PUMA BIOTECHNOLOGY INC PBYI
COM · Common Stock · CUSIP 74587V107 · ISIN US74587V1070
Pharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersLos Angeles, CA
- Websitepumabiotechnology.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.8m this quarter). Holder counts are more reliable. Shares outstanding: 51.6m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $8.11. Options: 4 managers hold calls ($775.3k notional), 2 hold puts ($202.7k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 83 |
| Q4 2022 | 89 |
| Q1 2023 | 79 |
| Q2 2023 | 69 |
| Q3 2023 | 70 |
| Q4 2023 | 83 |
| Q1 2024 | 94 |
| Q2 2024 | 100 |
| Q3 2024 | 101 |
| Q4 2024 | 113 |
| Q1 2025 | 117 |
| Q2 2025 | 122 |
| Q3 2025 | 132 |
| Q4 2025 | 151 |
| Q1 2026 | 157 |
| Q2 2026 | 161 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 50 | 39 |
| Q4 2024 | 62 | 36 |
| Q1 2025 | 66 | 44 |
| Q2 2025 | 62 | 48 |
| Q3 2025 | 66 | 47 |
| Q4 2025 | 81 | 53 |
| Q1 2026 | 84 | 56 |
| Q2 2026 | 81 | 67 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $1.7m | $1.1k | 0.00 |
| Q4 2025 | $698.8k | $1.8k | 0.00 |
| Q1 2026 | $775.1k | $1.3k | 0.00 |
| Q2 2026 | $775.3k | $202.7k | 0.26 |
Biggest buyers
| LSV ASSET MANAGEMENT | Added | +435.1k |
| AMERICAN CENTURY COMPANIES INC | Added | +403.6k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +322.1k |
| Invesco Ltd. | Added | +206.0k |
| BlackRock, Inc. | Added | +205.8k |
| TWO SIGMA INVESTMENTS, LP | Added | +127.6k |
| WELLINGTON MANAGEMENT GROUP LLP | New | +126.1k |
| UBS Group AG | Added | +102.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +91.0k |
| DIMENSIONAL FUND ADVISORS LP | Added | +81.9k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -875.3k |
| Connor, Clark & Lunn Investment Management Ltd. | Reduced | -139.9k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -106.2k |
| MORGAN STANLEY | Reduced | -94.1k |
| SEI INVESTMENTS CO | Reduced | -89.5k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -75.0k |
| FRANKLIN RESOURCES INC | Reduced | -43.4k |
| PRUDENTIAL FINANCIAL INC | Reduced | -39.4k |
| State of Wyoming | Reduced | -36.0k |
| D. E. Shaw & Co., Inc. | Reduced | -34.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $520.7k64.2k shares |
| JANE STREET GROUP, LLC | Reduced | $141.9k17.5k shares |
| GROUP ONE TRADING LLC | New | $73.0k9.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $39.7k4.9k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $195.5k24.1k shares |
| SIMPLEX TRADING, LLC | Added | $7.3k900 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
AUERBACH ALAN H
13D · may seek influence
filed 2026-10-06
Stated purposeThe information set forth or incorporated in Item 3 above is incorporated herein by reference. From time to time, Mr. Auerbach may acquire beneficial ownership of additional shares of Common Stock or other securities of the Issuer by purchase, as compensation from the Issuer, or otherwise, including, but not limited to, awards of restricted Common Shares, options to purchase Common Shares, and restricted stock units for Common Shares, or dispose of some or all of the shares of Common Stock beneficially owned by Mr. Auerbach in the open market or in privately negotiated transactions (which may be with the Issuer or with third parties) on such terms and at such times as Mr. Auerbach may deem advisable. Mr. Auerbach is the President, Chief Executive Officer and a director of the Issuer. In … Full filing |
16.0% |
| ACORN BIOVENTURES, L.P. 13G · passive investor +1.3 pts · filed 2025-02-14 | 8.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 5.6% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $195.7k | $195.7k |
| Q2 2025 | 0 | — | 6 | $311.6k | $311.6k |
| Q3 2025 | 0 | — | 4 | $319.0k | $319.0k |
| Q4 2025 | 0 | — | 1 | $97.2k | — |
| Q1 2026 | 0 | — | 3 | $321.7k | $321.7k |
| Q2 2026 | 0 | — | 5 | $572.9k | $572.9k |
| Q3 2026 | 0 | — | 5 | $1.1m | $1.1m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-14 | Cesano Alessandra Director | Sold plan | $566.8k62.1k shares |
| 2026-09-14 | WILSON TROY EDWARD Director | Sold plan | $45.5k5.0k shares |
| 2026-07-06 | AUERBACH ALAN H President and CEO, director | Sold plan | $363.9k44.1k shares |
| 2026-07-06 | NOUGUES MAXIMO F Chief Financial Officer | Sold plan | $77.5k9.4k shares |
| 2026-07-06 | HUNT DOUGLAS M Officer | Sold plan | $69.9k8.5k shares |
| 2026-06-12 | Senderowicz Adrian Director | Sold plan | $194.4k27.0k shares |
| 2026-06-12 | MOYES JAY M Director | Sold plan | $158.8k22.0k shares |
| 2026-06-12 | Dorval Allison Director | Sold plan | $83.6k11.6k shares |
| 2026-06-12 | WILSON TROY EDWARD Director | Sold plan | $77.8k10.8k shares |
| 2026-06-12 | Stuglik Brian M Director | Sold plan | $58.3k8.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| ACORN CAPITAL ADVISORS, LLC 9.14% of their portfolio | 4.1m $33.5m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 3.8m $30.9m | Added +205.8k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 2.3m $18.8m | Added +403.6k |
| ACADIAN ASSET MANAGEMENT LLC 0.02% of their portfolio | 2.1m $16.6m | Added +11.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 1.8m $14.9m | Reduced -106.2k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.8m $14.9m | Added +18.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.8m $14.8m | Added +91.0k |
| LSV ASSET MANAGEMENT 0.02% of their portfolio | 1.6m $13.1m | Added +435.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.5m $12.3m | Added +81.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $10.9m | Added +322.1k |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC 0.04% of their portfolio | 1.1m $9.1m | Reduced -14.4k |
| STATE STREET CORP 0.00% of their portfolio | 952.2k $7.7m | Added +34.6k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 873.3k $7.1m | Reduced -16.3k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.11% of their portfolio | 791.6k $6.4m | Added +16.3k |
| RITHOLTZ WEALTH MANAGEMENT 0.09% of their portfolio | 749.8k $6.1m | Reduced -24.5k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 725.2k $5.9m | Reduced -75.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 669.2k $5.4m | Reduced -563 |
| NORTHERN TRUST CORP 0.00% of their portfolio | 652.4k $5.3m | Added +10.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 642.9k $5.2m | Reduced -139.9k |
| UBS Group AG 0.00% of their portfolio | 636.8k $5.2m | Added +102.5k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 602.2k $4.9m | Reduced -875.3k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 532.5k $4.3m | Reduced -5.7k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 418.7k $3.4m | Reduced -89.5k |
| GLOBEFLEX CAPITAL L P 0.40% of their portfolio | 382.8k $3.1m | Added +33.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 360.7k $2.9m | Added +12.9k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 316.3k $2.6m | Reduced -34.9k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 309.1k $2.5m | Added +36.2k |
| Invesco Ltd. 0.00% of their portfolio | 301.0k $2.4m | Added +206.0k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 272.2k $2.2m | Added +20.6k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 269.1k $2.2m | Added +17.4k |
| MORGAN STANLEY 0.00% of their portfolio | 265.7k $2.2m | Reduced -94.1k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 250.8k $2.0m | Added +13.1k |
| Empowered Funds, LLC 0.01% of their portfolio | 220.3k $1.8m | Added +16.3k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 217.5k $1.8m | Added +22.7k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 213.6k $1.7m | Reduced -39.4k |
| FMR LLC 0.00% of their portfolio | 211.4k $1.7m | Added +19.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 211.3k $1.7m | Reduced -9.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 188.2k $1.5m | Reduced -20.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 172.0k $1.4m | Reduced -43.4k |
| Prospera Financial Services Inc 0.02% of their portfolio | 158.8k $1.3m | Reduced -14.3k |
| Haven Private, LLC 0.46% of their portfolio | 148.4k $1.2m | Reduced -6.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 140.6k $1.1m | Added +127.6k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 130.2k $1.1m | Added +6.7k |
| Round Rock Advisors LLC 0.13% of their portfolio | 128.9k $1.0m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 128.2k $1.0m | Added +12.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 126.1k $1.0m | New |
| STRS OHIO 0.00% of their portfolio | 84.6k $686.1k | Reduced -6.9k |
