STRUCTURE THERAPEUTICS INC GPCR
SPONSORED ADS · ADR · CUSIP 86366E106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $48.29. Options: 10 managers hold calls ($27.4m notional), 9 hold puts ($18.9m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 38 |
| Q2 2023 | 49 |
| Q3 2023 | 85 |
| Q4 2023 | 123 |
| Q1 2024 | 121 |
| Q2 2024 | 167 |
| Q3 2024 | 161 |
| Q4 2024 | 165 |
| Q1 2025 | 151 |
| Q2 2025 | 173 |
| Q3 2025 | 156 |
| Q4 2025 | 197 |
| Q1 2026 | 196 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 123 | 46 |
| Q3 2024 | 94 | 68 |
| Q4 2024 | 82 | 73 |
| Q1 2025 | 70 | 83 |
| Q2 2025 | 100 | 60 |
| Q3 2025 | 79 | 86 |
| Q4 2025 | 115 | 89 |
| Q1 2026 | 110 | 95 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $12.5m | $10.8m | 0.86 |
| Q3 2025 | $30.2m | $20.0m | 0.66 |
| Q4 2025 | $62.6m | $18.2m | 0.29 |
| Q1 2026 | $27.4m | $18.9m | 0.69 |
Biggest buyers
| AMERICAN CENTURY COMPANIES INC | Added | +931.1k |
| Paradigm Biocapital Advisors LP | New | +545.3k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +469.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +329.6k |
| ORBIMED ADVISORS LLC | Added | +313.6k |
| JANUS HENDERSON GROUP PLC | Added | +264.8k |
| Siren, L.L.C. | Added | +250.0k |
| Pentwater Capital Management LP | New | +245.0k |
| MORGAN STANLEY | Added | +217.6k |
| JPMORGAN CHASE & CO | Added | +199.8k |
Biggest sellers
| TCG Crossover Management, LLC | Reduced | -780.4k |
| CITADEL ADVISORS LLC | Sold out | -772.5k |
| DEUTSCHE BANK AG\ | Reduced | -509.3k |
| FRANKLIN RESOURCES INC | Reduced | -339.0k |
| EcoR1 Capital, LLC | Sold out | -334.4k |
| FMR LLC | Reduced | -308.8k |
| Capricorn Fund Managers Ltd | Sold out | -252.6k |
| ALLIANCEBERNSTEIN L.P. | Reduced | -210.0k |
| Monashee Investment Management LLC | Reduced | -175.0k |
| JANE STREET GROUP, LLC | Sold out | -147.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $10.0m206.7k shares |
| GOLDMAN SACHS GROUP INC | Unchanged | $8.4m173.5k shares |
| JANE STREET GROUP, LLC | Added | $3.1m63.6k shares |
| CITADEL ADVISORS LLC | Reduced | $2.9m60.1k shares |
| SIMPLEX TRADING, LLC | Added | $930.3k19.3k shares |
| Walleye Capital LLC | Reduced | $838.7k17.4k shares |
| Walleye Trading LLC | Reduced | $641.1k13.3k shares |
| GROUP ONE TRADING LLC | Reduced | $621.8k12.9k shares |
| Blue Owl Capital Holdings LP | New | $25.0k100.0k shares |
| JPMORGAN CHASE & CO | New | $17.6k400 shares |
Biggest puts
| DIADEMA PARTNERS LP | New | $6.1m127.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $5.7m117.5k shares |
| CITADEL ADVISORS LLC | Reduced | $2.6m54.3k shares |
| GROUP ONE TRADING LLC | Added | $2.3m47.1k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m26.0k shares |
| SIMPLEX TRADING, LLC | Added | $433.8k9.0k shares |
| Walleye Capital LLC | Reduced | $366.3k7.6k shares |
| Walleye Trading LLC | Reduced | $125.3k2.6k shares |
| Persistent Asset Partners Ltd | New | $42.6k323 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 | 13.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 | 9.4% |
| JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 | 7.7% |
| Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 | 6.0% |
Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q1 2026.
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.02% of their portfolio | 8.4m $405.0m | Reduced -308.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio | 7.3m $349.9m | Added +138.3k |
| Avoro Capital Advisors LLC 3.11% of their portfolio | 6.6m $316.0m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.12% of their portfolio | 5.4m $258.3m | Added +264.8k |
| Deep Track Capital, LP 4.26% of their portfolio | 4.3m $206.3m | Added +168.1k |
| BVF INC/IL 5.31% of their portfolio | 3.5m $166.7m | Reduced -19.7k |
| MORGAN STANLEY 0.01% of their portfolio | 2.3m $111.1m | Added +217.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 2.0m $96.4m | Added +329.6k |
| PRINCIPAL FINANCIAL GROUP INC 0.05% of their portfolio | 1.8m $84.5m | Added +469.6k |
| Driehaus Capital Management LLC 0.56% of their portfolio | 1.6m $76.0m | Reduced -65.1k |
| ORBIMED ADVISORS LLC 1.55% of their portfolio | 1.5m $71.1m | Added +313.6k |
| AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio | 1.4m $69.3m | Added +931.1k |
| BAKER BROS. ADVISORS LP 0.40% of their portfolio | 1.4m $69.0m | Unchanged |
| Siren, L.L.C. 1.78% of their portfolio | 1.3m $64.0m | Added +250.0k |
| Casdin Capital, LLC 4.29% of their portfolio | 1.2m $56.6m | Unchanged |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC 0.35% of their portfolio | 1.2m $55.5m | First filing |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.44% of their portfolio | 768.0k $37.0m | Unchanged |
| Pacific Heights Asset Management LLC 1.21% of their portfolio | 750.0k $36.1m | Added +50.0k |
| Rock Springs Capital Management LP 1.82% of their portfolio | 640.2k $30.9m | Reduced -108.0k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 638.8k $44.4m | Reduced -210.0k |
| Paradigm Biocapital Advisors LP 0.54% of their portfolio | 545.3k $26.3m | New |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 531.6k $25.6m | Reduced -339.0k |
| Logos Global Management LP 1.24% of their portfolio | 500.0k $24.1m | Reduced -100.0k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.04% of their portfolio | 467.8k $22.5m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 442.0k $21.3m | Added +11.9k |
| STEMPOINT CAPITAL LP 1.87% of their portfolio | 400.5k $19.3m | Added +49.5k |
| Aberdeen Group plc 0.03% of their portfolio | 391.8k $18.9m | Added +126.9k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 331.9k $16.0m | Reduced -509.3k |
| NATIONAL BANK OF CANADA /FI/ 0.02% of their portfolio | 305.4k $14.7m | Added +40.0k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 304.9k $14.7m | Added +88.7k |
| HSG Holding Ltd 0.38% of their portfolio | 266.1k $6.2m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 260.5k $12.6m | Added +36.2k |
| Catalio Capital Management, LP 2.57% of their portfolio | 255.4k $12.3m | Added +2.5k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.05% of their portfolio | 255.0k $12.3m | Added +5.0k |
| SEB Asset Management AB 0.05% of their portfolio | 245.0k $11.8m | First filing |
| Pentwater Capital Management LP 0.08% of their portfolio | 245.0k $11.8m | New |
| Parkman Healthcare Partners LLC 1.16% of their portfolio | 232.1k $11.2m | Added +177.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 227.1k $10.9m | Added +195.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 219.5k $10.6m | Reduced -66.0k |
| UBS Group AG 0.00% of their portfolio | 212.9k $10.3m | Added +10.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 212.8k $9.4m | Added +199.8k |
| Sio Capital Management, LLC 1.45% of their portfolio | 209.1k $10.1m | Added +7.6k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 204.8k $9.9m | Added +196.2k |
| TD Asset Management Inc 0.01% of their portfolio | 204.8k $9.9m | Added +30.1k |
| Woodline Partners LP 0.03% of their portfolio | 190.8k $9.2m | Added +66.9k |
| ArrowMark Colorado Holdings LLC 0.24% of their portfolio | 188.2k $9.1m | Reduced -83.0k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 181.4k $8.7m | Added +85.9k |
| Cormorant Asset Management, LP 0.43% of their portfolio | 175.0k $8.4m | New |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 168.9k $8.1m | Added +16.4k |
| Schonfeld Strategic Advisors LLC 0.06% of their portfolio | 165.4k $8.0m | Added +156.7k |
| Holocene Advisors, LP 0.02% of their portfolio | 159.0k $7.7m | New |
| TCG Crossover Management, LLC 0.19% of their portfolio | 140.4k $6.8m | Reduced -780.4k |
| Eversept Partners, LP 0.44% of their portfolio | 138.0k $6.7m | Added +10.5k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 134.0k $6.5m | Added +51.4k |
| NEXTBio Capital Management LP 2.98% of their portfolio | 133.2k $6.4m | Added +38.8k |
| Rhenman & Partners Asset Management AB 0.76% of their portfolio | 128.1k $6.2m | Reduced -19.5k |
| B Group, Inc. 4.56% of their portfolio | 127.5k $6.1m | Added +37.5k |
| Davern Capital Partners, LP 1.67% of their portfolio | 126.5k $6.1m | New |
| PFM Health Sciences, LP 0.64% of their portfolio | 126.4k $6.1m | Added +58.1k |
| HighVista Strategies LLC 1.65% of their portfolio | 123.9k $6.0m | Reduced -69.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 114.8k $5.5m | Added +18.4k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio | 109.6k $5.3m | Added +26.6k |
| Trexquant Investment LP 0.04% of their portfolio | 107.9k $5.2m | Added +17.9k |
| Jump Financial, LLC 0.08% of their portfolio | 107.9k $5.2m | New |
| Jones Hill Capital LP 1.04% of their portfolio | 100.6k $4.8m | First filing |
| Birchview Capital, LP 2.74% of their portfolio | 100.0k $4.8m | Added +10.0k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.17% of their portfolio | 97.1k $4.7m | Added +12.8k |
| Soleus Capital Management, L.P. 0.16% of their portfolio | 80.0k $3.9m | Reduced -10.0k |
| Avidity Partners Management LP 0.37% of their portfolio | 78.0k $3.4m | New |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 75.3k $3.6m | Added +40.2k |
| Boxer Capital Management, LLC 0.47% of their portfolio | 75.0k $3.6m | Unchanged |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 73.6k $3.5m | New |
| DIADEMA PARTNERS LP 1.44% of their portfolio | 72.2k $3.5m | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 69.1k $3.3m | Reduced -99.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 67.9k $3.3m | Added +12.7k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.81% of their portfolio | 66.9k $3.2m | Reduced -21.0k |
| Jefferies Financial Group Inc. 0.04% of their portfolio | 62.6k $3.0m | Reduced -40.4k |
| Susquehanna Portfolio Strategies, LLC 0.04% of their portfolio | 60.5k $2.9m | Reduced -7.6k |
| Burkehill Global Management, LP 0.14% of their portfolio | 60.0k $2.9m | Unchanged |
| ALPS ADVISORS INC 0.01% of their portfolio | 57.7k $2.8m | Added +7.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 55.8k $2.7m | Added +46.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 55.8k $2.7m | Reduced -59.4k |
| SPHERA FUNDS MANAGEMENT LTD. 0.42% of their portfolio | 50.8k $2.4m | Added +9.8k |
| Monashee Investment Management LLC 1.31% of their portfolio | 50.0k $2.4m | Reduced -175.0k |
| SEVEN GRAND MANAGERS, LLC 0.16% of their portfolio | 50.0k $2.4m | Unchanged |
| Buckland Partners Management Co LLC 1.46% of their portfolio | 50.0k $2.4m | Unchanged |
| BANQUE PICTET & CIE SA 0.03% of their portfolio | 49.4k $2.4m | Reduced -10.5k |
| STATE STREET CORP 0.00% of their portfolio | 47.6k $2.3m | Reduced -643 |
| Pier Capital, LLC 0.38% of their portfolio | 47.6k $2.3m | Reduced -1.2k |
| Brevan Howard Capital Management LP 0.02% of their portfolio | 47.3k $2.2m | Reduced -39.0k |
| DAFNA Capital Management LLC 0.51% of their portfolio | 46.5k $2.2m | Added +9.5k |
| ANTIPODES PARTNERS Ltd 0.04% of their portfolio | 45.4k $2.2m | Reduced -930 |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 45.1k $2.2m | Added +751 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 44.4k $2.1m | Reduced -14.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 44.4k $2.1m | Reduced -10.9k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 40.0k $1.9m | Reduced -14.4k |
| Headlands Technologies LLC 0.20% of their portfolio | 37.2k $1.8m | Reduced -6.6k |
| FLAX POND CAPITAL, LLC 1.40% of their portfolio | 36.0k $1.7m | Reduced -12.7k |
| PSquared Asset Management AG 0.59% of their portfolio | 35.0k $1.7m | New |
| Mariner, LLC 0.00% of their portfolio | 34.5k $1.7m | Reduced -9.7k |