OPUS GENETICS INC IRD
COM · Common Stock · CUSIP 67577R102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDurham, NC
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 20.9m as of 2023-03-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.75. Options: 4 managers hold calls ($75.6k notional), 2 hold puts ($6.0k).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 36 |
| Q1 2023 | 42 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 19 | 13 |
| Q1 2023 | 20 | 11 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $690.0k | $0 | 0.00 |
| Q4 2022 | $34.8k | $27.5k | 0.79 |
| Q1 2023 | $75.6k | $6.0k | 0.08 |
Biggest buyers
| VANGUARD GROUP INC | Added | +143.3k |
| Knoll Capital Management, LLC | New | +100.0k |
| MAI Capital Management | Added | +54.6k |
| Diametric Capital, LP | Added | +32.0k |
| TRUST CO OF TOLEDO NA /OH/ | New | +26.0k |
| OCCUDO QUANTITATIVE STRATEGIES LP | New | +19.6k |
| CAPTRUST FINANCIAL ADVISORS | New | +19.5k |
| Cornerstone Capital, Inc. | New | +16.4k |
| Bank of New York Mellon Corp | New | +16.4k |
| Richmond Brothers, Inc. | Added | +11.6k |
Biggest sellers
| CITADEL ADVISORS LLC | Reduced | -34.1k |
| BlackRock Inc. | Reduced | -19.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -15.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Sold out | -14.9k |
| MORGAN STANLEY | Reduced | -4.5k |
| OSAIC HOLDINGS, INC. | Reduced | -3.5k |
| GROUP ONE TRADING LLC | Reduced | -3.4k |
| Tower Research Capital LLC (TRC) | Reduced | -3.4k |
| Capital Analysts, LLC | Sold out | -1.6k |
| FIRST MANHATTAN CO. LLC. | Sold out | -600 |
Biggest calls
| CITADEL ADVISORS LLC | Added | $48.8k13.0k shares |
| SIMPLEX TRADING, LLC | Added | $22.0k6.0k shares |
| GROUP ONE TRADING LLC | Reduced | $4.9k1.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $6.0k1.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PERCEPTIVE ADVISORS LLC 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution new · filed 2026-05-13 | 8.5% |
| Caligan Partners LP 13G · institution -1.2 pts · filed 2026-08-14 | 7.3% |
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 | 6.6% |
| Nantahala Capital Management, LLC 13G · institution -3.5 pts · filed 2026-05-15 | 6.5% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 6.1% |
Fell to 5% or below in the last year: Foundation Fighting Blindness Retinal Degeneration Fund (4.7%, 2026-05-20), BIOS Fund III, LP (4.5%, 2026-05-13)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 2 | $37.1k | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 2 | $61.1k | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
None reported in Q1 2023.
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 846.7k $3.2m | Added +143.3k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.17% of their portfolio | 809.1k $3.0m | Added +3.0k |
| MAI Capital Management 0.03% of their portfolio | 494.7k $1.9m | Added +54.6k |
| Richmond Brothers, Inc. 2.15% of their portfolio | 340.5k $1.3m | Added +11.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 190.0k $712.0k | Added +469 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 181.4k $680.1k | Added +8.3k |
| Knoll Capital Management, LLC 0.63% of their portfolio | 100.0k $375.0k | New |
| STATE STREET CORP 0.00% of their portfolio | 62.2k $233.1k | Unchanged |
| Diametric Capital, LP 0.10% of their portfolio | 55.6k $208.7k | Added +32.0k |
| BlackRock Inc. 0.00% of their portfolio | 52.2k $195.8k | Reduced -19.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 32.1k $120.3k | Added +9.8k |
| MORGAN STANLEY 0.00% of their portfolio | 28.6k $107.3k | Reduced -4.5k |
| TRUST CO OF TOLEDO NA /OH/ 0.02% of their portfolio | 26.0k $97.5k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.6k $96.0k | Unchanged |
| Private Advisor Group, LLC 0.00% of their portfolio | 20.0k $75.0k | Unchanged |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.01% of their portfolio | 19.6k $73.6k | New |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 19.5k $73.1k | New |
| Legato Capital Management LLC 0.01% of their portfolio | 16.5k $61.7k | Unchanged |
| Cornerstone Capital, Inc. 0.01% of their portfolio | 16.4k $61.3k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 16.4k $61.3k | New |
| Bedel Financial Consulting, Inc. 0.01% of their portfolio | 15.0k $56.2k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 14.8k $55.3k | Reduced -15.5k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 13.8k $51.0k | Added +2.1k |
| Stokes Family Office, LLC 0.01% of their portfolio | 12.1k $45.5k | Unchanged |
| UNITED BANK 0.01% of their portfolio | 11.8k $44.2k | Not comparable |
| LINCOLN NATIONAL CORP 0.00% of their portfolio | 11.6k $43.5k | Unchanged |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 10.0k $37.5k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 3.9k $14.8k | Reduced -34.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.9k $10.9k | Added +2 |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 2.0k $7.5k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.7k $6.0k | Reduced -3.4k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 1.5k $5.4k | Reduced -3.4k |
| Hartford Financial Management Inc. 0.00% of their portfolio | 1.0k $3.8k | New |
| CarsonAllaria Wealth Management, Ltd. 0.00% of their portfolio | 1.0k $3.8k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 564 $2.1k | New |
| Aspire Private Capital, LLC 0.00% of their portfolio | 400 $1.5k | Unchanged |
| ICA Group Wealth Management, LLC 0.00% of their portfolio | 32 $121 | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 21 $79 | Reduced -3.5k |
| New England Capital Financial Advisors LLC 0.00% of their portfolio | 20 $75 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 5 $0 | Unchanged |
| TCI Wealth Advisors, Inc. 0.00% of their portfolio | 2 $8 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |