Vault-13

SOLENO THERAPEUTICS INC SLNO

COM · Common Stock · CUSIP 834203309

219 institutional holders +51 vs Q4 2024
54,564,55654.6m shares reported held*
$3.9bnreported value*
68 new 74 added 53 reduced 17 sold out net bought ≈ $254.4m (+3.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($767.9k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $71.50. Options: 29 managers hold calls ($285.1m notional), 29 hold puts ($236.3m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 20Q4 22: 26Q1 23: 21Q2 23: 23Q3 23: 55Q4 23: 77Q1 24: 99Q2 24: 115Q3 24: 144Q4 24: 168Q1 25: 219219Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 202220
Q4 202226
Q1 202321
Q2 202323
Q3 202355
Q4 202377
Q1 202499
Q2 2024115
Q3 2024144
Q4 2024168
Q1 2025219

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 23: 6 bought or addedQ2 23: 9 cut or sold outQ3 23: 41 bought or addedQ3 23: 12 cut or sold outQ3 23Q4 23: 55 bought or addedQ4 23: 22 cut or sold outQ1 24: 72 bought or addedQ1 24: 26 cut or sold outQ1 24Q2 24: 76 bought or addedQ2 24: 41 cut or sold outQ3 24: 96 bought or addedQ3 24: 42 cut or sold outQ3 24Q4 24: 114 bought or addedQ4 24: 50 cut or sold outQ1 25: 142 bought or addedQ1 25: 70 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 202369
Q3 20234112
Q4 20235522
Q1 20247226
Q2 20247641
Q3 20249642
Q4 202411450
Q1 202514270

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ2 24 calls: $2.1mQ2 24 puts: $15.7mQ2 24P/C 7.49Q3 24 calls: $44.5mQ3 24 puts: $24.0mQ3 24P/C 0.54Q4 24 calls: $120.4mQ4 24 puts: $123.4mQ4 24P/C 1.02Q1 25 calls: $285.1mQ1 25 puts: $236.3mQ1 25P/C 0.83
Numbers
QuarterCallsPutsP/C
Q2 2024$2.1m$15.7m7.49
Q3 2024$44.5m$24.0m0.54
Q4 2024$120.4m$123.4m1.02
Q1 2025$285.1m$236.3m0.83

Biggest buyers

ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,616,720+1.6m
FMR LLC Added +1,420,446+1.4m
Point72 Asset Management, L.P. New +915,995+916.0k
PRICE T ROWE ASSOCIATES INC /MD/ Added +769,700+769.7k
CITADEL ADVISORS LLC Added +603,634+603.6k
Polar Capital Holdings Plc New +500,000+500.0k
Capital World Investors New +464,833+464.8k
Invesco Ltd. Added +455,181+455.2k
Assenagon Asset Management S.A. New +434,514+434.5k
BANK OF AMERICA CORP /DE/ Added +380,110+380.1k

Biggest sellers

Nantahala Capital Management, LLC Reduced -2,171,943-2.2m
Vivo Capital, LLC Reduced -1,833,557-1.8m
Vestal Point Capital, LP Sold out -1,060,000-1.1m
Carlyle Group Inc. Reduced -514,666-514.7k
Commodore Capital LP Reduced -375,000-375.0k
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Sold out -299,244-299.2k
MARSHALL WACE, LLP Reduced -276,095-276.1k
TCG Crossover Management, LLC Reduced -275,000-275.0k
Sofinnova Investments, Inc. Reduced -272,777-272.8k
Altium Capital Management LLC Sold out -250,000-250.0k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $65.8m921.3k shares
Caption Management, LLC Reduced $44.9m628.0k shares
CITADEL ADVISORS LLC Added $31.6m441.9k shares
Kynam Capital Management, LP New $21.6m302.5k shares
Ikarian Capital, LLC New $17.4m243.0k shares
DIADEMA PARTNERS LP Added $15.7m219.4k shares
GROUP ONE TRADING LLC Added $15.2m212.2k shares
SIMPLEX TRADING, LLC Added $13.0m182.3k shares
JANE STREET GROUP, LLC Reduced $9.2m128.8k shares
Artia Global Partners LP New $7.1m100.0k shares

