added +105.4k |
| PERCEPTIVE ADVISORS LLC 0.06% of their portfolio | 467.0k $3.7m | New |
| ROYCE & ASSOCIATES LP 0.03% of their portfolio | 461.2k $3.7m | Added +205.1k |
| Man Group plc 0.01% of their portfolio | 455.4k $3.6m | Added +179.0k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 440.7k $3.5m | Added +56.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 430.5k $3.4m | Added +167.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 427.5k $3.4m | Added +119.0k |
| Jupiter Topco LLC 0.00% of their portfolio | 415.0k $3.3m | First filing |
| Y-Intercept (Hong Kong) Ltd 0.06% of their portfolio | 411.3k $3.3m | Added +249.6k |
| Squarepoint Ops LLC 0.01% of their portfolio | 365.7k $2.9m | Reduced -248.8k |
| HRT FINANCIAL LP 0.01% of their portfolio | 365.7k $2.9m | Added +194.6k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 339.5k $2.7m | Reduced -239.7k |
| Trexquant Investment LP 0.02% of their portfolio | 339.1k $2.7m | Reduced -494.1k |
| Swiss National Bank 0.00% of their portfolio | 337.5k $2.7m | Added +9.2k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 318.2k $2.5m | Added +21.7k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.12% of their portfolio | 300.8k $2.4m | Added +49.7k |
| Jefferies Financial Group Inc. 0.02% of their portfolio | 293.7k $2.3m | Added +205.9k |
| CenterBook Partners LP 0.11% of their portfolio | 280.6k $2.2m | Reduced -968.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 266.9k $2.1m | Added +57.8k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio | 263.5k $2.1m | Reduced -200.5k |
| Cliffwater LLC 0.52% of their portfolio | 263.2k $2.1m | New |
| Legato Capital Management LLC 0.16% of their portfolio | 241.3k $1.9m | Added +7.2k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 227.6k $1.8m | Added +122.8k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 227.4k $1.8m | Added +18.9k |
| GROUP ONE TRADING LLC 0.05% of their portfolio | 226.6k $1.8m | Added +8.5k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 219.2k $1.7m | Reduced -155.6k |
| Apella Capital, LLC 0.03% of their portfolio | 215.9k $1.9m | Reduced -20.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 214.2k $1.7m | Added +23.1k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 205.9k $1.6m | Added +2.7k |
| Voleon Capital Management LP 0.03% of their portfolio | 204.7k $1.6m | Added +158.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 202.9k $1.6m | Reduced -5.4k |
| Aquatic Capital Management LLC 0.05% of their portfolio | 200.0k $1.6m | New |
| Caption Management, LLC 0.06% of their portfolio | 197.9k $1.6m | Reduced -7.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 186.8k $1.5m | Added +6.5k |
| Corient Private Wealth LP 0.00% of their portfolio | 184.1k $1.5m | New |
| Virtus Investment Advisers, LLC 0.32% of their portfolio | 171.3k $1.4m | Added +133.2k |
| BARCLAYS PLC 0.00% of their portfolio | 166.6k $1.3m | Added +28.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 157.5k $1.2m | Added +99.2k |
| Creative Planning 0.00% of their portfolio | 154.1k $1.2m | Added +20.8k |
| Quarry LP 0.19% of their portfolio | 150.1k $1.2m | Added +25.1k |
| GLOBEFLEX CAPITAL L P 0.15% of their portfolio | 145.9k $1.2m | Added +22.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 145.3k $842.9k | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 143.3k $1.1m | Added +1.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 139.9k $1.1m | Reduced -146.2k |
| CITIGROUP INC 0.00% of their portfolio | 134.3k $1.1m | Added +47.0k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 133.4k $1.1m | Added +29.9k |
| DIADEMA PARTNERS LP 0.37% of their portfolio | 132.7k $1.1m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 131.7k $1.0m | Reduced -2.1m |
| LPL Financial LLC 0.00% of their portfolio | 128.9k $1.0m | Added +35.1k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 127.1k $1.0m | Reduced -280.5k |
| Gotham Asset Management, LLC 0.00% of their portfolio | 123.9k $981.4k | Added +80.7k |
| Quantbot Technologies LP 0.03% of their portfolio | 111.1k $879.9k | Added +83.0k |
| Invesco Ltd. 0.00% of their portfolio | 109.9k $870.2k | Added +6.6k |
| Palo Alto Investors LP 0.11% of their portfolio | 104.4k $826.9k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 100.2k $793.3k | Added +23.4k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 98.4k $779.6k | Added +16.8k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 93.3k $739.3k | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 88.9k $704.0k | Added +8.7k |
| GSA CAPITAL PARTNERS LLP 0.04% of their portfolio | 82.8k $656.0k | Reduced -18.6k |