| Nuveen, LLC 0.00% of their portfolio | 82.3k $667.4k | Added +3.2k |
| EVERGREEN CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 73.7k $598.0k | Reduced -22.3k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 73.5k $596.1k | Added +50.7k |
| Trexquant Investment LP 0.00% of their portfolio | 72.2k $585.7k | New |
| Vise Technologies, Inc. 0.01% of their portfolio | 72.0k $584.2k | Added +31.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.00% of their portfolio | 61.3k $497.0k | Unchanged |
| OpenArc Corporate Advisory, LLC 0.01% of their portfolio | 59.5k $482.5k | Reduced -30.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 57.5k $466.4k | Added +4.5k |
| D'Orazio & Associates, Inc. 0.05% of their portfolio | 48.7k $394.8k | Reduced -1.2k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 46.3k $375.2k | Added +17.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 43.2k $350.3k | Added +10.0k |
| Man Group plc 0.00% of their portfolio | 41.5k $336.6k | Reduced -5.9k |
| WINTON GROUP Ltd 0.01% of their portfolio | 40.5k $328.5k | Reduced -25.8k |
| XTX Topco Ltd 0.00% of their portfolio | 40.3k $326.8k | Added +25.2k |
| State of Wyoming 0.03% of their portfolio | 39.8k $323.0k | Reduced -36.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 37.6k $305.0k | Added +21.3k |
| EntryPoint Capital, LLC 0.07% of their portfolio | 37.4k $303.2k | Reduced -16.1k |
| Baron Wealth Management LLC 0.08% of their portfolio | 36.4k $295.0k | Reduced -1.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 36.3k $295.0k | Added +5.0k |
| Creative Planning 0.00% of their portfolio | 35.7k $289.8k | Added +12.6k |
| LPL Financial LLC 0.00% of their portfolio | 34.5k $280.1k | Reduced -2.1k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 34.5k $279.7k | Reduced -4.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 31.7k $257.5k | Reduced -8.6k |
| Kathmere Capital Management, LLC 0.01% of their portfolio | 31.2k $252.8k | Added +1.4k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 29.2k $236.7k | Added +2.6k |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 26.2k $212.7k | New |
| MARTINGALE ASSET MANAGEMENT L P 0.00% of their portfolio | 25.4k $205.7k | New |
| Metis Global Partners, LLC 0.00% of their portfolio | 25.3k $204.9k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 24.9k $201.7k | Added +9.0k |
| C2C Wealth Management, LLC 0.15% of their portfolio | 23.6k $191.6k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 21.7k $175.7k | Added +18.2k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 21.5k $174.8k | Added +3.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 21.4k $136.5k | Added +7.6k |
| One Wealth Advisors, LLC 0.02% of their portfolio | 21.1k $171.0k | Unchanged |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 20.4k $165.3k | Reduced -252 |
| BAILARD, INC. 0.00% of their portfolio | 18.1k $146.8k | Unchanged |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 17.9k $143.4k | Added +879 |
| Spark Investment Management LLC 0.27% of their portfolio | 17.0k $137.9k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 15.7k $127.5k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 15.5k $125.5k | Reduced -613 |
| Lido Advisors, LLC 0.00% of their portfolio | 15.0k $122.0k | New |
| Mariner, LLC 0.00% of their portfolio | 14.9k $120.6k | Added +220 |
| Caprock Group, LLC 0.00% of their portfolio | 13.9k $112.4k | Reduced -12.1k |
| PERKINS CAPITAL MANAGEMENT INC 0.08% of their portfolio | 13.4k $108.7k | Added +900 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. 0.00% of their portfolio | 13.3k $108.0k | Added +352 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 13.2k $105.6k | Added +1.6k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 12.2k $98.7k | Added +500 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 12.1k $97.8k | Added +291 |
| R Squared Ltd 0.05% of their portfolio | 12.0k $97.2k | New |
| Abel Hall, LLC 0.02% of their portfolio | 11.5k $93.4k | Added +46 |
| BARCLAYS PLC 0.00% of their portfolio | 11.2k $90.8k | Reduced -2.8k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 10.7k $86.5k | Reduced -4.2k |
| Cerity Partners LLC 0.00% of their portfolio | 10.5k $85.3k | Reduced -2.5k |