Biggest puts

Nantahala Capital Management, LLC New $42.9m600.0k shares
Sofinnova Investments, Inc. New $37.8m529.3k shares
MILLENNIUM MANAGEMENT LLC Added $24.4m341.8k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $21.9m307.1k shares
DIADEMA PARTNERS LP Added $15.5m217.0k shares
Caption Management, LLC Reduced $12.3m172.1k shares
JPMORGAN CHASE & CO Added $11.2m156.8k shares
Artia Global Partners LP New $9.8m136.9k shares
Walleye Capital LLC New $7.9m110.0k shares
Ikarian Capital, LLC Added $7.1m100.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-04-24 6.9% +1.4 pts 3.5m 2026-04-24
ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 6.4% 2.8m 2025-02-12
STATE STREET CORP 13G · institution new · filed 2026-05-12 5.2% new 2.7m 2026-05-12

Fell to 5% or below in the last year: WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-08-13), PRICE T ROWE ASSOCIATES INC /MD/ (2.0%, 2026-05-15), Avoro Capital Advisors LLC (4.5%, 2026-05-15), JANUS HENDERSON GROUP PLC (2.3%, 2026-05-07), FMR LLC (0.4%, 2026-05-07), VANGUARD GROUP INC (0.0%, 2026-03-27), Vivo Opportunity Fund Holdings, L.P. (4.2%, 2025-11-14), Adage Capital Management, L.P. (2.6%, 2025-11-13; now reported by ADAGE CAPITAL PARTNERS GP, L.L.C.)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.20% of their portfolio LONDON, X0 5,140,8995.1m $370.0m $370.0m 0.20% Reduced -47.4k -47,366
2 Vivo Capital, LLC 42.19% of their portfolio Palo Alto, CA 4,458,2944.5m $318.5m $318.5m 42.19% Reduced -1.8m -1,833,557
3 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.58% of their portfolio Boston, MA 4,392,6964.4m $313.9m $313.9m 0.58% Added +1.6m +1,616,720
4 Avoro Capital Advisors LLC 2.82% of their portfolio NEW YORK, NY 2,525,0002.5m $180.4m $180.4m 2.82% Unchanged
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 2,400,4182.4m $171.5m $171.5m 0.02% Added +769.7k +769,700
6 FMR LLC 0.01% of their portfolio BOSTON, MA 2,233,4732.2m $159.6m $159.6m 0.01% Added +1.4m +1,420,446
7 BlackRock, Inc. 0.00% of their portfolio New York, NY 1,913,3261.9m $136.7m $136.7m 0.00% Reduced -96.5k -96,464
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,866,3261.9m $133.3m $133.3m 0.00% Reduced -18.2k -18,207
9 Nantahala Capital Management, LLC 10.38% of their portfolio NEW CANAAN, CT 1,757,0231.8m $125.5m $125.5m 10.38% Reduced -2.2m -2,171,943
10 CITADEL ADVISORS LLC 0.11% of their portfolio MIAMI, FL 1,576,0441.6m $112.6m $112.6m 0.11% Added +603.6k +603,634
11 PERCEPTIVE ADVISORS LLC 3.82% of their portfolio NEW YORK, NY 1,506,6021.5m $107.6m $107.6m 3.82% Added +5.6k +5,562
12 WESTFIELD CAPITAL MANAGEMENT CO LP 0.42% of their portfolio BOSTON, MA 1,211,2451.2m $86.5m $86.5m 0.42% Added +329.8k +329,785
13 Holocene Advisors, LP 0.25% of their portfolio New York, NY 1,196,9901.2m $85.5m $85.5m 0.25% Added +241.5k +241,523
14 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,169,1991.2m $83.5m $83.5m 0.00% Reduced -177.8k -177,820
15 Commodore Capital LP 6.05% of their portfolio NEW YORK, NY 1,150,0001.1m $82.2m $82.2m 6.05% Reduced -375.0k -375,000
16 Point72 Asset Management, L.P. 0.18% of their portfolio STAMFORD, CT 915,995916.0k $65.4m $65.4m 0.18% New
17 Carlyle Group Inc. 1.62% of their portfolio WASHINGTON, DC 860,980861.0k $61.4m $61.4m 1.62% Reduced -514.7k -514,666
18 Pictet Asset Management Holding SA 0.07% of their portfolio CAROUGE, V8 837,836837.8k $59.9m $59.9m 0.07% Reduced -14.0k -14,002
19 Siren, L.L.C. 2.93% of their portfolio New York, NY 727,337727.3k $52.0m $52.0m 2.93% Added +375.5k +375,519
20 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 693,644693.6k $49.6m $49.6m 0.01% Reduced -88.6k -88,621
21 MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio NEW YORK, NY 679,291679.3k $48.5m $48.5m 0.05% Added +202.5k +202,490
22 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 633,110633.1k $45.2m $45.2m 0.01% Added +213.7k +213,667
23 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 615,736615.7k $44.0m $44.0m 0.00% Added +16.6k +16,617
24 PFM Health Sciences, LP 3.26% of their portfolio SAN FRANCISCO, CA 595,206595.2k $42.5m $42.5m 3.26% Added +287.7k +287,703
25 EMERALD ADVISERS, LLC 1.82% of their portfolio LEOLA, PA 564,481564.5k $40.3m $40.3m 1.82% Reduced -16.4k -16,438
26 Alyeska Investment Group, L.P. 0.15% of their portfolio CHICAGO, IL 529,209529.2k $37.8m $37.8m 0.15% Added +105.1k +105,128
27 Polar Capital Holdings Plc 0.22% of their portfolio London, X0 500,000500.0k $35.7m $35.7m 0.22% New
28 Frazier Life Sciences Management, L.P. 1.63% of their portfolio PALO ALTO, CA 499,159499.2k $35.7m $35.7m 1.63% Reduced -200.0k -200,000
29 Artia Global Partners LP 10.44% of their portfolio MIAMI, FL 498,473498.5k $35.6m $35.6m 10.44% Added +4.0k +4,049
30 Sofinnova Investments, Inc. 2.61% of their portfolio Menlo Park, CA 484,471484.5k $34.6m $34.6m 2.61% Reduced -272.8k -272,777
31 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 467,193467.2k $33.4m $33.4m 0.01% Added +455.2k +455,181
32 Capital World Investors 0.01% of their portfolio LOS ANGELES, CA 464,833464.8k $33.2m $33.2m 0.01% New
33 Assenagon Asset Management S.A. 0.06% of their portfolio SENNINGERBERG, N4 434,514434.5k $31.0m $31.0m 0.06% New
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 430,059430.1k $30.7m $30.7m 0.00% Added +380.1k +380,110
35 EMERALD MUTUAL FUND ADVISERS TRUST 1.88% of their portfolio LEOLA, PA 371,697371.7k $26.6m $26.6m 1.88% Added +3.1k +3,123
36 Woodline Partners LP 0.16% of their portfolio San Francisco, CA 349,664349.7k $25.0m $25.0m 0.16% Added +48.1k +48,102
37 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 302,664302.7k $21.6m $21.6m 0.00% Added +234.6k +234,649
38 Caption Management, LLC 0.96% of their portfolio OKLAHOMA CITY, OK 295,000295.0k $21.1m $21.1m 0.96% Added +271.9k +271,852
39 TCG Crossover Management, LLC 2.68% of their portfolio PALO ALTO, CA 275,000275.0k $19.6m $19.6m 2.68% Reduced -275.0k -275,000
40 SOROS FUND MANAGEMENT LLC 0.34% of their portfolio NEW YORK, NY 270,663270.7k $19.3m $19.3m 0.34% New
41 Logos Global Management LP 3.18% of their portfolio San Francisco, CA 250,000250.0k $17.9m $17.9m 3.18% Reduced -100.0k -100,000
42 Driehaus Capital Management LLC 0.17% of their portfolio Chicago, IL 247,737247.7k $17.7m $17.7m 0.17% New
43 Tri Locum Partners LP 8.61% of their portfolio NEW YORK, NY 234,920234.9k $16.8m $16.8m 8.61% New
44 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 232,336232.3k $16.6m $16.6m 0.00% Added +5.4k +5,447
45 Qube Research & Technologies Ltd 0.02% of their portfolio LONDON, X0 223,287223.3k $16.0m $16.0m 0.02% Added +104.7k +104,673
46 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 213,984214.0k $15.3m $15.3m 0.00% Reduced -3.6k -3,566
47 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 212,359212.4k $15.2m $15.2m 0.00% Added +2.1k +2,122
48 TimesSquare Capital Management, LLC 0.24% of their portfolio NEW YORK, NY 206,600206.6k $14.8m $14.8m 0.24% Reduced -133.2k -133,174
49 SAMLYN CAPITAL, LLC 0.22% of their portfolio New York, NY 190,882190.9k $13.6m $13.6m 0.22% Reduced -187.2k -187,221
50 COMERICA BANK 0.06% of their portfolio DALLAS, TX 188,093188.1k $13.4m $13.4m 0.06% Added +66.9k +66,880
51 Checkpoint Capital L.P. 6.78% of their portfolio SAN FRANCISCO, CA 172,902172.9k $12.4m $12.4m 6.78% Added +102.9k +102,875
52 SILVERARC CAPITAL MANAGEMENT, LLC 2.48% of their portfolio BOSTON, MA 166,417166.4k $11.9m $11.9m 2.48% New
53 Catalio Capital Management, LP 2.85% of their portfolio NEW YORK, NY 160,962161.0k $11.5m $11.5m 2.85% New
54 HSBC HOLDINGS PLC 0.01% of their portfolio LONDON, X0 152,957153.0k $10.9m $10.9m 0.01% New
55 Soleus Capital Management, L.P. 0.84% of their portfolio GREENWICH, CT 150,000150.0k $10.7m $10.7m 0.84% New
56 Rock Springs Capital Management LP 0.51% of their portfolio Baltimore, MD 124,095124.1k $8.9m $8.9m 0.51% Unchanged
57 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 123,754123.8k $8.8m $8.8m 0.01% Reduced -276.1k -276,095
58 Ally Bridge Group (NY) LLC 8.36% of their portfolio NEW YORK, NY 120,449120.4k $8.6m $8.6m 8.36% Added +32.8k +32,820
59 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 118,470118.5k $8.5m $8.5m 0.00% Reduced -985 -985
60 Atika Capital Management LLC 1.10% of their portfolio NEW YORK, NY 100,600100.6k $7.2m $7.2m 1.10% Added +29.9k +29,900
61 READYSTATE ASSET MANAGEMENT LP 0.36% of their portfolio CHICAGO, IL 99,42299.4k $7.1m $7.1m 0.36% Added +49.4k +49,422
62 Walleye Capital LLC 0.08% of their portfolio NEW YORK, NY 97,53697.5k $7.0m $7.0m 0.08% Added +20.6k +20,602
63 DIADEMA PARTNERS LP 5.31% of their portfolio MORRISTOWN, NJ 93,00293.0k $6.6m $6.6m 5.31% Added +21.0k +21,014
64 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 84,83084.8k $6.1m $6.1m 0.00% First filing
65 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 81,06381.1k $5.8m $5.8m 0.01% Added +71.9k +71,862
66 Nan Fung Group Holdings Ltd 4.64% of their portfolio KAI TAK, K3 79,65079.7k $5.7m $5.7m 4.64% Unchanged
67 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 78,32978.3k $5.6m $5.6m 0.00% Reduced -48.3k -48,346
68 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 74,01074.0k $5.3m $5.3m 0.00% Added +14.3k +14,276
69 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.06% of their portfolio New York, NY 72,58272.6k $5.2m $5.2m 0.06% New
70 Allspring Global Investments Holdings, LLC 0.01% of their portfolio CHARLOTTE, NC 67,34967.3k $4.8m $4.8m 0.01% Reduced -60.7k -60,679
