PRELUDE THERAPEUTICS INC PRLD
COM · Common Stock · CUSIP 74065P101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWilmington, DE
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 56.6m as of 2025-08-11, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.81. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 53 |
| Q4 2022 | 60 |
| Q1 2023 | 56 |
| Q2 2023 | 56 |
| Q3 2023 | 61 |
| Q4 2023 | 57 |
| Q1 2024 | 59 |
| Q2 2024 | 62 |
| Q3 2024 | 71 |
| Q4 2024 | 63 |
| Q1 2025 | 60 |
| Q2 2025 | 51 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 31 | 18 |
| Q4 2023 | 36 | 23 |
| Q1 2024 | 24 | 26 |
| Q2 2024 | 24 | 28 |
| Q3 2024 | 35 | 27 |
| Q4 2024 | 31 | 28 |
| Q1 2025 | 22 | 30 |
| Q2 2025 | 20 | 39 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $1.0k | $621 | 0.60 |
| Q4 2024 | $8.2k | $0 | 0.00 |
| Q1 2025 | $18.4k | $0 | 0.00 |
| Q2 2025 | $0 | $0 | — |
Biggest buyers
| CANTOR FITZGERALD, L. P. | New | +211.9k |
| MILLENNIUM MANAGEMENT LLC | Added | +101.7k |
| JANE STREET GROUP, LLC | New | +91.8k |
| Shay Capital LLC | New | +75.0k |
| GSA CAPITAL PARTNERS LLP | New | +71.4k |
| Y-Intercept (Hong Kong) Ltd | New | +47.8k |
| MARSHALL WACE, LLP | New | +41.7k |
| CITADEL ADVISORS LLC | Added | +33.6k |
| XTX Topco Ltd | Added | +17.9k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +11.2k |
Biggest sellers
| Boxer Capital Management, LLC | Sold out | -2.1m |
| BlackRock, Inc. | Reduced | -615.2k |
| STATE STREET CORP | Reduced | -188.5k |
| Nuveen, LLC | Sold out | -187.6k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -187.4k |
| DEUTSCHE BANK AG\ | Sold out | -80.7k |
| NORTHERN TRUST CORP | Reduced | -78.8k |
| VANGUARD GROUP INC | Reduced | -76.6k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -74.9k |
| Marex Group Ltd | Sold out | -56.3k |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
ORBIMED ADVISORS LLC
13D · may seek influence
filed 2026-04-23
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
16.0% |
BAKER BROS. ADVISORS LP
13D · may seek influence
-8.0 pts · filed 2026-04-22
Stated purposeItem 4 of Schedule 13D is supplemented and amended, as the case may be, as follows: The disclosure in Item 6 below is incorporated herein by reference. On April 20, 2026, Prelude Therapeutics Incorporated (the "Issuer") entered into an underwriting agreement (the "Underwriting Agreement") with Goldman Sachs & Co. LLC, Evercore Group L.L.C. and Citizens JMP Securities LLC (the "Underwriters"), related to a public offering (the "Offering") of 18,018,014 shares of common stock of the Issuer ("Common Stock"), at a price to the public of $4.44 per share and in lieu of Common Stock to investors who so chose, prefunded warrants to purchase up to 2,252,252 shares of the Issuer's Common Stock (the "Prefunded Warrants"), at a price to the public of $4.4399 per warrant with an exercise price of $0.… Full filing |
15.5% |
| Vaddi Krishna 13G · exempt (held before listing) -0.7 pts · filed 2026-02-13 | 13.2% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-04-28 | 9.9% |
| INCYTE CORP 13G · passive investor new · filed 2025-11-07 | 9.9% |
| Soleus Private Equity Fund III, L.P. 13G · passive investor new · filed 2026-07-08 | 5.2% |
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 3 | $225.7k | 0 | — | — |
| Q1 2025 | 2 | $648.7k | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| ORBIMED ADVISORS LLC 0.22% of their portfolio | 10.9m $8.8m | Unchanged |
| BAKER BROS. ADVISORS LP 0.08% of their portfolio | 10.1m $8.2m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 932.6k $754.5k | Reduced -76.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 927.6k $743.0k | Reduced -48.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 581.8k $470.9k | Reduced -74.9k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 540.6k $436.0k | Added +11.2k |
| BlackRock, Inc. 0.00% of their portfolio | 432.6k $350.1k | Reduced -615.2k |
| MORGAN STANLEY 0.00% of their portfolio | 284.4k $230.2k | Reduced -18.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 248.4k $201.1k | Added +101.7k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 225.0k $182.1k | Reduced -35.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 217.6k $176.1k | Reduced -187.4k |
| CANTOR FITZGERALD, L. P. 0.00% of their portfolio | 211.9k $171.5k | New |
| TD Asset Management Inc 0.00% of their portfolio | 160.7k $130.0k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 155.0k $125.4k | Reduced -28.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 149.2k $120.7k | Reduced -6.0k |
| UBS Group AG 0.00% of their portfolio | 104.2k $84.3k | Added +8.0k |
| STATE STREET CORP 0.00% of their portfolio | 97.6k $79.0k | Reduced -188.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 91.8k $74.3k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 88.5k $71.6k | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 80.8k $65.4k | Reduced -33.2k |
| Shay Capital LLC 0.01% of their portfolio | 75.0k $60.7k | New |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 71.4k $58.0k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 69.3k $56.1k | Unchanged |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 47.8k $38.7k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 43.6k $35.3k | Added +9.8k |
| XTX Topco Ltd 0.00% of their portfolio | 42.6k $34.5k | Added +17.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 41.7k $33.8k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 40.0k $32.4k | Reduced -37.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 38.1k $30.9k | Reduced -78.8k |
| Cerity Partners LLC 0.00% of their portfolio | 36.4k $29.5k | Added +1.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 33.6k $27.2k | Added +33.6k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 17.4k $13.9k | Reduced -3.2k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 16.8k $13.6k | Added +3.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 11.3k $9.1k | Reduced -4.2k |
| FMR LLC 0.00% of their portfolio | 11.2k $9.0k | Reduced -9.1k |
| BARCLAYS PLC 0.00% of their portfolio | 8.6k $7.0k | Reduced -14.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 5.7k $4.0k | Added +2.3k |
| CITIGROUP INC 0.00% of their portfolio | 4.7k $3.8k | Reduced -4.6k |
| CWM, LLC 0.00% of their portfolio | 4.0k $3.0k | Added +668 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 2.7k $2.2k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.9k $1.6k | Reduced -21.8k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.6k $1.3k | Added +1.2k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.2k $956 | Reduced -12 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 500 $405 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 297 $240 | Reduced -7.6k |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 148 $120 | Added +139 |
| Essential Partners LLC 0.00% of their portfolio | 87 $70 | First filing |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 52 $42 | Reduced -19.6k |
| IFP Advisors, Inc 0.00% of their portfolio | 34 $28 | New |
| True Wealth Design, LLC 0.00% of their portfolio | 13 $11 | Added +3 |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |