Vault-13

OPUS GENETICS INC IRD

COM · Common Stock · CUSIP 67577R102

42 institutional holders +6 vs Q4 2022
3,457,0823.5m shares reported held*
16.5% of all shares outstanding*
$13.0mreported value*
10 new 10 added 7 reduced 4 sold out net bought ≈ $1.4m (+375.7k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 20.9m as of 2023-03-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.75. Options: 4 managers hold calls ($75.6k notional), 2 hold puts ($6.0k).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 38Q4 22: 36Q1 23: 4242Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 202238
Q4 202236
Q1 202342

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
20020Q4 22: 19 bought or addedQ4 22: 13 cut or sold outQ4 22Q1 23: 20 bought or addedQ1 23: 11 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221913
Q1 20232011

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600k$800kQ3 22 calls: $690.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $34.8kQ4 22 puts: $27.5kQ4 22P/C 0.79Q1 23 calls: $75.6kQ1 23 puts: $6.0kQ1 23P/C 0.08
Numbers
QuarterCallsPutsP/C
Q3 2022$690.0k$00.00
Q4 2022$34.8k$27.5k0.79
Q1 2023$75.6k$6.0k0.08

Biggest buyers

VANGUARD GROUP INC Added +143,348+143.3k
Knoll Capital Management, LLC New +100,000+100.0k
MAI Capital Management Added +54,619+54.6k
Diametric Capital, LP Added +32,050+32.0k
TRUST CO OF TOLEDO NA /OH/ New +26,000+26.0k
OCCUDO QUANTITATIVE STRATEGIES LP New +19,623+19.6k
CAPTRUST FINANCIAL ADVISORS New +19,501+19.5k
Cornerstone Capital, Inc. New +16,357+16.4k
Bank of New York Mellon Corp New +16,350+16.4k
Richmond Brothers, Inc. Added +11,556+11.6k

Biggest sellers

CITADEL ADVISORS LLC Reduced -34,066-34.1k
BlackRock Inc. Reduced -19,501-19.5k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -15,451-15.5k
CHARLES SCHWAB INVESTMENT MANAGEMENT INC Sold out -14,928-14.9k
MORGAN STANLEY Reduced -4,527-4.5k
OSAIC HOLDINGS, INC. Reduced -3,500-3.5k
GROUP ONE TRADING LLC Reduced -3,411-3.4k
Tower Research Capital LLC (TRC) Reduced -3,382-3.4k
Capital Analysts, LLC Sold out -1,636-1.6k
FIRST MANHATTAN CO. LLC. Sold out -600-600

Biggest calls

CITADEL ADVISORS LLC Added $48.8k13.0k shares
SIMPLEX TRADING, LLC Added $22.0k6.0k shares
GROUP ONE TRADING LLC Reduced $4.9k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $6.0k1.6k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
PERCEPTIVE ADVISORS LLC 13G · passive investor no change · filed 2026-08-14 10.0% no change 9.2m≈ $37.6m 2026-08-14
Adage Capital Management, L.P. 13G · institution new · filed 2026-05-13 8.5% new 6.0m≈ $24.8m 2026-05-13
Caligan Partners LP 13G · institution -1.2 pts · filed 2026-08-14 7.3% -1.2 pts 6.1m≈ $25.0m 2026-08-14
BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 6.6% -0.5 pts 5.5m≈ $22.5m 2026-08-14
Nantahala Capital Management, LLC 13G · institution -3.5 pts · filed 2026-05-15 6.5% -3.5 pts 4.8m≈ $19.9m 2026-05-15
BlackRock, Inc. 13G · institution new · filed 2026-10-27 6.1% new 5.0m≈ $20.7m 2026-10-27

Fell to 5% or below in the last year: Foundation Fighting Blindness Retinal Degeneration Fund (4.7%, 2026-05-20), BIOS Fund III, LP (4.5%, 2026-05-13)

Insider purchases and sales in Q1 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q2 21: 0 buyingQ2 21: 0 sellingQ3 21: 0 buyingQ3 21: 0 sellingQ3 21Q4 21: 2 buyingQ4 21: 0 sellingQ1 22: 0 buyingQ1 22: 0 sellingQ1 22Q2 22: 2 buyingQ2 22: 0 sellingQ3 22: 0 buyingQ3 22: 0 sellingQ3 22Q4 22: 0 buyingQ4 22: 0 sellingQ1 23: 0 buyingQ1 23: 0 sellingQ1 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20210—0——
Q3 20210—0——
Q4 20212$37.1k0——
Q1 20220—0——
Q2 20222$61.1k0——
Q3 20220—0——
Q4 20220—0——
Q1 20230—0——

None reported in Q1 2023.

