Vault-13

SERES THERAPEUTICS INC

COM · CUSIP 81750R102

139 institutional holders +15 vs Q1 2023
111,942,028111.9m shares reported held*
$536.3mreported value*
34 new 58 added 26 reduced 21 sold out net sold ≈ $55.9m (-11.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $4.79. Options: 10 managers hold calls ($12.8m notional), 10 hold puts ($4.2m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 120Q4 22: 125Q1 23: 124Q2 23: 139139Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022120
Q4 2022125
Q1 2023124
Q2 2023139

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 59 bought or addedQ4 22: 54 cut or sold outQ4 22Q1 23: 61 bought or addedQ1 23: 57 cut or sold outQ1 23Q2 23: 92 bought or addedQ2 23: 47 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20225954
Q1 20236157
Q2 20239247

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ3 22 calls: $2.3mQ3 22 puts: $1.3mQ3 22P/C 0.57Q4 22 calls: $1.9mQ4 22 puts: $1.2mQ4 22P/C 0.67Q1 23 calls: $1.8mQ1 23 puts: $2.6mQ1 23P/C 1.42Q2 23 calls: $12.8mQ2 23 puts: $4.2mQ2 23P/C 0.33
Numbers
QuarterCallsPutsP/C
Q3 2022$2.3m$1.3m0.57
Q4 2022$1.9m$1.2m0.67
Q1 2023$1.8m$2.6m1.42
Q2 2023$12.8m$4.2m0.33

Biggest buyers

STATE STREET CORP Added +4,796,626+4.8m
Soleus Capital Management, L.P. New +2,045,983+2.0m
MILLENNIUM MANAGEMENT LLC Added +1,351,434+1.4m
BlackRock Inc. Added +1,232,141+1.2m
Avoro Capital Advisors LLC Added +1,205,000+1.2m
GREAT POINT PARTNERS LLC New +938,067+938.1k
BANK OF AMERICA CORP /DE/ Added +786,699+786.7k
JENNISON ASSOCIATES LLC Added +727,622+727.6k
Point72 Asset Management, L.P. Added +727,600+727.6k
ExodusPoint Capital Management, LP New +594,895+594.9k

Biggest sellers

FMR LLC Reduced -18,637,708-18.6m
JANUS HENDERSON GROUP PLC Reduced -5,227,873-5.2m
FEDERATED HERMES, INC. Reduced -3,882,555-3.9m
Kynam Capital Management, LP Sold out -768,913-768.9k
VANGUARD GROUP INC Reduced -495,953-496.0k
CITADEL ADVISORS LLC Reduced -487,920-487.9k
JPMORGAN CHASE & CO Reduced -484,022-484.0k
RENAISSANCE TECHNOLOGIES LLC Sold out -398,200-398.2k
Walleye Capital LLC Sold out -362,324-362.3k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -269,645-269.6k

Biggest calls

JANE STREET GROUP, LLC New $4.5m944.6k shares
GROUP ONE TRADING LLC Added $4.4m918.7k shares
CITIGROUP INC Added $1.3m263.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $1.2m251.6k shares
CITADEL ADVISORS LLC Added $666.3k139.1k shares
SIMPLEX TRADING, LLC Added $593.0k123.9k shares
WOLVERINE TRADING, LLC New $120.1k25.6k shares
Belvedere Trading LLC New $62.3k13.0k shares
Cutler Group LLC / CA New $2.0k2.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $1.1m224.2k shares
CITADEL ADVISORS LLC Added $1.1m219.6k shares
GROUP ONE TRADING LLC Added $757.8k158.2k shares
CITIGROUP INC Added $638.0k133.2k shares
SIMPLEX TRADING, LLC Reduced $398.0k83.1k shares
JANE STREET GROUP, LLC Added $252.4k52.7k shares
WOLVERINE TRADING, LLC New $53.0k11.3k shares
Belvedere Trading LLC New $4.3k900 shares
Cutler Group LLC / CA New $2.0k2.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution filed 2025-02-12 12.8% 21.8m 2025-02-12

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Flagship Pioneering, LLC 4.94% of their portfolio CAMBRIDGE, MA 23,117,04523.1m $110.7m $110.7m 4.94% Unchanged
2 FMR LLC 0.01% of their portfolio BOSTON, MA 19,185,20819.2m $91.9m $91.9m 0.01% Reduced -18.6m -18,637,708
3 FEDERATED HERMES, INC. 0.14% of their portfolio PITTSBURGH, PA 11,394,80111.4m $54.6m $54.6m 0.14% Reduced -3.9m -3,882,555
4 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 8,564,9358.6m $41.0m $41.0m 0.00% Added +4.8m +4,796,626
5 BlackRock Inc. 0.00% of their portfolio New York, NY 7,481,2277.5m $35.8m $35.8m 0.00% Added +1.2m +1,232,141
6 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 6,072,9426.1m $29.1m $29.1m 0.02% Reduced -5.2m -5,227,873
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 5,357,1835.4m $25.7m $25.7m 0.00% Reduced -496.0k -495,953
8 Eversept Partners, LP 1.56% of their portfolio NEW YORK, NY 3,076,7563.1m $14.7m $14.7m 1.56% Added +540.1k +540,091
9 Avoro Capital Advisors LLC 0.16% of their portfolio NEW YORK, NY 2,500,0002.5m $12.0m $12.0m 0.16% Added +1.2m +1,205,000
10 Soleus Capital Management, L.P. 1.09% of their portfolio GREENWICH, CT 2,045,9832.0m $9.8m $9.8m 1.09% New
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,961,3582.0m $9.4m $9.4m 0.00% Added +325.8k +325,849
12 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 1,759,9141.8m $8.4m $8.4m 0.01% Added +1.4m +1,351,434
13 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 1,392,3561.4m $6.7m $6.7m 0.01% Added +727.6k +727,622
14 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,193,8961.2m $5.7m $5.7m 0.00% Added +786.7k +786,699
15 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 1,020,4001.0m $4.9m $4.9m 0.02% Added +727.6k +727,600
16 Handelsbanken Fonder AB 0.03% of their portfolio STOCKHOLM, V7 1,000,0001.0m $4.8m $4.8m 0.03% Added +200.0k +200,000
17 GREAT POINT PARTNERS LLC 0.90% of their portfolio Greenwich, CT 938,067938.1k $4.5m $4.5m 0.90% New
18 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 925,163925.2k $4.4m $4.4m 0.00% Added +184.5k +184,489
19 Hudson Bay Capital Management LP 0.04% of their portfolio STAMFORD, CT 880,000880.0k $4.2m $4.2m 0.04% Added +39.2k +39,229
20 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 773,387773.4k $3.7m $3.7m 0.02% Added +534.1k +534,100
21 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 714,269714.3k $3.4m $3.4m 0.00% Added +80.4k +80,400
22 Lion Point Capital, LP 2.46% of their portfolio NEW YORK, NY 691,803691.8k $3.3m $3.3m 2.46% Added +95.0k +95,000
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 656,794656.8k $3.1m $3.1m 0.00% Added +336.0k +336,046
24 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 594,895594.9k $2.9m $2.9m 0.03% New
25 Simplify Asset Management Inc. 0.48% of their portfolio Las Vegas, NV 550,626550.6k $2.6m $2.6m 0.48% Unchanged
26 Knott David M Jr 0.91% of their portfolio SYOSSET, NY 470,000470.0k $2.3m $2.3m 0.91% Added +155.0k +155,000
27 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 461,170461.2k $2.2m $2.2m 0.00% Added +267.0k +266,954
28 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 370,905370.9k $1.8m $1.8m 0.00% Added +260.8k +260,845
29 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 323,007323.0k $1.5m $1.5m 0.00% Added +72.5k +72,538
30 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 314,427314.4k $1.5m $1.5m 0.00% Reduced -269.6k -269,645
31 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 280,935280.9k $1.3m $1.3m 0.00% Reduced -88.8k -88,760
32 SIT INVESTMENT ASSOCIATES INC 0.03% of their portfolio Minneapolis, MN 262,325262.3k $1.3m $1.3m 0.03% Unchanged
33 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 255,106255.1k $1.2m $1.2m 0.00% Added +59.9k +59,884
34 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 254,339254.3k $1.2m $1.2m 0.00% Reduced -40.1k -40,107
35 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 243,595243.6k $1.2m $1.2m 0.01% New
36 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 222,257222.3k $1.1m $1.1m 0.01% New
37 Swiss National Bank 0.00% of their portfolio ZURICH, V8 219,600219.6k $1.1m $1.1m 0.00% Added +4.5k +4,500
38 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 206,145206.1k $987.4k $987.4k 0.00% New
39 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 189,181189.2k $906.1k $906.1k 0.00% Added +188.1k +188,139
40 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 171,808171.8k $823.0k $823.0k 0.00% Added +116.9k +116,885
41 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 170,782170.8k $818.0k $818.0k 0.00% Added +48.0k +47,992
42 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 154,663154.7k $740.8k $740.8k 0.00% Added +59.1k +59,124
43 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 139,999140.0k $670.6k $670.6k 0.00% Reduced -484.0k -484,022
44 PROFUND ADVISORS LLC 0.04% of their portfolio BETHESDA, MD 139,249139.2k $667.0k $667.0k 0.04% Added +94.4k +94,390
45 Alpha DNA Investment Management LLC 0.38% of their portfolio Columbia, MD 138,536138.5k $663.6k $663.6k 0.38% New
46 Parallax Volatility Advisers, L.P. 0.02% of their portfolio San Francisco, CA 134,901134.9k $646.2k $646.2k 0.02% New
47 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 134,800134.8k $645.7k $645.7k 0.00% Added +40.5k +40,498
48 HARVARD MANAGEMENT CO INC 0.06% of their portfolio BOSTON, MA 131,847131.8k $632.0k $632.0k 0.06% Unchanged
49 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 121,109121.1k $580.1k $580.1k 0.00% Added +7.4k +7,351
50 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 115,058115.1k $551.1k $551.1k 0.00% Added +19.4k +19,388
51 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 104,100104.1k $498.6k $498.6k 0.00% Unchanged
52 OCCUDO QUANTITATIVE STRATEGIES LP 0.05% of their portfolio FORT LAUDERDALE, FL 102,608102.6k $491.5k $491.5k 0.05% New
53 NATIXIS 0.00% of their portfolio PARIS, I0 99,00099.0k $474.2k $474.2k 0.00% New
54 CANTOR FITZGERALD, L. P. 0.01% of their portfolio NEW YORK, NY 97,40797.4k $466.6k $466.6k 0.01% New
55 AE Wealth Management LLC 0.00% of their portfolio TOPEKA, KS 95,18895.2k $456.0k $456.0k 0.00% New
56 Mach-1 Financial Group, LLC 0.18% of their portfolio Rogers, AR 94,96195.0k $454.9k $454.9k 0.18% New
57 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 94,09594.1k $533.5k $533.5k 0.00% Unchanged
58 Janney Montgomery Scott LLC 0.00% of their portfolio PHILADELPHIA, PA 90,28590.3k $432.0k $432.0k 0.00% Reduced -12.0k -11,996
59 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 87,33487.3k $418.3k $418.3k 0.00% Reduced -4.6k -4,598
60 Legal & General Group Plc 0.00% of their portfolio London, X0 86,64786.6k $415.0k $415.0k 0.00% Added +44.3k +44,344
61 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 85,66185.7k $410.3k $410.3k 0.00% Added +75.9k +75,893
62 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 79,83379.8k $382.4k $382.4k 0.00% Added +40.3k +40,253
63 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 79,44479.4k $377.9k $377.9k 0.00% Added +17.2k +17,204
64 UBS Group AG 0.00% of their portfolio ZURICH, V8 73,23173.2k $350.8k $350.8k 0.00% Reduced -36.9k -36,872
65 Corton Capital Inc. 0.15% of their portfolio Carrying Place, A6 65,77265.8k $315.0k $315.0k 0.15% New
66 SIMPLEX TRADING, LLC 0.01% of their portfolio CHICAGO, IL 61,02061.0k $292.0k $292.0k 0.01% Reduced -54.1k -54,080
67 Clear Creek Financial Management, LLC 0.04% of their portfolio SILVERDALE, WA 54,20054.2k $259.6k $259.6k 0.04% New
68 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 51,43951.4k $246.4k $246.4k 0.00% Added +13.8k +13,822
69 EDGEWOOD MANAGEMENT LLC 0.00% of their portfolio GREENWICH, CT 50,00050.0k $239.5k $239.5k 0.00% Reduced -50.0k -50,000
70 HarbourVest Partners LLC 0.07% of their portfolio Boston, MA 49,36349.4k $236.4k $236.4k 0.07% Unchanged
71 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 48,45148.5k $232.1k $232.1k 0.00% Reduced -12.8k -12,762
72 IRONWOOD INVESTMENT MANAGEMENT LLC 0.13% of their portfolio BOSTON, MA 46,96147.0k $224.9k $224.9k 0.13% Reduced -835 -835
73 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 46,82046.8k $224.3k $224.3k 0.00% Added +12.8k +12,814
74 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 45,20545.2k $216.5k $216.5k 0.00% Added +8.0k +8,013
75 Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio FAIRFIELD, IA 44,84444.8k $215.0k $215.0k 0.00% New
76 Dynamic Technology Lab Private Ltd 0.03% of their portfolio SINGAPORE, U0 43,63143.6k $209.0k $209.0k 0.03% New
77 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 42,60942.6k $205.0k $205.0k 0.00% Added +15.5k +15,518
78 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 41,77341.8k $200.1k $200.1k 0.00% Reduced -487.9k -487,920
79 E Fund Management Co., Ltd. 0.02% of their portfolio GUANGZHOU, F4 41,58141.6k $199.0k $199.0k 0.02% Added +28.0k +27,996
80 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 41,09641.1k $196.9k $196.9k 0.00% Added +6.1k +6,069
81 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 39,93639.9k $191.3k $191.3k 0.00% Added +11.3k +11,309
82 OPPENHEIMER & CO INC 0.00% of their portfolio NEW YORK, NY 38,81938.8k $185.9k $185.9k 0.00% Added +1.7k +1,708
83 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 38,79238.8k $185.8k $185.8k 0.00% Added +11.2k +11,203
84 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 38,59038.6k $184.8k $184.8k 0.00% Added +6.0k +6,020
85 Vontobel Holding Ltd. 0.00% of their portfolio ZURICH, V8 35,86535.9k $171.8k $171.8k 0.00% Added +15.3k +15,326
86 Delphia (USA) Inc. 0.26% of their portfolio Toronto, A6 33,91333.9k $162.4k $162.4k 0.26% New
87 Kestra Advisory Services, LLC 0.00% of their portfolio AUSTIN, TX 31,38131.4k $150.3k $150.3k 0.00% New
88 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 30,59330.6k $146.5k $146.5k 0.00% Added +6.6k +6,583
89 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 29,00829.0k $138.9k $138.9k 0.00% Unchanged
90 Alpine Global Management, LLC 0.02% of their portfolio NEW YORK, NY 28,33228.3k $135.7k $135.7k 0.02% New
91 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 28,33028.3k $135.7k $135.7k 0.00% Reduced -550 -550
92 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio AUSTIN, TX 27,36027.4k $131.0k $131.0k 0.00% Reduced -3.3k -3,345
93 Graham Capital Management, L.P. 0.00% of their portfolio ROWAYTON, CT 24,88124.9k $119.2k $119.2k 0.00% New
94 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 22,51622.5k $107.9k $107.9k 0.00% New
95 HighTower Advisors, LLC 0.00% of their portfolio CHICAGO, IL 21,00021.0k $101.0k $101.0k 0.00% Added +6.5k +6,500
96 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 20,92720.9k $100.2k $100.2k 0.00% Added +4.0k +3,997
97 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 19,70719.7k $94.4k $94.4k 0.00% New
98 PFG Investments, LLC 0.02% of their portfolio WOODBURY, NY 19,50019.5k $93.4k $93.4k 0.02% Reduced -1.0k -1,000
99 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 18,30018.3k $87.7k $87.7k 0.00% Unchanged
100 Aries Wealth Management 0.03% of their portfolio PORTLAND, ME 18,00018.0k $86.2k $86.2k 0.03% Added +6.0k +6,000