Vault-13

SOLENO THERAPEUTICS INC SLNO

COM · Common Stock · CUSIP 834203309

250 institutional holders +9 vs Q3 2025
64,909,26764.9m shares reported held*
$3.0bnreported value*
54 new 102 added 66 reduced 48 sold out net sold ≈ $47.9m (-1.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.5m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $46.31. Options: 25 managers hold calls ($112.3m notional), 14 hold puts ($59.8m).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 20Q4 22: 26Q1 23: 21Q2 23: 23Q3 23: 55Q4 23: 77Q1 24: 99Q2 24: 115Q3 24: 144Q4 24: 168Q1 25: 219Q2 25: 236Q3 25: 241Q4 25: 250250Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202220
Q4 202226
Q1 202321
Q2 202323
Q3 202355
Q4 202377
Q1 202499
Q2 2024115
Q3 2024144
Q4 2024168
Q1 2025219
Q2 2025236
Q3 2025241
Q4 2025250

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q1 24: 72 bought or addedQ1 24: 26 cut or sold outQ2 24: 76 bought or addedQ2 24: 41 cut or sold outQ2 24Q3 24: 96 bought or addedQ3 24: 42 cut or sold outQ4 24: 114 bought or addedQ4 24: 50 cut or sold outQ4 24Q1 25: 142 bought or addedQ1 25: 70 cut or sold outQ2 25: 156 bought or addedQ2 25: 91 cut or sold outQ2 25Q3 25: 170 bought or addedQ3 25: 101 cut or sold outQ4 25: 156 bought or addedQ4 25: 114 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20247226
Q2 20247641
Q3 20249642
Q4 202411450
Q1 202514270
Q2 202515691
Q3 2025170101
Q4 2025156114

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ1 25 calls: $285.1mQ1 25 puts: $236.3mQ1 25P/C 0.83Q2 25 calls: $162.6mQ2 25 puts: $181.4mQ2 25P/C 1.12Q3 25 calls: $154.1mQ3 25 puts: $174.6mQ3 25P/C 1.13Q4 25 calls: $112.3mQ4 25 puts: $59.8mQ4 25P/C 0.53
Numbers
QuarterCallsPutsP/C
Q1 2025$285.1m$236.3m0.83
Q2 2025$162.6m$181.4m1.12
Q3 2025$154.1m$174.6m1.13
Q4 2025$112.3m$59.8m0.53

Biggest buyers

JANUS HENDERSON GROUP PLC Added +1,122,015+1.1m
WELLINGTON MANAGEMENT GROUP LLP Added +1,010,704+1.0m
Deep Track Capital, LP New +1,000,000+1.0m
Woodline Partners LP Added +840,946+840.9k
READYSTATE ASSET MANAGEMENT LP Added +668,640+668.6k
STATE STREET CORP Added +476,590+476.6k
Nantahala Capital Management, LLC Added +450,239+450.2k
Squarepoint Ops LLC Added +399,700+399.7k
Assenagon Asset Management S.A. New +384,166+384.2k
BlackRock, Inc. Added +379,387+379.4k

Biggest sellers

ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -1,401,576-1.4m
Vivo Capital, LLC Reduced -1,383,294-1.4m
Holocene Advisors, LP Sold out -997,069-997.1k
WESTFIELD CAPITAL MANAGEMENT CO LP Sold out -899,157-899.2k
JPMORGAN CHASE & CO Reduced -699,371-699.4k
Capital World Investors Reduced -678,992-679.0k
Invesco Ltd. Reduced -625,506-625.5k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -584,208-584.2k
EVENTIDE ASSET MANAGEMENT, LLC Sold out -467,435-467.4k
Siren, L.L.C. Sold out -467,342-467.3k

Biggest calls

Ikarian Capital, LLC Added $24.5m528.9k shares
Nantahala Capital Management, LLC Added $23.2m502.0k shares
CITIGROUP INC Added $11.8m255.4k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $11.8m254.9k shares
BOOTHBAY FUND MANAGEMENT, LLC Added $6.5m140.0k shares
Jefferies Financial Group Inc. New $5.5m119.2k shares
CITADEL ADVISORS LLC Added $4.9m105.8k shares
Hudson Bay Capital Management LP Reduced $4.9m105.6k shares
Centiva Capital, LP Reduced $2.7m57.3k shares
DIADEMA PARTNERS LP Added $2.5m53.1k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $16.5m357.3k shares
Caption Management, LLC Reduced $15.9m342.5k shares
CITADEL ADVISORS LLC Added $9.1m197.5k shares
SIMPLEX TRADING, LLC Added $5.0m107.0k shares
JANE STREET GROUP, LLC Reduced $4.1m87.5k shares
GROUP ONE TRADING LLC Added $2.2m47.9k shares
Jefferies Financial Group Inc. Reduced $2.1m46.1k shares
MILLENNIUM MANAGEMENT LLC Reduced $1.3m27.0k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $819.5k17.7k shares
Walleye Capital LLC Added $787.1k17.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-04-24 6.9% +1.4 pts 3.5m 2026-04-24
ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 6.4% 2.8m 2025-02-12
STATE STREET CORP 13G · institution new · filed 2026-05-12 5.2% new 2.7m 2026-05-12

Fell to 5% or below in the last year: WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-08-13), PRICE T ROWE ASSOCIATES INC /MD/ (2.0%, 2026-05-15), Avoro Capital Advisors LLC (4.5%, 2026-05-15), FMR LLC (0.4%, 2026-05-07), JANUS HENDERSON GROUP PLC (2.3%, 2026-05-07), VANGUARD GROUP INC (0.0%, 2026-03-27), Vivo Opportunity Fund Holdings, L.P. (4.2%, 2025-11-14)

