STRUCTURE THERAPEUTICS INC GPCR
SPONSORED ADS · ADR · CUSIP 86366E106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $42.70. Options: 20 managers hold calls ($61.4m notional), 13 hold puts ($19.8m).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 38 |
| Q2 2023 | 49 |
| Q3 2023 | 85 |
| Q4 2023 | 123 |
| Q1 2024 | 121 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 26 | 14 |
| Q3 2023 | 71 | 12 |
| Q4 2023 | 84 | 41 |
| Q1 2024 | 71 | 61 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $0 | $0 | — |
| Q3 2023 | $0 | $0 | — |
| Q4 2023 | $70.3m | $24.2m | 0.34 |
| Q1 2024 | $61.4m | $19.8m | 0.32 |
Biggest buyers
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.5m |
| Alyeska Investment Group, L.P. | Added | +1.1m |
| RA CAPITAL MANAGEMENT, L.P. | Added | +1.0m |
| Capital Research Global Investors | Added | +553.9k |
| JANUS HENDERSON GROUP PLC | Added | +532.3k |
| Capital International Investors | Added | +431.5k |
| MONEY CONCEPTS CAPITAL CORP | New | +376.6k |
| Bellevue Group AG | Added | +351.6k |
| Frazier Life Sciences Management, L.P. | Added | +312.0k |
| MORGAN STANLEY | Added | +306.8k |
Biggest sellers
| Avoro Capital Advisors LLC | Sold out | -2.3m |
| FMR LLC | Reduced | -1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -946.3k |
| TCG Crossover Management, LLC | Reduced | -511.2k |
| Logos Global Management LP | Reduced | -350.0k |
| Deep Track Capital, LP | Reduced | -259.9k |
| MPM BIOIMPACT LLC | Sold out | -230.7k |
| Avidity Partners Management LP | Reduced | -216.0k |
| Sofinnova Investments, Inc. | Reduced | -166.1k |
| Pictet Asset Management Holding SA | Sold out | -138.8k |
Biggest calls
| Logos Global Management LP | New | $19.3m450.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $11.9m278.1k shares |
| JANE STREET GROUP, LLC | Added | $7.3m170.9k shares |
| Avidity Partners Management LP | Reduced | $6.4m150.0k shares |
| Caption Management, LLC | Reduced | $4.8m112.5k shares |
| CITADEL ADVISORS LLC | Added | $4.0m92.7k shares |
| SIMPLEX TRADING, LLC | Added | $2.8m65.0k shares |
| Jefferies Financial Group Inc. | New | $2.0m46.9k shares |
| Walleye Trading LLC | Added | $878.6k20.5k shares |
| DeepCurrents Investment Group LLC | New | $642.9k150 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.3m148.1k shares |
| Ikarian Capital, LLC | New | $5.2m120.4k shares |
| CITADEL ADVISORS LLC | Added | $2.1m48.6k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $1.5m34.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.2m27.2k shares |
| GROUP ONE TRADING LLC | Reduced | $998.6k23.3k shares |
| J. Goldman & Co LP | New | $870.1k20.3k shares |
| JANE STREET GROUP, LLC | Reduced | $835.8k19.5k shares |
| BARCLAYS PLC | New | $390.0k9.1k shares |
| Walleye Trading LLC | Reduced | $167.2k3.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 | 13.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 | 9.4% |
| JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 | 7.7% |
| Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 | 6.0% |
Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q1 2024.
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 5.8m $249.8m | Added +1.5m |
| FMR LLC 0.01% of their portfolio | 2.9m $126.4m | Reduced -1.1m |
| Driehaus Capital Management LLC 1.06% of their portfolio | 2.5m $106.7m | Reduced -108.8k |
| FEDERATED HERMES, INC. 0.22% of their portfolio | 2.3m $96.7m | Reduced -10.0k |
| JANUS HENDERSON GROUP PLC 0.05% of their portfolio | 2.1m $89.0m | Added +532.3k |
| TCG Crossover Management, LLC 5.42% of their portfolio | 1.6m $68.5m | Reduced -511.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.6m $66.9m | Reduced -118.5k |
| Capital Research Global Investors 0.01% of their portfolio | 1.5m $65.5m | Added +553.9k |
| RA CAPITAL MANAGEMENT, L.P. 0.82% of their portfolio | 1.5m $64.7m | Added +1.0m |
| Alyeska Investment Group, L.P. 0.35% of their portfolio | 1.3m $55.8m | Added +1.1m |
| Capital International Investors 0.01% of their portfolio | 1.3m $54.9m | Added +431.5k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 1.3m $54.7m | Added +122.9k |
| T. Rowe Price Investment Management, Inc. 0.03% of their portfolio | 1.2m $52.1m | Reduced -95.9k |
| Casdin Capital, LLC 3.56% of their portfolio | 1.1m $47.9m | Added +25.0k |
| BlackRock Inc. 0.00% of their portfolio | 1.1m $46.6m | Added +25.4k |
| HSG Holding Ltd 3.56% of their portfolio | 1.1m $38.4m | Reduced -244 |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.77% of their portfolio | 1.0m $44.3m | Added +210.9k |
| MORGAN STANLEY 0.00% of their portfolio | 880.9k $37.8m | Added +306.8k |
| Avidity Partners Management LP 1.32% of their portfolio | 864.0k $37.0m | Reduced -216.0k |
| BVF INC/IL 0.96% of their portfolio | 813.0k $34.8m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 810.6k $34.7m | Reduced -946.3k |
| Logos Global Management LP 3.25% of their portfolio | 720.1k $30.9m | Reduced -350.0k |
| Capital World Investors 0.00% of their portfolio | 634.2k $27.2m | Unchanged |
| Frazier Life Sciences Management, L.P. 1.14% of their portfolio | 629.2k $27.0m | Added +312.0k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 535.7k $23.0m | Reduced -6.6k |
| Octagon Capital Advisors LP 2.64% of their portfolio | 506.6k $21.7m | Added +92.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 448.7k $19.2m | Added +20.9k |
| BRAIDWELL LP 0.60% of their portfolio | 435.8k $18.7m | Added +155.7k |
| FRED ALGER MANAGEMENT, LLC 0.09% of their portfolio | 413.4k $17.7m | Added +122.3k |
| Rock Springs Capital Management LP 0.45% of their portfolio | 412.6k $17.7m | Added +126.0k |
| Boxer Capital, LLC 0.85% of their portfolio | 400.0k $17.1m | Unchanged |
| MONEY CONCEPTS CAPITAL CORP 1.49% of their portfolio | 376.6k $16.1m | New |
| Bellevue Group AG 0.24% of their portfolio | 363.9k $15.6m | Added +351.6k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 261.5k $11.2m | New |
| ArrowMark Colorado Holdings LLC 0.12% of their portfolio | 255.2k $10.9m | Reduced -23.5k |
| Invesco Ltd. 0.00% of their portfolio | 212.1k $9.1m | Added +16.4k |
| Altitude Crest Partners Inc. 3.76% of their portfolio | 205.2k $8.8m | New |
| Woodline Partners LP 0.07% of their portfolio | 179.9k $7.7m | Added +673 |
| Artal Group S.A. 0.17% of their portfolio | 151.8k $6.5m | Added +65.2k |
| First Light Asset Management, LLC 0.49% of their portfolio | 149.1k $6.4m | New |
| TD Asset Management Inc 0.01% of their portfolio | 143.1k $6.1m | Reduced -14.2k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 135.5k $5.8m | New |
| Candriam S.C.A. 0.04% of their portfolio | 135.0k $5.8m | Reduced -75.0k |
| TANG CAPITAL MANAGEMENT LLC 0.45% of their portfolio | 100.0k $4.3m | New |
| Pier Capital, LLC 0.58% of their portfolio | 97.6k $4.2m | Added +61.9k |
| Monashee Investment Management LLC 0.48% of their portfolio | 94.7k $4.1m | Reduced -97.1k |
| Walleye Capital LLC 0.04% of their portfolio | 93.8k $4.0m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 90.9k $3.9m | Added +74.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 90.7k $3.9m | Added +27.9k |
| UBS Group AG 0.00% of their portfolio | 82.7k $3.5m | Added +23.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 81.8k $3.5m | Added +70.1k |
| BARCLAYS PLC 0.00% of their portfolio | 81.3k $3.5m | Added +80.4k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.13% of their portfolio | 77.1k $3.3m | Unchanged |
| Ghost Tree Capital, LLC 1.03% of their portfolio | 75.0k $3.2m | Reduced -75.0k |
| Caption Management, LLC 0.33% of their portfolio | 70.0k $3.0m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 61.5k $2.6m | Added +8.3k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 58.0k $2.5m | New |
| FIL Ltd 0.00% of their portfolio | 56.9k $2.4m | Added +47.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 48.9k $2.1m | Added +33.2k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 47.3k $2.0m | Reduced -816 |
| HAP Trading, LLC 0.54% of their portfolio | 40.9k $1.8m | New |
| Deep Track Capital, LP 0.05% of their portfolio | 40.1k $1.7m | Reduced -259.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 38.2k $1.6m | Reduced -38.3k |
| HighVista Strategies LLC 0.57% of their portfolio | 37.4k $1.6m | Reduced -37.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 35.2k $1.5m | Reduced -70.5k |
| WEXFORD CAPITAL LP 0.28% of their portfolio | 32.5k $1.4m | Unchanged |
| Trexquant Investment LP 0.03% of their portfolio | 29.9k $1.3m | New |
| TrueMark Investments, LLC 1.18% of their portfolio | 29.9k $1.3m | Added +3.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 28.9k $1.2m | Added +6.7k |
| AlphaCentric Advisors LLC 0.71% of their portfolio | 27.5k $1.2m | Reduced -2.5k |
| EFG Asset Management (North America) Corp. 0.19% of their portfolio | 26.2k $1.1m | Added +8.8k |
| SIMPLEX TRADING, LLC 0.03% of their portfolio | 23.0k $984.0k | Added +10.6k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 21.7k $930.6k | Reduced -6.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 21.5k $921.0k | Added +15.0k |
| NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio | 17.8k $761.9k | Added +17.8k |
| FORA Capital, LLC 0.06% of their portfolio | 17.1k $732.5k | New |
| M&T Bank Corp 0.00% of their portfolio | 16.1k $690.5k | Added +1.5k |
| NATIXIS ADVISORS, LLC 0.00% of their portfolio | 14.7k $629.0k | Reduced -874 |
| Squarepoint Ops LLC 0.00% of their portfolio | 13.8k $592.8k | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 13.7k $589.0k | Added +2.1k |
| STATE STREET CORP 0.00% of their portfolio | 12.7k $543.9k | Reduced -1.2k |
| BRANDYWINE MANAGERS, LLC 0.51% of their portfolio | 12.0k $514.6k | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.12% of their portfolio | 10.0k $428.6k | New |
| NEOS Investment Management LLC 0.03% of their portfolio | 9.9k $426.4k | New |
| China Universal Asset Management Co., Ltd. 0.05% of their portfolio | 9.4k $401.9k | Added +5.0k |
| LPL Financial LLC 0.00% of their portfolio | 8.8k $376.9k | New |
| Sofinnova Investments, Inc. 0.02% of their portfolio | 8.7k $374.3k | Reduced -166.1k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 8.7k $371.6k | New |
| Quadcap Wealth Management, LLC 0.08% of their portfolio | 8.0k $342.3k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 7.7k $328.7k | Reduced -31.1k |
| Virtu Financial LLC 0.02% of their portfolio | 7.2k $308.0k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 7.2k $307.1k | Reduced -33.5k |
| XTX Topco Ltd 0.04% of their portfolio | 7.0k $298.9k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 6.6k $282.4k | Reduced -210 |
| Bayesian Capital Management, LP 0.03% of their portfolio | 6.1k $261.8k | Added +22 |
| SECTORAL ASSET MANAGEMENT INC 0.10% of their portfolio | 6.0k $255.6k | Added +2.6k |
| Cutler Group LLC / CA 0.13% of their portfolio | 5.9k $252.0k | Added +800 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 5.2k $221.0k | New |
| Bleichroeder LP 0.05% of their portfolio | 5.0k $214.3k | Unchanged |
| Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio | 4.9k $208.6k | New |