SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($241.3k this quarter). Holder counts are more reliable. Shares outstanding: 89.3m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.86. Options: 10 managers hold calls ($26.1m notional), 6 hold puts ($2.8m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 139 |
| Q4 2022 | 160 |
| Q1 2023 | 164 |
| Q2 2023 | 167 |
| Q3 2023 | 176 |
| Q4 2023 | 178 |
| Q1 2024 | 191 |
| Q2 2024 | 197 |
| Q3 2024 | 211 |
| Q4 2024 | 217 |
| Q1 2025 | 220 |
| Q2 2025 | 218 |
| Q3 2025 | 228 |
| Q4 2025 | 230 |
| Q1 2026 | 247 |
| Q2 2026 | 242 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 120 | 83 |
| Q4 2024 | 115 | 90 |
| Q1 2025 | 119 | 84 |
| Q2 2025 | 115 | 99 |
| Q3 2025 | 124 | 98 |
| Q4 2025 | 109 | 109 |
| Q1 2026 | 137 | 93 |
| Q2 2026 | 129 | 116 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $25.0m | $12.5m | 0.50 |
| Q4 2025 | $30.0m | $14.4m | 0.48 |
| Q1 2026 | $15.3m | $8.1m | 0.53 |
| Q2 2026 | $26.1m | $2.8m | 0.11 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +1.9m |
| STATE STREET CORP | Added | +1.2m |
| LOOMIS SAYLES & CO L P | New | +923.6k |
| GOLDMAN SACHS GROUP INC | Added | +864.5k |
| Candriam S.C.A. | Added | +770.7k |
| BlackRock, Inc. | Added | +765.6k |
| UBS Group AG | Added | +740.1k |
| ORBIMED ADVISORS LLC | Added | +579.7k |
| FIRST TRUST ADVISORS LP | New | +456.7k |
| Qube Research & Technologies Ltd | Added | +441.1k |
Biggest sellers
| STEMPOINT CAPITAL LP | Sold out | -2.4m |
| Point72 Asset Management, L.P. | Sold out | -2.0m |
| Walleye Capital LLC | Reduced | -379.3k |
| CITADEL ADVISORS LLC | Reduced | -372.7k |
| D. E. Shaw & Co., Inc. | Reduced | -361.9k |
| Integral Health Asset Management, LLC | Sold out | -350.0k |
| JANE STREET GROUP, LLC | Sold out | -335.5k |
| MORGAN STANLEY | Reduced | -305.0k |
| CANADA PENSION PLAN INVESTMENT BOARD | Sold out | -229.6k |
| BANK OF AMERICA CORP /DE/ | Reduced | -204.7k |
Biggest calls
| SILVERARC CAPITAL MANAGEMENT, LLC | Added | $15.2m693.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.7m259.4k shares |
| CITADEL ADVISORS LLC | Reduced | $1.5m70.4k shares |
| CITIGROUP INC | Added | $1.3m60.0k shares |
| BARCLAYS PLC | New | $1.1m49.6k shares |
| SIMPLEX TRADING, LLC | Added | $546.5k25.0k shares |
| JANE STREET GROUP, LLC | Reduced | $430.6k19.7k shares |
| IMC-Chicago, LLC | New | $247.0k11.3k shares |
| Walleye Capital LLC | Added | $139.9k6.4k shares |
| GROUP ONE TRADING LLC | Reduced | $13.1k600 shares |
Biggest puts
| CITIGROUP INC | Added | $1.3m60.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.0m47.9k shares |
| CITADEL ADVISORS LLC | Reduced | $354.1k16.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $52.5k2.4k shares |
| Walleye Capital LLC | Reduced | $10.9k500 shares |
| GROUP ONE TRADING LLC | Reduced | $6.6k300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 3 | $453.7k | $117.6k |
| Q2 2025 | 4 | $241.9k | 0 | — | — |
| Q3 2025 | 0 | — | 3 | $3.5m | $3.5m |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 2 | $628.3k | — |
| Q2 2026 | 0 | — | 3 | $1.3m | $1.2m |
| Q3 2026 | 0 | — | 1 | $784.8k | $784.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-07-08 | Metzger Michael A Chief Executive Officer, director | Sold plan | $784.8k32.4k shares |
| 2026-06-12 | Botwood Nicholas A.J. Head of R&D, CMO | Sold plan | $566.6k31.2k shares |
| 2026-06-11 | Botwood Nicholas A.J. Head of R&D, CMO | Sold plan | $617.0k34.3k shares |
| 2026-06-01 | Metzger Michael A Chief Executive Officer, director | Sold | $130.0k6.8k shares |
| 2026-06-01 | Goldan Keith A. Chief Financial Officer | Sold | $22.4k1.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 9.0m $197.2m | Added +765.6k |
| Kynam Capital Management, LP 9.73% of their portfolio | 8.1m $176.0m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 5.9m $128.1m | Added +864.5k |
| STATE STREET CORP 0.00% of their portfolio | 5.7m $123.7m | Added +1.2m |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 4.0m $88.4m | Reduced -204.7k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.9m $85.9m | Added +105.3k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.86% of their portfolio | 3.8m $82.6m | Unchanged |
| Eversept Partners, LP 3.33% of their portfolio | 2.8m $61.2m | Reduced -87.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.6m $56.5m | Added +427.1k |
| Hood River Capital Management LLC 0.41% of their portfolio | 2.6m $56.1m | Added +210.0k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 7.37% of their portfolio | 2.5m $54.6m | Unchanged |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 2.3m $50.0m | Added +136.4k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 2.1m $44.9m | Added +1.9m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.9m $42.0m | Added +184.7k |
| UBS Group AG 0.01% of their portfolio | 1.9m $41.4m | Added +740.1k |
| Elmind Capital, LP 10.19% of their portfolio | 1.9m $40.6m | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio | 1.8m $39.1m | Added +57.6k |
| Candriam S.C.A. 0.17% of their portfolio | 1.7m $37.0m | Added +770.7k |
| Soleus Capital Management, L.P. 1.23% of their portfolio | 1.6m $35.6m | Reduced -98.9k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 1.6m $34.5m | Reduced -1.5k |
| ORBIMED ADVISORS LLC 0.64% of their portfolio | 1.5m $33.7m | Added +579.7k |
| Nuveen, LLC 0.01% of their portfolio | 1.4m $29.8m | Reduced -130.1k |
| MPM BIOIMPACT LLC 1.78% of their portfolio | 1.3m $29.2m | Reduced -7.2k |
| Aisling Capital Management LP 6.10% of their portfolio | 1.3m $28.8m | Unchanged |
| Woodline Partners LP 0.08% of their portfolio | 1.3m $27.3m | Unchanged |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 1.2m $27.1m | Reduced -361.9k |
| Catalio Capital Management, LP 4.99% of their portfolio | 1.2m $26.6m | Added +172.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 2.95% of their portfolio | 1.2m $26.5m | Added +325.4k |
| Prosight Management, LP 4.52% of their portfolio | 1.2m $26.2m | Added +430.0k |
| Trails Edge Capital Partners, LP 3.85% of their portfolio | 1.1m $24.3m | Added +408.2k |
| ALGERT GLOBAL LLC 0.27% of their portfolio | 1.1m $23.0m | Added +122.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.0m $22.7m | Added +35.6k |
| SPHERA FUNDS MANAGEMENT LTD. 3.17% of their portfolio | 1.0m $22.2m | Added +290.0k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 923.6k $20.2m | New |
| Parkman Healthcare Partners LLC 1.97% of their portfolio | 877.3k $19.2m | Reduced -24.3k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 867.8k $19.0m | Reduced -123.1k |
| Palo Alto Investors LP 2.61% of their portfolio | 865.0k $18.9m | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 853.3k $18.7m | Reduced -127.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 845.5k $18.5m | Added +89.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 814.3k $17.8m | Added +99.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 633.5k $13.8m | Added +33.0k |
| MORGAN STANLEY 0.00% of their portfolio | 589.0k $12.9m | Reduced -305.0k |
| Rhenman & Partners Asset Management AB 1.16% of their portfolio | 560.2k $12.2m | Added +181.0k |
| Apis Capital Advisors, LLC 1.18% of their portfolio | 556.0k $12.2m | Added +6.0k |
| PANAGORA ASSET MANAGEMENT INC 0.04% of their portfolio | 546.5k $11.9m | Added +297.1k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 477.2k $10.4m | Added +441.1k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 456.7k $10.0m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 454.1k $9.9m | Added +257.5k |
| Granahan Investment Management, LLC 0.35% of their portfolio | 447.0k $9.8m | Added +140.7k |
| Knott David M Jr 5.05% of their portfolio | 437.2k $9.6m | Added +15.2k |
| Jump Financial, LLC 0.08% of their portfolio | 402.8k $8.8m | New |