71 ACUTA CAPITAL PARTNERS, LLC 5.56% of their portfolio REDWOOD CITY, CA 67,13667.1k $4.8m $4.8m 5.56% New
72 Global IMC LLC 1.21% of their portfolio SOLANA BEACH, CA 62,43662.4k $4.5m $4.5m 1.21% New
73 UBS Group AG 0.00% of their portfolio ZURICH, V8 57,47757.5k $4.1m $4.1m 0.00% Added +7.3k +7,322
74 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 55,11855.1k $3.9m $3.9m 0.00% Added +1.3k +1,285
75 LORD, ABBETT & CO. LLC 0.01% of their portfolio JERSEY CITY, NJ 55,06155.1k $3.9m $3.9m 0.01% New
76 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 53,04153.0k $3.8m $3.8m 0.00% Added +1.9k +1,884
77 Quadrature Capital Ltd 0.08% of their portfolio LONDON, X0 51,76251.8k $3.7m $3.7m 0.08% New
78 F/m Investments LLC 0.14% of their portfolio WASHINGTON, DC 50,76750.8k $3.6m $3.6m 0.14% Added +3.0k +2,973
79 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 50,27450.3k $3.6m $3.6m 0.01% Added +23.7k +23,742
80 Swiss National Bank 0.00% of their portfolio ZURICH, V8 50,10050.1k $3.6m $3.6m 0.00% Added +4.2k +4,200
81 TANG CAPITAL MANAGEMENT LLC 0.20% of their portfolio SAN DIEGO, CA 50,00050.0k $3.6m $3.6m 0.20% Unchanged
82 683 Capital Management, LLC 0.36% of their portfolio NEW YORK, NY 50,00050.0k $3.6m $3.6m 0.36% Unchanged
83 Affinity Asset Advisors, LLC 0.56% of their portfolio NEW YORK, NY 50,00050.0k $3.6m $3.6m 0.56% Reduced -80.0k -80,000
84 Informed Momentum Co LLC 0.61% of their portfolio SOLANA BEACH, CA 49,54849.5k $3.5m $3.5m 0.61% New
85 HARBOR CAPITAL ADVISORS, INC. 0.15% of their portfolio CHICAGO, IL 46,93146.9k $3.4m $3.4m 0.15% Added +9.6k +9,635
86 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 46,35346.4k $3.3m $3.3m 0.01% Reduced -20.1k -20,127
87 Exome Asset Management LLC 2.78% of their portfolio NEW YORK, NY 43,44143.4k $3.1m $3.1m 2.78% Reduced -33.8k -33,844
88 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 40,71540.7k $2.9m $2.9m 0.00% Added +13.2k +13,211
89 Y-Intercept (Hong Kong) Ltd 0.20% of their portfolio HONG KONG, K3 40,42540.4k $2.9m $2.9m 0.20% New
90 FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 40,39440.4k $2.9m $2.9m 0.02% Added +25.6k +25,589
91 Resolute Capital Asset Partners LLC 1.61% of their portfolio DENVER, CO 40,00040.0k $2.9m $2.9m 1.61% New
92 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 37,73137.7k $2.7m $2.7m 0.00% Added +13.9k +13,921
93 Atle Fund Management AB 1.17% of their portfolio STOCKHOLM, V7 37,09837.1k $2.7m $2.7m 1.17% Added +6.2k +6,158
94 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 36,49536.5k $2.6m $2.6m 0.01% New
95 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 36,43936.4k $2.6m $2.6m 0.00% Added +2.0k +2,044
96 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 35,70635.7k $2.6m $2.6m 0.02% New
97 GILDER GAGNON HOWE & CO LLC 0.03% of their portfolio New York, NY 33,08633.1k $2.4m $2.4m 0.03% New
98 Granahan Investment Management, LLC 0.12% of their portfolio WALTHAM, MA 32,49132.5k $2.3m $2.3m 0.12% New
99 Avidity Partners Management LP 0.47% of their portfolio DALLAS, TX 32,00032.0k $2.3m $2.3m 0.47% New
100 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 31,29431.3k $2.2m $2.2m 0.00% Added +9.3k +9,317