TREVI THERAPEUTICS INC TRVI
COM · Common Stock · CUSIP 89532M101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew Haven, CT
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($377.5k this quarter). Holder counts are more reliable. Shares outstanding: 121.8m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.47. Options: 8 managers hold calls ($7.8m notional), 9 hold puts ($3.7m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 41 |
| Q4 2022 | 38 |
| Q1 2023 | 37 |
| Q2 2023 | 54 |
| Q3 2023 | 56 |
| Q4 2023 | 64 |
| Q1 2024 | 81 |
| Q2 2024 | 78 |
| Q3 2024 | 94 |
| Q4 2024 | 111 |
| Q1 2025 | 138 |
| Q2 2025 | 155 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 18 | 21 |
| Q4 2023 | 37 | 17 |
| Q1 2024 | 38 | 32 |
| Q2 2024 | 40 | 25 |
| Q3 2024 | 48 | 21 |
| Q4 2024 | 67 | 31 |
| Q1 2025 | 95 | 43 |
| Q2 2025 | 103 | 55 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $452.6k | $18.0k | 0.04 |
| Q4 2024 | $926.5k | $1.1m | 1.14 |
| Q1 2025 | $10.7m | $2.2m | 0.21 |
| Q2 2025 | $7.8m | $3.7m | 0.48 |
Biggest buyers
| ALLIANCEBERNSTEIN L.P. | Added | +4.3m |
| Rubric Capital Management LP | Added | +4.0m |
| BlackRock, Inc. | Added | +2.9m |
| ORBIMED ADVISORS LLC | Added | +2.2m |
| Woodline Partners LP | Added | +2.0m |
| NEA Management Company, LLC | Added | +1.9m |
| ROYAL BANK OF CANADA | Added | +1.6m |
| VANGUARD GROUP INC | Added | +1.5m |
| EVENTIDE ASSET MANAGEMENT, LLC | New | +1.4m |
| CITADEL ADVISORS LLC | New | +1.3m |
Biggest sellers
| ARMISTICE CAPITAL, LLC | Sold out | -3.0m |
| VIKING GLOBAL INVESTORS LP | Reduced | -1.7m |
| Ally Bridge Group (NY) LLC | Sold out | -686.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -666.0k |
| Point72 Asset Management, L.P. | Reduced | -639.3k |
| Venrock Adviser, LLC | Sold out | -615.5k |
| Ikarian Capital, LLC | Sold out | -575.0k |
| MAI Capital Management | Reduced | -537.5k |
| Invesco Ltd. | Reduced | -530.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -440.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.5m457.3k shares |
| Caption Management, LLC | Reduced | $2.0m367.6k shares |
| GROUP ONE TRADING LLC | Added | $1.1m201.1k shares |
| CITADEL ADVISORS LLC | Added | $1.1m198.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $769.0k140.6k shares |
| JANE STREET GROUP, LLC | Reduced | $260.4k47.6k shares |
| PFS Partners, LLC | New | $42.1k7.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| Caption Management, LLC | New | $820.5k150.0k shares |
| GROUP ONE TRADING LLC | Added | $718.2k131.3k shares |
| SIMPLEX TRADING, LLC | Added | $626.0k114.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $546.5k99.9k shares |
| JANE STREET GROUP, LLC | New | $491.8k89.9k shares |
| CITADEL ADVISORS LLC | Added | $467.1k85.4k shares |
| JPMORGAN CHASE & CO | New | $54.7k10.0k shares |
| LMR Partners LLP | New | $547100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
New Enterprise Associates 16, L.P.
13D · may seek influence
-1.1 pts · filed 2026-05-07
Stated purposeThe Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount … Full filing |
10.5% |
| FMR LLC 13G · institution +2.5 pts · filed 2026-08-06 | 8.8% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -3.6 pts · filed 2025-11-14 | 7.0% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-10-27 | 6.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), Rubric Capital Management LP (2.9%, 2026-02-13), VIKING GLOBAL INVESTORS LP (4.2%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 1 | $4.8k | $4.8k |
| Q4 2023 | 0 | — | 1 | $1.6k | $1.6k |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 3 | $232.5k | — |
| Q3 2024 | 0 | — | 3 | $338.0k | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 3 | $601.1k | $549.1k |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| NEA Management Company, LLC 5.44% of their portfolio | 13.2m $72.3m | Added +1.9m |
| Frazier Life Sciences Management, L.P. 2.24% of their portfolio | 10.3m $56.1m | Unchanged |
| Rubric Capital Management LP 0.75% of their portfolio | 8.5m $46.7m | Added +4.0m |
| BlackRock, Inc. 0.00% of their portfolio | 8.2m $44.9m | Added +2.9m |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.3m $29.1m | Added +1.5m |
| Vivo Capital, LLC 2.51% of their portfolio | 4.5m $24.5m | Added +1.0m |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 4.3m $23.4m | Added +4.3m |
| Woodline Partners LP 0.12% of their portfolio | 4.0m $22.1m | Added +2.0m |
| Siren, L.L.C. 1.11% of their portfolio | 3.9m $21.5m | Added +1.1m |
| Octagon Capital Advisors LP 4.41% of their portfolio | 3.7m $20.1m | Added +350.0k |
| MPM BIOIMPACT LLC 3.23% of their portfolio | 3.4m $18.6m | Reduced -21.4k |
| ORBIMED ADVISORS LLC 0.46% of their portfolio | 3.3m $18.1m | Added +2.2m |
| Affinity Asset Advisors, LLC 2.05% of their portfolio | 2.5m $13.9m | Added +1.3m |
| MARSHALL WACE, LLP 0.02% of their portfolio | 2.5m $13.6m | Reduced -76.3k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 2.4m $12.9m | Added +595.8k |
| ACORN CAPITAL ADVISORS, LLC 7.67% of their portfolio | 2.1m $11.7m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 1.8m $10.0m | Added +408.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.8m $9.8m | Added +172.0k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 1.7m $9.5m | Reduced -639.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.6m $9.0m | Added +1.6m |
| VIKING GLOBAL INVESTORS LP 0.02% of their portfolio | 1.5m $8.4m | Reduced -1.7m |
| EVENTIDE ASSET MANAGEMENT, LLC 0.13% of their portfolio | 1.4m $7.6m | New |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.3m $7.2m | New |
| Artia Global Partners LP 1.85% of their portfolio | 1.3m $7.2m | New |
| Pivotal bioVenture Partners Investment Advisor LLC 3.89% of their portfolio | 1.1m $6.3m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $6.0m | Added +965.7k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 1.1m $5.9m | Added +567.3k |
| MORGAN STANLEY 0.00% of their portfolio | 1.0m $5.6m | Added +529.4k |
| J. Goldman & Co LP 0.17% of their portfolio | 979.1k $5.4m | Added +778.0k |
| Logos Global Management LP 0.62% of their portfolio | 850.0k $4.6m | Added +425.3k |
| MAI Capital Management 0.03% of their portfolio | 847.6k $4.6m | Reduced -537.5k |
| SPHERA FUNDS MANAGEMENT LTD. 1.14% of their portfolio | 800.0k $4.4m | New |
| Soleus Capital Management, L.P. 0.26% of their portfolio | 700.0k $3.8m | New |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 650.0k $3.6m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 576.5k $3.2m | Added +10.3k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 569.7k $3.1m | Added +229.8k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.60% of their portfolio | 539.6k $3.0m | Added +9.6k |
| Burkehill Global Management, LP 0.21% of their portfolio | 525.0k $2.9m | New |
| BARCLAYS PLC 0.00% of their portfolio | 515.5k $2.8m | Added +377.5k |
| ACUTA CAPITAL PARTNERS, LLC 3.77% of their portfolio | 493.7k $2.7m | Reduced -292.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 489.3k $2.7m | Added +400.4k |
| Informed Momentum Co LLC 0.40% of their portfolio | 486.6k $2.7m | Reduced -64.3k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 447.9k $2.4m | Added +321.6k |
| Opaleye Management Inc. 0.43% of their portfolio | 390.0k $2.1m | Reduced -405.0k |
| FMR LLC 0.00% of their portfolio | 368.5k $2.0m | Added +362.5k |
| UBS Group AG 0.00% of their portfolio | 354.2k $1.9m | Added +261.2k |
| Tejara Capital Ltd 0.83% of their portfolio | 326.4k $1.8m | Added +146.9k |
| Invesco Ltd. 0.00% of their portfolio | 322.3k $1.8m | Reduced -530.6k |
| Rosalind Advisors, Inc. 0.79% of their portfolio | 300.0k $1.6m | Reduced -312.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 299.0k $1.6m | Added +87.2k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 226.4k $1.2m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 225.9k $1.2m | Added +18.4k |
| DIADEMA PARTNERS LP 0.63% of their portfolio | 185.8k $1.0m | Added +5.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 172.0k $940.7k | Added +44.5k |
| Nuveen, LLC 0.00% of their portfolio | 169.5k $926.9k | Reduced -104.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 166.3k $909.5k | Added +189 |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 157.2k $860.1k | Reduced -666.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 154.9k $847.1k | Added +36.9k |
| SECTORAL ASSET MANAGEMENT INC 0.48% of their portfolio | 134.2k $733.8k | Added +52.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 127.6k $697.9k | Reduced -153.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 126.9k $695.0k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 120.2k $657.7k | Added +2.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 117.2k $641.3k | Reduced -57.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 106.4k $582.0k | Added +15.9k |
| CANTOR FITZGERALD, L. P. 0.01% of their portfolio | 100.0k $547.0k | New |
| LMR Partners LLP 0.01% of their portfolio | 100.0k $547.0k | Unchanged |
| OPPENHEIMER & CO INC 0.01% of their portfolio | 99.8k $546.0k | Reduced -612 |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.01% of their portfolio | 87.0k $475.6k | New |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 86.8k $475.0k | New |
| PFS Partners, LLC 0.22% of their portfolio | 79.0k $432.1k | Unchanged |
| Polar Asset Management Partners Inc. 0.01% of their portfolio | 74.3k $406.4k | Added +10.2k |
| XTX Topco Ltd 0.01% of their portfolio | 64.6k $353.3k | Added +54.2k |
| ALPS ADVISORS INC 0.00% of their portfolio | 64.3k $351.7k | New |
| CITIGROUP INC 0.00% of their portfolio | 64.0k $349.9k | Added +10.1k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 62.4k $342.2k | Added +34.7k |
| WealthTrust Axiom LLC 0.10% of their portfolio | 61.5k $336.4k | Reduced -2.0k |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 59.4k $325.1k | Reduced -17.3k |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 55.0k $300.6k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 54.3k $297.3k | Reduced -9.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 49.9k $273.1k | Added +12.6k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 45.0k $246.0k | Reduced -35.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 44.7k $244.3k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 43.4k $237.6k | Added +5.8k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 43.0k $235.3k | Added +21.0k |
| Persistent Asset Partners Ltd 0.21% of their portfolio | 42.8k $234.1k | Added +1.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 41.5k $227.3k | Reduced -2.6k |
| AXQ CAPITAL, LP 0.07% of their portfolio | 41.5k $227.0k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 41.2k $225.2k | Added +75 |
| Graham Capital Management, L.P. 0.01% of their portfolio | 40.1k $219.1k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 38.6k $211.0k | Added +6.4k |
| TRUST CO OF TOLEDO NA /OH/ 0.02% of their portfolio | 36.5k $199.7k | Unchanged |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 35.0k $191.4k | New |
| Trexquant Investment LP 0.00% of their portfolio | 34.0k $185.8k | New |
| UNITED BANK 0.02% of their portfolio | 31.2k $170.7k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 31.0k $169.5k | Added +25.4k |
| ADAR1 Capital Management, LLC 0.03% of their portfolio | 30.0k $164.1k | New |
| Dauntless Investment Group, LLC 0.75% of their portfolio | 29.0k $158.6k | Not comparable |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 28.3k $154.9k | Added +3.9k |
| Engineers Gate Manager LP 0.00% of their portfolio | 28.2k $154.0k | New |
| KENNEDY CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.9k $152.3k | Added +595 |