PRAXIS PRECISION MEDICINES I PRAX
COM NEW · Common Stock · CUSIP 74006W207
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($588.6k this quarter). Holder counts are more reliable. Shares outstanding: 27.9m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $334.84. Options: 10 managers hold calls ($56.6m notional), 13 hold puts ($316.8m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 59 |
| Q1 2024 | 112 |
| Q2 2024 | 114 |
| Q3 2024 | 135 |
| Q4 2024 | 164 |
| Q1 2025 | 153 |
| Q2 2025 | 146 |
| Q3 2025 | 152 |
| Q4 2025 | 251 |
| Q1 2026 | 293 |
| Q2 2026 | 311 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 74 | 58 |
| Q4 2024 | 88 | 63 |
| Q1 2025 | 79 | 96 |
| Q2 2025 | 89 | 68 |
| Q3 2025 | 87 | 63 |
| Q4 2025 | 190 | 59 |
| Q1 2026 | 192 | 101 |
| Q2 2026 | 178 | 133 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $27.3m | $22.7m | 0.83 |
| Q4 2025 | $219.3m | $237.6m | 1.08 |
| Q1 2026 | $53.8m | $187.0m | 3.48 |
| Q2 2026 | $56.6m | $316.8m | 5.60 |
Biggest buyers
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +578.4k |
| Invesco Ltd. | Added | +476.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +312.1k |
| Polar Capital Holdings Plc | New | +279.1k |
| WESTFIELD CAPITAL MANAGEMENT CO LP | Added | +218.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +199.7k |
| FMR LLC | Added | +156.0k |
| STATE STREET CORP | Added | +142.2k |
| AMERICAN CENTURY COMPANIES INC | Added | +109.1k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | Added | +100.0k |
Biggest sellers
| Orbis Allan Gray Ltd | Reduced | -942.7k |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -373.8k |
| Cormorant Asset Management, LP | Reduced | -245.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -161.9k |
| Soleus Capital Management, L.P. | Reduced | -153.0k |
| STEMPOINT CAPITAL LP | Reduced | -75.3k |
| ArrowMark Colorado Holdings LLC | Reduced | -71.8k |
| Vivo Capital, LLC | Reduced | -67.8k |
| Sofinnova Investments, Inc. | Reduced | -57.2k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -48.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $23.3m69.7k shares |
| JANE STREET GROUP, LLC | Reduced | $9.1m27.3k shares |
| Ikarian Capital, LLC | New | $6.7m20.0k shares |
| CITADEL ADVISORS LLC | Reduced | $6.3m18.8k shares |
| SPHERA FUNDS MANAGEMENT LTD. | New | $4.2m12.5k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $2.0m6.1k shares |
| Squarepoint Ops LLC | Reduced | $1.9m5.7k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $1.7m5.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $903.9k2.7k shares |
| HRT FINANCIAL LP | Reduced | $401.0k1.2k shares |
Biggest puts
| Caption Management, LLC | Added | $75.3m224.8k shares |
| Verition Fund Management LLC | New | $67.3m201.1k shares |
| Nantahala Capital Management, LLC | New | $67.0m200.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $41.9m125.1k shares |
| 683 Capital Management, LLC | Reduced | $37.0m110.4k shares |
| JANE STREET GROUP, LLC | Reduced | $14.6m43.7k shares |
| CITADEL ADVISORS LLC | Reduced | $8.1m24.2k shares |
| J. Goldman & Co LP | Reduced | $3.0m9.0k shares |
| Squarepoint Ops LLC | Added | $937.4k2.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $703.1k2.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| JANUS HENDERSON GROUP PLC 13G · institution -0.1 pts · filed 2025-11-14 | 12.3% |
| FMR LLC 13G · institution +2.3 pts · filed 2026-05-06 | 7.7% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor +0.5 pts · filed 2026-02-17 | 7.2% |
| BAKER BROS. ADVISORS LP 13G · institution new · filed 2026-05-15 | 6.3% |
| ORBIS INVESTMENT MANAGEMENT LTD 13G · institution -3.4 pts · filed 2026-08-14 | 5.5% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (0.2%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Adage Capital Management, L.P. (3.8%, 2026-02-12), PRICE T ROWE ASSOCIATES INC /MD/ (4.8%, 2025-11-14), Cormorant Asset Management, LP (4.0%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 2 | $1.1m | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 2 | $7.5m | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 1 | $3.6m | $3.6m |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-06-24 | DeSimone Jill Director | Sold plan | $3.6m11.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Jupiter Topco LLC 0.47% of their portfolio | 3.4m $1.1bn | First filing |
| FMR LLC 0.03% of their portfolio | 2.3m $775.7m | Added +156.0k |
| BlackRock, Inc. 0.01% of their portfolio | 2.3m $767.5m | Reduced -32.3k |
| PERCEPTIVE ADVISORS LLC 10.58% of their portfolio | 2.0m $681.6m | Unchanged |
| BAKER BROS. ADVISORS LP 2.94% of their portfolio | 1.8m $587.0m | Unchanged |
| Orbis Allan Gray Ltd 1.76% of their portfolio | 1.5m $512.2m | Reduced -942.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 1.3m $447.0m | Added +578.4k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 1.2m $413.6m | Added +13.4k |
| STATE STREET CORP 0.01% of their portfolio | 1.0m $343.7m | Added +142.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.48% of their portfolio | 1.0m $340.0m | Added +199.7k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 3.36% of their portfolio | 963.4k $322.5m | Unchanged |
| Driehaus Capital Management LLC 1.86% of their portfolio | 959.0k $321.1m | Added +9.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio | 943.0k $315.7m | Added +312.1k |
| MORGAN STANLEY 0.02% of their portfolio | 854.1k $285.9m | Added +20.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 748.0k $250.5m | Added +97.1k |
| Cormorant Asset Management, LP 10.98% of their portfolio | 640.0k $214.3m | Reduced -245.5k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 548.8k $183.7m | Reduced -161.9k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 546.9k $183.1m | Added +12.3k |
| Invesco Ltd. 0.01% of their portfolio | 537.5k $180.0m | Added +476.2k |
| Hood River Capital Management LLC 1.03% of their portfolio | 425.2k $142.3m | Added +66.5k |
| NORGES BANK 0.01% of their portfolio | 347.0k $116.2m | Not comparable |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 327.1k $109.5m | Added +51.0k |
| Pictet Asset Management Holding SA 0.09% of their portfolio | 291.7k $98.0m | Added +5.0k |
| Polar Capital Holdings Plc 0.26% of their portfolio | 279.1k $93.5m | New |
| Vivo Capital, LLC 8.29% of their portfolio | 271.1k $90.8m | Reduced -67.8k |
| Logos Global Management LP 3.75% of their portfolio | 260.0k $87.0m | Reduced -25.0k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 240.9k $80.6m | Added +13.0k |
| AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio | 237.3k $79.5m | Added +109.1k |
| ORBIMED ADVISORS LLC 1.46% of their portfolio | 230.1k $77.0m | Added +57.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 220.0k $73.7m | Added +4.6k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.24% of their portfolio | 218.9k $73.3m | Added +218.2k |
| Woodline Partners LP 0.21% of their portfolio | 200.0k $67.0m | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 188.4k $63.1m | Added +45.3k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 188.2k $63.0m | Added +18.3k |
| Affinity Asset Advisors, LLC 3.03% of their portfolio | 185.0k $61.9m | Added +15.0k |
| Soleus Capital Management, L.P. 2.05% of their portfolio | 177.5k $59.4m | Reduced -153.0k |
| Aberdeen Group plc 0.08% of their portfolio | 166.4k $55.7m | Reduced -6.1k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 160.5k $53.7m | Reduced -14.8k |
| Qube Research & Technologies Ltd 0.06% of their portfolio | 152.5k $51.0m | Added +24.2k |
| MARSHALL WACE, LLP 0.04% of their portfolio | 137.0k $45.9m | Added +91.9k |
| UBS Group AG 0.01% of their portfolio | 131.0k $43.9m | Added +22.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 125.9k $42.1m | Reduced -48.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.04% of their portfolio | 122.2k $40.9m | Added +94.1k |
| Nuveen, LLC 0.01% of their portfolio | 108.0k $36.2m | Added +36.0k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 107.4k $36.0m | Added +100.0k |
| MetLife Investment Management, LLC 0.14% of their portfolio | 90.5k $30.3m | Added +9.6k |
| NEUBERGER BERMAN GROUP LLC 0.02% of their portfolio | 89.5k $30.0m | Added +63.5k |
| Velan Capital Investment Management LP 18.21% of their portfolio | 88.8k $29.7m | Reduced -12.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 85.4k $28.6m | Reduced -1.7k |
