Vault-13

STRUCTURE THERAPEUTICS INC GPCR

SPONSORED ADS · ADR · CUSIP 86366E106

196 institutional holders -1 vs Q4 2025
66,964,76567.0m shares reported held*
$3.2bnreported value*
37 new 73 added 57 reduced 38 sold out net bought ≈ $59.6m (+1.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $48.29. Options: 10 managers hold calls ($27.4m notional), 9 hold puts ($18.9m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0100200Q1 23: 38Q2 23: 49Q3 23: 85Q4 23: 123Q1 24: 121Q2 24: 167Q3 24: 161Q4 24: 165Q1 25: 151Q2 25: 173Q3 25: 156Q4 25: 197Q1 26: 196196Q1 23Q4 23Q3 24Q2 25Q1 26
Numbers
QuarterHolders
Q1 202338
Q2 202349
Q3 202385
Q4 2023123
Q1 2024121
Q2 2024167
Q3 2024161
Q4 2024165
Q1 2025151
Q2 2025173
Q3 2025156
Q4 2025197
Q1 2026196

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 24: 123 bought or addedQ2 24: 46 cut or sold outQ3 24: 94 bought or addedQ3 24: 68 cut or sold outQ3 24Q4 24: 82 bought or addedQ4 24: 73 cut or sold outQ1 25: 70 bought or addedQ1 25: 83 cut or sold outQ1 25Q2 25: 100 bought or addedQ2 25: 60 cut or sold outQ3 25: 79 bought or addedQ3 25: 86 cut or sold outQ3 25Q4 25: 115 bought or addedQ4 25: 89 cut or sold outQ1 26: 110 bought or addedQ1 26: 95 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 202412346
Q3 20249468
Q4 20248273
Q1 20257083
Q2 202510060
Q3 20257986
Q4 202511589
Q1 202611095

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60m$80mQ2 25 calls: $12.5mQ2 25 puts: $10.8mQ2 25P/C 0.86Q3 25 calls: $30.2mQ3 25 puts: $20.0mQ3 25P/C 0.66Q4 25 calls: $62.6mQ4 25 puts: $18.2mQ4 25P/C 0.29Q1 26 calls: $27.4mQ1 26 puts: $18.9mQ1 26P/C 0.69
Numbers
QuarterCallsPutsP/C
Q2 2025$12.5m$10.8m0.86
Q3 2025$30.2m$20.0m0.66
Q4 2025$62.6m$18.2m0.29
Q1 2026$27.4m$18.9m0.69

Biggest buyers

AMERICAN CENTURY COMPANIES INC Added +931,072+931.1k
Paradigm Biocapital Advisors LP New +545,287+545.3k
PRINCIPAL FINANCIAL GROUP INC Added +469,554+469.6k
PRICE T ROWE ASSOCIATES INC /MD/ Added +329,558+329.6k
ORBIMED ADVISORS LLC Added +313,600+313.6k
JANUS HENDERSON GROUP PLC Added +264,833+264.8k
Siren, L.L.C. Added +250,000+250.0k
Pentwater Capital Management LP New +245,000+245.0k
MORGAN STANLEY Added +217,623+217.6k
JPMORGAN CHASE & CO Added +199,847+199.8k

Biggest sellers

TCG Crossover Management, LLC Reduced -780,446-780.4k
CITADEL ADVISORS LLC Sold out -772,518-772.5k
DEUTSCHE BANK AG\ Reduced -509,295-509.3k
FRANKLIN RESOURCES INC Reduced -338,987-339.0k
EcoR1 Capital, LLC Sold out -334,380-334.4k
FMR LLC Reduced -308,802-308.8k
Capricorn Fund Managers Ltd Sold out -252,600-252.6k
ALLIANCEBERNSTEIN L.P. Reduced -210,038-210.0k
Monashee Investment Management LLC Reduced -175,000-175.0k
JANE STREET GROUP, LLC Sold out -147,217-147.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $10.0m206.7k shares
GOLDMAN SACHS GROUP INC Unchanged $8.4m173.5k shares
JANE STREET GROUP, LLC Added $3.1m63.6k shares
CITADEL ADVISORS LLC Reduced $2.9m60.1k shares
SIMPLEX TRADING, LLC Added $930.3k19.3k shares
Walleye Capital LLC Reduced $838.7k17.4k shares
Walleye Trading LLC Reduced $641.1k13.3k shares
GROUP ONE TRADING LLC Reduced $621.8k12.9k shares
Blue Owl Capital Holdings LP New $25.0k100.0k shares
JPMORGAN CHASE & CO New $17.6k400 shares

Biggest puts

DIADEMA PARTNERS LP New $6.1m127.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $5.7m117.5k shares
CITADEL ADVISORS LLC Reduced $2.6m54.3k shares
GROUP ONE TRADING LLC Added $2.3m47.1k shares
JANE STREET GROUP, LLC Reduced $1.3m26.0k shares
SIMPLEX TRADING, LLC Added $433.8k9.0k shares
Walleye Capital LLC Reduced $366.3k7.6k shares
Walleye Trading LLC Reduced $125.3k2.6k shares
Persistent Asset Partners Ltd New $42.6k323 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 13.2% -1.8 pts 28.2m 2026-08-06
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 10.1% -1.8 pts 21.4m 2026-02-10
Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 9.4% new 16.2m 2025-11-14
JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 7.7% -0.3 pts 4.4m 2025-11-14
Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 6.0% -1.4 pts 12.3m 2026-02-13

Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)

Insider purchases and sales in Q1 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

None reported in Q1 2026.

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.02% of their portfolio BOSTON, MA 8,403,4498.4m $405.0m $405.0m 0.02% Reduced -308.8k -308,802
2 WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio Boston, MA 7,260,2877.3m $349.9m $349.9m 0.07% Added +138.3k +138,303
3 Avoro Capital Advisors LLC 3.11% of their portfolio NEW YORK, NY 6,555,5556.6m $316.0m $316.0m 3.11% Unchanged
4 JANUS HENDERSON GROUP PLC 0.12% of their portfolio LONDON, X0 5,354,9815.4m $258.3m $258.3m 0.12% Added +264.8k +264,833
5 Deep Track Capital, LP 4.26% of their portfolio GREENWICH, CT 4,279,8484.3m $206.3m $206.3m 4.26% Added +168.1k +168,066
6 BVF INC/IL 5.31% of their portfolio San Francisco, CA 3,459,3583.5m $166.7m $166.7m 5.31% Reduced -19.7k -19,664
7 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 2,305,4572.3m $111.1m $111.1m 0.01% Added +217.6k +217,623
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 2,000,6962.0m $96.4m $96.4m 0.01% Added +329.6k +329,558
9 PRINCIPAL FINANCIAL GROUP INC 0.05% of their portfolio DES MOINES, IA 1,753,7641.8m $84.5m $84.5m 0.05% Added +469.6k +469,554
10 Driehaus Capital Management LLC 0.56% of their portfolio Chicago, IL 1,577,3561.6m $76.0m $76.0m 0.56% Reduced -65.1k -65,088
11 ORBIMED ADVISORS LLC 1.55% of their portfolio New York, NY 1,475,4031.5m $71.1m $71.1m 1.55% Added +313.6k +313,600
12 AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio KANSAS CITY, MO 1,438,0311.4m $69.3m $69.3m 0.04% Added +931.1k +931,072
13 BAKER BROS. ADVISORS LP 0.40% of their portfolio NEW YORK, NY 1,432,5291.4m $69.0m $69.0m 0.40% Unchanged
14 Siren, L.L.C. 1.78% of their portfolio New York, NY 1,328,6981.3m $64.0m $64.0m 1.78% Added +250.0k +250,000
15 Casdin Capital, LLC 4.29% of their portfolio New York, NY 1,175,0001.2m $56.6m $56.6m 4.29% Unchanged
16 CAPITOLIS LIQUID GLOBAL MARKETS LLC 0.35% of their portfolio NEW YORK, NY 1,151,3001.2m $55.5m $55.5m 0.35% First filing
17 DEERFIELD MANAGEMENT COMPANY, L.P. 0.44% of their portfolio New York, NY 767,993768.0k $37.0m $37.0m 0.44% Unchanged
18 Pacific Heights Asset Management LLC 1.21% of their portfolio San Francisco, CA 750,000750.0k $36.1m $36.1m 1.21% Added +50.0k +50,000
19 Rock Springs Capital Management LP 1.82% of their portfolio Baltimore, MD 640,217640.2k $30.9m $30.9m 1.82% Reduced -108.0k -108,019
20 ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio NASHVILLE, TN 638,813638.8k $44.4m $44.4m 0.01% Reduced -210.0k -210,038
21 Paradigm Biocapital Advisors LP 0.54% of their portfolio NEW YORK, NY 545,287545.3k $26.3m $26.3m 0.54% New
22 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 531,595531.6k $25.6m $25.6m 0.01% Reduced -339.0k -338,987
23 Logos Global Management LP 1.24% of their portfolio San Francisco, CA 500,000500.0k $24.1m $24.1m 1.24% Reduced -100.0k -100,000
24 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.04% of their portfolio TORONTO, A6 467,800467.8k $22.5m $22.5m 0.04% Unchanged
25 BlackRock, Inc. 0.00% of their portfolio New York, NY 441,975442.0k $21.3m $21.3m 0.00% Added +11.9k +11,893
26 STEMPOINT CAPITAL LP 1.87% of their portfolio NEW YORK, NY 400,534400.5k $19.3m $19.3m 1.87% Added +49.5k +49,461
27 Aberdeen Group plc 0.03% of their portfolio EDINBURGH, X0 391,809391.8k $18.9m $18.9m 0.03% Added +126.9k +126,940
28 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 331,867331.9k $16.0m $16.0m 0.01% Reduced -509.3k -509,295
29 NATIONAL BANK OF CANADA /FI/ 0.02% of their portfolio MONTREAL, A8 305,400305.4k $14.7m $14.7m 0.02% Added +40.0k +40,000
30 Balyasny Asset Management L.P. 0.03% of their portfolio Chicago, IL 304,934304.9k $14.7m $14.7m 0.03% Added +88.7k +88,735
31 HSG Holding Ltd 0.38% of their portfolio NA, K3 266,062266.1k $6.2m $6.2m 0.38% Unchanged
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 260,543260.5k $12.6m $12.6m 0.00% Added +36.2k +36,211
33 Catalio Capital Management, LP 2.57% of their portfolio NEW YORK, NY 255,379255.4k $12.3m $12.3m 2.57% Added +2.5k +2,478
34 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.05% of their portfolio JUPITER, FL 254,969255.0k $12.3m $12.3m 0.05% Added +5.0k +4,969
35 SEB Asset Management AB 0.05% of their portfolio STOCKHOLM, V7 245,043245.0k $11.8m $11.8m 0.05% First filing
36 Pentwater Capital Management LP 0.08% of their portfolio Naples, FL 245,000245.0k $11.8m $11.8m 0.08% New
37 Parkman Healthcare Partners LLC 1.16% of their portfolio STAMFORD, CT 232,093232.1k $11.2m $11.2m 1.16% Added +177.1k +177,093
38 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 227,132227.1k $10.9m $10.9m 0.00% Added +195.5k +195,454
39 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 219,516219.5k $10.6m $10.6m 0.00% Reduced -66.0k -66,002
40 UBS Group AG 0.00% of their portfolio ZURICH, V8 212,919212.9k $10.3m $10.3m 0.00% Added +10.4k +10,442
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 212,803212.8k $9.4m $9.4m 0.00% Added +199.8k +199,847
42 Sio Capital Management, LLC 1.45% of their portfolio NEW YORK, NY 209,093209.1k $10.1m $10.1m 1.45% Added +7.6k +7,593
43 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 204,790204.8k $9.9m $9.9m 0.01% Added +196.2k +196,167
44 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 204,762204.8k $9.9m $9.9m 0.01% Added +30.1k +30,088
45 Woodline Partners LP 0.03% of their portfolio San Francisco, CA 190,808190.8k $9.2m $9.2m 0.03% Added +66.9k +66,906
46 ArrowMark Colorado Holdings LLC 0.24% of their portfolio Denver, CO 188,195188.2k $9.1m $9.1m 0.24% Reduced -83.0k -83,018
47 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 181,415181.4k $8.7m $8.7m 0.01% Added +85.9k +85,872
48 Cormorant Asset Management, LP 0.43% of their portfolio BOSTON, MA 175,000175.0k $8.4m $8.4m 0.43% New
49 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 168,931168.9k $8.1m $8.1m 0.01% Added +16.4k +16,371
50 Schonfeld Strategic Advisors LLC 0.06% of their portfolio NEW YORK, NY 165,426165.4k $8.0m $8.0m 0.06% Added +156.7k +156,699
51 Holocene Advisors, LP 0.02% of their portfolio New York, NY 159,009159.0k $7.7m $7.7m 0.02% New
52 TCG Crossover Management, LLC 0.19% of their portfolio PALO ALTO, CA 140,411140.4k $6.8m $6.8m 0.19% Reduced -780.4k -780,446
53 Eversept Partners, LP 0.44% of their portfolio NEW YORK, NY 138,036138.0k $6.7m $6.7m 0.44% Added +10.5k +10,475
54 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio PHILADELPHIA, PA 134,015134.0k $6.5m $6.5m 0.01% Added +51.4k +51,370
55 NEXTBio Capital Management LP 2.98% of their portfolio AUSTIN, TX 133,239133.2k $6.4m $6.4m 2.98% Added +38.8k +38,796
56 Rhenman & Partners Asset Management AB 0.76% of their portfolio Stockholm, V7 128,100128.1k $6.2m $6.2m 0.76% Reduced -19.5k -19,500
57 B Group, Inc. 4.56% of their portfolio DALLAS, TX 127,500127.5k $6.1m $6.1m 4.56% Added +37.5k +37,500
58 Davern Capital Partners, LP 1.67% of their portfolio NY, NY 126,461126.5k $6.1m $6.1m 1.67% New
59 PFM Health Sciences, LP 0.64% of their portfolio SAN FRANCISCO, CA 126,383126.4k $6.1m $6.1m 0.64% Added +58.1k +58,135
60 HighVista Strategies LLC 1.65% of their portfolio BOSTON, MA 123,909123.9k $6.0m $6.0m 1.65% Reduced -69.1k -69,092
61 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 114,814114.8k $5.5m $5.5m 0.00% Added +18.4k +18,427
62 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 109,638109.6k $5.3m $5.3m 0.01% Added +26.6k +26,586
63 Trexquant Investment LP 0.04% of their portfolio STAMFORD, CT 107,884107.9k $5.2m $5.2m 0.04% Added +17.9k +17,939
64 Jump Financial, LLC 0.08% of their portfolio Chicago, IL 107,857107.9k $5.2m $5.2m 0.08% New
65 Jones Hill Capital LP 1.04% of their portfolio NEW YORK, NY 100,593100.6k $4.8m $4.8m 1.04% First filing
66 Birchview Capital, LP 2.74% of their portfolio BURLINGTON, VT 100,000100.0k $4.8m $4.8m 2.74% Added +10.0k +10,000
67 PEREGRINE CAPITAL MANAGEMENT LLC 0.17% of their portfolio MINNEAPOLIS, MN 97,11797.1k $4.7m $4.7m 0.17% Added +12.8k +12,793
68 Soleus Capital Management, L.P. 0.16% of their portfolio GREENWICH, CT 80,00080.0k $3.9m $3.9m 0.16% Reduced -10.0k -10,000
69 Avidity Partners Management LP 0.37% of their portfolio DALLAS, TX 78,00078.0k $3.4m $3.4m 0.37% New
70 TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio STAMFORD, CT 75,30175.3k $3.6m $3.6m 0.02% Added +40.2k +40,248
71 Boxer Capital Management, LLC 0.47% of their portfolio San Diego, CA 75,00075.0k $3.6m $3.6m 0.47% Unchanged
72 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 73,59973.6k $3.5m $3.5m 0.01% New
73 DIADEMA PARTNERS LP 1.44% of their portfolio MORRISTOWN, NJ 72,23472.2k $3.5m $3.5m 1.44% New
74 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 69,10769.1k $3.3m $3.3m 0.00% Reduced -99.5k -99,477
75 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 67,86267.9k $3.3m $3.3m 0.00% Added +12.7k +12,714
76 PLATINUM INVESTMENT MANAGEMENT LTD 0.81% of their portfolio SYDNEY AUSTRALIA 2000, C3 66,86466.9k $3.2m $3.2m 0.81% Reduced -21.0k -21,010
77 Jefferies Financial Group Inc. 0.04% of their portfolio NEW YORK, NY 62,59262.6k $3.0m $3.0m 0.04% Reduced -40.4k -40,401
78 Susquehanna Portfolio Strategies, LLC 0.04% of their portfolio Bala Cynwyd, PA 60,51760.5k $2.9m $2.9m 0.04% Reduced -7.6k -7,572
79 Burkehill Global Management, LP 0.14% of their portfolio NEW YORK, NY 60,00060.0k $2.9m $2.9m 0.14% Unchanged
80 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 57,66757.7k $2.8m $2.8m 0.01% Added +7.9k +7,941
81 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 55,84255.8k $2.7m $2.7m 0.00% Added +46.8k +46,843
82 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 55,80055.8k $2.7m $2.7m 0.00% Reduced -59.4k -59,400
83 SPHERA FUNDS MANAGEMENT LTD. 0.42% of their portfolio TEL AVIV, L3 50,80050.8k $2.4m $2.4m 0.42% Added +9.8k +9,800
84 Monashee Investment Management LLC 1.31% of their portfolio Boston, MA 50,00050.0k $2.4m $2.4m 1.31% Reduced -175.0k -175,000
85 SEVEN GRAND MANAGERS, LLC 0.16% of their portfolio BRONXVILLE, NY 50,00050.0k $2.4m $2.4m 0.16% Unchanged
86 Buckland Partners Management Co LLC 1.46% of their portfolio HARRISON, NY 50,00050.0k $2.4m $2.4m 1.46% Unchanged
87 BANQUE PICTET & CIE SA 0.03% of their portfolio GENEVA 73, V8 49,36749.4k $2.4m $2.4m 0.03% Reduced -10.5k -10,514
88 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 47,58147.6k $2.3m $2.3m 0.00% Reduced -643 -643
89 Pier Capital, LLC 0.38% of their portfolio STAMFORD, CT 47,55147.6k $2.3m $2.3m 0.38% Reduced -1.2k -1,206
90 Brevan Howard Capital Management LP 0.02% of their portfolio ST. HELIER, Y9 47,26647.3k $2.2m $2.2m 0.02% Reduced -39.0k -39,044
91 DAFNA Capital Management LLC 0.51% of their portfolio LOS ANGELES, CA 46,50046.5k $2.2m $2.2m 0.51% Added +9.5k +9,500
92 ANTIPODES PARTNERS Ltd 0.04% of their portfolio ROYAL EXCHANGE, C3 45,36145.4k $2.2m $2.2m 0.04% Reduced -930 -930
93 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 45,13945.1k $2.2m $2.2m 0.00% Added +751 +751
94 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 44,41644.4k $2.1m $2.1m 0.00% Reduced -14.8k -14,822
95 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 44,41044.4k $2.1m $2.1m 0.00% Reduced -10.9k -10,890
96 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 39,98440.0k $1.9m $1.9m 0.00% Reduced -14.4k -14,357
97 Headlands Technologies LLC 0.20% of their portfolio CHICAGO, IL 37,15637.2k $1.8m $1.8m 0.20% Reduced -6.6k -6,573
98 FLAX POND CAPITAL, LLC 1.40% of their portfolio MERION STATION, PA 36,00036.0k $1.7m $1.7m 1.40% Reduced -12.7k -12,721
99 PSquared Asset Management AG 0.59% of their portfolio ZURICH, V8 35,00035.0k $1.7m $1.7m 0.59% New
100 Mariner, LLC 0.00% of their portfolio Overland Park, KS 34,48034.5k $1.7m $1.7m 0.00% Reduced -9.7k -9,675