| Aberdeen Group plc 0.01% of their portfolio | 372.8k $8.1m | Added +85.8k |
| Squarepoint Ops LLC 0.02% of their portfolio | 370.3k $8.1m | Added +188.8k |
| JUPITER ASSET MANAGEMENT LTD 0.04% of their portfolio | 366.6k $8.0m | New |
| HRT FINANCIAL LP 0.02% of their portfolio | 363.1k $7.9m | Added +274.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 346.9k $7.6m | Added +62.6k |
| Hennion & Walsh Asset Management, Inc. 0.21% of their portfolio | 342.9k $7.5m | Added +128.1k |
| Jones Hill Capital LP 1.58% of their portfolio | 340.0k $7.4m | New |
| DAFNA Capital Management LLC 1.40% of their portfolio | 335.3k $7.3m | Added +117.9k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 327.6k $7.2m | Added +285.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 321.6k $7.0m | Reduced -176.6k |
| Brevan Howard Capital Management LP 0.09% of their portfolio | 309.1k $6.8m | Added +104.2k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 308.5k $6.7m | New |
| Verition Fund Management LLC 0.05% of their portfolio | 304.9k $6.7m | New |
| MACKENZIE FINANCIAL CORP 0.01% of their portfolio | 280.1k $6.1m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 258.3k $5.6m | Reduced -372.7k |
| Trexquant Investment LP 0.03% of their portfolio | 255.9k $5.6m | Added +54.2k |
| SECTOR GAMMA AS 1.15% of their portfolio | 241.7k $5.3m | Reduced -44.3k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 236.7k $5.2m | Reduced -23.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 231.4k $5.1m | Reduced -27.1k |
| Pinnacle Financial Partners, Inc. 0.03% of their portfolio | 217.2k $4.7m | Added +14.9k |
| Man Group plc 0.01% of their portfolio | 213.7k $4.7m | Added +31.7k |
| Y-Intercept (Hong Kong) Ltd 0.09% of their portfolio | 212.7k $4.6m | New |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 207.9k $4.5m | Added +195.6k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 207.2k $4.5m | Reduced -124.4k |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group 1.15% of their portfolio | 200.0k $4.4m | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 195.7k $4.3m | Added +175.4k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 193.1k $4.2m | Reduced -24.5k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 180.0k $3.9m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 168.1k $3.7m | Added +6.7k |
| Atom Investors LP 0.32% of their portfolio | 162.5k $3.6m | Added +6.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 161.3k $3.5m | Added +11.5k |
| SummitTX Capital, L.P. 0.08% of their portfolio | 140.8k $3.1m | Added +74.5k |
| Invesco Ltd. 0.00% of their portfolio | 138.1k $3.0m | Reduced -114.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 135.0k $3.0m | Added +33.5k |
| Torray Investment Partners LLC 0.39% of their portfolio | 133.8k $2.9m | Added +29.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 132.4k $2.9m | Added +17.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 130.1k $2.8m | Added +49.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 128.2k $2.8m | Added +21.1k |
| Pale Fire Capital SE 0.20% of their portfolio | 125.5k $2.7m | Reduced -158.9k |
| CAPITAL FUND MANAGEMENT S.A. 0.02% of their portfolio | 125.1k $2.7m | Reduced -20.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 124.2k $2.7m | Added +655 |
| PFM Health Sciences, LP 0.22% of their portfolio | 118.4k $2.6m | Reduced -126.6k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 115.2k $2.5m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 106.0k $2.5m | Reduced -182.5k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 97.8k $2.1m | Reduced -26.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 95.3k $2.1m | Added +20.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 93.5k $2.0m | Reduced -9.5k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.42% of their portfolio | 84.0k $1.8m | New |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 83.5k $1.8m | Added +41.7k |