SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.4m this quarter). Holder counts are more reliable. Shares outstanding: 60.2m as of 2022-11-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $24.03. Options: 7 managers hold calls ($5.4m notional), 3 hold puts ($442.0k).
Biggest calls
| CITADEL ADVISORS LLC | — | $2.2m91.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | — | $2.0m84.8k shares |
| Nantahala Capital Management, LLC | — | $721.0k30.0k shares |
| JANE STREET GROUP, LLC | — | $382.0k15.9k shares |
| SIMPLEX TRADING, LLC | — | $81.0k3.4k shares |
| GROUP ONE TRADING LLC | — | $2.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | — | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | — | $440.0k18.3k shares |
| SIMPLEX TRADING, LLC | — | $2.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | — | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q3 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2020 | 0 | — | 0 | — | — |
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 4 | $5.5m | — |
| Q1 2022 | 0 | — | 2 | $39.6k | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 6 | $16.7m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2022-09-30 | Metzger Michael A Chief Executive Officer, director | Sold | $740.7k29.6k shares |
| 2022-09-30 | Katkin Keith Director | Sold | $89.3k3.6k shares |
| 2022-09-20 | Morrison Briggs President, Head of R&D, director | Sold | $1.4m59.6k shares |
| 2022-09-19 | Morrison Briggs President, Head of R&D, director | Sold | $2.6m114.3k shares |
| 2022-09-16 | Morrison Briggs President, Head of R&D, director | Sold | $2.9m125.0k shares |
| 2022-09-16 | Podlesak Dennis Director | Sold | $280.6k12.0k shares |
| 2022-09-15 | Podlesak Dennis Director | Sold | $1.6m66.8k shares |
| 2022-09-15 | Morrison Briggs President, Head of R&D, director | Sold | $1.6m66.8k shares |
| 2022-09-14 | Morrison Briggs President, Head of R&D, director | Sold | $2.1m87.6k shares |
| 2022-08-24 | Ordentlich Peter Chief Scientific Officer | Sold | $626.0k25.0k shares |
| 2022-08-05 | Legault Pierre Director | Sold | $552.5k24.0k shares |
| 2022-07-25 | Metzger Michael A Chief Executive Officer, director | Sold | $665.5k31.6k shares |
| 2022-07-07 | Metzger Michael A Chief Executive Officer, director | Sold | $2.1k100 shares |
| 2022-07-06 | Metzger Michael A Chief Executive Officer, director | Sold | $316.2k15.0k shares |
| 2022-07-01 | Morrison Briggs President, Head of R&D, director | Sold | $1.2m62.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2022
| Manager | Shares | Change |
|---|---|---|
| Avidity Partners Management LP 2.92% of their portfolio | 5.6m $134.3m | — |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 4.4m $105.4m | — |
| BlackRock Inc. 0.00% of their portfolio | 4.1m $99.5m | — |
| Frazier Life Sciences Management, L.P. 6.31% of their portfolio | 3.4m $82.0m | — |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.8m $67.3m | — |
| STATE STREET CORP 0.00% of their portfolio | 2.6m $62.9m | — |
| Kynam Capital Management, LP 11.54% of their portfolio | 2.3m $54.6m | — |
| Avoro Capital Advisors LLC 0.99% of their portfolio | 2.2m $53.4m | — |
| ORBIMED ADVISORS LLC 0.90% of their portfolio | 2.0m $48.2m | — |
| BVF INC/IL 1.78% of their portfolio | 1.8m $43.2m | — |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 1.6m $39.6m | — |
| Nantahala Capital Management, LLC 3.24% of their portfolio | 1.4m $33.1m | — |
| CITADEL ADVISORS LLC 0.04% of their portfolio | 1.4m $32.8m | — |
| PFM Health Sciences, LP 1.18% of their portfolio | 1.3m $31.0m | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 1.2m $30.0m | — |
| Eversept Partners, LP 3.45% of their portfolio | 1.2m $29.1m | — |
| 683 Capital Management, LLC 2.19% of their portfolio | 1.1m $27.2m | — |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 1.1m $27.0m | — |
| Paradigm Biocapital Advisors LP 3.67% of their portfolio | 1.1m $26.1m | — |
| Aisling Capital Management LP 16.36% of their portfolio | 1.0m $24.6m | — |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 968.1k $23.3m | — |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 923.2k $22.2m | — |
| HealthCor Management, L.P. 2.58% of their portfolio | 859.2k $20.6m | — |
| SPHERA FUNDS MANAGEMENT LTD. 3.50% of their portfolio | 822.7k $19.8m | — |
| Woodline Partners LP 0.28% of their portfolio | 789.3k $19.0m | — |
| Commodore Capital LP 2.85% of their portfolio | 738.1k $17.7m | — |
| Foresite Capital Management IV, LLC 5.33% of their portfolio | 690.0k $16.6m | — |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 616.3k $14.8m | — |
| Palo Alto Investors LP 1.16% of their portfolio | 612.6k $14.7m | — |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 568.1k $13.7m | — |
| CITIGROUP INC 0.02% of their portfolio | 531.0k $12.8m | — |
| Sofinnova Investments, Inc. 0.80% of their portfolio | 525.0k $12.6m | — |
| NORTHERN TRUST CORP 0.00% of their portfolio | 504.0k $12.1m | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 385.1k $9.3m | — |
| TWO SIGMA ADVISERS, LP 0.03% of their portfolio | 371.8k $8.9m | — |
| DAFNA Capital Management LLC 2.30% of their portfolio | 355.5k $8.5m | — |
| LORD, ABBETT & CO. LLC 0.03% of their portfolio | 335.0k $8.0m | — |
| ACUTA CAPITAL PARTNERS, LLC 3.47% of their portfolio | 324.6k $7.8m | — |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 302.1k $7.3m | — |
| UBS Group AG 0.00% of their portfolio | 285.5k $6.9m | — |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 276.7k $6.7m | — |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 211.4k $5.1m | — |
| Ghost Tree Capital, LLC 1.96% of their portfolio | 200.0k $4.8m | — |
| Bank of New York Mellon Corp 0.00% of their portfolio | 189.2k $4.5m | — |
| NORGES BANK 0.00% of their portfolio | 188.2k $4.5m | — |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 180.0k $4.3m | — |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 165.9k $4.0m | — |
| FMR LLC 0.00% of their portfolio | 165.9k $4.0m | — |
| MORGAN STANLEY 0.00% of their portfolio | 158.6k $3.8m | — |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 146.4k $3.5m | — |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 128.0k $3.1m | — |
| Swiss National Bank 0.00% of their portfolio | 113.3k $2.7m | — |
| BAKER BROS. ADVISORS LP 0.02% of their portfolio | 110.7k $2.7m | — |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 108.8k $2.6m | — |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 105.7k $2.5m | — |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 94.5k $2.3m | — |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 78.8k $1.9m | — |
| Global IMC LLC 0.49% of their portfolio | 76.6k $1.8m | — |
| Invesco Ltd. 0.00% of their portfolio | 76.4k $1.8m | — |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 68.8k $1.7m | — |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 66.3k $1.6m | — |
| Crestline Management, L.P. 0.21% of their portfolio | 63.6k $1.5m | — |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 62.1k $1.5m | — |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 58.5k $1.4m | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 56.1k $1.3m | — |
| Informed Momentum Co LLC 0.27% of their portfolio | 52.2k $1.3m | — |
| ALGERT GLOBAL LLC 0.07% of their portfolio | 48.9k $1.2m | — |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 46.2k $1.1m | — |
| MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio | 45.6k $1.1m | — |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio | 45.2k $1.1m | — |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 45.2k $1.1m | — |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 43.3k $1.0m | — |
| Ziegler Capital Management, LLC 0.04% of their portfolio | 41.6k $1.0m | — |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 40.7k $979.0k | — |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 37.4k $898.0k | — |
| HighVista Strategies LLC 0.51% of their portfolio | 37.1k $892.0k | — |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 35.8k $861.0k | — |
| Gyon Technologies Capital Management, LP 0.25% of their portfolio | 33.0k $792.0k | — |
| ALPS ADVISORS INC 0.01% of their portfolio | 30.9k $741.0k | — |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 28.3k $687.0k | — |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 28.1k $675.0k | — |
| MetLife Investment Management, LLC 0.01% of their portfolio | 27.0k $649.5k | — |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 26.9k $646.0k | — |
| Sigma Planning Corp 0.02% of their portfolio | 25.6k $616.0k | — |
| CAXTON ASSOCIATES LP 0.11% of their portfolio | 25.6k $615.0k | — |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 25.3k $607.0k | — |
| STRS OHIO 0.00% of their portfolio | 24.9k $598.0k | — |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 23.5k $565.0k | — |
| SG Americas Securities, LLC 0.01% of their portfolio | 22.9k $549.0k | — |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 21.9k $527.0k | — |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 21.6k $518.0k | — |
| Verition Fund Management LLC 0.00% of their portfolio | 21.5k $516.0k | — |
| BIT Capital GmbH 0.10% of their portfolio | 20.8k $498.9k | — |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 20.1k $484.0k | — |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 20.0k $481.4k | — |
| Legal & General Group Plc 0.00% of their portfolio | 19.2k $462.0k | — |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 16.7k $401.0k | — |
| SEI INVESTMENTS CO 0.00% of their portfolio | 16.0k $385.0k | — |
| Allianz Asset Management GmbH 0.00% of their portfolio | 16.0k $384.0k | — |
| TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio | 15.7k $378.0k | — |