PRIME MEDICINE INC PRME
COM · Common Stock · CUSIP 74168J101 · ISIN US74168J1016
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersCambridge, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($16.7m this quarter). Holder counts are more reliable. Shares outstanding: 120.0m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.14. Options: 5 managers hold calls ($771.9k notional), 4 hold puts ($274.7k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 68 |
| Q1 2023 | 77 |
| Q2 2023 | 80 |
| Q3 2023 | 84 |
| Q4 2023 | 106 |
| Q1 2024 | 116 |
| Q2 2024 | 123 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 48 | 14 |
| Q2 2023 | 52 | 26 |
| Q3 2023 | 46 | 21 |
| Q4 2023 | 53 | 39 |
| Q1 2024 | 62 | 47 |
| Q2 2024 | 69 | 50 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $97.3k | $9.5k | 0.10 |
| Q4 2023 | $374.9k | $558.2k | 1.49 |
| Q1 2024 | $406.6k | $489.0k | 1.20 |
| Q2 2024 | $771.9k | $274.7k | 0.36 |
Biggest buyers
| BlackRock Inc. | Added | +1.4m |
| MILLENNIUM MANAGEMENT LLC | Added | +895.6k |
| T. Rowe Price Investment Management, Inc. | Added | +635.6k |
| DEUTSCHE BANK AG\ | Added | +440.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +379.7k |
| STATE STREET CORP | Added | +325.1k |
| VANGUARD GROUP INC | Added | +277.4k |
| Nuveen Asset Management, LLC | Added | +242.1k |
| Trexquant Investment LP | New | +228.2k |
| WESTWOOD HOLDINGS GROUP INC | Added | +199.2k |
Biggest sellers
| Avidity Partners Management LP | Reduced | -1.3m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -976.6k |
| MORGAN STANLEY | Reduced | -411.4k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -362.4k |
| Schonfeld Strategic Advisors LLC | Sold out | -330.5k |
| Deep Track Capital, LP | Sold out | -303.7k |
| Amova Asset Management Americas, Inc. | Reduced | -126.3k |
| Sumitomo Mitsui Trust Group, Inc. | Reduced | -126.3k |
| CITADEL ADVISORS LLC | Reduced | -95.5k |
| Susquehanna Portfolio Strategies, LLC | Reduced | -87.6k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $380.4k74.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $272.4k53.0k shares |
| SIMPLEX TRADING, LLC | Added | $114.0k22.2k shares |
| GROUP ONE TRADING LLC | Added | $5.1k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $241.6k47.0k shares |
| CITADEL ADVISORS LLC | Reduced | $22.1k4.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $11.0k2.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GV 2019, L.P. 13G · passive investor filed 2025-11-12 | 12.3% |
| ARCH Venture Fund XII, L.P. 13D · may seek influence filed 2025-08-11 | 10.4% |
Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (3.3%, 2026-02-17)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 2 | $6.8m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 1 | $20.0m | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Alphabet Inc. 3.92% of their portfolio | 15.1m $77.4m | Unchanged |
| ARK Investment Management LLC 0.28% of their portfolio | 6.1m $31.5m | Added +133.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 6.1m $31.2m | Added +277.4k |
| BlackRock Inc. 0.00% of their portfolio | 5.1m $26.3m | Added +1.4m |
| FMR LLC 0.00% of their portfolio | 3.9m $20.2m | Added +3.5k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 3.7m $19.2m | Added +635.6k |
| Sumitomo Mitsui Trust Group, Inc. 0.01% of their portfolio | 3.2m $16.6m | Reduced -126.3k |
| Amova Asset Management Americas, Inc. 0.19% of their portfolio | 3.2m $16.5m | Reduced -126.3k |
| Redmile Group, LLC 0.64% of their portfolio | 2.1m $10.7m | Unchanged |
| MWG Management Ltd. 10.06% of their portfolio | 1.8m $9.2m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.5m $7.9m | Reduced -976.6k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.3m $6.8m | Added +895.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $6.7m | Added +379.7k |
| STATE STREET CORP 0.00% of their portfolio | 1.1m $5.7m | Added +325.1k |
| BAKER BROS. ADVISORS LP 0.07% of their portfolio | 1.0m $5.3m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.08% of their portfolio | 897.0k $4.6m | Added +11.6k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.02% of their portfolio | 750.0k $3.9m | Unchanged |
| EcoR1 Capital, LLC 0.11% of their portfolio | 700.0k $3.6m | Unchanged |
| Avidity Partners Management LP 0.15% of their portfolio | 694.0k $3.6m | Reduced -1.3m |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 681.5k $3.5m | Added +173.4k |
| Greenwich Wealth Management LLC 0.25% of their portfolio | 653.0k $3.4m | Added +75.0k |
| SAMSARA BIOCAPITAL, LLC 0.58% of their portfolio | 540.3k $2.8m | Unchanged |
| MOORE CAPITAL MANAGEMENT, LP 0.06% of their portfolio | 500.0k $2.6m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 492.3k $2.5m | Added +194.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 461.0k $2.4m | Added +440.3k |
| Vestal Point Capital, LP 0.17% of their portfolio | 450.0k $2.3m | Added +90.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 427.4k $2.2m | Added +6.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 393.5k $2.0m | Added +53.5k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 392.4k $2.0m | Added +242.1k |
| Casdin Capital, LLC 0.14% of their portfolio | 367.2k $1.9m | Unchanged |
| Bollard Group LLC 0.05% of their portfolio | 361.1k $1.9m | Unchanged |
| WESTWOOD HOLDINGS GROUP INC 0.01% of their portfolio | 358.6k $1.8m | Added +199.2k |
| Trexquant Investment LP 0.02% of their portfolio | 228.2k $1.2m | New |
| MORGAN STANLEY 0.00% of their portfolio | 184.0k $945.6k | Reduced -411.4k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 176.5k $907.2k | Added +12.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 170.6k $876.7k | Added +64.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 168.4k $865.7k | Added +140.9k |
| FIL Ltd 0.00% of their portfolio | 138.3k $710.7k | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. 0.11% of their portfolio | 127.4k $655.0k | Reduced -77.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 105.9k $544.3k | Added +84.6k |
| Vestmark Advisory Solutions, Inc. 0.02% of their portfolio | 103.5k $532.1k | Reduced -44.0k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 103.2k $530.4k | Reduced -46.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 79.4k $407.9k | Added +41.2k |
| CHELSEA COUNSEL CO 0.20% of their portfolio | 77.7k $399.3k | Added +72.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 76.4k $392.6k | Reduced -7.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 70.2k $360.8k | Added +32.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 70.1k $360.3k | Added +17.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 63.5k $326.2k | Added +3.9k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 62.1k $319.0k | New |
| ROYCE & ASSOCIATES LP 0.00% of their portfolio | 61.0k $313.5k | Added +14.8k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 49.4k $253.8k | Added +28.2k |
| PDT Partners, LLC 0.02% of their portfolio | 49.3k $253.5k | New |
| TD Asset Management Inc 0.00% of their portfolio | 46.4k $238.7k | Reduced -82.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 45.8k $235.2k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 45.4k $233.5k | Added +18.8k |
| Virtu Financial LLC 0.02% of their portfolio | 42.7k $220.0k | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 37.6k $193.5k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 34.3k $176.1k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 34.1k $175.4k | Added +12.9k |
| PEAK6 Investments LLC 0.01% of their portfolio | 34.0k $174.8k | Added +17.0k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 30.5k $156.8k | First filing |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 29.9k $153.7k | New |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 29.2k $150.3k | Reduced -87.6k |
| CORNERCAP INVESTMENT COUNSEL INC 0.02% of their portfolio | 28.9k $148.7k | Reduced -318 |
| Green Alpha Advisors, LLC 0.11% of their portfolio | 26.2k $134.9k | Reduced -7.5k |
| BENJAMIN F. EDWARDS & COMPANY, INC. 0.00% of their portfolio | 25.3k $130.0k | Added +24.9k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 24.1k $124.1k | Reduced -50.8k |
| UBS Group AG 0.00% of their portfolio | 22.5k $115.8k | Reduced -20.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 22.2k $113.0k | Reduced -52 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 21.7k $111.3k | Reduced -1.2k |
| OPPENHEIMER & CO INC 0.00% of their portfolio | 21.0k $108.1k | Added +855 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 20.4k $104.6k | Added +8.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 19.5k $100.4k | First filing |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 19.2k $98.6k | Added +6.3k |
| BARCLAYS PLC 0.00% of their portfolio | 19.1k $98.2k | Reduced -8.5k |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.01% of their portfolio | 18.9k $97.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 17.5k $90.0k | Reduced -26.5k |
| Alpine Global Management, LLC 0.02% of their portfolio | 17.4k $89.3k | New |
| Clarius Group, LLC 0.01% of their portfolio | 16.1k $82.7k | Unchanged |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 14.1k $72.5k | Reduced -8.3k |
| Invesco Ltd. 0.00% of their portfolio | 13.4k $69.1k | Added +2.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 12.7k $65.4k | Reduced -95.5k |
| ProShare Advisors LLC 0.00% of their portfolio | 12.7k $65.3k | Reduced -2.6k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 12.2k $62.6k | Reduced -5.4k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 12.1k $62.2k | New |
| VIRTUS ADVISERS, LLC 0.03% of their portfolio | 11.5k $58.9k | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 11.4k $58.7k | New |
| CIBC WORLD MARKET INC. 0.00% of their portfolio | 11.3k $58.0k | Reduced -712 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 10.7k $55.0k | Reduced -908 |
| BROWN BROTHERS HARRIMAN & CO 0.00% of their portfolio | 10.1k $51.7k | Unchanged |
| STRS OHIO 0.00% of their portfolio | 10.0k $51.4k | Reduced -24.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 8.4k $43.4k | Added +11 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 7.7k $39.8k | Added +7.7k |
| Legal & General Group Plc 0.00% of their portfolio | 6.3k $32.3k | Added +1.9k |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 6.2k $33.9k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.1k $31.0k | Added +4.4k |
| ORG Partners LLC 0.00% of their portfolio | 5.3k $28.9k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5.2k $26.5k | Reduced -1.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 4.1k $21.1k | Added +132 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.9k $20.1k | Unchanged |