Vault-13

OPKO HEALTH INC OPK

COM · Common Stock · CUSIP 68375N103 · ISIN US68375N1037

Medical test and medication company

221 institutional holders
185,321,469185.3m shares reported held*
24.0% of all shares outstanding*
$350.3mreported value*

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 772.7m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.89. Options: 12 managers hold calls ($6.5m notional), 12 hold puts ($9.4m).

Biggest calls

GROUP ONE TRADING LLC — $2.9m1.5m shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP — $1.3m686.7k shares
SIMPLEX TRADING, LLC — $650.0k344.1k shares
JANE STREET GROUP, LLC — $581.0k307.6k shares
Caption Management, LLC — $567.0k300.0k shares
CITADEL ADVISORS LLC — $314.0k165.9k shares
WOLVERINE TRADING, LLC — $101.0k53.9k shares
Marathon Trading Investment Management LLC — $38.0k20.0k shares
HAP Trading, LLC — $4.0k44.4k shares
JPMORGAN CHASE & CO — $1.0k600 shares

Biggest puts

GROUP ONE TRADING LLC — $2.9m1.5m shares
WOLVERINE ASSET MANAGEMENT LLC — $2.3m1.2m shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP — $2.1m1.1m shares
JANE STREET GROUP, LLC — $778.0k411.8k shares
Caption Management, LLC — $567.0k300.0k shares
CITADEL ADVISORS LLC — $363.0k192.2k shares
SIMPLEX TRADING, LLC — $276.0k146.1k shares
WOLVERINE TRADING, LLC — $37.0k19.7k shares
HAP Trading, LLC — $19.0k15.5k shares
Cutler Group LLC / CA — $15.0k14.4k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FROST PHILLIP MD ET AL 13D · may seek influence +1.3 pts · filed 2026-07-01 34.1% +1.3 pts 255.4m≈ $383.1m 2026-07-01
Rubric Capital Management LP 13G · institution filed 2025-07-09 6.0% 47.8m≈ $71.7m 2025-07-09

