TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($106.6m this quarter). Holder counts are more reliable. Shares outstanding: 62.7m as of 2026-07-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $102.81. Options: 8 managers hold calls ($38.5m notional), 6 hold puts ($14.8m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
| Q3 2024 | 247 |
| Q4 2024 | 248 |
| Q1 2025 | 264 |
| Q2 2025 | 245 |
| Q3 2025 | 239 |
| Q4 2025 | 244 |
| Q1 2026 | 282 |
| Q2 2026 | 337 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 120 | 128 |
| Q4 2024 | 111 | 112 |
| Q1 2025 | 135 | 105 |
| Q2 2025 | 112 | 140 |
| Q3 2025 | 132 | 96 |
| Q4 2025 | 116 | 115 |
| Q1 2026 | 138 | 116 |
| Q2 2026 | 186 | 132 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $4.7m | $2.5m | 0.53 |
| Q4 2025 | $4.6m | $3.2m | 0.70 |
| Q1 2026 | $10.8m | $6.2m | 0.57 |
| Q2 2026 | $38.5m | $14.8m | 0.38 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +3.6m |
| FMR LLC | Added | +2.8m |
| D. E. Shaw & Co., Inc. | Added | +1.1m |
| Stephens Investment Management Group LLC | New | +767.4k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +708.8k |
| VOYA INVESTMENT MANAGEMENT LLC | Added | +661.5k |
| MORGAN STANLEY | Added | +643.0k |
| FIL Ltd | New | +641.1k |
| T. Rowe Price Investment Management, Inc. | New | +597.9k |
| FRED ALGER MANAGEMENT, LLC | Added | +462.4k |
Biggest sellers
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | Reduced | -3.1m |
| EdgePoint Investment Group Inc. | Reduced | -2.9m |
| ARK Investment Management LLC | Reduced | -1.8m |
| Artisan Partners Limited Partnership | Reduced | -1.6m |
| Soleus Capital Management, L.P. | Reduced | -1.1m |
| Balyasny Asset Management L.P. | Reduced | -719.0k |
| Point72 Asset Management, L.P. | Sold out | -669.7k |
| JANE STREET GROUP, LLC | Reduced | -514.9k |
| Amova Asset Management Americas, Inc. | Reduced | -496.4k |
| Sumitomo Mitsui Trust Group, Inc. | Reduced | -495.8k |
Biggest calls
| PEAK6 LLC | New | $11.8m114.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $9.0m87.4k shares |
| JANE STREET GROUP, LLC | Added | $8.0m78.1k shares |
| CITADEL ADVISORS LLC | Added | $7.8m76.2k shares |
| MILLENNIUM MANAGEMENT LLC | New | $884.8k8.6k shares |
| SIMPLEX TRADING, LLC | Added | $421.8k4.1k shares |
| GROUP ONE TRADING LLC | Added | $288.1k2.8k shares |
| IMC-Chicago, LLC | New | $236.6k2.3k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $7.4m72.2k shares |
| MILLENNIUM MANAGEMENT LLC | New | $2.9m28.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.7m25.8k shares |
| JANE STREET GROUP, LLC | Reduced | $1.7m16.7k shares |
| SIMPLEX TRADING, LLC | Added | $51.4k500 shares |
| GROUP ONE TRADING LLC | Reduced | $30.9k300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 7 | $4.9m | $351.8k |
| Q1 2025 | 0 | — | 7 | $1.9m | $250.0k |
| Q2 2025 | 0 | — | 6 | $1.8m | — |
| Q3 2025 | 0 | — | 6 | $879.3k | — |
| Q4 2025 | 0 | — | 7 | $5.8m | $176.3k |
| Q1 2026 | 0 | — | 8 | $10.3m | $5.9m |
| Q2 2026 | 0 | — | 8 | $15.5m | $10.0m |
| Q3 2026 | 0 | — | 8 | $99.8m | $94.9m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-24 | Leproust Emily M. Chief Executive Officer, director | Sold plan | $922.9k5.2k shares |
| 2026-09-21 | Leproust Emily M. Chief Executive Officer, director | Sold | $279.2k1.7k shares |
| 2026-09-21 | Cho Dennis Officer | Sold | $57.6k348 shares |
| 2026-09-21 | Green Paula SVP of Human Resources | Sold | $48.7k294 shares |
| 2026-09-17 | Leproust Emily M. Chief Executive Officer, director | Sold plan | $56.3m356.5k shares |
| 2026-09-08 | Leproust Emily M. Chief Executive Officer, director | Sold | $282.3k2.3k shares |
| 2026-09-08 | Green Paula SVP of Human Resources | Sold | $111.2k907 shares |
| 2026-09-08 | Cho Dennis Officer | Sold | $50.5k412 shares |
| 2026-09-08 | WERNER ROBERT F. Chief Accounting Officer | Sold | $29.2k238 shares |
| 2026-08-25 | Leproust Emily M. Chief Executive Officer, director | Sold plan | $6.3m41.6k shares |
| 2026-08-24 | WERNER ROBERT F. Chief Accounting Officer | Sold | $120.2k854 shares |
| 2026-08-21 | Leproust Emily M. Chief Executive Officer, director | Sold | $923.3k6.6k shares |
| 2026-08-21 | Finn Patrick John President and COO | Sold | $562.7k4.0k shares |
| 2026-08-21 | Laponis Adam Chief Financial Officer | Sold | $273.3k2.0k shares |
| 2026-08-21 | Cho Dennis Officer | Sold | $222.2k1.6k shares |
| 2026-08-21 | Green Paula SVP of Human Resources | Sold | $189.1k1.4k shares |
| 2026-08-21 | WERNER ROBERT F. Chief Accounting Officer | Sold | $93.0k669 shares |
| 2026-08-19 | Cho Dennis Officer | Sold plan | $1.8m14.2k shares |
| 2026-08-18 | Finn Patrick John President and COO | Sold plan | $9.2m78.4k shares |
| 2026-08-12 | Leproust Emily M. Chief Executive Officer, director | Sold plan | $2.5m20.0k shares |
| 2026-08-12 | BLAKE KATRYN Director | Sold | $275.3k2.2k shares |
| 2026-08-10 | Leproust Emily M. Chief Executive Officer, director | Sold plan | $14.2m113.3k shares |
| 2026-08-07 | CHESS ROBERT Director | Sold plan | $2.0m18.4k shares |
| 2026-08-05 | Cho Dennis Officer | Sold plan | $1.6m14.2k shares |
| 2026-08-03 | Leproust Emily M. Chief Executive Officer, director | Sold | $435.2k5.1k shares |
| 2026-08-03 | Finn Patrick John President and COO | Sold | $246.4k2.9k shares |
| 2026-08-03 | Green Paula SVP of Human Resources | Sold | $96.7k1.1k shares |
| 2026-08-03 | Cho Dennis Officer | Sold | $91.3k1.1k shares |
| 2026-08-03 | WERNER ROBERT F. Chief Accounting Officer | Sold | $14.2k167 shares |
| 2026-07-23 | Finn Patrick John President and COO | Sold | $210.1k2.2k shares |
The latest 30 of 70 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 5.8m $600.2m | Added +279.5k |
| Artisan Partners Limited Partnership 0.81% of their portfolio | 4.8m $494.0m | Reduced -1.6m |
| FMR LLC 0.02% of their portfolio | 4.7m $483.8m | Added +2.8m |
| ARK Investment Management LLC 3.04% of their portfolio | 4.5m $468.1m | Reduced -1.8m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.04% of their portfolio | 3.6m $373.9m | Added +3.6m |
| STATE STREET CORP 0.01% of their portfolio | 3.2m $332.6m | Reduced -438.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 2.8m $290.6m | Added +175.9k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.7m $277.7m | Added +60.2k |
| EdgePoint Investment Group Inc. 1.96% of their portfolio | 2.5m $259.4m | Reduced -2.9m |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.67% of their portfolio | 2.2m $223.7m | Reduced -3.1m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 1.29% of their portfolio | 2.1m $219.8m | Added +708.8k |
| Invesco Ltd. 0.02% of their portfolio | 1.9m $198.4m | Reduced -243.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.6m $166.6m | Added +99.6k |
| Thrivent Financial for Lutherans 0.25% of their portfolio | 1.4m $147.5m | Added +121.0k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 1.4m $144.9m | Reduced -297.1k |
| MORGAN STANLEY 0.01% of their portfolio | 1.2m $122.4m | Added +643.0k |
