Vault-13

STRUCTURE THERAPEUTICS INC GPCR

SPONSORED ADS · ADR · CUSIP 86366E106

121 institutional holders -2 vs Q4 2023
44,254,36444.3m shares reported held*
$1.9bnreported value*
25 new 46 added 35 reduced 26 sold out net bought ≈ $58.9m (+1.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $42.70. Options: 20 managers hold calls ($61.4m notional), 13 hold puts ($19.8m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q1 23: 38Q2 23: 49Q3 23: 85Q4 23: 123Q1 24: 121121Q1 23Q2 23Q3 23Q4 23Q1 24
Numbers
QuarterHolders
Q1 202338
Q2 202349
Q3 202385
Q4 2023123
Q1 2024121

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q2 23: 26 bought or addedQ2 23: 14 cut or sold outQ2 23Q3 23: 71 bought or addedQ3 23: 12 cut or sold outQ3 23Q4 23: 84 bought or addedQ4 23: 41 cut or sold outQ4 23Q1 24: 71 bought or addedQ1 24: 61 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q2 20232614
Q3 20237112
Q4 20238441
Q1 20247161

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60m$80mQ2 23 calls: $0Q2 23 puts: $0Q2 23P/C —Q3 23 calls: $0Q3 23 puts: $0Q3 23P/C —Q4 23 calls: $70.3mQ4 23 puts: $24.2mQ4 23P/C 0.34Q1 24 calls: $61.4mQ1 24 puts: $19.8mQ1 24P/C 0.32
Numbers
QuarterCallsPutsP/C
Q2 2023$0$0—
Q3 2023$0$0—
Q4 2023$70.3m$24.2m0.34
Q1 2024$61.4m$19.8m0.32

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +1,455,330+1.5m
Alyeska Investment Group, L.P. Added +1,122,309+1.1m
RA CAPITAL MANAGEMENT, L.P. Added +1,023,530+1.0m
Capital Research Global Investors Added +553,948+553.9k
JANUS HENDERSON GROUP PLC Added +532,284+532.3k
Capital International Investors Added +431,540+431.5k
MONEY CONCEPTS CAPITAL CORP New +376,568+376.6k
Bellevue Group AG Added +351,626+351.6k
Frazier Life Sciences Management, L.P. Added +312,004+312.0k
MORGAN STANLEY Added +306,761+306.8k

Biggest sellers

Avoro Capital Advisors LLC Sold out -2,333,333-2.3m
FMR LLC Reduced -1,085,820-1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -946,316-946.3k
TCG Crossover Management, LLC Reduced -511,163-511.2k
Logos Global Management LP Reduced -350,000-350.0k
Deep Track Capital, LP Reduced -259,863-259.9k
MPM BIOIMPACT LLC Sold out -230,696-230.7k
Avidity Partners Management LP Reduced -216,000-216.0k
Sofinnova Investments, Inc. Reduced -166,105-166.1k
Pictet Asset Management Holding SA Sold out -138,797-138.8k

Biggest calls

Logos Global Management LP New $19.3m450.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $11.9m278.1k shares
JANE STREET GROUP, LLC Added $7.3m170.9k shares
Avidity Partners Management LP Reduced $6.4m150.0k shares
Caption Management, LLC Reduced $4.8m112.5k shares
CITADEL ADVISORS LLC Added $4.0m92.7k shares
SIMPLEX TRADING, LLC Added $2.8m65.0k shares
Jefferies Financial Group Inc. New $2.0m46.9k shares
Walleye Trading LLC Added $878.6k20.5k shares
DeepCurrents Investment Group LLC New $642.9k150 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $6.3m148.1k shares
Ikarian Capital, LLC New $5.2m120.4k shares
CITADEL ADVISORS LLC Added $2.1m48.6k shares
BOOTHBAY FUND MANAGEMENT, LLC New $1.5m34.9k shares
SIMPLEX TRADING, LLC Reduced $1.2m27.2k shares
GROUP ONE TRADING LLC Reduced $998.6k23.3k shares
J. Goldman & Co LP New $870.1k20.3k shares
JANE STREET GROUP, LLC Reduced $835.8k19.5k shares
BARCLAYS PLC New $390.0k9.1k shares
Walleye Trading LLC Reduced $167.2k3.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 13.2% -1.8 pts 28.2m 2026-08-06
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 10.1% -1.8 pts 21.4m 2026-02-10
Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 9.4% new 16.2m 2025-11-14
JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 7.7% -0.3 pts 4.4m 2025-11-14
Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 6.0% -1.4 pts 12.3m 2026-02-13

Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)

Insider purchases and sales in Q1 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

None reported in Q1 2024.

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 5,827,6565.8m $249.8m $249.8m 0.04% Added +1.5m +1,455,330
2 FMR LLC 0.01% of their portfolio BOSTON, MA 2,948,7642.9m $126.4m $126.4m 0.01% Reduced -1.1m -1,085,820
3 Driehaus Capital Management LLC 1.06% of their portfolio Chicago, IL 2,490,3032.5m $106.7m $106.7m 1.06% Reduced -108.8k -108,776
4 FEDERATED HERMES, INC. 0.22% of their portfolio PITTSBURGH, PA 2,257,2062.3m $96.7m $96.7m 0.22% Reduced -10.0k -10,000
5 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 2,076,7002.1m $89.0m $89.0m 0.05% Added +532.3k +532,284
6 TCG Crossover Management, LLC 5.42% of their portfolio PALO ALTO, CA 1,598,4211.6m $68.5m $68.5m 5.42% Reduced -511.2k -511,163
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,560,9501.6m $66.9m $66.9m 0.01% Reduced -118.5k -118,486
8 Capital Research Global Investors 0.01% of their portfolio Los Angeles, CA 1,527,4831.5m $65.5m $65.5m 0.01% Added +553.9k +553,948
9 RA CAPITAL MANAGEMENT, L.P. 0.82% of their portfolio BOSTON, MA 1,510,3621.5m $64.7m $64.7m 0.82% Added +1.0m +1,023,530
10 Alyeska Investment Group, L.P. 0.35% of their portfolio CHICAGO, IL 1,300,9861.3m $55.8m $55.8m 0.35% Added +1.1m +1,122,309
11 Capital International Investors 0.01% of their portfolio Los Angeles, CA 1,281,5641.3m $54.9m $54.9m 0.01% Added +431.5k +431,540
12 CITADEL ADVISORS LLC 0.05% of their portfolio MIAMI, FL 1,275,8621.3m $54.7m $54.7m 0.05% Added +122.9k +122,877
13 T. Rowe Price Investment Management, Inc. 0.03% of their portfolio BALTIMORE, MD 1,216,3031.2m $52.1m $52.1m 0.03% Reduced -95.9k -95,892
14 Casdin Capital, LLC 3.56% of their portfolio New York, NY 1,116,8671.1m $47.9m $47.9m 3.56% Added +25.0k +25,000
15 BlackRock Inc. 0.00% of their portfolio New York, NY 1,086,4131.1m $46.6m $46.6m 0.00% Added +25.4k +25,355
16 HSG Holding Ltd 3.56% of their portfolio NA, K3 1,064,9821.1m $38.4m $38.4m 3.56% Reduced -244 -244
17 DEERFIELD MANAGEMENT COMPANY, L.P. 0.77% of their portfolio New York, NY 1,033,6801.0m $44.3m $44.3m 0.77% Added +210.9k +210,867
18 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 880,899880.9k $37.8m $37.8m 0.00% Added +306.8k +306,761
19 Avidity Partners Management LP 1.32% of their portfolio DALLAS, TX 864,000864.0k $37.0m $37.0m 1.32% Reduced -216.0k -216,000
20 BVF INC/IL 0.96% of their portfolio San Francisco, CA 812,988813.0k $34.8m $34.8m 0.96% Unchanged
21 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio Boston, MA 810,602810.6k $34.7m $34.7m 0.07% Reduced -946.3k -946,316
22 Logos Global Management LP 3.25% of their portfolio San Francisco, CA 720,058720.1k $30.9m $30.9m 3.25% Reduced -350.0k -350,000
23 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 634,160634.2k $27.2m $27.2m 0.00% Unchanged
24 Frazier Life Sciences Management, L.P. 1.14% of their portfolio PALO ALTO, CA 629,194629.2k $27.0m $27.0m 1.14% Added +312.0k +312,004
25 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 535,747535.7k $23.0m $23.0m 0.01% Reduced -6.6k -6,576
26 Octagon Capital Advisors LP 2.64% of their portfolio NEW YORK, NY 506,604506.6k $21.7m $21.7m 2.64% Added +92.6k +92,604
27 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 448,671448.7k $19.2m $19.2m 0.00% Added +20.9k +20,936
28 BRAIDWELL LP 0.60% of their portfolio STAMFORD, CT 435,823435.8k $18.7m $18.7m 0.60% Added +155.7k +155,665
29 FRED ALGER MANAGEMENT, LLC 0.09% of their portfolio NEW YORK, NY 413,377413.4k $17.7m $17.7m 0.09% Added +122.3k +122,280
30 Rock Springs Capital Management LP 0.45% of their portfolio Baltimore, MD 412,649412.6k $17.7m $17.7m 0.45% Added +126.0k +125,973
31 Boxer Capital, LLC 0.85% of their portfolio San Diego, CA 400,000400.0k $17.1m $17.1m 0.85% Unchanged
32 MONEY CONCEPTS CAPITAL CORP 1.49% of their portfolio PALM BEACH GARDENS, FL 376,568376.6k $16.1m $16.1m 1.49% New
33 Bellevue Group AG 0.24% of their portfolio ZURICH, V8 363,926363.9k $15.6m $15.6m 0.24% Added +351.6k +351,626
34 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 261,459261.5k $11.2m $11.2m 0.01% New
35 ArrowMark Colorado Holdings LLC 0.12% of their portfolio Denver, CO 255,249255.2k $10.9m $10.9m 0.12% Reduced -23.5k -23,483
36 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 212,074212.1k $9.1m $9.1m 0.00% Added +16.4k +16,447
37 Altitude Crest Partners Inc. 3.76% of their portfolio Stamford, CT 205,166205.2k $8.8m $8.8m 3.76% New
38 Woodline Partners LP 0.07% of their portfolio San Francisco, CA 179,892179.9k $7.7m $7.7m 0.07% Added +673 +673
39 Artal Group S.A. 0.17% of their portfolio LUXEMBOURG, N4 151,780151.8k $6.5m $6.5m 0.17% Added +65.2k +65,180
40 First Light Asset Management, LLC 0.49% of their portfolio Edina, MN 149,113149.1k $6.4m $6.4m 0.49% New
41 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 143,100143.1k $6.1m $6.1m 0.01% Reduced -14.2k -14,158
42 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 135,538135.5k $5.8m $5.8m 0.01% New
43 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 135,000135.0k $5.8m $5.8m 0.04% Reduced -75.0k -75,000
44 TANG CAPITAL MANAGEMENT LLC 0.45% of their portfolio SAN DIEGO, CA 100,000100.0k $4.3m $4.3m 0.45% New
45 Pier Capital, LLC 0.58% of their portfolio STAMFORD, CT 97,55797.6k $4.2m $4.2m 0.58% Added +61.9k +61,904
46 Monashee Investment Management LLC 0.48% of their portfolio Boston, MA 94,71494.7k $4.1m $4.1m 0.48% Reduced -97.1k -97,141
47 Walleye Capital LLC 0.04% of their portfolio NEW YORK, NY 93,79493.8k $4.0m $4.0m 0.04% New
48 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 90,94290.9k $3.9m $3.9m 0.00% Added +74.2k +74,173
49 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 90,65790.7k $3.9m $3.9m 0.00% Added +27.9k +27,900
50 UBS Group AG 0.00% of their portfolio ZURICH, V8 82,71482.7k $3.5m $3.5m 0.00% Added +23.1k +23,077
51 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 81,79281.8k $3.5m $3.5m 0.01% Added +70.1k +70,090
52 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 81,26281.3k $3.5m $3.5m 0.00% Added +80.4k +80,430
53 PLATINUM INVESTMENT MANAGEMENT LTD 0.13% of their portfolio SYDNEY AUSTRALIA 2000, C3 77,09377.1k $3.3m $3.3m 0.13% Unchanged
54 Ghost Tree Capital, LLC 1.03% of their portfolio NEW YORK, NY 75,00075.0k $3.2m $3.2m 1.03% Reduced -75.0k -75,000
55 Caption Management, LLC 0.33% of their portfolio OKLAHOMA CITY, OK 70,00070.0k $3.0m $3.0m 0.33% New
56 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 61,53161.5k $2.6m $2.6m 0.00% Added +8.3k +8,327
57 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 58,00058.0k $2.5m $2.5m 0.00% New
58 FIL Ltd 0.00% of their portfolio HAMILTON, D0 56,93856.9k $2.4m $2.4m 0.00% Added +47.6k +47,634
59 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 48,86248.9k $2.1m $2.1m 0.00% Added +33.2k +33,170
60 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 47,26947.3k $2.0m $2.0m 0.00% Reduced -816 -816
61 HAP Trading, LLC 0.54% of their portfolio NEW YORK, NY 40,92040.9k $1.8m $1.8m 0.54% New
62 Deep Track Capital, LP 0.05% of their portfolio GREENWICH, CT 40,13740.1k $1.7m $1.7m 0.05% Reduced -259.9k -259,863
63 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 38,17638.2k $1.6m $1.6m 0.00% Reduced -38.3k -38,328
64 HighVista Strategies LLC 0.57% of their portfolio BOSTON, MA 37,44437.4k $1.6m $1.6m 0.57% Reduced -37.4k -37,388
65 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 35,24135.2k $1.5m $1.5m 0.00% Reduced -70.5k -70,529
66 WEXFORD CAPITAL LP 0.28% of their portfolio WEST PALM BEACH, FL 32,46232.5k $1.4m $1.4m 0.28% Unchanged
67 Trexquant Investment LP 0.03% of their portfolio STAMFORD, CT 29,94129.9k $1.3m $1.3m 0.03% New
68 TrueMark Investments, LLC 1.18% of their portfolio CHICAGO, IL 29,88429.9k $1.3m $1.3m 1.18% Added +3.6k +3,562
69 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 28,89628.9k $1.2m $1.2m 0.00% Added +6.7k +6,702
70 AlphaCentric Advisors LLC 0.71% of their portfolio SAN JUAN, PR 27,50027.5k $1.2m $1.2m 0.71% Reduced -2.5k -2,500
71 EFG Asset Management (North America) Corp. 0.19% of their portfolio Portland, OR 26,15326.2k $1.1m $1.1m 0.19% Added +8.8k +8,763
72 SIMPLEX TRADING, LLC 0.03% of their portfolio CHICAGO, IL 22,96523.0k $984.0k $984.0k 0.03% Added +10.6k +10,643
73 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 21,71221.7k $930.6k $930.6k 0.00% Reduced -6.7k -6,681
74 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 21,49221.5k $921.0k $921.0k 0.00% Added +15.0k +14,955
75 NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio TOKYO, M0 17,77717.8k $761.9k $761.9k 0.00% Added +17.8k +17,777
76 FORA Capital, LLC 0.06% of their portfolio MIAMI, FL 17,09017.1k $732.5k $732.5k 0.06% New
77 M&T Bank Corp 0.00% of their portfolio BUFFALO, NY 16,12016.1k $690.5k $690.5k 0.00% Added +1.5k +1,520
78 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 14,68414.7k $629.0k $629.0k 0.00% Reduced -874 -874
79 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 13,83213.8k $592.8k $592.8k 0.00% New
80 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 13,73313.7k $589.0k $589.0k 0.01% Added +2.1k +2,077
81 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 12,69112.7k $543.9k $543.9k 0.00% Reduced -1.2k -1,245
82 BRANDYWINE MANAGERS, LLC 0.51% of their portfolio HOCKESSIN, DE 12,00712.0k $514.6k $514.6k 0.51% Unchanged
83 SILVERARC CAPITAL MANAGEMENT, LLC 0.12% of their portfolio BOSTON, MA 10,00010.0k $428.6k $428.6k 0.12% New
84 NEOS Investment Management LLC 0.03% of their portfolio Westport, CT 9,9499.9k $426.4k $426.4k 0.03% New
85 China Universal Asset Management Co., Ltd. 0.05% of their portfolio SHANGHAI, F4 9,3769.4k $401.9k $401.9k 0.05% Added +5.0k +5,027
86 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 8,7948.8k $376.9k $376.9k 0.00% New
87 Sofinnova Investments, Inc. 0.02% of their portfolio Menlo Park, CA 8,7338.7k $374.3k $374.3k 0.02% Reduced -166.1k -166,105
88 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 8,6698.7k $371.6k $371.6k 0.00% New
89 Quadcap Wealth Management, LLC 0.08% of their portfolio Frisco, TX 7,9868.0k $342.3k $342.3k 0.08% New
90 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 7,6707.7k $328.7k $328.7k 0.00% Reduced -31.1k -31,128
91 Virtu Financial LLC 0.02% of their portfolio New York, NY 7,1867.2k $308.0k $308.0k 0.02% New
92 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 7,1657.2k $307.1k $307.1k 0.00% Reduced -33.5k -33,511
93 XTX Topco Ltd 0.04% of their portfolio LONDON, X0 6,9757.0k $298.9k $298.9k 0.04% New
94 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 6,5906.6k $282.4k $282.4k 0.00% Reduced -210 -210
95 Bayesian Capital Management, LP 0.03% of their portfolio Brooklyn, NY 6,1086.1k $261.8k $261.8k 0.03% Added +22 +22
96 SECTORAL ASSET MANAGEMENT INC 0.10% of their portfolio MONTREAL, A8 5,9646.0k $255.6k $255.6k 0.10% Added +2.6k +2,564
97 Cutler Group LLC / CA 0.13% of their portfolio SAN FRANCISCO, CA 5,9005.9k $252.0k $252.0k 0.13% Added +800 +800
98 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 5,1575.2k $221.0k $221.0k 0.00% New
99 Bleichroeder LP 0.05% of their portfolio NEW YORK, NY 5,0005.0k $214.3k $214.3k 0.05% Unchanged
100 Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio HONG KONG, K3 4,8674.9k $208.6k $208.6k 0.02% New