SIONNA THERAPEUTICS INC SION
COM · Common Stock · CUSIP 829401108
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($89.2k this quarter). Holder counts are more reliable. Shares outstanding: 44.6m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $41.14.
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2025 | 48 |
| Q2 2025 | 66 |
| Q3 2025 | 78 |
| Q4 2025 | 101 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2025 | 44 | 18 |
| Q3 2025 | 40 | 24 |
| Q4 2025 | 66 | 27 |
Biggest buyers
| CITADEL ADVISORS LLC | Added | +1.1m |
| EVENTIDE ASSET MANAGEMENT, LLC | New | +639.0k |
| STATE STREET CORP | Added | +453.2k |
| BlackRock, Inc. | Added | +447.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +193.6k |
| SUPERSTRING CAPITAL MANAGEMENT LP | New | +180.6k |
| Artia Global Partners LP | New | +119.7k |
| JENNISON ASSOCIATES LLC | Added | +117.9k |
| Invesco Ltd. | New | +111.2k |
| Ensign Peak Advisors, Inc | New | +79.9k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -2.7m |
| Atlas Venture Life Science Advisors, LLC | Reduced | -619.9k |
| RA CAPITAL MANAGEMENT, L.P. | Reduced | -540.3k |
| BRAIDWELL LP | Sold out | -314.0k |
| Soleus Capital Management, L.P. | Reduced | -145.0k |
| ORBIMED ADVISORS LLC | Reduced | -143.3k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -133.5k |
| Aberdeen Group plc | Reduced | -110.6k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | -67.3k |
| FRANKLIN RESOURCES INC | Reduced | -66.7k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TPG GP A, LLC
13D · may seek influence
new · filed 2025-02-18
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Initial Public Offering On February 6, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with Goldman Sachs & Co. LLC, TD Securities (USA) LLC, Stifel, Nicolaus & Company, Incorporated and Guggenheim Securities, LLC (the "Underwriters") providing for the offer and sale by the Issuer (the "Offering"), and purchase by the Underwriters, of 10,588,233 shares of Common Stock at a price to the public of $18.00 per share. On February 10, 2025, the Offering closed (the "Closing"). The Rise Fund Sling, L.P. purchased 1,125,000 shares of Common Stock in the Offering at a price of $18.00 per share … Full filing |
15.2% |
| RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -8.3 pts · filed 2026-09-21 | 14.3% |
| VIKING GLOBAL INVESTORS LP 13G · passive investor +0.4 pts · filed 2026-05-15 | 7.1% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.8 pts · filed 2026-04-20
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
6.6% |
Enavate Sciences GP, LLC
13D · may seek influence
new · filed 2025-02-18
Stated purposeThe Reporting Persons purchased the aforementioned securities for investment purposes with the aim of increasing the value of their investments and the Issuer. Subject to applicable legal requirements, one or more of the Reporting Persons may purchase additional securities of the Issuer from time to time in open market or private transactions, depending on its evaluation of the Issuer's business, prospects and financial condition, the market for the Issuer's securities, other developments concerning the Issuer, the reaction of the Issuer to the Reporting Persons' ownership of the Issuer's securities, other opportunities available to the Reporting Persons, and general economic, money market and stock market conditions. In addition, depending upon the factors referred to above, the Reportin… Full filing |
5.6% |
| Atlas Venture Fund XI, L.P. 13D · may seek influence -1.1 pts · filed 2025-10-20 | 5.4% |
Fell to 5% or below in the last year: Qatar Investment Authority (4.5%, 2026-05-12)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 4 | $31.2m | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 4 | $6.5m | $6.5m |
| Q4 2025 | 0 | — | 6 | $52.4m | $30.9m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-24 | Thompson Peter A. Director · See footnotes | Sold plan | $1.5m33.4k shares |
| 2025-12-24 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $1.5m33.4k shares |
| 2025-12-19 | Thompson Peter A. Director · See footnotes | Sold plan | $38.9k875 shares |
| 2025-12-19 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $38.9k875 shares |
| 2025-12-18 | Thompson Peter A. Director · See footnotes | Sold plan | $4.4k100 shares |
| 2025-12-18 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $4.4k100 shares |
| 2025-12-17 | Thompson Peter A. Director · See footnotes | Sold plan | $40.0k900 shares |
| 2025-12-17 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $40.0k900 shares |
| 2025-12-05 | Fitzpatrick Jennifer Chief Legal Officer | Sold plan | $415.3k10.2k shares |
| 2025-11-26 | Thompson Peter A. Director · See footnotes | Sold plan | $71.2k1.6k shares |
| 2025-11-26 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $71.2k1.6k shares |
| 2025-11-25 | Thompson Peter A. Director · See footnotes | Sold plan | $530.3k11.9k shares |
| 2025-11-25 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $530.3k11.9k shares |
| 2025-11-24 | Thompson Peter A. Director · See footnotes | Sold plan | $4.2m94.6k shares |
| 2025-11-24 | ORBIMED ADVISORS LLC +1 Director · See footnotes | Sold plan | $4.2m94.6k shares |
| 2025-11-21 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $994.7k25.2k shares |
| 2025-11-20 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $206.0k5.1k shares |
| 2025-11-19 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $1.9m47.4k shares |
| 2025-11-18 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $273.9k6.9k shares |
| 2025-11-17 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $3.3m82.0k shares |
| 2025-10-28 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $2.5m62.6k shares |
| 2025-10-24 | RA Capital Healthcare Fund LP +5 Director · See footnotes | Sold | $12.3m311.0k shares |
| 2025-10-21 | Cloonan Michael President & CEO, director | Sold plan | $3.6m99.8k shares |
| 2025-10-21 | Booth Bruce Director · By Atlas Venture Fund XI, L.P. | Sold plan | $2.5m73.5k shares |
| 2025-10-21 | Booth Bruce Director · By Atlas Venture Opportunity Fund II, L.P. | Sold plan | $527.7k15.4k shares |
| 2025-10-20 | Booth Bruce Director · By Atlas Venture Fund XI, L.P. | Sold plan | $1.5m46.3k shares |
| 2025-10-20 | Booth Bruce Director · By Atlas Venture Opportunity Fund II, L.P. | Sold plan | $311.7k9.7k shares |
| 2025-10-17 | Booth Bruce Director · By Atlas Venture Fund XI, L.P. | Sold plan | $1.6m50.5k shares |
| 2025-10-17 | Booth Bruce Director · By Atlas Venture Opportunity Fund II, L.P. | Sold plan | $343.2k10.6k shares |
| 2025-10-16 | Booth Bruce Director · By Atlas Venture Fund XI, L.P. | Sold plan | $4.5m139.9k shares |
The latest 30 of 47 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 4.17% of their portfolio | 9.9m $407.5m | Reduced -540.3k |
| TPG GP A, LLC 10.33% of their portfolio | 6.7m $277.5m | Unchanged |
| ORBIMED ADVISORS LLC 3.00% of their portfolio | 3.6m $146.5m | Reduced -143.3k |
| VIKING GLOBAL INVESTORS LP 0.35% of their portfolio | 3.2m $131.4m | Unchanged |
| Atlas Venture Life Science Advisors, LLC 14.24% of their portfolio | 3.0m $123.2m | Reduced -619.9k |
| ENAVATE SCIENCES GP, LLC 20.12% of their portfolio | 2.5m $101.9m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 1.3m $53.1m | Added +447.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.2m $50.7m | Reduced -2.7m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.2m $48.7m | Added +41.8k |
| PERCEPTIVE ADVISORS LLC 0.89% of their portfolio | 1.2m $48.5m | Unchanged |
| JENNISON ASSOCIATES LLC 0.03% of their portfolio | 1.1m $45.9m | Added +117.9k |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 1.1m $44.7m | Added +1.1m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.51% of their portfolio | 970.6k $39.9m | Unchanged |
| Aberdeen Group plc 0.05% of their portfolio | 840.0k $34.6m | Reduced -110.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 831.4k $34.2m | Added +193.6k |
| STATE STREET CORP 0.00% of their portfolio | 693.4k $28.5m | Added +453.2k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.41% of their portfolio | 639.0k $26.3m | New |
| BAKER BROS. ADVISORS LP 0.10% of their portfolio | 400.0k $16.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 380.0k $15.6m | Added +63.5k |
| Siren, L.L.C. 0.37% of their portfolio | 300.0k $12.3m | Reduced -25.0k |
| Soleus Capital Management, L.P. 0.47% of their portfolio | 268.5k $11.0m | Reduced -145.0k |
| Kalehua Capital Management LLC 8.02% of their portfolio | 197.1k $8.1m | First filing |
| SUPERSTRING CAPITAL MANAGEMENT LP 3.98% of their portfolio | 180.6k $7.4m | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 175.5k $7.2m | Reduced -66.7k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 136.2k $5.6m | Reduced -50.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 123.7k $5.1m | Added +12.2k |
| Artia Global Partners LP 0.79% of their portfolio | 119.7k $4.9m | New |
| TD Asset Management Inc 0.00% of their portfolio | 113.4k $4.7m | Added +26.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 112.1k $4.6m | Added +14.4k |
| Invesco Ltd. 0.00% of their portfolio | 111.2k $4.6m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 101.6k $4.2m | Reduced -51.5k |
| Rock Springs Capital Management LP 0.21% of their portfolio | 99.4k $4.1m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 89.2k $3.7m | Added +42.5k |
| Driehaus Capital Management LLC 0.02% of their portfolio | 83.8k $3.4m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 80.5k $3.3m | Reduced -133.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 79.9k $3.3m | New |