| D. E. Shaw & Co., Inc. 0.08% of their portfolio | 1.2m $122.0m | Added +1.1m |
| BAILLIE GIFFORD & CO 0.10% of their portfolio | 1.1m $111.8m | Reduced -128.4k |
| Driehaus Capital Management LLC 0.61% of their portfolio | 1.0m $105.2m | Added +437.8k |
| Sumitomo Mitsui Trust Group, Inc. 0.06% of their portfolio | 1.0m $102.9m | Reduced -495.8k |
| Amova Asset Management Americas, Inc. 1.33% of their portfolio | 999.7k $102.8m | Reduced -496.4k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 922.6k $94.9m | Added +338.4k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 862.0k $88.7m | Reduced -358.4k |
| LOOMIS SAYLES & CO L P 0.11% of their portfolio | 861.3k $88.6m | Added +369.0k |
| Stephens Investment Management Group LLC 0.85% of their portfolio | 767.4k $78.9m | New |
| First Light Asset Management, LLC 4.55% of their portfolio | 727.9k $74.9m | Reduced -150.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.06% of their portfolio | 671.9k $69.1m | Added +661.5k |
| FIL Ltd 0.05% of their portfolio | 641.1k $66.0m | New |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 597.9k $61.5m | New |
| NORTHERN TRUST CORP 0.01% of their portfolio | 591.7k $60.9m | Added +63.7k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 582.7k $59.9m | Reduced -198.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 568.3k $58.5m | Reduced -170.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 563.8k $58.0m | Reduced -260.2k |
| FRED ALGER MANAGEMENT, LLC 0.19% of their portfolio | 558.2k $57.4m | Added +462.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 557.1k $57.3m | Added +20.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 546.6k $56.2m | Reduced -57.4k |
| Nuveen, LLC 0.01% of their portfolio | 522.0k $53.7m | Added +228.4k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 487.0k $50.1m | Added +449.2k |
| Tao Capital Management LP 2.54% of their portfolio | 478.8k $49.3m | Reduced -350.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.06% of their portfolio | 462.1k $47.5m | Reduced -211.8k |
| JENNISON ASSOCIATES LLC 0.03% of their portfolio | 453.2k $46.6m | Reduced -152.0k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 443.5k $45.6m | Added +20.4k |
| Allspring Global Investments Holdings, LLC 0.07% of their portfolio | 418.1k $42.8m | Reduced -37.3k |
| UBS Group AG 0.01% of their portfolio | 413.1k $42.5m | Reduced -39.4k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 396.9k $40.8m | New |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 347.1k $35.7m | Reduced -3.5k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 340.1k $35.0m | Added +306.8k |
| Granahan Investment Management, LLC 1.15% of their portfolio | 314.9k $32.4m | New |
| LORD, ABBETT & CO. LLC 0.09% of their portfolio | 299.3k $30.8m | Added +199.6k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 298.1k $30.7m | New |
| SEI INVESTMENTS CO 0.03% of their portfolio | 294.9k $30.3m | Reduced -59.5k |
| BLAIR WILLIAM & CO/IL 0.07% of their portfolio | 256.6k $26.4m | Added +199.1k |
| Trexquant Investment LP 0.16% of their portfolio | 255.3k $26.3m | Added +85.2k |
| USS Investment Management Ltd 0.10% of their portfolio | 241.2k $24.8m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 205.2k $20.5m | Reduced -519 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.13% of their portfolio | 196.5k $20.2m | Reduced -47.5k |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 1.26% of their portfolio | 191.8k $19.7m | Reduced -92.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 191.7k $19.7m | Added +10.9k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 190.9k $19.6m | Added +86.2k |