| First Turn Management, LLC 2.99% of their portfolio | 83.5k $28.0m | Added +41.1k |
| ACUTA CAPITAL PARTNERS, LLC 19.32% of their portfolio | 82.8k $27.7m | Reduced -2.1k |
| Alyeska Investment Group, L.P. 0.07% of their portfolio | 80.8k $27.1m | Added +8.7k |
| ADAR1 Capital Management, LLC 1.17% of their portfolio | 74.3k $24.9m | Added +72.8k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.23% of their portfolio | 74.2k $24.8m | Added +20.8k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 73.0k $24.4m | Added +4.6k |
| Ikarian Capital, LLC 3.99% of their portfolio | 72.8k $24.4m | Added +1.3k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 71.5k $23.0m | Added +43.8k |
| 72 Investment Holdings, LLC 44.18% of their portfolio | 65.9k $22.1m | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC 2.45% of their portfolio | 65.7k $22.0m | Reduced -5.9k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 64.3k $21.5m | Added +33.1k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 64.3k $21.5m | Added +6.5k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 62.0k $20.8m | Added +56.7k |
| Candriam S.C.A. 0.09% of their portfolio | 60.9k $20.4m | Reduced -2.8k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 58.4k $19.6m | Reduced -210 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.03% of their portfolio | 56.8k $19.0m | New |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 51.0k $17.1m | Added +27.9k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 48.1k $16.1m | Added +686 |
| Boxer Capital Management, LLC 1.17% of their portfolio | 46.5k $15.6m | Unchanged |
| Swiss National Bank 0.01% of their portfolio | 46.1k $15.4m | Reduced -600 |
| ArrowMark Colorado Holdings LLC 0.64% of their portfolio | 46.0k $15.4m | Reduced -71.8k |
| California Public Employees Retirement System 0.01% of their portfolio | 45.4k $15.2m | Added +3.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 44.1k $15.8m | Reduced -36.1k |
| KVP Capital Advisors, LP 10.54% of their portfolio | 42.9k $14.4m | Unchanged |
| SEB Asset Management AB 0.05% of their portfolio | 42.7k $14.3m | New |
| Squarepoint Ops LLC 0.03% of their portfolio | 42.5k $14.2m | Added +40.5k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 40.1k $13.4m | Added +10.6k |
| Integral Health Asset Management, LLC 0.55% of their portfolio | 40.0k $13.4m | Unchanged |
| EVENTIDE ASSET MANAGEMENT, LLC 0.17% of their portfolio | 38.7k $13.0m | Added +44 |
| PFM Health Sciences, LP 1.12% of their portfolio | 38.6k $12.9m | Added +3.1k |
| STEMPOINT CAPITAL LP 2.16% of their portfolio | 37.2k $12.5m | Reduced -75.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 36.2k $12.1m | Reduced -2.0k |
| Burkehill Global Management, LP 0.42% of their portfolio | 35.0k $11.7m | Unchanged |
| University of Wisconsin Foundation 9.21% of their portfolio | 34.7k $11.6m | Added +9.5k |
| B Group, Inc. 6.32% of their portfolio | 33.2k $11.1m | Unchanged |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 32.3k $10.8m | Reduced -532 |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 31.6k $10.6m | Added +413 |
| HighVista Strategies LLC 2.31% of their portfolio | 30.2k $10.1m | Added +3.9k |
| LORD, ABBETT & CO. LLC 0.03% of their portfolio | 29.7k $9.9m | Added +43 |
| Clearbridge Investments, LLC 0.01% of their portfolio | 28.0k $9.4m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 27.9k $9.3m | Added +16.3k |
| Exome Asset Management LLC 5.62% of their portfolio | 27.2k $9.1m | Reduced -18.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 27.2k $9.1m | Reduced -559 |
| TD Asset Management Inc 0.01% of their portfolio | 27.2k $9.1m | Reduced -8.0k |
| CAPITAL FUND MANAGEMENT S.A. 0.06% of their portfolio | 27.1k $9.1m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 26.6k $8.9m | Reduced -874 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 26.1k $8.8m | Reduced -3.9k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.28% of their portfolio | 25.8k $8.6m | New |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 24.7k $8.7m | New |
| CASTLEARK MANAGEMENT LLC 0.22% of their portfolio | 24.4k $8.2m | New |
| CITIGROUP INC 0.00% of their portfolio | 23.6k $7.9m | Added +18.0k |