SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.1m this quarter). Holder counts are more reliable. Shares outstanding: 85.1m as of 2024-07-25, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $20.53. Options: 10 managers hold calls ($6.7m notional), 7 hold puts ($3.2m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 139 |
| Q4 2022 | 160 |
| Q1 2023 | 164 |
| Q2 2023 | 167 |
| Q3 2023 | 176 |
| Q4 2023 | 178 |
| Q1 2024 | 191 |
| Q2 2024 | 197 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 95 | 51 |
| Q1 2023 | 106 | 57 |
| Q2 2023 | 104 | 63 |
| Q3 2023 | 95 | 70 |
| Q4 2023 | 111 | 77 |
| Q1 2024 | 112 | 73 |
| Q2 2024 | 112 | 77 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $66.1m | $67.5m | 1.02 |
| Q4 2023 | $20.0m | $14.9m | 0.74 |
| Q1 2024 | $8.8m | $9.1m | 1.02 |
| Q2 2024 | $6.7m | $3.2m | 0.47 |
Biggest buyers
| Avidity Partners Management LP | Added | +922.5k |
| Point72 Asset Management, L.P. | Added | +716.2k |
| First Turn Management, LLC | New | +640.4k |
| Prosight Management, LP | New | +551.5k |
| Sofinnova Investments, Inc. | Added | +545.1k |
| Commodore Capital LP | Added | +506.1k |
| Eversept Partners, LP | Added | +480.5k |
| Soleus Capital Management, L.P. | Added | +457.5k |
| Nantahala Capital Management, LLC | Added | +441.2k |
| MILLENNIUM MANAGEMENT LLC | Added | +383.6k |
Biggest sellers
| MORGAN STANLEY | Reduced | -4.7m |
| T. Rowe Price Investment Management, Inc. | Reduced | -2.2m |
| BVF INC/IL | Sold out | -1.9m |
| STATE STREET CORP | Reduced | -1.2m |
| Iron Triangle Partners LP | Sold out | -973.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -802.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -634.1k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Reduced | -551.4k |
| Schonfeld Strategic Advisors LLC | Reduced | -524.8k |
| Logos Global Management LP | Sold out | -350.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.0m145.8k shares |
| Point72 Asset Management, L.P. | New | $1.3m62.5k shares |
| JANE STREET GROUP, LLC | Added | $893.1k43.5k shares |
| CITADEL ADVISORS LLC | Reduced | $513.2k25.0k shares |
| PEAK6 Investments LLC | New | $503.0k24.5k shares |
| WOLVERINE TRADING, LLC | Reduced | $207.4k10.1k shares |
| JPMORGAN CHASE & CO | Unchanged | $188.9k9.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $98.0k4.8k shares |
| GROUP ONE TRADING LLC | Reduced | $32.8k1.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JPMORGAN CHASE & CO | Unchanged | $1.4m68.4k shares |
| CITADEL ADVISORS LLC | Reduced | $638.5k31.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $603.6k29.4k shares |
| WOLVERINE TRADING, LLC | Reduced | $334.6k16.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $145.0k7.1k shares |
| GROUP ONE TRADING LLC | Reduced | $30.8k1.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 6 | $16.7m | — |
| Q4 2022 | 0 | — | 3 | $1.9m | — |
| Q1 2023 | 0 | — | 4 | $4.5m | — |
| Q2 2023 | 0 | — | 2 | $3.3m | $3.3m |
| Q3 2023 | 0 | — | 2 | $3.7m | $3.7m |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 1 | $25.0k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-14 | Goldan Keith A. Chief Financial Officer | Bought | $25.0k1.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.00% of their portfolio | 7.9m $162.3m | Added +354.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 7.3m $150.7m | Reduced -97.6k |
| Kynam Capital Management, LP 12.30% of their portfolio | 5.7m $117.5m | Added +62.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.8m $98.5m | Reduced -129.9k |
| Avoro Capital Advisors LLC 1.06% of their portfolio | 3.9m $79.8m | Reduced -333.8k |
| STATE STREET CORP 0.00% of their portfolio | 3.6m $74.4m | Reduced -1.2m |
| Eversept Partners, LP 5.68% of their portfolio | 3.6m $74.2m | Added +480.5k |
| Avidity Partners Management LP 2.91% of their portfolio | 3.3m $68.5m | Added +922.5k |
| Point72 Asset Management, L.P. 0.18% of their portfolio | 2.8m $57.1m | Added +716.2k |
| Sofinnova Investments, Inc. 2.79% of their portfolio | 2.2m $44.2m | Added +545.1k |
| ORBIMED ADVISORS LLC 0.79% of their portfolio | 1.9m $39.5m | Added +176.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $39.2m | Added +132.1k |
| MARSHALL WACE, LLP 0.05% of their portfolio | 1.8m $37.6m | Reduced -201.6k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.6m $31.9m | Added +59.5k |
| Woodline Partners LP 0.30% of their portfolio | 1.5m $31.7m | Added +1.2k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.4m $29.6m | Added +133.9k |
| STEMPOINT CAPITAL LP 8.53% of their portfolio | 1.4m $29.0m | Added +311.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.3m $25.9m | Reduced -105.2k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.1m $21.9m | Added +383.6k |
| Aisling Capital Management LP 9.11% of their portfolio | 1.0m $21.0m | Unchanged |
| Candriam S.C.A. 0.12% of their portfolio | 970.1k $19.9m | Reduced -74.9k |
| TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio | 930.9k $19.1m | Added +212.4k |
| Nantahala Capital Management, LLC 0.94% of their portfolio | 906.5k $18.6m | Added +441.2k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 2.84% of their portfolio | 895.0k $18.4m | Unchanged |
| Foresite Capital Management IV, LLC 12.07% of their portfolio | 875.0k $18.0m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 860.0k $17.7m | Reduced -40.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 852.2k $17.5m | Reduced -802.8k |
| Soleus Capital Management, L.P. 1.50% of their portfolio | 826.5k $17.0m | Added +457.5k |
| Commodore Capital LP 1.16% of their portfolio | 825.0k $16.9m | Added +506.1k |
| SPHERA FUNDS MANAGEMENT LTD. 2.75% of their portfolio | 822.0k $16.9m | Added +9.1k |
| MORGAN STANLEY 0.00% of their portfolio | 756.2k $15.5m | Reduced -4.7m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 696.7k $14.3m | Reduced -45.1k |
| DAFNA Capital Management LLC 3.22% of their portfolio | 657.1k $13.5m | Reduced -2.5k |
| FEDERATED HERMES, INC. 0.03% of their portfolio | 656.2k $13.5m | Added +117.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 654.5k $13.4m | Added +19.3k |
| First Turn Management, LLC 2.14% of their portfolio | 640.4k $13.1m | New |
| ExodusPoint Capital Management, LP 0.14% of their portfolio | 625.7k $12.8m | Added +339.4k |
| TWO SIGMA ADVISERS, LP 0.03% of their portfolio | 621.3k $12.8m | Added +165.4k |
| Parkman Healthcare Partners LLC 1.68% of their portfolio | 600.7k $12.3m | Reduced -184.1k |
| Granahan Investment Management, LLC 0.49% of their portfolio | 594.4k $12.2m | Added +197.5k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 556.4k $11.4m | Added +163.7k |
| Prosight Management, LP 3.38% of their portfolio | 551.5k $11.3m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 521.1k $10.7m | Added +9.6k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 518.9k $10.7m | Added +4.0k |
| ALGERT GLOBAL LLC 0.30% of their portfolio | 432.1k $8.9m | Added +6.5k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 428.9k $8.8m | Added +151.0k |
| Saturn V Capital Management LP 3.26% of their portfolio | 419.7k $8.6m | Added +21.7k |
| Palo Alto Investors LP 0.96% of their portfolio | 405.2k $8.3m | Unchanged |
| PFM Health Sciences, LP 0.43% of their portfolio | 387.4k $8.0m | Reduced -271.3k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.88% of their portfolio | 370.0k $7.6m | New |
| Ghost Tree Capital, LLC 2.50% of their portfolio | 350.0k $7.2m | Added +200.0k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 297.3k $6.1m | Added +203.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 291.8k $6.0m | Added +46.5k |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 283.8k $5.8m | Reduced -2.2m |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 260.9k $5.4m | Reduced -524.8k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 242.9k $5.0m | Reduced -73 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 228.6k $4.7m | Reduced -551.4k |
| Rhenman & Partners Asset Management AB 0.45% of their portfolio | 228.5k $4.7m | Added +50.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 214.3k $4.4m | Added +135.2k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.12% of their portfolio | 198.7k $4.1m | Added +2.6k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 190.0k $3.9m | Added +156.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 183.6k $3.8m | Reduced -13.4k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 177.9k $3.7m | Reduced -195.3k |
| TWINBEECH CAPITAL LP 0.07% of their portfolio | 167.7k $3.4m | Added +95.8k |
| Zimmer Partners, LP 0.06% of their portfolio | 155.0k $3.2m | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 153.4k $3.1m | Added +56.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 153.3k $3.1m | Added +39.8k |
| Swiss National Bank 0.00% of their portfolio | 150.6k $3.1m | Unchanged |
| Casdin Capital, LLC 0.24% of their portfolio | 150.0k $3.1m | Unchanged |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 146.6k $3.0m | Added +138.1k |
| Verition Fund Management LLC 0.02% of their portfolio | 144.6k $3.0m | Reduced -202.3k |
| Crestline Management, L.P. 0.23% of their portfolio | 143.3k $2.9m | Added +39.6k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 134.4k $2.8m | Added +118.7k |
| UBS Group AG 0.00% of their portfolio | 125.2k $2.6m | Reduced -144.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 119.3k $2.4m | Added +10.3k |
| Yelin Lapidot Holdings Management Ltd. 0.41% of their portfolio | 114.5k $2.4m | Unchanged |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.06% of their portfolio | 110.5k $2.3m | Added +2.0k |
| Knott David M Jr 0.85% of their portfolio | 103.8k $2.1m | Added +38.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 102.0k $2.1m | Reduced -634.1k |
| AXIOM INVESTORS LLC /DE 0.02% of their portfolio | 95.1k $2.0m | Added +1.1k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 94.3k $1.9m | Reduced -20.1k |
| Trexquant Investment LP 0.03% of their portfolio | 93.9k $1.9m | Added +19.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 85.2k $1.8m | Added +7.8k |
| Propel Bio Management, LLC 1.11% of their portfolio | 83.3k $1.7m | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 82.8k $1.7m | Reduced -154.2k |
| BIT Capital GmbH 0.15% of their portfolio | 79.8k $1.6m | Added +12.8k |
| BARCLAYS PLC 0.00% of their portfolio | 77.1k $1.6m | Reduced -25.1k |
| SEVEN EIGHT CAPITAL, LP 0.16% of their portfolio | 76.0k $1.6m | Added +66.3k |
| Engineers Gate Manager LP 0.04% of their portfolio | 75.8k $1.6m | Added +33.4k |
| Graham Capital Management, L.P. 0.05% of their portfolio | 75.7k $1.6m | Reduced -4.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 75.3k $1.5m | Reduced -1.2k |
| Simplify Asset Management Inc. 0.14% of their portfolio | 75.2k $1.5m | Reduced -144 |
| Legal & General Group Plc 0.00% of their portfolio | 74.4k $1.5m | Added +4.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 70.2k $1.4m | Reduced -38.5k |
| ALPS ADVISORS INC 0.01% of their portfolio | 66.3k $1.4m | Added +6.4k |
| Lion Point Capital, LP 4.18% of their portfolio | 65.0k $1.3m | Unchanged |
| Nicholas Investment Partners, LP 0.13% of their portfolio | 62.4k $1.3m | New |
| FOX RUN MANAGEMENT, L.L.C. 0.22% of their portfolio | 55.8k $1.1m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 53.2k $1.1m | Reduced -3.1k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 52.3k $1.1m | Added +11.1k |