Vault-13

PRELUDE THERAPEUTICS INC PRLD

COM · Common Stock · CUSIP 74065P101

51 institutional holders -9 vs Q1 2025
27,190,91527.2m shares reported held*
48.0% of all shares outstanding*
$22.0mreported value*
7 new 13 added 22 reduced 17 sold out net sold ≈ $2.7m (-3.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 56.6m as of 2025-08-11, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.81. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0255075Q3 22: 53Q4 22: 60Q1 23: 56Q2 23: 56Q3 23: 61Q4 23: 57Q1 24: 59Q2 24: 62Q3 24: 71Q4 24: 63Q1 25: 60Q2 25: 5151Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202253
Q4 202260
Q1 202356
Q2 202356
Q3 202361
Q4 202357
Q1 202459
Q2 202462
Q3 202471
Q4 202463
Q1 202560
Q2 202551

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q3 23: 31 bought or addedQ3 23: 18 cut or sold outQ4 23: 36 bought or addedQ4 23: 23 cut or sold outQ4 23Q1 24: 24 bought or addedQ1 24: 26 cut or sold outQ2 24: 24 bought or addedQ2 24: 28 cut or sold outQ2 24Q3 24: 35 bought or addedQ3 24: 27 cut or sold outQ4 24: 31 bought or addedQ4 24: 28 cut or sold outQ4 24Q1 25: 22 bought or addedQ1 25: 30 cut or sold outQ2 25: 20 bought or addedQ2 25: 39 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20233118
Q4 20233623
Q1 20242426
Q2 20242428
Q3 20243527
Q4 20243128
Q1 20252230
Q2 20252039

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5k$10k$15k$20kQ3 24 calls: $1.0kQ3 24 puts: $621Q3 24P/C 0.60Q4 24 calls: $8.2kQ4 24 puts: $0Q4 24P/C 0.00Q1 25 calls: $18.4kQ1 25 puts: $0Q1 25P/C 0.00Q2 25 calls: $0Q2 25 puts: $0Q2 25P/C —
Numbers
QuarterCallsPutsP/C
Q3 2024$1.0k$6210.60
Q4 2024$8.2k$00.00
Q1 2025$18.4k$00.00
Q2 2025$0$0—

Biggest buyers

CANTOR FITZGERALD, L. P. New +211,859+211.9k
MILLENNIUM MANAGEMENT LLC Added +101,653+101.7k
JANE STREET GROUP, LLC New +91,753+91.8k
Shay Capital LLC New +75,000+75.0k
GSA CAPITAL PARTNERS LLP New +71,378+71.4k
Y-Intercept (Hong Kong) Ltd New +47,788+47.8k
MARSHALL WACE, LLP New +41,747+41.7k
CITADEL ADVISORS LLC Added +33,591+33.6k
XTX Topco Ltd Added +17,873+17.9k
ACADIAN ASSET MANAGEMENT LLC Added +11,238+11.2k

Biggest sellers

Boxer Capital Management, LLC Sold out -2,108,014-2.1m
BlackRock, Inc. Reduced -615,166-615.2k
STATE STREET CORP Reduced -188,454-188.5k
Nuveen, LLC Sold out -187,613-187.6k
GEODE CAPITAL MANAGEMENT, LLC Reduced -187,387-187.4k
DEUTSCHE BANK AG\ Sold out -80,723-80.7k
NORTHERN TRUST CORP Reduced -78,780-78.8k
VANGUARD GROUP INC Reduced -76,634-76.6k
RENAISSANCE TECHNOLOGIES LLC Reduced -74,900-74.9k
Marex Group Ltd Sold out -56,270-56.3k

Biggest calls

Biggest puts

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
ORBIMED ADVISORS LLC 13D · may seek influence filed 2026-04-23
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing
16.0% 12.9m≈ $68.9m 2026-04-23
BAKER BROS. ADVISORS LP 13D · may seek influence -8.0 pts · filed 2026-04-22
Stated purposeItem 4 of Schedule 13D is supplemented and amended, as the case may be, as follows: The disclosure in Item 6 below is incorporated herein by reference. On April 20, 2026, Prelude Therapeutics Incorporated (the "Issuer") entered into an underwriting agreement (the "Underwriting Agreement") with Goldman Sachs & Co. LLC, Evercore Group L.L.C. and Citizens JMP Securities LLC (the "Underwriters"), related to a public offering (the "Offering") of 18,018,014 shares of common stock of the Issuer ("Common Stock"), at a price to the public of $4.44 per share and in lieu of Common Stock to investors who so chose, prefunded warrants to purchase up to 2,252,252 shares of the Issuer's Common Stock (the "Prefunded Warrants"), at a price to the public of $4.4399 per warrant with an exercise price of $0.… Full filing
15.5% -8.0 pts 10.3m≈ $54.9m 2026-04-22
Vaddi Krishna 13G · exempt (held before listing) -0.7 pts · filed 2026-02-13 13.2% -0.7 pts 6.7m≈ $36.0m 2026-02-13
RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-04-28 9.9% new 6.5m≈ $34.5m 2026-04-28
INCYTE CORP 13G · passive investor new · filed 2025-11-07 9.9% new 4.4m≈ $23.3m 2025-11-07
Soleus Private Equity Fund III, L.P. 13G · passive investor new · filed 2026-07-08 5.2% new 3.4m≈ $18.0m 2026-07-08

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q3 23: 0 buyingQ3 23: 0 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 0 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 3 buyingQ4 24: 0 sellingQ4 24Q1 25: 2 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20230—0——
Q4 20230—0——
Q1 20240—0——
Q2 20240—0——
Q3 20240—0——
Q4 20243$225.7k0——
Q1 20252$648.7k0——
Q2 20250—0——

None reported in Q2 2025.

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 ORBIMED ADVISORS LLC 0.22% of their portfolio New York, NY 10,909,25610.9m $8.8m $8.8m 0.22% Unchanged
2 BAKER BROS. ADVISORS LP 0.08% of their portfolio NEW YORK, NY 10,123,82410.1m $8.2m $8.2m 0.08% Unchanged
3 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 932,570932.6k $754.5k $754.5k 0.00% Reduced -76.6k -76,634
4 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 927,608927.6k $743.0k $743.0k 0.00% Reduced -48.5k -48,539
5 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 581,800581.8k $470.9k $470.9k 0.00% Reduced -74.9k -74,900
6 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 540,565540.6k $436.0k $436.0k 0.00% Added +11.2k +11,238
7 BlackRock, Inc. 0.00% of their portfolio New York, NY 432,559432.6k $350.1k $350.1k 0.00% Reduced -615.2k -615,166
8 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 284,382284.4k $230.2k $230.2k 0.00% Reduced -18.4k -18,397
9 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 248,423248.4k $201.1k $201.1k 0.00% Added +101.7k +101,653
10 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 225,000225.0k $182.1k $182.1k 0.00% Reduced -35.4k -35,400
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 217,568217.6k $176.1k $176.1k 0.00% Reduced -187.4k -187,387
12 CANTOR FITZGERALD, L. P. 0.00% of their portfolio NEW YORK, NY 211,859211.9k $171.5k $171.5k 0.00% New
13 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 160,652160.7k $130.0k $130.0k 0.00% Unchanged
14 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 154,977155.0k $125.4k $125.4k 0.00% Reduced -28.7k -28,690
15 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 149,178149.2k $120.7k $120.7k 0.00% Reduced -6.0k -6,037
16 UBS Group AG 0.00% of their portfolio ZURICH, V8 104,204104.2k $84.3k $84.3k 0.00% Added +8.0k +8,048
17 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 97,59297.6k $79.0k $79.0k 0.00% Reduced -188.5k -188,454
18 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 91,75391.8k $74.3k $74.3k 0.00% New
19 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 88,50088.5k $71.6k $71.6k 0.00% Unchanged
20 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 80,84580.8k $65.4k $65.4k 0.00% Reduced -33.2k -33,205
21 Shay Capital LLC 0.01% of their portfolio NEW YORK, NY 75,00075.0k $60.7k $60.7k 0.01% New
22 GSA CAPITAL PARTNERS LLP 0.00% of their portfolio LONDON, X0 71,37871.4k $58.0k $58.0k 0.00% New
23 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 69,25269.3k $56.1k $56.1k 0.00% Unchanged
24 Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio HONG KONG, K3 47,78847.8k $38.7k $38.7k 0.00% New
25 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 43,64743.6k $35.3k $35.3k 0.00% Added +9.8k +9,824
26 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 42,57342.6k $34.5k $34.5k 0.00% Added +17.9k +17,873
27 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 41,74741.7k $33.8k $33.8k 0.00% New
28 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 39,97740.0k $32.4k $32.4k 0.00% Reduced -37.9k -37,893
29 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 38,12738.1k $30.9k $30.9k 0.00% Reduced -78.8k -78,780
30 Cerity Partners LLC 0.00% of their portfolio NEW YORK, NY 36,39336.4k $29.5k $29.5k 0.00% Added +1.8k +1,828
31 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 33,62533.6k $27.2k $27.2k 0.00% Added +33.6k +33,591
32 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 17,41117.4k $13.9k $13.9k 0.00% Reduced -3.2k -3,219
33 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 16,79916.8k $13.6k $13.6k 0.00% Added +3.2k +3,213
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 11,29311.3k $9.1k $9.1k 0.00% Reduced -4.2k -4,153
35 FMR LLC 0.00% of their portfolio BOSTON, MA 11,16711.2k $9.0k $9.0k 0.00% Reduced -9.1k -9,071
36 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 8,6028.6k $7.0k $7.0k 0.00% Reduced -14.5k -14,543
37 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 5,6545.7k $4.0k $4.0k 0.00% Added +2.3k +2,310
38 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 4,7184.7k $3.8k $3.8k 0.00% Reduced -4.6k -4,582
39 CWM, LLC 0.00% of their portfolio OMAHA, NE 4,0144.0k $3.0k $3.0k 0.00% Added +668 +668
40 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 2,7412.7k $2.2k $2.2k 0.00% Unchanged
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,9491.9k $1.6k $1.6k 0.00% Reduced -21.8k -21,831
42 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 1,6341.6k $1.3k $1.3k 0.00% Added +1.2k +1,234
43 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 1,1801.2k $956 $956 0.00% Reduced -12 -12
44 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 500500 $405 $405 0.00% Unchanged
45 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 297297 $240 $240 0.00% Reduced -7.6k -7,615
46 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 148148 $120 $120 0.00% Added +139 +139
47 Essential Partners LLC 0.00% of their portfolio RANCHO SANTA FE, CA 8787 $70 $70 0.00% First filing
48 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 5252 $42 $42 0.00% Reduced -19.6k -19,616
49 IFP Advisors, Inc 0.00% of their portfolio TAMPA, FL 3434 $28 $28 0.00% New
50 True Wealth Design, LLC 0.00% of their portfolio AKRON, OH 1313 $11 $11 0.00% Added +3 +3
51 CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio BIRMINGHAM, AL 00 $0 $0 — Unchanged