PYXIS ONCOLOGY INC PYXS
COMMON STOCK · Common Stock · CUSIP 747324101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 58.1m as of 2024-03-20, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.26. Options: 6 managers hold calls ($543.1k notional), 4 hold puts ($203.2k).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 32 |
| Q1 2023 | 48 |
| Q2 2023 | 49 |
| Q3 2023 | 55 |
| Q4 2023 | 52 |
| Q1 2024 | 72 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 13 | 15 |
| Q1 2023 | 32 | 15 |
| Q2 2023 | 35 | 23 |
| Q3 2023 | 29 | 20 |
| Q4 2023 | 17 | 23 |
| Q1 2024 | 52 | 14 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $80.8k | $0 | 0.00 |
| Q3 2023 | $47.4k | $0 | 0.00 |
| Q4 2023 | $24.0k | $2.0k | 0.08 |
| Q1 2024 | $543.1k | $203.2k | 0.37 |
Biggest buyers
| Deep Track Capital, LP | New | +4.2m |
| Balyasny Asset Management L.P. | New | +2.6m |
| STEMPOINT CAPITAL LP | New | +1.8m |
| Ikarian Capital, LLC | New | +1.7m |
| Laurion Capital Management LP | Added | +690.4k |
| MILLENNIUM MANAGEMENT LLC | Added | +569.7k |
| SUPERSTRING CAPITAL MANAGEMENT LP | New | +493.8k |
| BOOTHBAY FUND MANAGEMENT, LLC | New | +492.5k |
| Monashee Investment Management LLC | New | +442.5k |
| GOLDMAN SACHS GROUP INC | New | +336.7k |
Biggest sellers
| Vestal Point Capital, LP | Sold out | -440.0k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -216.2k |
| Harvest Investment Services, LLC | Sold out | -111.9k |
| CITADEL ADVISORS LLC | Reduced | -102.7k |
| TWO SIGMA INVESTMENTS, LP | Sold out | -91.6k |
| TWO SIGMA ADVISERS, LP | Reduced | -48.6k |
| LPL Financial LLC | Sold out | -11.4k |
| ACADIAN ASSET MANAGEMENT LLC | Sold out | -11.3k |
| Bleakley Financial Group, LLC | Sold out | -11.2k |
| Kingsview Wealth Management, LLC | Sold out | -10.7k |
Biggest calls
| MILLENNIUM MANAGEMENT LLC | New | $180.6k42.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $148.7k34.9k shares |
| GROUP ONE TRADING LLC | Added | $85.6k20.1k shares |
| SIMPLEX TRADING, LLC | Added | $80.0k18.8k shares |
| CITADEL ADVISORS LLC | Added | $48.1k11.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| MILLENNIUM MANAGEMENT LLC | New | $136.3k32.0k shares |
| CITADEL ADVISORS LLC | Added | $63.9k15.0k shares |
| SIMPLEX TRADING, LLC | New | $3.0k900 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GordonMD Global Investments LP 13G · passive investor -1.1 pts · filed 2026-10-09 | 16.4% |
Sullivan Lara
13D · may seek influence
+0.9 pts · filed 2025-04-02
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The response to Item 3 of this Amendment No. 5 is incorporated by reference herein. Full filing |
11.2% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-07-10 | 10.0% |
| Laurion Capital Management LP 13G · institution filed 2026-02-09 | 7.7% |
| Coastlands Capital LP 13G · institution new · filed 2026-10-05 | 5.4% |
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 2 | $73.5k | 1 | $81.4k | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
None reported in Q1 2024.
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| Deep Track Capital, LP 0.51% of their portfolio | 4.2m $17.8m | New |
| Laurion Capital Management LP 0.46% of their portfolio | 3.9m $16.4m | Added +690.4k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 2.6m $11.1m | New |
| STEMPOINT CAPITAL LP 2.04% of their portfolio | 1.8m $7.6m | New |
| Ikarian Capital, LLC 1.93% of their portfolio | 1.7m $7.1m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $6.0m | Added +94.7k |
| Aberdeen Group plc 0.01% of their portfolio | 708.3k $3.0m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 583.0k $2.5m | Added +569.7k |
| SUPERSTRING CAPITAL MANAGEMENT LP 1.39% of their portfolio | 493.8k $2.1m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.06% of their portfolio | 492.5k $2.1m | New |
| Monashee Investment Management LLC 0.22% of their portfolio | 442.5k $1.9m | New |
| HHLR ADVISORS, LTD. 0.04% of their portfolio | 382.6k $1.6m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 340.1k $1.4m | Added +31.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 336.7k $1.4m | New |
| Decheng Capital LLC 0.19% of their portfolio | 326.8k $1.4m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 321.7k $1.4m | Added +11.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 231.5k $986.2k | Reduced -4.7k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 175.3k $746.6k | Added +160.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 165.0k $702.9k | Added +40.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 162.1k $690.6k | Added +146.0k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 153.0k $651.8k | Added +153.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 148.0k $630.0k | Reduced -216.2k |
| Man Group plc 0.00% of their portfolio | 147.2k $627.0k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 139.1k $592.0k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 133.6k $569.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 130.6k $556.3k | Added +124.2k |
| STATE STREET CORP 0.00% of their portfolio | 109.4k $465.9k | Added +26.3k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 101.8k $433.7k | Unchanged |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 89.5k $381.0k | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio | 82.4k $351.2k | New |
| CORNERCAP INVESTMENT COUNSEL INC 0.05% of their portfolio | 74.9k $319.1k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 69.5k $295.9k | Added +57.6k |
| Yu Fan 0.41% of their portfolio | 69.3k $295.2k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 68.4k $291.2k | New |
| XTX Topco Ltd 0.04% of their portfolio | 65.9k $280.6k | Added +45.3k |
| Cable Car Capital, LP 0.37% of their portfolio | 61.6k $262.4k | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 61.2k $260.9k | Added +951 |
| Marathon Trading Investment Management LLC 0.10% of their portfolio | 57.0k $242.8k | New |
| PIER 88 INVESTMENT PARTNERS LLC 0.05% of their portfolio | 51.4k $218.8k | New |
| UNIVERSITY OF CHICAGO 0.30% of their portfolio | 48.7k $207.6k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 44.7k $190.4k | New |
| Jump Financial, LLC 0.00% of their portfolio | 40.5k $172.3k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 37.4k $159.1k | Added +23.6k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 36.0k $153.3k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 30.2k $129.0k | Added +17.3k |
| Point72 Asia (Singapore) Pte. Ltd. 0.03% of their portfolio | 29.8k $127.1k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 29.7k $126.6k | Added +9.9k |
| Cetera Investment Advisers 0.00% of their portfolio | 29.4k $125.1k | Added +9.0k |
| UBS Group AG 0.00% of their portfolio | 28.2k $120.3k | Added +25.3k |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 28.1k $119.5k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 25.6k $109.0k | Added +24.6k |
| SCHULHOFF & CO INC 0.04% of their portfolio | 22.0k $93.7k | Unchanged |
| NEOS Investment Management LLC 0.00% of their portfolio | 16.2k $69.2k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 15.6k $66.5k | Reduced -48.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 14.5k $61.9k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 13.8k $59.0k | New |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 11.8k $50.3k | New |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 10.1k $43.0k | New |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 10.0k $42.6k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 9.7k $41.3k | Added +4.1k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 4.1k $17.5k | Reduced -102.7k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 3.1k $13.3k | Added +485 |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 1.1k $5 | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.0k $4.3k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 834 $3.6k | Reduced -1.7k |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 581 $2.5k | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 250 $1.1k | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 200 $852 | Unchanged |
| Coston, McIsaac & Partners 0.00% of their portfolio | 30 $0 | Unchanged |
| West Branch Capital LLC 0.00% of their portfolio | 25 $107 | Unchanged |
| FMR LLC 0.00% of their portfolio | 1 $4 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |