OPUS GENETICS INC IRD
COM · Common Stock · CUSIP 67577R102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDurham, NC
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 21.0m as of 2023-08-09, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.34. Options: 7 managers hold calls ($1.4m notional), 2 hold puts ($35.6k).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 36 |
| Q1 2023 | 42 |
| Q2 2023 | 49 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 19 | 13 |
| Q1 2023 | 20 | 11 |
| Q2 2023 | 31 | 19 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $690.0k | $0 | 0.00 |
| Q4 2022 | $34.8k | $27.5k | 0.79 |
| Q1 2023 | $75.6k | $6.0k | 0.08 |
| Q2 2023 | $1.4m | $35.6k | 0.03 |
Biggest buyers
| Stratos Wealth Partners, LTD. | New | +49.2k |
| RICE HALL JAMES & ASSOCIATES, LLC | Added | +40.2k |
| VANGUARD GROUP INC | Added | +39.2k |
| Squarepoint Ops LLC | New | +34.8k |
| BLAIR WILLIAM & CO/IL | New | +33.3k |
| OSAIC HOLDINGS, INC. | Added | +32.7k |
| TUCKER ASSET MANAGEMENT LLC | New | +29.1k |
| ACADIAN ASSET MANAGEMENT LLC | New | +28.2k |
| AMERICAN CENTURY COMPANIES INC | New | +28.1k |
| ROYAL BANK OF CANADA | Added | +21.4k |
Biggest sellers
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -90.4k |
| Diametric Capital, LP | Reduced | -27.4k |
| OCCUDO QUANTITATIVE STRATEGIES LP | Sold out | -19.6k |
| Cornerstone Capital, Inc. | Sold out | -16.4k |
| Bank of New York Mellon Corp | Sold out | -16.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Sold out | -14.8k |
| SIMPLEX TRADING, LLC | Sold out | -13.8k |
| Private Advisor Group, LLC | Reduced | -9.8k |
| MAI Capital Management | Reduced | -9.6k |
| STATE STREET CORP | Reduced | -9.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $653.6k150.6k shares |
| Caption Management, LLC | New | $390.6k90.0k shares |
| SIMPLEX TRADING, LLC | Added | $124.0k28.8k shares |
| GROUP ONE TRADING LLC | Added | $99.4k22.9k shares |
| Belvedere Trading LLC | New | $75.1k17.3k shares |
| CITADEL ADVISORS LLC | Added | $73.3k16.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $35.6k8.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PERCEPTIVE ADVISORS LLC 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution new · filed 2026-05-13 | 8.5% |
| Caligan Partners LP 13G · institution -1.2 pts · filed 2026-08-14 | 7.3% |
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 | 6.6% |
| Nantahala Capital Management, LLC 13G · institution -3.5 pts · filed 2026-05-15 | 6.5% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 6.1% |
Fell to 5% or below in the last year: Foundation Fighting Blindness Retinal Degeneration Fund (4.7%, 2026-05-20), BIOS Fund III, LP (4.5%, 2026-05-13)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 2 | $37.1k | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 2 | $61.1k | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
None reported in Q2 2023.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 885.9k $3.8m | Added +39.2k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.21% of their portfolio | 849.3k $3.7m | Added +40.2k |
| MAI Capital Management 0.03% of their portfolio | 485.0k $2.1m | Reduced -9.6k |
| Richmond Brothers, Inc. 2.40% of their portfolio | 341.9k $1.5m | Added +1.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 194.0k $842.2k | Added +12.7k |
| Knoll Capital Management, LLC 0.53% of their portfolio | 100.0k $434.0k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 99.6k $432.0k | Reduced -90.4k |
| BlackRock Inc. 0.00% of their portfolio | 55.4k $240.4k | Added +3.2k |
| STATE STREET CORP 0.00% of their portfolio | 52.9k $229.5k | Reduced -9.3k |
| Stratos Wealth Partners, LTD. 0.00% of their portfolio | 49.2k $213.5k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 34.8k $151.2k | New |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 33.3k $144.4k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 32.8k $142.2k | Added +32.7k |
| TRUST CO OF TOLEDO NA /OH/ 0.02% of their portfolio | 32.4k $140.6k | Added +6.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 31.2k $135.3k | Reduced -903 |
| MORGAN STANLEY 0.00% of their portfolio | 30.8k $133.9k | Added +2.2k |
| TUCKER ASSET MANAGEMENT LLC 0.04% of their portfolio | 29.1k $126.3k | New |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 28.2k $122.0k | New |
| Diametric Capital, LP 0.05% of their portfolio | 28.2k $122.4k | Reduced -27.4k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 28.1k $121.9k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.6k $111.1k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 21.4k $93.0k | Added +21.4k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 19.1k $82.8k | New |
| THOMPSON DAVIS & CO., INC. 0.09% of their portfolio | 18.2k $78.9k | New |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 18.0k $78.1k | Reduced -1.5k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 17.4k $75.3k | New |
| XTX Topco Ltd 0.01% of their portfolio | 16.9k $73.4k | New |
| Legato Capital Management LLC 0.01% of their portfolio | 16.5k $71.4k | Unchanged |
| Bedel Financial Consulting, Inc. 0.01% of their portfolio | 15.0k $65.1k | Unchanged |
| Stokes Family Office, LLC 0.01% of their portfolio | 12.2k $53.2k | Added +130 |
| UNITED BANK 0.01% of their portfolio | 11.8k $51.2k | Unchanged |
| LINCOLN NATIONAL CORP 0.00% of their portfolio | 11.7k $50.8k | Added +100 |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC 0.00% of their portfolio | 11.5k $50.0k | New |
| Private Advisor Group, LLC 0.00% of their portfolio | 10.2k $44.3k | Reduced -9.8k |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 10.0k $43.4k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 8.8k $38.0k | Added +8.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.9k $12.7k | Added +6 |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 2.0k $8.7k | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 1.2k $5.1k | Added +1.2k |
| TOTH FINANCIAL ADVISORY CORP 0.00% of their portfolio | 1.0k $4.3k | New |
| OPTIMUM INVESTMENT ADVISORS 0.00% of their portfolio | 1.0k $4.3k | New |
| CarsonAllaria Wealth Management, Ltd. 0.00% of their portfolio | 1.0k $4.3k | Unchanged |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 192 $833 | New |
| FMR LLC 0.00% of their portfolio | 100 $434 | New |
| ICA Group Wealth Management, LLC 0.00% of their portfolio | 30 $130 | Reduced -2 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 29 $125 | New |
| New England Capital Financial Advisors LLC 0.00% of their portfolio | 20 $87 | Unchanged |
| TD Waterhouse Canada Inc. 0.00% of their portfolio | 20 $87 | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5 $22 | Reduced -1.7k |