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.02% of their portfolio BOSTON, MA 8,079,3048.1m $374.1m $374.1m 0.02% Added +79.6k +79,622
2 JANUS HENDERSON GROUP PLC 0.15% of their portfolio LONDON, X0 7,178,3547.2m $332.3m $332.3m 0.15% Added +1.1m +1,122,015
3 BlackRock, Inc. 0.00% of their portfolio New York, NY 3,871,6393.9m $179.3m $179.3m 0.00% Added +379.4k +379,387
4 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 3,322,7993.3m $153.8m $153.8m 0.03% Added +1.0m +1,010,704
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 3,318,6983.3m $153.7m $153.7m 0.02% Reduced -584.2k -584,208
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,060,3613.1m $141.7m $141.7m 0.00% Added +253.2k +253,212
7 Avoro Capital Advisors LLC 1.32% of their portfolio NEW YORK, NY 2,900,0002.9m $134.3m $134.3m 1.32% Added +322.2k +322,223
8 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,649,6262.6m $122.7m $122.7m 0.00% Added +476.6k +476,590
9 Nantahala Capital Management, LLC 3.63% of their portfolio NEW CANAAN, CT 1,314,0021.3m $60.8m $60.8m 3.63% Added +450.2k +450,239
10 MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio NEW YORK, NY 1,236,3211.2m $57.2m $57.2m 0.04% Added +256.5k +256,495
11 Commodore Capital LP 3.70% of their portfolio NEW YORK, NY 1,200,0001.2m $55.6m $55.6m 3.70% Reduced -150.0k -150,000
12 BRAIDWELL LP 1.76% of their portfolio STAMFORD, CT 1,187,8591.2m $55.0m $55.0m 1.76% Reduced -94.1k -94,130
13 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,163,3381.2m $53.9m $53.9m 0.00% Added +78.4k +78,386
14 Polar Capital Holdings Plc 0.24% of their portfolio London, X0 1,136,9291.1m $52.6m $52.6m 0.24% Reduced -54.2k -54,194
15 Woodline Partners LP 0.20% of their portfolio San Francisco, CA 1,111,7781.1m $51.5m $51.5m 0.20% Added +840.9k +840,946
16 Deep Track Capital, LP 1.06% of their portfolio GREENWICH, CT 1,000,0001.0m $46.3m $46.3m 1.06% New
17 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 913,050913.0k $42.3m $42.3m 0.01% Added +357.6k +357,612
18 Vivo Capital, LLC 2.68% of their portfolio Palo Alto, CA 894,909894.9k $41.4m $41.4m 2.68% Reduced -1.4m -1,383,294
19 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 875,019875.0k $40.5m $40.5m 0.00% Reduced -625.5k -625,506
20 READYSTATE ASSET MANAGEMENT LP 1.79% of their portfolio CHICAGO, IL 874,447874.4k $40.5m $40.5m 1.79% Added +668.6k +668,640
21 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 823,958824.0k $38.1m $38.1m 0.01% Reduced -11.8k -11,793
22 Pictet Asset Management Holding SA 0.03% of their portfolio CAROUGE, V8 624,128624.1k $28.9m $28.9m 0.03% Added +73.5k +73,504
23 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 621,811621.8k $28.8m $28.8m 0.01% Reduced -5.4k -5,416
24 Hood River Capital Management LLC 0.31% of their portfolio PALM BEACH GARDENS, FL 618,005618.0k $28.6m $28.6m 0.31% Added +4.6k +4,611
25 Artia Global Partners LP 3.97% of their portfolio MIAMI, FL 533,698533.7k $24.7m $24.7m 3.97% Reduced -138.5k -138,478
26 Squarepoint Ops LLC 0.04% of their portfolio NEW YORK, NY 468,654468.7k $21.7m $21.7m 0.04% Added +399.7k +399,700
27 SCHRODER INVESTMENT MANAGEMENT GROUP 0.02% of their portfolio London, X0 449,848449.8k $20.8m $20.8m 0.02% Added +169.6k +169,552
28 EMERALD ADVISERS, LLC 0.59% of their portfolio LEOLA, PA 412,651412.7k $19.1m $19.1m 0.59% Reduced -215.1k -215,105
29 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 401,186401.2k $18.6m $18.6m 0.00% Added +11.8k +11,830
30 GREAT POINT PARTNERS LLC 6.00% of their portfolio Greenwich, CT 400,000400.0k $18.5m $18.5m 6.00% Added +175.0k +175,000
31 KINGDON CAPITAL MANAGEMENT, L.L.C. 2.83% of their portfolio NEW YORK, NY 399,900399.9k $18.5m $18.5m 2.83% Added +98.9k +98,900
32 Assenagon Asset Management S.A. 0.03% of their portfolio SENNINGERBERG, N4 384,166384.2k $17.8m $17.8m 0.03% New
33 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 365,418365.4k $16.9m $16.9m 0.00% Added +11.2k +11,184
34 Catalio Capital Management, LP 2.95% of their portfolio NEW YORK, NY 360,340360.3k $16.7m $16.7m 2.95% Reduced -57.9k -57,905
35 Integral Health Asset Management, LLC 0.76% of their portfolio New York, NY 325,000325.0k $15.0m $15.0m 0.76% New
36 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 308,830308.8k $14.3m $14.3m 0.01% Reduced -141.3k -141,296
37 Logos Global Management LP 0.93% of their portfolio San Francisco, CA 300,000300.0k $13.9m $13.9m 0.93% New
38 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 287,639287.6k $13.3m $13.3m 0.00% Added +121.8k +121,794
39 Aberdeen Group plc 0.02% of their portfolio EDINBURGH, X0 287,456287.5k $13.3m $13.3m 0.02% New
40 Qube Research & Technologies Ltd 0.02% of their portfolio LONDON, X0 287,293287.3k $13.3m $13.3m 0.02% Added +221.5k +221,521
41 Penn Capital Management Company, LLC 1.02% of their portfolio PHILADELPHIA, PA 275,782275.8k $12.8m $12.8m 1.02% New
42 PFM Health Sciences, LP 1.16% of their portfolio SAN FRANCISCO, CA 247,893247.9k $11.5m $11.5m 1.16% Added +4.5k +4,492
43 Rock Springs Capital Management LP 0.59% of their portfolio Baltimore, MD 247,053247.1k $11.4m $11.4m 0.59% Added +92.5k +92,525
44 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio BALA CYNWYD, PA 244,358244.4k $11.3m $11.3m 0.02% Added +228.3k +228,340
45 EMERALD MUTUAL FUND ADVISERS TRUST 0.52% of their portfolio LEOLA, PA 232,485232.5k $10.8m $10.8m 0.52% Reduced -147.4k -147,415
46 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 227,751227.8k $10.5m $10.5m 0.02% Reduced -432.8k -432,814
47 Alyeska Investment Group, L.P. 0.03% of their portfolio CHICAGO, IL 217,500217.5k $10.1m $10.1m 0.03% Added +25.0k +25,000
48 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 212,818212.8k $9.9m $9.9m 0.01% Added +204.7k +204,710
49 SummitTX Capital, L.P. 0.30% of their portfolio FORT WORTH, TX 211,727211.7k $9.8m $9.8m 0.30% Added +78.9k +78,911
50 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 208,595208.6k $9.7m $9.7m 0.00% Added +46.5k +46,497
51 Skandinaviska Enskilda Banken AB (publ) 0.03% of their portfolio STOCKHOLM, V7 187,475187.5k $8.7m $8.7m 0.03% Added +64.7k +64,736
52 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 185,317185.3k $8.6m $8.6m 0.01% Added +169.7k +169,717
53 Clark Capital Management Group, Inc. 0.05% of their portfolio PHILADELPHIA, PA 180,250180.2k $8.3m $8.3m 0.05% New
54 UBS Group AG 0.00% of their portfolio ZURICH, V8 169,506169.5k $7.8m $7.8m 0.00% Added +11.2k +11,198
55 Ally Bridge Group (NY) LLC 12.35% of their portfolio NEW YORK, NY 168,029168.0k $7.8m $7.8m 12.35% Reduced -134.5k -134,454
56 Engineers Gate Manager LP 0.09% of their portfolio NEW YORK, NY 168,005168.0k $7.8m $7.8m 0.09% New
57 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 157,685157.7k $7.3m $7.3m 0.00% Reduced -13.3k -13,295
58 Buckley Capital Advisors, LLC 6.01% of their portfolio MIAMI BEACH, FL 149,150149.2k $6.9m $6.9m 6.01% First filing
59 Brevan Howard Capital Management LP 0.13% of their portfolio ST. HELIER, Y9 147,800147.8k $6.8m $6.8m 0.13% Added +133.5k +133,540
60 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 145,522145.5k $6.7m $6.7m 0.00% Reduced -679.0k -678,992
61 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 141,982142.0k $6.6m $6.6m 0.00% Added +5.2k +5,205
62 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 141,740141.7k $6.6m $6.6m 0.01% New
63 Granahan Investment Management, LLC 0.27% of their portfolio WALTHAM, MA 137,592137.6k $6.4m $6.4m 0.27% Added +28.3k +28,339
64 SPHERA FUNDS MANAGEMENT LTD. 1.32% of their portfolio TEL AVIV, L3 136,314136.3k $6.3m $6.3m 1.32% Added +94.7k +94,708
65 Eagle Health Investments LP 1.37% of their portfolio Greenwich, CT 135,100135.1k $6.3m $6.3m 1.37% New
66 HighVista Strategies LLC 1.61% of their portfolio BOSTON, MA 135,069135.1k $6.3m $6.3m 1.61% Added +116.4k +116,369
67 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 132,912132.9k $6.2m $6.2m 0.05% Added +122.6k +122,576
68 Seven Fleet Capital Management LP 4.08% of their portfolio MOUNTAIN VIEW, CA 130,079130.1k $6.0m $6.0m 4.08% First filing
69 ROYCE & ASSOCIATES LP 0.06% of their portfolio New York, NY 129,043129.0k $6.0m $6.0m 0.06% Added +98.1k +98,056
70 NAN FUNG TRINITY (HK) LTD 0.45% of their portfolio CENTRAL, HONG KONG, K3 123,850123.8k $5.7m $5.7m 0.45% Unchanged
71 FRONTIER CAPITAL MANAGEMENT CO LLC 0.06% of their portfolio Boston, MA 119,695119.7k $5.5m $5.5m 0.06% Added +1.4k +1,351
72 PEREGRINE CAPITAL MANAGEMENT LLC 0.17% of their portfolio MINNEAPOLIS, MN 119,564119.6k $5.5m $5.5m 0.17% Added +26.6k +26,559
73 Centiva Capital, LP 0.33% of their portfolio New York, NY 118,804118.8k $5.5m $5.5m 0.33% New
74 SILVERARC CAPITAL MANAGEMENT, LLC 0.79% of their portfolio BOSTON, MA 117,485117.5k $5.4m $5.4m 0.79% New
75 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 115,517115.5k $5.3m $5.3m 0.00% Reduced -699.4k -699,371
76 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 100,622100.6k $4.7m $4.7m 0.00% Added +6.0k +5,997
77 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 95,59795.6k $4.4m $4.4m 0.02% Added +3.1k +3,122
78 Swiss National Bank 0.00% of their portfolio ZURICH, V8 89,10089.1k $4.1m $4.1m 0.00% Added +12.4k +12,400
79 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.04% of their portfolio New York, NY 83,16683.2k $3.9m $3.9m 0.04% Added +4.3k +4,333
80 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 72,48272.5k $3.4m $3.4m 0.01% Added +32.3k +32,290
81 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 72,36072.4k $3.4m $3.4m 0.00% Added +14.0k +13,968
82 Militia Capital Partners, LP 0.62% of their portfolio AUSTIN, TX 69,98070.0k $3.2m $3.2m 0.62% New
83 National Philanthropic Trust 0.03% of their portfolio Jenkintown, PA 69,54569.5k $3.2m $3.2m 0.03% New
84 Ikarian Capital, LLC 0.41% of their portfolio DALLAS, TX 68,82368.8k $3.2m $3.2m 0.41% Added +12.9k +12,877
85 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 67,33067.3k $3.1m $3.1m 0.00% Reduced -46.5k -46,503
86 Atle Fund Management AB 0.93% of their portfolio STOCKHOLM, V7 62,73562.7k $2.9m $2.9m 0.93% Added +2.6k +2,579
87 KVP Capital Advisors, LP 2.86% of their portfolio SAN FRANCISCO, CA 59,70059.7k $2.8m $2.8m 2.86% First filing
88 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 58,75258.8k $2.7m $2.7m 0.00% Added +21.7k +21,655
89 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 55,06855.1k $2.5m $2.5m 0.00% Reduced -4.8k -4,792
90 Jump Financial, LLC 0.03% of their portfolio Chicago, IL 54,48754.5k $2.5m $2.5m 0.03% New
91 DV Trading LLC 0.22% of their portfolio CHICAGO, IL 54,00054.0k $2.5m $2.5m 0.22% First filing
92 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 52,64352.6k $2.4m $2.4m 0.00% Added +22.2k +22,163
93 SIMPLEX TRADING, LLC 0.06% of their portfolio CHICAGO, IL 49,10849.1k $2.3m $2.3m 0.06% Added +24.0k +23,999
94 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 48,44548.4k $2.2m $2.2m 0.00% Reduced -8.0k -8,000
95 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 46,67846.7k $2.2m $2.2m 0.00% Reduced -47.7k -47,665
96 Moody Aldrich Partners LLC 0.40% of their portfolio MARBLEHEAD, MA 46,30646.3k $2.1m $2.1m 0.40% Reduced -5.0k -4,968
97 WINTON GROUP Ltd 0.07% of their portfolio LONDON, X0 44,20044.2k $2.0m $2.0m 0.07% New
98 BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 43,86243.9k $2.0m $2.0m 0.05% Added +9.6k +9,632
99 BANQUE PICTET & CIE SA 0.02% of their portfolio GENEVA 73, V8 43,79643.8k $2.0m $2.0m 0.02% New
100 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 42,29042.3k $2.0m $2.0m 0.00% Unchanged