TANGO THERAPEUTICS INC TNGX
COM · Common Stock · CUSIP 87583X109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2017
- Websitetangotx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($111.8k this quarter). Holder counts are more reliable. Shares outstanding: 111.3m as of 2025-07-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.12. Options: 5 managers hold calls ($1.3m notional), 3 hold puts ($96.8k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 87 |
| Q4 2022 | 83 |
| Q1 2023 | 93 |
| Q2 2023 | 90 |
| Q3 2023 | 101 |
| Q4 2023 | 122 |
| Q1 2024 | 127 |
| Q2 2024 | 121 |
| Q3 2024 | 122 |
| Q4 2024 | 139 |
| Q1 2025 | 123 |
| Q2 2025 | 116 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 55 | 37 |
| Q4 2023 | 73 | 36 |
| Q1 2024 | 58 | 56 |
| Q2 2024 | 56 | 59 |
| Q3 2024 | 54 | 51 |
| Q4 2024 | 74 | 55 |
| Q1 2025 | 57 | 68 |
| Q2 2025 | 62 | 59 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $23.9k | $16.6k | 0.69 |
| Q4 2024 | $4.3k | $13.6k | 3.14 |
| Q1 2025 | $1.5k | $0 | 0.00 |
| Q2 2025 | $1.3m | $96.8k | 0.07 |
Biggest buyers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +5.9m |
| Woodline Partners LP | Added | +5.5m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +4.5m |
| RA CAPITAL MANAGEMENT, L.P. | New | +2.0m |
| Commodore Capital LP | New | +1.5m |
| BlackRock, Inc. | Added | +1.4m |
| Siren, L.L.C. | Added | +799.5k |
| Soleus Capital Management, L.P. | New | +730.0k |
| Candriam S.C.A. | New | +708.8k |
| Vivo Capital, LLC | New | +600.0k |
Biggest sellers
| Blue Owl Capital Holdings LP | Reduced | -1.3m |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -891.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP | Sold out | -655.2k |
| Boxer Capital Management, LLC | Reduced | -609.5k |
| ORBIMED ADVISORS LLC | Sold out | -550.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -519.2k |
| SAMSARA BIOCAPITAL, LLC | Reduced | -420.0k |
| JANE STREET GROUP, LLC | Sold out | -352.9k |
| BANK OF AMERICA CORP /DE/ | Reduced | -304.3k |
| GSA CAPITAL PARTNERS LLP | Sold out | -241.7k |
Biggest calls
| DIADEMA PARTNERS LP | New | $1.0m200.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $230.4k45.0k shares |
| Persistent Asset Partners Ltd | New | $55.4k461 shares |
| SIMPLEX TRADING, LLC | Added | $14.0k2.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $82.9k16.2k shares |
| Belvedere Trading LLC | New | $13.8k2.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BCTG Holdings, LLC
13D · may seek influence
filed 2025-01-02
Stated purposeItem 4 is hereby amended by the addition of the following: The disclosure set forth above in Item 3 is hereby incorporated herein. Full filing |
10.0% |
| FARALLON PARTNERS L L C/CA 13G · passive investor filed 2026-02-06 | 10.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-14 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 9.3% |
| Farallon Capital Partners, L.P. 13G · passive investor -1.9 pts · filed 2026-05-11 | 7.8% |
| TCG Crossover GP II, LLC 13G · passive investor -1.1 pts · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +6.9 pts · filed 2026-05-06 | 6.9% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.3% |
| GOLDMAN SACHS GROUP INC 13G · institution new · filed 2026-08-14 | 6.0% |
Fell to 5% or below in the last year: Woodline Partners LP (2.5%, 2026-08-14), Nextech Crossover I GP S.a r.l. (0.0%, 2026-08-14), Adage Capital Management, L.P. (3.4%, 2026-08-12), Invus Global Management, LLC (4.0%, 2026-05-04), VANGUARD GROUP INC (0.0%, 2026-03-27), EcoR1 Capital, LLC (0.0%, 2026-02-17), Third Rock Ventures IV, L.P. (4.7%, 2026-02-10)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 1 | $63.0k | — |
| Q1 2024 | 0 | — | 4 | $302.3k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $74.0k | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $143.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| TRV GP IV, LLC 52.85% of their portfolio | 16.9m $86.3m | Unchanged |
| TCG Crossover Management, LLC 6.28% of their portfolio | 10.7m $55.0m | Unchanged |
| EcoR1 Capital, LLC 3.23% of their portfolio | 10.6m $54.4m | Unchanged |
| Boxer Capital Management, LLC 25.18% of their portfolio | 9.8m $50.0m | Reduced -609.5k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.21% of their portfolio | 9.2m $46.9m | Added +4.5m |
| Woodline Partners LP 0.16% of their portfolio | 6.0m $30.9m | Added +5.5m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 5.9m $30.2m | New |
| Nextech Invest Ltd. 5.36% of their portfolio | 5.5m $28.3m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 5.5m $28.0m | Added +1.4m |
| GILEAD SCIENCES, INC. 1.94% of their portfolio | 4.9m $24.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.0m $20.6m | Added +151.3k |
| Nantahala Capital Management, LLC 1.25% of their portfolio | 3.4m $17.6m | Added +451.6k |
| Siren, L.L.C. 0.89% of their portfolio | 3.4m $17.2m | Added +799.5k |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 3.2m $16.6m | Added +27.9k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 3.2m $16.2m | Reduced -143.2k |
| Bain Capital Life Sciences Investors, LLC 1.74% of their portfolio | 2.7m $13.9m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.17% of their portfolio | 2.0m $10.2m | New |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.8m $9.1m | Added +301.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.8m $9.1m | Added +385.5k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 1.7m $8.9m | Reduced -99.5k |
| Commodore Capital LP 0.54% of their portfolio | 1.5m $7.7m | New |
| STATE STREET CORP 0.00% of their portfolio | 1.4m $7.1m | Added +238.2k |
| Blue Owl Capital Holdings LP 1.35% of their portfolio | 814.4k $4.2m | Reduced -1.3m |
| Soleus Capital Management, L.P. 0.26% of their portfolio | 730.0k $3.7m | New |
| Candriam S.C.A. 0.02% of their portfolio | 708.8k $3.6m | New |
| ArrowMark Colorado Holdings LLC 0.07% of their portfolio | 708.4k $3.6m | Unchanged |
| BESSEMER GROUP INC 0.01% of their portfolio | 708.4k $3.6m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 601.4k $3.1m | Added +53.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 600.5k $3.1m | Added +151.1k |
| Vivo Capital, LLC 0.31% of their portfolio | 600.0k $3.1m | New |
| MORGAN STANLEY 0.00% of their portfolio | 534.6k $2.7m | Added +284.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 525.1k $2.7m | Reduced -80.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 504.5k $2.6m | Added +503.1k |
| Nuveen, LLC 0.00% of their portfolio | 443.0k $2.3m | Added +240.8k |
| READYSTATE ASSET MANAGEMENT LP 0.09% of their portfolio | 418.5k $2.1m | New |
| UBS Group AG 0.00% of their portfolio | 277.1k $1.4m | Added +123.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 242.4k $1.2m | Added +175.8k |
| CONGRESS ASSET MANAGEMENT CO 0.01% of their portfolio | 227.2k $1.2m | Reduced -167 |
| Fisher Asset Management, LLC 0.00% of their portfolio | 224.1k $1.1m | Unchanged |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 218.8k $1.1m | Reduced -519.2k |
| SAMSARA BIOCAPITAL, LLC 0.22% of their portfolio | 210.0k $1.1m | Reduced -420.0k |
| STEMPOINT CAPITAL LP 0.34% of their portfolio | 208.8k $1.1m | New |
| TRV GP VI, LLC 1.55% of their portfolio | 194.2k $994.2k | Unchanged |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 191.3k $979.6k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 188.0k $962.5k | Added +74.8k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio | 159.8k $818.4k | Reduced -72.9k |
| BARCLAYS PLC 0.00% of their portfolio | 138.7k $709.9k | Added +75.6k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 125.2k $641.1k | Added +342 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 125.0k $640.0k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 112.3k $574.8k | Added +45.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 108.2k $553.9k | Reduced -64.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 106.0k $542.8k | Added +41.1k |
| Invesco Ltd. 0.00% of their portfolio | 95.3k $487.9k | Added +24.8k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 82.0k $419.0k | Reduced -891.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 78.9k $404.2k | Reduced -63.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 66.7k $341.4k | Added +35.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 65.5k $335.4k | Reduced -109.0k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $502.0k | Unchanged |
| Polar Asset Management Partners Inc. 0.01% of their portfolio | 56.1k $287.2k | New |
| XTX Topco Ltd 0.01% of their portfolio | 55.8k $285.7k | Reduced -112.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 55.1k $281.9k | Reduced -51.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 52.7k $269.6k | Reduced -1.1k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 49.9k $255.0k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 49.2k $252.0k | Added +26.4k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 47.7k $244.4k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 47.1k $241.4k | Reduced -304.3k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 45.7k $233.9k | Added +5.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 42.0k $215.0k | Added +13.4k |
| Allostery Investments LP 2.61% of their portfolio | 40.0k $204.8k | New |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 39.5k $202.0k | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 38.4k $197.0k | Added +16.1k |
| Clear Harbor Asset Management, LLC 0.01% of their portfolio | 30.3k $155.1k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 30.3k $155.1k | Reduced -11.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 28.8k $147.5k | Added +9.4k |
| Simplicity Wealth,LLC 0.01% of their portfolio | 27.0k $138.0k | Unchanged |
| EverSource Wealth Advisors, LLC 0.01% of their portfolio | 26.6k $136.4k | Added +26.6k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 22.2k $113.8k | Reduced -30.7k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 21.8k $111.5k | Added +86 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.3k $109.0k | Reduced -7.5k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 20.4k $104.3k | Added +9.7k |
| ProShare Advisors LLC 0.00% of their portfolio | 19.8k $101.2k | Added +4.6k |
| Virtus Investment Advisers, LLC 0.03% of their portfolio | 18.6k $95.3k | Reduced -39.0k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 17.6k $90.4k | Added +8.4k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 12.8k $65.4k | Unchanged |
| Belvedere Trading LLC 0.00% of their portfolio | 11.2k $57.5k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 10.3k $52.7k | Reduced -118.8k |
| Northeast Financial Consultants Inc 0.00% of their portfolio | 10.0k $51.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 9.5k $48.5k | Added +2.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 8.6k $44.1k | Reduced -38.9k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 7.8k $40.1k | Added +3.5k |
| Legal & General Group Plc 0.00% of their portfolio | 7.0k $35.8k | Added +1.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 6.6k $33.7k | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 6.2k $31.7k | Reduced -611 |
| FMR LLC 0.00% of their portfolio | 5.6k $28.6k | Reduced -5.2k |
| CWM, LLC 0.00% of their portfolio | 4.9k $25.0k | Added +3.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 4.8k $24.5k | Added +1.3k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 4.2k $21.4k | Added +454 |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 2.7k $13.6k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 2.1k $10.6k | Added +2.0k |
| AMALGAMATED BANK 0.00% of their portfolio | 1.6k $8.0k | Unchanged |