Insider purchases and sales in Q3 2022

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q4 20: 0 buyingQ4 20: 0 sellingQ1 21: 0 buyingQ1 21: 0 sellingQ1 21Q2 21: 0 buyingQ2 21: 0 sellingQ3 21: 0 buyingQ3 21: 0 sellingQ3 21Q4 21: 0 buyingQ4 21: 0 sellingQ1 22: 1 buyingQ1 22: 0 sellingQ1 22Q2 22: 2 buyingQ2 22: 0 sellingQ3 22: 1 buyingQ3 22: 0 sellingQ3 22
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20200—0——
Q1 20210—0——
Q2 20210—0——
Q3 20210—0——
Q4 20210—0——
Q1 20221$4.8m0——
Q2 20222$5.9m0——
Q3 20221$2.5m0——
DateInsiderTradeSharesPrice ValueTheir holding
2022-09-26 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.80 $90.0k50.0k shares +<1%
2022-09-23 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.85 $92.3k50.0k shares +<1%
2022-09-22 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.90 $94.9k50.0k shares +<1%
2022-09-21 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.91 $95.6k50.0k shares +<1%
2022-09-20 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.94 $97.0k50.0k shares +<1%
2022-09-19 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 50,000 $1.97 $98.6k50.0k shares +<1%
2022-09-15 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 200,000 $2.07 $413.5k200.0k shares +<1%
2022-09-02 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 100,000 $2.14 $214.2k100.0k shares +<1%
2022-08-17 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 200,000 $2.54 $508.6k200.0k shares +<1%
2022-08-05 FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote Bought 350,000 $2.29 $803.1k350.0k shares +<1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q3 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 40,284,77340.3m $76.1m $76.1m 0.00% —
2 BlackRock Inc. 0.00% of their portfolio New York, NY 34,508,00334.5m $65.2m $65.2m 0.00% —
3 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 10,823,64110.8m $20.5m $20.5m 0.01% —
4 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 10,374,27310.4m $19.6m $19.6m 0.00% —
5 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 7,829,1887.8m $14.8m $14.8m 0.00% —
6 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 5,968,3066.0m $11.3m $11.3m 0.02% —
7 ORACLE INVESTMENT MANAGEMENT INC 5.53% of their portfolio GREENWICH, CT 5,102,7565.1m $9.6m $9.6m 5.53% —
8 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 3,905,3543.9m $7.4m $7.4m 0.00% —
9 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 3,813,5303.8m $7.2m $7.2m 0.00% —
10 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 3,372,1293.4m $6.4m $6.4m 0.00% —
11 NORGES BANK 0.00% of their portfolio OSLO, Q8 3,233,3853.2m $6.1m $6.1m 0.00% —
12 TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio NEW YORK, NY 2,887,3692.9m $5.5m $5.5m 0.02% —
13 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 2,836,3432.8m $5.4m $5.4m 0.01% —
14 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 2,806,5542.8m $5.3m $5.3m 0.00% —
15 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 2,374,1762.4m $4.5m $4.5m 0.00% —
16 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 2,280,1812.3m $4.3m $4.3m 0.00% —
17 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 2,201,6362.2m $4.2m $4.2m 0.00% —
18 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 2,142,3922.1m $4.0m $4.0m 0.01% —
19 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 2,142,1842.1m $4.0m $4.0m 0.01% —
20 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 2,122,3972.1m $4.0m $4.0m 0.01% —
21 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 2,043,3302.0m $3.9m $3.9m 0.00% —
22 Phoenix Financial Ltd. 0.07% of their portfolio Givatayim, L3 1,628,8621.6m $3.0m $3.0m 0.07% —
23 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 1,621,4301.6m $3.1m $3.1m 0.00% —
24 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,347,9091.3m $2.5m $2.5m 0.00% —
25 NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio STOCKHOLM, V7 1,290,6091.3m $2.5m $2.5m 0.00% —
26 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 1,235,9571.2m $2.3m $2.3m 0.00% —
27 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 1,086,7331.1m $2.1m $2.1m 0.00% —
28 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 1,049,5911.0m $2.0m $2.0m 0.00% —
29 Swiss National Bank 0.00% of their portfolio ZURICH, V8 1,047,2001.0m $2.0m $2.0m 0.00% —
30 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 850,208850.2k $1.6m $1.6m 0.00% —
31 GROUP ONE TRADING LLC 0.05% of their portfolio CHICAGO, IL 835,828835.8k $1.6m $1.6m 0.05% —
32 AWM Investment Company, Inc. 0.23% of their portfolio NEW YORK, NY 800,000800.0k $1.5m $1.5m 0.23% —
33 JUPITER ASSET MANAGEMENT LTD 0.02% of their portfolio London, X0 765,198765.2k $1.4m $1.4m 0.02% —
34 Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio VANCOUVER, A1 757,240757.2k $1.4m $1.4m 0.01% —
35 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 648,706648.7k $1.2m $1.2m 0.00% —
36 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 606,000606.0k $1.1m $1.1m 0.00% —
37 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 540,577540.6k $1.0m $1.0m 0.00% —
38 AXA S.A. 0.00% of their portfolio PARIS, I0 523,850523.9k $990.0k $990.0k 0.00% —
39 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 478,378478.4k $904.0k $904.0k 0.01% —
40 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 477,599477.6k $903.0k $903.0k 0.01% —
41 Candriam S.C.A. 0.01% of their portfolio STRASSEN, N4 452,348452.3k $855.0k $855.0k 0.01% —
42 Graham Capital Management, L.P. 0.04% of their portfolio ROWAYTON, CT 450,638450.6k $851.0k $851.0k 0.04% —
43 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 450,334450.3k $851.0k $851.0k 0.00% —
44 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 445,083445.1k $841.0k $841.0k 0.01% —
45 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 421,404421.4k $796.0k $796.0k 0.01% —
46 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 409,282409.3k $773.0k $773.0k 0.00% —
47 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 407,607407.6k $770.0k $770.0k 0.00% —
48 Legal & General Group Plc 0.00% of their portfolio London, X0 376,343376.3k $712.0k $712.0k 0.00% —
49 OCCUDO QUANTITATIVE STRATEGIES LP 0.05% of their portfolio FORT LAUDERDALE, FL 349,563349.6k $661.0k $661.0k 0.05% —
50 TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio STAMFORD, CT 341,105341.1k $645.0k $645.0k 0.02% —
51 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 334,071334.1k $631.4k $631.4k 0.00% —
52 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 333,249333.2k $630.0k $630.0k 0.00% —
53 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 331,249331.2k $626.0k $626.0k 0.00% —
54 Engineers Gate Manager LP 0.04% of their portfolio NEW YORK, NY 313,110313.1k $592.0k $592.0k 0.04% —
55 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 272,058272.1k $515.0k $515.0k 0.00% —
56 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 261,700261.7k $495.0k $495.0k 0.00% —
57 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 246,922246.9k $466.0k $466.0k 0.00% —
58 ETF MANAGERS GROUP, LLC 0.01% of their portfolio Summit, NJ 227,801227.8k $431.0k $431.0k 0.01% —
59 Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio Parsippany, NJ 221,951222.0k $419.0k $419.0k 0.03% —
60 UBS Group AG 0.00% of their portfolio ZURICH, V8 218,538218.5k $413.0k $413.0k 0.00% —
61 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 214,381214.4k $405.2k $405.2k 0.00% —
62 Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio FAIRFIELD, IA 210,316210.3k $397.0k $397.0k 0.00% —
63 Teton Advisors, Inc. 0.10% of their portfolio Rye, NY 210,000210.0k $397.0k $397.0k 0.10% —
64 X-Square Capital, LLC 0.25% of their portfolio GUAYNABO, PR 205,396205.4k $388.0k $388.0k 0.25% —
65 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 203,567203.6k $385.0k $385.0k 0.00% —
66 GAMCO INVESTORS, INC. ET AL 0.00% of their portfolio GREENWICH, CT 200,000200.0k $378.0k $378.0k 0.00% —
67 GABELLI FUNDS LLC 0.00% of their portfolio Rye, NY 200,000200.0k $378.0k $378.0k 0.00% —
68 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 191,675191.7k $362.0k $362.0k 0.00% —
69 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 190,685190.7k $360.4k $360.4k 0.00% —
70 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 190,553190.6k $360.0k $360.0k 0.00% —
71 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 176,020176.0k $333.0k $333.0k 0.00% —
72 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 175,722175.7k $332.0k $332.0k 0.00% —
73 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 170,750170.8k $322.7k $322.7k 0.00% —
74 CAPITAL ADVISORS INC/OK 0.01% of their portfolio TULSA, OK 164,625164.6k $285.0k $285.0k 0.01% —
75 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 151,267151.3k $287.0k $287.0k 0.00% —
76 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 149,557149.6k $283.0k $283.0k 0.00% —
77 New York Life Investment Management LLC 0.00% of their portfolio New York, NY 146,311146.3k $277.0k $277.0k 0.00% —
78 VAN ECK ASSOCIATES CORP 0.00% of their portfolio NEW YORK, NY 141,935141.9k $268.0k $268.0k 0.00% —
79 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 137,544137.5k $260.0k $260.0k 0.00% —
80 WILBANKS SMITH & THOMAS ASSET MANAGEMENT LLC 0.01% of their portfolio NORFOLK, VA 135,976136.0k $257.0k $257.0k 0.01% —
81 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 131,279131.3k $248.0k $248.0k 0.00% —
82 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 120,370120.4k $227.0k $227.0k 0.00% —
83 Csenge Advisory Group 0.02% of their portfolio CLEARWATER, FL 117,000117.0k $221.0k $221.0k 0.02% —
84 HIGHLINE WEALTH PARTNERS LLC 0.16% of their portfolio SHERMAN OAKS, CA 106,680106.7k $201.6k $201.6k 0.16% —
85 Handelsbanken Fonder AB 0.00% of their portfolio STOCKHOLM, V7 101,621101.6k $192.0k $192.0k 0.00% —
86 Quantbot Technologies LP 0.01% of their portfolio NEW YORK, NY 101,051101.1k $190.0k $190.0k 0.01% —
87 INTREPID CAPITAL MANAGEMENT INC 0.15% of their portfolio JACKSONVILLE BEACH, FL 100,000100.0k $189.0k $189.0k 0.15% —
88 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 97,53097.5k $184.0k $184.0k 0.01% —
89 Creative Planning 0.00% of their portfolio OVERLAND PARK, KS 94,69794.7k $179.0k $179.0k 0.00% —
90 Dynamic Technology Lab Private Ltd 0.02% of their portfolio SINGAPORE, U0 91,63491.6k $173.0k $173.0k 0.02% —
91 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 91,09491.1k $171.0k $171.0k 0.00% —
92 Weiss Multi-Strategy Advisers LLC 0.00% of their portfolio NEW YORK, NY 85,00085.0k $161.0k $161.0k 0.00% —
93 HOLLENCREST CAPITAL MANAGEMENT 0.02% of their portfolio NEWPORT BEACH, CA 83,98084.0k $159.0k $159.0k 0.02% —
94 Caption Management, LLC 0.03% of their portfolio OKLAHOMA CITY, OK 80,00080.0k $151.0k $151.0k 0.03% —
95 SHELL ASSET MANAGEMENT CO 0.01% of their portfolio THE HAGUE, P7 78,57678.6k $149.0k $149.0k 0.01% —
96 AE Wealth Management LLC 0.00% of their portfolio TOPEKA, KS 78,31378.3k $148.0k $148.0k 0.00% —
97 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 73,39173.4k $139.0k $139.0k 0.00% —
98 XTX Topco Ltd 0.03% of their portfolio LONDON, X0 71,44071.4k $135.0k $135.0k 0.03% —
99 LEVIN CAPITAL STRATEGIES, L.P. 0.02% of their portfolio NEW YORK, NY 70,00070.0k $132.0k $132.0k 0.02% —
100 BDO Wealth Advisors, LLC 0.02% of their portfolio JACKSONVILLE, FL 70,00070.0k $132.0k $132.0k 0.02% —