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 846,702846.7k $3.2m $3.2m 0.00% Added +143.3k +143,348
2 RICE HALL JAMES & ASSOCIATES, LLC 0.17% of their portfolio San Diego, CA 809,117809.1k $3.0m $3.0m 0.17% Added +3.0k +3,050
3 MAI Capital Management 0.03% of their portfolio INDEPENDENCE, OH 494,690494.7k $1.9m $1.9m 0.03% Added +54.6k +54,619
4 Richmond Brothers, Inc. 2.15% of their portfolio JACKSON, MI 340,526340.5k $1.3m $1.3m 2.15% Added +11.6k +11,556
5 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 189,969190.0k $712.0k $712.0k 0.00% Added +469 +469
6 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 181,370181.4k $680.1k $680.1k 0.00% Added +8.3k +8,303
7 Knoll Capital Management, LLC 0.63% of their portfolio MIAMI, FL 100,000100.0k $375.0k $375.0k 0.63% New
8 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 62,17362.2k $233.1k $233.1k 0.00% Unchanged
9 Diametric Capital, LP 0.10% of their portfolio BOSTON, MA 55,64855.6k $208.7k $208.7k 0.10% Added +32.0k +32,050
10 BlackRock Inc. 0.00% of their portfolio New York, NY 52,20152.2k $195.8k $195.8k 0.00% Reduced -19.5k -19,501
11 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 32,07032.1k $120.3k $120.3k 0.00% Added +9.8k +9,789
12 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 28,61428.6k $107.3k $107.3k 0.00% Reduced -4.5k -4,527
13 TRUST CO OF TOLEDO NA /OH/ 0.02% of their portfolio HOLLAND, OH 26,00026.0k $97.5k $97.5k 0.02% New
14 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 25,59225.6k $96.0k $96.0k 0.00% Unchanged
15 Private Advisor Group, LLC 0.00% of their portfolio MORRISTOWN, NJ 20,00020.0k $75.0k $75.0k 0.00% Unchanged
16 OCCUDO QUANTITATIVE STRATEGIES LP 0.01% of their portfolio FORT LAUDERDALE, FL 19,62319.6k $73.6k $73.6k 0.01% New
17 CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio RALEIGH, NC 19,50119.5k $73.1k $73.1k 0.00% New
18 Legato Capital Management LLC 0.01% of their portfolio San Francisco, CA 16,45616.5k $61.7k $61.7k 0.01% Unchanged
19 Cornerstone Capital, Inc. 0.01% of their portfolio Palo Alto, CA 16,35716.4k $61.3k $61.3k 0.01% New
20 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 16,35016.4k $61.3k $61.3k 0.00% New
21 Bedel Financial Consulting, Inc. 0.01% of their portfolio INDIANAPOLIS, IN 15,00015.0k $56.2k $56.2k 0.01% Unchanged
22 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 14,75114.8k $55.3k $55.3k 0.00% Reduced -15.5k -15,451
23 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 13,77613.8k $51.0k $51.0k 0.00% Added +2.1k +2,140
24 Stokes Family Office, LLC 0.01% of their portfolio NEW ORLEANS, LA 12,12012.1k $45.5k $45.5k 0.01% Unchanged
25 UNITED BANK 0.01% of their portfolio VIENNA, VA 11,80011.8k $44.2k $44.2k 0.01% Not comparable
26 LINCOLN NATIONAL CORP 0.00% of their portfolio RADNOR, PA 11,60011.6k $43.5k $43.5k 0.00% Unchanged
27 KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio AUSTIN, TX 10,00010.0k $37.5k $37.5k 0.00% New
28 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 3,9463.9k $14.8k $14.8k 0.00% Reduced -34.1k -34,066
29 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 2,9142.9k $10.9k $10.9k 0.00% Added +2 +2
30 NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio MONTREAL, A8 2,0002.0k $7.5k $7.5k 0.00% New
31 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,7211.7k $6.0k $6.0k 0.00% Reduced -3.4k -3,382
32 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 1,4511.5k $5.4k $5.4k 0.00% Reduced -3.4k -3,411
33 Hartford Financial Management Inc. 0.00% of their portfolio WEST HARTFORD, CT 1,0001.0k $3.8k $3.8k 0.00% New
34 CarsonAllaria Wealth Management, Ltd. 0.00% of their portfolio GLEN CARBON, IL 1,0001.0k $3.8k $3.8k 0.00% Unchanged
35 UBS Group AG 0.00% of their portfolio ZURICH, V8 564564 $2.1k $2.1k 0.00% New
36 Aspire Private Capital, LLC 0.00% of their portfolio Cornelius, NC 400400 $1.5k $1.5k 0.00% Unchanged
37 ICA Group Wealth Management, LLC 0.00% of their portfolio DENVER, CO 3232 $121 $121 0.00% Unchanged
38 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 2121 $79 $79 0.00% Reduced -3.5k -3,500
39 New England Capital Financial Advisors LLC 0.00% of their portfolio MERIDEN, CT 2020 $75 $75 0.00% Unchanged
40 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 55 $0 $0 0.00% Unchanged
41 TCI Wealth Advisors, Inc. 0.00% of their portfolio Tucson, AZ 22 $8 $8 0.00% Unchanged
42 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged