Vault-13

SOLENO THERAPEUTICS INC SLNO

COM · Common Stock · CUSIP 834203309

227 institutional holders -23 vs Q4 2025
62,266,54062.3m shares reported held*
$2.1bnreported value*
35 new 91 added 70 reduced 60 sold out net sold ≈ $94.6m (-2.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($18.8k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $33.44. Options: 10 managers hold calls ($52.0m notional), 9 hold puts ($87.0m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 20Q4 22: 26Q1 23: 21Q2 23: 23Q3 23: 55Q4 23: 77Q1 24: 99Q2 24: 115Q3 24: 144Q4 24: 168Q1 25: 219Q2 25: 236Q3 25: 241Q4 25: 250Q1 26: 227227Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 202220
Q4 202226
Q1 202321
Q2 202323
Q3 202355
Q4 202377
Q1 202499
Q2 2024115
Q3 2024144
Q4 2024168
Q1 2025219
Q2 2025236
Q3 2025241
Q4 2025250
Q1 2026227

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 24: 76 bought or addedQ2 24: 41 cut or sold outQ3 24: 96 bought or addedQ3 24: 42 cut or sold outQ3 24Q4 24: 114 bought or addedQ4 24: 50 cut or sold outQ1 25: 142 bought or addedQ1 25: 70 cut or sold outQ1 25Q2 25: 156 bought or addedQ2 25: 91 cut or sold outQ3 25: 170 bought or addedQ3 25: 101 cut or sold outQ3 25Q4 25: 156 bought or addedQ4 25: 114 cut or sold outQ1 26: 126 bought or addedQ1 26: 130 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 20247641
Q3 20249642
Q4 202411450
Q1 202514270
Q2 202515691
Q3 2025170101
Q4 2025156114
Q1 2026126130

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ2 25 calls: $162.6mQ2 25 puts: $181.4mQ2 25P/C 1.12Q3 25 calls: $154.1mQ3 25 puts: $174.6mQ3 25P/C 1.13Q4 25 calls: $112.3mQ4 25 puts: $59.8mQ4 25P/C 0.53Q1 26 calls: $52.0mQ1 26 puts: $87.0mQ1 26P/C 1.67
Numbers
QuarterCallsPutsP/C
Q2 2025$162.6m$181.4m1.12
Q3 2025$154.1m$174.6m1.13
Q4 2025$112.3m$59.8m0.53
Q1 2026$52.0m$87.0m1.67

Biggest buyers

Khrom Capital Management LLC New +1,511,481+1.5m
WELLINGTON MANAGEMENT GROUP LLP Added +1,103,982+1.1m
Vestal Point Capital, LP New +730,000+730.0k
Polar Capital Holdings Plc Added +561,926+561.9k
Kynam Capital Management, LP New +560,000+560.0k
RENAISSANCE TECHNOLOGIES LLC New +447,300+447.3k
Nantahala Capital Management, LLC Added +430,122+430.1k
Caption Management, LLC Added +378,043+378.0k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added +305,519+305.5k
Candriam S.C.A. New +281,620+281.6k

Biggest sellers

PRICE T ROWE ASSOCIATES INC /MD/ Reduced -2,292,761-2.3m
FMR LLC Reduced -2,290,894-2.3m
Invesco Ltd. Reduced -830,205-830.2k
MILLENNIUM MANAGEMENT LLC Reduced -629,808-629.8k
Avoro Capital Advisors LLC Reduced -600,000-600.0k
Vivo Capital, LLC Reduced -600,000-600.0k
Commodore Capital LP Reduced -547,568-547.6k
GOLDMAN SACHS GROUP INC Reduced -527,252-527.3k
Artia Global Partners LP Reduced -465,208-465.2k
GREAT POINT PARTNERS LLC Sold out -400,000-400.0k

Biggest calls

Nantahala Capital Management, LLC Added $25.1m750.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.9m296.9k shares
GROUP ONE TRADING LLC Added $4.2m124.9k shares
ORBIMED ADVISORS LLC New $3.3m100.0k shares
JANE STREET GROUP, LLC Added $2.4m72.5k shares
SIMPLEX TRADING, LLC Added $2.1m62.4k shares
CITADEL ADVISORS LLC Reduced $1.9m56.1k shares
TUDOR INVESTMENT CORP ET AL Added $1.4m42.4k shares
IMC-Chicago, LLC Added $1.3m38.0k shares
DLD Asset Management, LP New $334.7k10.0k shares

Biggest puts

Caption Management, LLC Added $39.1m1.2m shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $24.1m721.2k shares
JANE STREET GROUP, LLC Added $9.3m279.2k shares
Ally Bridge Group (NY) LLC New $6.7m200.0k shares
CITADEL ADVISORS LLC Reduced $2.4m73.1k shares
GROUP ONE TRADING LLC Added $2.2m64.7k shares
SIMPLEX TRADING, LLC Reduced $1.8m53.0k shares
MILLENNIUM MANAGEMENT LLC Reduced $669.6k20.0k shares
IMC-Chicago, LLC Added $582.6k17.4k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-04-24 6.9% +1.4 pts 3.5m 2026-04-24
ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 6.4% 2.8m 2025-02-12
STATE STREET CORP 13G · institution new · filed 2026-05-12 5.2% new 2.7m 2026-05-12

Fell to 5% or below in the last year: WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-08-13), PRICE T ROWE ASSOCIATES INC /MD/ (2.0%, 2026-05-15), Avoro Capital Advisors LLC (4.5%, 2026-05-15), JANUS HENDERSON GROUP PLC (2.3%, 2026-05-07), FMR LLC (0.4%, 2026-05-07), VANGUARD GROUP INC (0.0%, 2026-03-27), Vivo Opportunity Fund Holdings, L.P. (4.2%, 2025-11-14), Adage Capital Management, L.P. (2.6%, 2025-11-13; now reported by ADAGE CAPITAL PARTNERS GP, L.L.C.)

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.11% of their portfolio LONDON, X0 7,099,3287.1m $237.6m $237.6m 0.11% Reduced -79.0k -79,026
2 FMR LLC 0.01% of their portfolio BOSTON, MA 5,788,4105.8m $193.8m $193.8m 0.01% Reduced -2.3m -2,290,894
3 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 4,426,7814.4m $148.2m $148.2m 0.03% Added +1.1m +1,103,982
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 3,742,7743.7m $125.3m $125.3m 0.00% Reduced -128.9k -128,865
5 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,680,8022.7m $89.8m $89.8m 0.00% Added +31.2k +31,176
6 Avoro Capital Advisors LLC 0.76% of their portfolio NEW YORK, NY 2,300,0002.3m $77.0m $77.0m 0.76% Reduced -600.0k -600,000
7 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 2,153,2182.2m $72.1m $72.1m 0.00% First filing
8 Nantahala Capital Management, LLC 3.64% of their portfolio NEW CANAAN, CT 1,744,1241.7m $58.4m $58.4m 3.64% Added +430.1k +430,122
9 Polar Capital Holdings Plc 0.25% of their portfolio London, X0 1,698,8551.7m $56.9m $56.9m 0.25% Added +561.9k +561,926
10 Khrom Capital Management LLC 4.63% of their portfolio Miami Beach, FL 1,511,4811.5m $50.6m $50.6m 4.63% New
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,237,5501.2m $41.4m $41.4m 0.00% Added +74.2k +74,212
12 Woodline Partners LP 0.14% of their portfolio San Francisco, CA 1,112,1041.1m $37.2m $37.2m 0.14% Added +326 +326
13 Deep Track Capital, LP 0.75% of their portfolio GREENWICH, CT 1,078,7101.1m $36.1m $36.1m 0.75% Added +78.7k +78,710
14 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,025,9371.0m $34.4m $34.4m 0.00% Reduced -2.3m -2,292,761
15 BRAIDWELL LP 1.07% of their portfolio STAMFORD, CT 959,259959.3k $32.1m $32.1m 1.07% Reduced -228.6k -228,600
16 READYSTATE ASSET MANAGEMENT LP 1.86% of their portfolio CHICAGO, IL 952,165952.2k $31.9m $31.9m 1.86% Added +77.7k +77,718
17 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 835,178835.2k $28.0m $28.0m 0.01% Added +11.2k +11,220
18 Vestal Point Capital, LP 0.68% of their portfolio NEW YORK, NY 730,000730.0k $24.4m $24.4m 0.68% New
19 Commodore Capital LP 1.26% of their portfolio NEW YORK, NY 652,432652.4k $21.8m $21.8m 1.26% Reduced -547.6k -547,568
20 SCHRODER INVESTMENT MANAGEMENT GROUP 0.02% of their portfolio London, X0 648,827648.8k $19.8m $19.8m 0.02% Added +199.0k +198,979
21 Hood River Capital Management LLC 0.21% of their portfolio PALM BEACH GARDENS, FL 623,421623.4k $20.9m $20.9m 0.21% Added +5.4k +5,416
22 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 616,217616.2k $20.6m $20.6m 0.02% Reduced -7.9k -7,911
23 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 606,513606.5k $20.3m $20.3m 0.02% Reduced -629.8k -629,808
24 Catalio Capital Management, LP 4.04% of their portfolio NEW YORK, NY 577,808577.8k $19.3m $19.3m 4.04% Added +217.5k +217,468
25 KINGDON CAPITAL MANAGEMENT, L.L.C. 3.22% of their portfolio NEW YORK, NY 575,000575.0k $19.3m $19.3m 3.22% Added +175.1k +175,100
26 Kynam Capital Management, LP 1.19% of their portfolio PRINCETON, NJ 560,000560.0k $18.7m $18.7m 1.19% New
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio BALA CYNWYD, PA 549,877549.9k $18.4m $18.4m 0.02% Added +305.5k +305,519
28 Qube Research & Technologies Ltd 0.02% of their portfolio LONDON, X0 483,884483.9k $16.2m $16.2m 0.02% Added +196.6k +196,591
29 VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 477,321477.3k $16.0m $16.0m 0.00% First filing
30 RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio NEW YORK, NY 447,300447.3k $15.0m $15.0m 0.02% New
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 439,902439.9k $14.7m $14.7m 0.00% Added +231.3k +231,307
32 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 432,535432.5k $14.5m $14.5m 0.01% Added +219.7k +219,717
33 Caption Management, LLC 0.67% of their portfolio OKLAHOMA CITY, OK 420,143420.1k $14.1m $14.1m 0.67% Added +378.0k +378,043
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 405,910405.9k $13.6m $13.6m 0.00% Added +4.7k +4,724
35 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 393,523393.5k $13.2m $13.2m 0.00% Added +28.1k +28,105
36 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 386,545386.5k $12.9m $12.9m 0.01% Added +77.7k +77,715
37 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 385,798385.8k $12.9m $12.9m 0.00% Reduced -527.3k -527,252
38 Ikarian Capital, LLC 1.65% of their portfolio DALLAS, TX 344,123344.1k $11.5m $11.5m 1.65% Added +275.3k +275,300
39 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 342,758342.8k $11.5m $11.5m 0.00% First filing
40 Integral Health Asset Management, LLC 0.58% of their portfolio New York, NY 325,000325.0k $10.9m $10.9m 0.58% Unchanged
41 Vivo Capital, LLC 0.82% of their portfolio Palo Alto, CA 294,909294.9k $9.9m $9.9m 0.82% Reduced -600.0k -600,000
42 Aberdeen Group plc 0.02% of their portfolio EDINBURGH, X0 287,456287.5k $9.6m $9.6m 0.02% Unchanged
43 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 281,620281.6k $9.4m $9.4m 0.05% New
44 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 277,851277.9k $9.3m $9.3m 0.00% Reduced -344.0k -343,960
45 EMERALD ADVISERS, LLC 0.29% of their portfolio LEOLA, PA 274,138274.1k $9.2m $9.2m 0.29% Reduced -138.5k -138,513
46 Penn Capital Management Company, LLC 0.70% of their portfolio PHILADELPHIA, PA 268,785268.8k $9.0m $9.0m 0.70% Reduced -7.0k -6,997
47 Rock Springs Capital Management LP 0.51% of their portfolio Baltimore, MD 257,253257.3k $8.6m $8.6m 0.51% Added +10.2k +10,200
48 Logos Global Management LP 0.43% of their portfolio San Francisco, CA 250,000250.0k $8.4m $8.4m 0.43% Reduced -50.0k -50,000
49 PFM Health Sciences, LP 0.87% of their portfolio SAN FRANCISCO, CA 248,180248.2k $8.3m $8.3m 0.87% Added +287 +287
50 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 242,262242.3k $8.1m $8.1m 0.00% Reduced -45.4k -45,377
51 UBS Group AG 0.00% of their portfolio ZURICH, V8 225,147225.1k $7.5m $7.5m 0.00% Added +55.6k +55,641
52 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 221,928221.9k $7.4m $7.4m 0.05% Added +89.0k +89,016
53 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 221,214221.2k $7.4m $7.4m 0.01% Added +214.6k +214,619
54 Alyeska Investment Group, L.P. 0.02% of their portfolio CHICAGO, IL 217,500217.5k $7.3m $7.3m 0.02% Unchanged
55 SPHERA FUNDS MANAGEMENT LTD. 1.25% of their portfolio TEL AVIV, L3 216,281216.3k $7.2m $7.2m 1.25% Added +80.0k +79,967
56 RICE HALL JAMES & ASSOCIATES, LLC 0.38% of their portfolio San Diego, CA 206,147206.1k $6.9m $6.9m 0.38% New
57 Hudson Bay Capital Management LP 0.04% of their portfolio STAMFORD, CT 203,291203.3k $6.8m $6.8m 0.04% Added +203.0k +202,952
58 EMERALD MUTUAL FUND ADVISERS TRUST 0.33% of their portfolio LEOLA, PA 200,727200.7k $6.7m $6.7m 0.33% Reduced -31.8k -31,758
59 National Philanthropic Trust 0.07% of their portfolio Jenkintown, PA 200,000200.0k $6.7m $6.7m 0.07% Added +130.5k +130,455
60 Ally Bridge Group (NY) LLC 6.65% of their portfolio NEW YORK, NY 200,000200.0k $6.7m $6.7m 6.65% Added +32.0k +31,971
61 Boxer Capital Management, LLC 0.88% of their portfolio San Diego, CA 200,000200.0k $6.7m $6.7m 0.88% New
62 SEB Asset Management AB 0.03% of their portfolio STOCKHOLM, V7 187,475187.5k $6.3m $6.3m 0.03% First filing
63 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 185,337185.3k $6.2m $6.2m 0.01% Reduced -283.3k -283,317
64 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 185,317185.3k $6.2m $6.2m 0.01% Unchanged
65 Buckley Capital Advisors, LLC 5.15% of their portfolio MIAMI BEACH, FL 181,750181.8k $6.1m $6.1m 5.15% Added +32.6k +32,600
66 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 174,204174.2k $5.8m $5.8m 0.00% New
67 HighVista Strategies LLC 1.53% of their portfolio BOSTON, MA 165,227165.2k $5.5m $5.5m 1.53% Added +30.2k +30,158
68 NICOLET BANKSHARES INC 0.19% of their portfolio GREEN BAY, WI 156,766156.8k $5.2m $5.2m 0.19% New
69 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 148,374148.4k $5.0m $5.0m 0.00% Added +6.4k +6,392
70 Brevan Howard Capital Management LP 0.05% of their portfolio ST. HELIER, Y9 135,621135.6k $4.5m $4.5m 0.05% Reduced -12.2k -12,179
71 NAN FUNG TRINITY (HK) LTD 0.46% of their portfolio CENTRAL, HONG KONG, K3 126,050126.0k $4.2m $4.2m 0.46% Added +2.2k +2,200
72 BOOTHBAY FUND MANAGEMENT, LLC 0.10% of their portfolio NEW YORK, NY 124,519124.5k $4.2m $4.2m 0.10% Added +80.7k +80,657
73 Seven Fleet Capital Management LP 1.22% of their portfolio MOUNTAIN VIEW, CA 115,770115.8k $3.9m $3.9m 1.22% Reduced -14.3k -14,309
74 Granahan Investment Management, LLC 0.19% of their portfolio WALTHAM, MA 114,825114.8k $3.8m $3.8m 0.19% Reduced -22.8k -22,767
75 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 104,738104.7k $3.5m $3.5m 0.00% Added +4.1k +4,116
76 Tetragon Partners GP Ltd 0.67% of their portfolio GRAND CAYMAN, E9 102,125102.1k $3.4m $3.4m 0.67% New
77 Centiva Capital, LP 0.16% of their portfolio New York, NY 101,234101.2k $3.4m $3.4m 0.16% Reduced -17.6k -17,570
78 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 90,90790.9k $3.0m $3.0m 0.01% Added +18.4k +18,425
79 Swiss National Bank 0.00% of their portfolio ZURICH, V8 90,30090.3k $3.0m $3.0m 0.00% Added +1.2k +1,200
80 Atle Fund Management AB 0.71% of their portfolio STOCKHOLM, V7 90,18490.2k $2.2m $2.2m 0.71% Added +27.4k +27,449
81 Anson Funds Management LP 0.19% of their portfolio DALLAS, TX 88,46288.5k $3.0m $3.0m 0.19% New
82 XTX Topco Ltd 0.05% of their portfolio LONDON, X0 85,68085.7k $2.9m $2.9m 0.05% Added +49.4k +49,386
83 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio New York, NY 82,83482.8k $2.8m $2.8m 0.03% Reduced -332 -332
84 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 79,62279.6k $2.7m $2.7m 0.01% Reduced -16.0k -15,975
85 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 71,98672.0k $2.4m $2.4m 0.00% Reduced -374 -374
86 Artia Global Partners LP 0.52% of their portfolio MIAMI, FL 68,49068.5k $2.3m $2.3m 0.52% Reduced -465.2k -465,208
87 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 62,94662.9k $2.1m $2.1m 0.00% Reduced -4.4k -4,384
88 Exome Asset Management LLC 1.21% of their portfolio NEW YORK, NY 61,67361.7k $2.1m $2.1m 1.21% New
89 KVP Capital Advisors, LP 1.49% of their portfolio SAN FRANCISCO, CA 59,70059.7k $2.0m $2.0m 1.49% Unchanged
90 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 59,28559.3k $2.0m $2.0m 0.00% Added +4.2k +4,217
91 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 58,69258.7k $2.0m $2.0m 0.00% Added +12.0k +12,014
92 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 58,38858.4k $2.0m $2.0m 0.00% Added +17.7k +17,671
93 Diametric Capital, LP 0.51% of their portfolio BOSTON, MA 57,83257.8k $1.9m $1.9m 0.51% Added +26.5k +26,504
94 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% of their portfolio Paris, I0 57,82857.8k $1.9m $1.9m 0.00% Added +18.9k +18,870
95 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 56,65656.7k $1.9m $1.9m 0.00% Added +22.0k +21,993
96 SummitTX Capital, L.P. 0.06% of their portfolio FORT WORTH, TX 56,58556.6k $1.9m $1.9m 0.06% Reduced -155.1k -155,142
97 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 56,11856.1k $1.9m $1.9m 0.01% New
98 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 54,21954.2k $1.8m $1.8m 0.00% Reduced -103.5k -103,466
99 DV Trading LLC 0.16% of their portfolio CHICAGO, IL 54,00054.0k $1.8m $1.8m 0.16% Unchanged
100 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 51,48051.5k $1.6m $1.6m 0.00% Reduced -64.0k -64,037