| Longaeva Partners L.P. 0.39% of their portfolio | 79.7k $3.3m | Added +18.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 69.4k $2.9m | Added +37.3k |
| SEVEN GRAND MANAGERS, LLC 0.16% of their portfolio | 50.0k $2.1m | New |
| MORGAN STANLEY 0.00% of their portfolio | 49.9k $2.1m | Added +27.0k |
| BARCLAYS PLC 0.00% of their portfolio | 48.2k $2.0m | Added +30.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 43.6k $1.8m | Added +37.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.25% of their portfolio | 41.5k $1.7m | Reduced -67.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 38.3k $1.6m | Reduced -3.9k |
| ALPS ADVISORS INC 0.01% of their portfolio | 36.6k $1.5m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 36.3k $1.5m | Added +24.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 35.1k $1.4m | Added +7.7k |
| POLEN CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 31.3k $1.3m | Unchanged |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 24.7k $1.0m | New |
| Nuveen, LLC 0.00% of their portfolio | 23.7k $976.4k | Added +7.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 21.9k $902.7k | Added +20.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 17.7k $727.9k | Added +454 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 17.6k $722.0k | Added +10.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 16.4k $673.0k | Added +6.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 15.6k $642.6k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 10.7k $440.0k | New |
| China Universal Asset Management Co., Ltd. 0.03% of their portfolio | 10.3k $422.6k | Added +5.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 10.0k $412.6k | Added +433 |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 9.2k $379.0k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 8.9k $367.1k | Added +3.3k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 8.6k $352.4k | Added +532 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 7.6k $312.2k | Added +103 |
| KENNEDY CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 6.8k $277.8k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 6.4k $263.3k | New |
| Virtus Investment Advisers, LLC 0.07% of their portfolio | 6.2k $255.9k | Reduced -478 |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 6.2k $254.2k | New |
| DARK FOREST CAPITAL MANAGEMENT LP 0.01% of their portfolio | 6.0k $246.5k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 5.7k $236.2k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 5.3k $218.0k | Unchanged |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 5.2k $197.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 5.2k $213.3k | Added +4.5k |
| XTX Topco Ltd 0.01% of their portfolio | 4.9k $202.7k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 4.9k $201.7k | New |
| CIBC Private Wealth Group LLC 0.00% of their portfolio | 4.5k $185.1k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 4.2k $174.1k | Added +998 |
| AlphaCentric Advisors LLC 0.11% of their portfolio | 2.7k $111.9k | First filing |
| Cygnus Capital Advisors, LLC 0.07% of their portfolio | 2.4k $99.0k | First filing |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 2.3k $93.1k | Reduced -116 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 2.2k $89.2k | New |
| Legal & General Group Plc 0.00% of their portfolio | 1.7k $69.2k | Reduced -5.7k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 1.4k $57.8k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 1.3k $53.6k | Added +43 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.1k $46.4k | Reduced -3.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 988 $40.6k | Added +217 |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 876 $36.0k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 504 $21.0k | Added +83 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 489 $21.0k | Added +111 |
| FMR LLC 0.00% of their portfolio | 384 $15.8k | Added +150 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 190 $7.8k | New |
| GAMMA Investing LLC 0.00% of their portfolio | 177 $7.3k | Added +24 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 149 $6.0k | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 105 $4.3k | Added +75 |
| CWM, LLC 0.00% of their portfolio | 80 $3.0k | Added +20 |
| US BANCORP \DE\ 0.00% of their portfolio | 65 $2.7k | Reduced -46 |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 48 $2.0k | New |
| Aster Capital Management (DIFC) Ltd 0.00% of their portfolio | 37 $1.5k | Reduced -372 |
| Allworth Financial LP 0.00% of their portfolio | 28 $1.2k | Added +6 |
| Hughes Financial Services, LLC 0.00% of their portfolio | 25 $1.0k | Reduced -19 |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 20 $823 | Unchanged |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 5 $206 | Unchanged |