| Freshford Capital Management, LLC 6.25% of their portfolio | 177.4k $18.3m | Reduced -81.5k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.08% of their portfolio | 177.4k $18.3m | Added +24.2k |
| Metavasi Capital LP 7.04% of their portfolio | 176.0k $18.1m | Added +76.0k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 153.7k $15.8m | Added +22.4k |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 145.6k $15.0m | Added +37.3k |
| ARMISTICE CAPITAL, LLC 0.40% of their portfolio | 142.0k $14.6m | New |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.46% of their portfolio | 139.0k $14.3m | Reduced -81.1k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 129.4k $13.3m | Added +4.6k |
| Science & Technology Partners, L.P. 2.24% of their portfolio | 129.2k $13.3m | New |
| Legal & General Group Plc 0.00% of their portfolio | 122.0k $12.5m | Reduced -6.1k |
| PARNASSUS INVESTMENTS, LLC 0.03% of their portfolio | 120.0k $12.3m | New |
| Swiss National Bank 0.01% of their portfolio | 113.8k $11.7m | Reduced -5.2k |
| OSTERWEIS CAPITAL MANAGEMENT INC 0.54% of their portfolio | 111.5k $11.5m | Reduced -99.7k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 108.3k $10.7m | Reduced -77.7k |
| Atika Capital Management LLC 1.10% of their portfolio | 108.0k $11.1m | New |
| Soleus Capital Management, L.P. 0.37% of their portfolio | 104.6k $10.8m | Reduced -1.1m |
| TD Asset Management Inc 0.01% of their portfolio | 104.0k $10.7m | Added +97.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 100.1k $10.3m | Added +21.0k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 99.4k $10.2m | Added +9.3k |
| Mawer Investment Management Ltd. 0.07% of their portfolio | 99.3k $10.2m | New |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 97.6k $10.0m | Added +31.1k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 94.6k $9.7m | Added +57.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 90.1k $9.3m | Added +25.5k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 89.3k $9.2m | Reduced -63.4k |
| HRT FINANCIAL LP 0.02% of their portfolio | 88.0k $9.1m | New |
| ODDO BHF ASSET MANAGEMENT SAS 0.42% of their portfolio | 88.0k $9.1m | Reduced -58.0k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 86.3k $8.9m | Reduced -514.9k |
| Vestmark Advisory Solutions, Inc. 0.08% of their portfolio | 85.1k $8.8m | Reduced -24.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 79.8k $8.2m | Added +55.2k |
| CITIGROUP INC 0.00% of their portfolio | 77.6k $8.0m | Reduced -382.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 77.3k $8.0m | Added +46.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 75.5k $7.8m | Added +5.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 75.0k $3.6m | Added +7.6k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 74.3k $7.6m | Reduced -698 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 66.6k $6.9m | Added +1.1k |
| LPL Financial LLC 0.00% of their portfolio | 63.9k $6.6m | Added +7.0k |
| Informed Momentum Co LLC 0.57% of their portfolio | 62.6k $6.4m | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 58.5k $6.0m | Reduced -48.2k |
| Man Group plc 0.01% of their portfolio | 58.3k $6.0m | Reduced -38.2k |
| POLEN CAPITAL MANAGEMENT LLC 0.05% of their portfolio | 55.3k $5.7m | Added +31.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 54.8k $5.6m | Added +2.6k |