MONTE ROSA THERAPEUTICS INC GLUE
COM · Common Stock · CUSIP 61225M102
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($8.9m this quarter). Holder counts are more reliable. Shares outstanding: 85.3m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $24.19. Options: 9 managers hold calls ($20.7m notional), 3 hold puts ($1.4m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 70 |
| Q4 2022 | 67 |
| Q1 2023 | 70 |
| Q2 2023 | 69 |
| Q3 2023 | 72 |
| Q4 2023 | 72 |
| Q1 2024 | 69 |
| Q2 2024 | 76 |
| Q3 2024 | 82 |
| Q4 2024 | 106 |
| Q1 2025 | 107 |
| Q2 2025 | 117 |
| Q3 2025 | 129 |
| Q4 2025 | 161 |
| Q1 2026 | 191 |
| Q2 2026 | 193 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 52 | 19 |
| Q4 2024 | 64 | 29 |
| Q1 2025 | 44 | 62 |
| Q2 2025 | 76 | 35 |
| Q3 2025 | 63 | 54 |
| Q4 2025 | 98 | 56 |
| Q1 2026 | 129 | 61 |
| Q2 2026 | 109 | 82 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $1.8m | $3.9m | 2.11 |
| Q4 2025 | $4.8m | $6.4m | 1.34 |
| Q1 2026 | $4.2m | $1.4m | 0.33 |
| Q2 2026 | $20.7m | $1.4m | 0.07 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +2.1m |
| BlackRock, Inc. | Added | +1.2m |
| Vestal Point Capital, LP | Added | +996.5k |
| Woodline Partners LP | Added | +888.4k |
| Opaleye Management Inc. | New | +745.0k |
| Nantahala Capital Management, LLC | Added | +652.0k |
| FIRST TRUST ADVISORS LP | New | +647.8k |
| BOONE CAPITAL MANAGEMENT LLC | New | +615.3k |
| Nextech Invest Ltd. | Added | +456.9k |
| STATE STREET CORP | Added | +377.4k |
Biggest sellers
| AMERICAN CENTURY COMPANIES INC | Reduced | -1.2m |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | -893.7k |
| BRAIDWELL LP | Reduced | -755.0k |
| MONTANOVA CAPITAL, LLC | Reduced | -677.3k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Sold out | -647.7k |
| Cormorant Asset Management, LP | Sold out | -400.0k |
| Alphabet Inc. | Reduced | -311.8k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -276.6k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -191.4k |
| NORTHERN TRUST CORP | Reduced | -174.5k |
Biggest calls
| Caption Management, LLC | New | $7.3m300.0k shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | $7.3m300.0k shares |
| DIADEMA PARTNERS LP | New | $4.1m170.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $885.7k36.6k shares |
| DLD Asset Management, LP | New | $484.2k20.0k shares |
| Persistent Asset Partners Ltd | New | $258.1k434 shares |
| CITADEL ADVISORS LLC | Reduced | $213.0k8.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $154.9k6.4k shares |
| GROUP ONE TRADING LLC | Reduced | $50.8k2.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.0m43.1k shares |
| JANE STREET GROUP, LLC | Reduced | $225.1k9.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $164.6k6.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution +3.0 pts · filed 2026-07-08 | 10.5% |
| BAKER BROS. ADVISORS LP 13G · institution +3.3 pts · filed 2026-05-15 | 10.0% |
| Dimension Capital I, L.P. 13G · passive investor -0.6 pts · filed 2026-04-22 | 8.1% |
New Enterprise Associates 17, L.P.
13D · may seek influence
-1.8 pts · filed 2026-07-06
Stated purposeThe information provided in Item 5(c) is hereby incorporated by reference. Depending on market conditions and other factors, NEA 17 and the Reporting Persons may dispose of additional shares of the Issuer. Full filing |
7.9% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +0.4 pts · filed 2026-05-15 | 6.3% |
| BlackRock, Inc. 13G · institution new · filed 2025-02-04 | 6.3% |
| TCG Crossover GP II, LLC 13G · passive investor -1.7 pts · filed 2026-05-15 | 5.5% |
| Vestal Point Capital, LP 13G · institution new · filed 2026-08-14 | 5.4% |
Fell to 5% or below in the last year: MONTANOVA CAPITAL, LLC (4.2%, 2026-08-14), Versant Venture Capital VI, L.P. (3.4%, 2026-01-09), Avoro Capital Advisors LLC (0.0%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 1 | $58.4k | 0 | — | — |
| Q2 2025 | 0 | — | 1 | $9.2k | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 6 | $1.1m | $226.3k |
| Q2 2026 | 0 | — | 6 | $2.4m | $1.8m |
| Q3 2026 | 0 | — | 3 | $461.8k | $241.6k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-07-16 | Warmuth Markus President & CEO, director | Sold | $220.2k9.5k shares |
| 2026-07-15 | Champoux Jennifer Chief Operating Officer | Sold plan | $101.7k4.4k shares |
| 2026-07-06 | Townson Sharon Chief Scientific Officer | Sold plan | $139.9k6.0k shares |
| 2026-06-30 | Janku Filip Chief Medical Officer | Sold plan | $132.5k5.4k shares |
| 2026-06-29 | Manning Anthony M. Director | Sold | $231.1k10.0k shares |
| 2026-06-29 | Janku Filip Chief Medical Officer | Sold plan | $137.7k6.0k shares |
| 2026-06-24 | Janku Filip Chief Medical Officer | Sold plan | $642.6k30.0k shares |
| 2026-06-23 | Janku Filip Chief Medical Officer | Sold plan | $239.5k11.8k shares |
| 2026-06-23 | Townson Sharon Chief Scientific Officer | Sold plan | $60.0k3.0k shares |
| 2026-06-23 | Champoux Jennifer Chief Operating Officer | Sold plan | $43.5k2.2k shares |
| 2026-06-17 | Townson Sharon Chief Scientific Officer | Sold plan | $57.0k3.0k shares |
| 2026-06-17 | Champoux Jennifer Chief Operating Officer | Sold plan | $41.3k2.2k shares |
| 2026-06-01 | Warmuth Markus President & CEO, director | Sold plan | $106.2k5.5k shares |
| 2026-05-29 | Townson Sharon Chief Scientific Officer | Sold plan | $119.2k6.0k shares |
| 2026-05-27 | Champoux Jennifer Chief Operating Officer | Sold plan | $43.5k2.2k shares |
| 2026-05-22 | Champoux Jennifer Chief Operating Officer | Sold plan | $41.3k2.2k shares |
| 2026-05-21 | Manning Anthony M. Director | Sold | $180.1k10.0k shares |
| 2026-05-01 | Warmuth Markus President & CEO, director | Sold plan | $103.4k5.5k shares |
| 2026-04-14 | Warmuth Markus President & CEO, director | Sold | $141.1k8.0k shares |
| 2026-04-09 | Nickson Philip Chief Business & Legal Officer | Sold | $103.4k5.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 8.9m $214.4m | Added +2.1m |
| NEA Management Company, LLC 11.72% of their portfolio | 7.7m $186.2m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 6.8m $165.6m | Added +1.2m |
| TCG Crossover Management, LLC 2.69% of their portfolio | 4.6m $111.9m | Unchanged |
| Vestal Point Capital, LP 2.60% of their portfolio | 4.6m $111.3m | Added +996.5k |
| BVF INC/IL 2.76% of their portfolio | 4.5m $108.0m | Unchanged |
| BAKER BROS. ADVISORS LP 0.53% of their portfolio | 4.3m $105.2m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 3.7m $90.3m | Added +377.4k |
| MONTANOVA CAPITAL, LLC 1.81% of their portfolio | 3.5m $85.9m | Reduced -677.3k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.4m $82.6m | Added +312.7k |
| Versant Venture Management, LLC 47.34% of their portfolio | 3.2m $77.0m | Unchanged |
| BRAIDWELL LP 2.19% of their portfolio | 2.5m $59.3m | Reduced -755.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $45.1m | Added +323.3k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 1.6m $39.3m | Reduced -1.2m |
| MARSHALL WACE, LLP 0.03% of their portfolio | 1.6m $38.6m | Added +160.4k |
| Aisling Capital Management LP 7.98% of their portfolio | 1.6m $37.6m | Unchanged |
| Nantahala Capital Management, LLC 0.96% of their portfolio | 1.3m $31.6m | Added +652.0k |
| Bellevue Group AG 0.61% of their portfolio | 1.2m $28.8m | Reduced -60.0k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 1.2m $28.5m | Added +136.1k |
| MPM BIOIMPACT LLC 1.71% of their portfolio | 1.2m $28.1m | Reduced -15.8k |
| SILVERARC CAPITAL MANAGEMENT, LLC 2.98% of their portfolio | 1.1m $26.8m | Reduced -893.7k |
| Jupiter Topco LLC 0.01% of their portfolio | 1.1m $26.0m | First filing |
| Frazier Life Sciences Management, L.P. 0.53% of their portfolio | 1.0m $24.2m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 998.3k $24.2m | Reduced -3.3k |
| Woodline Partners LP 0.07% of their portfolio | 962.9k $23.3m | Added +888.4k |
| FMR LLC 0.00% of their portfolio | 934.4k $22.6m | Reduced -89.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 791.9k $19.2m | Added +276.0k |
| MORGAN STANLEY 0.00% of their portfolio | 789.5k $19.1m | Added +105.5k |
| Nextech Invest Ltd. 0.87% of their portfolio | 761.2k $18.4m | Added +456.9k |
| Opaleye Management Inc. 1.63% of their portfolio | 745.0k $18.0m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 652.1k $15.8m | Reduced -174.5k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 647.8k $15.7m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 616.3k $14.9m | Added +69.6k |
| BOONE CAPITAL MANAGEMENT LLC 3.48% of their portfolio | 615.3k $14.9m | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.24% of their portfolio | 552.6k $13.4m | Added +23.9k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 520.6k $12.6m | Reduced -137.8k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 505.5k $12.2m | Added +98.4k |
| Parkwood LLC 0.88% of their portfolio | 505.0k $12.2m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 450.0k $10.9m | Added +200.0k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.17% of their portfolio | 405.5k $9.8m | Added +373.6k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 383.3k $9.3m | Added +347.3k |
| Alphabet Inc. 0.01% of their portfolio | 372.5k $9.0m | Reduced -311.8k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 363.5k $8.8m | Added +48.7k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 352.9k $8.5m | Reduced -39.4k |
| Empowered Funds, LLC 0.04% of their portfolio | 329.3k $8.0m | Added +23.9k |
| Duquesne Family Office LLC 0.17% of their portfolio | 297.6k $7.2m | New |
| TD Asset Management Inc 0.01% of their portfolio | 285.9k $6.9m | Reduced -1.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 254.6k $6.2m | Reduced -133.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 222.5k $5.4m | Added +17.8k |
| Longaeva Partners L.P. 0.15% of their portfolio | 216.8k $5.2m | New |
| ADAR1 Capital Management, LLC 0.25% of their portfolio | 216.8k $5.2m | Added +1.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 207.4k $5.0m | Added +78.6k |
| UBS Group AG 0.00% of their portfolio | 200.8k $4.9m | Added +48.2k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 200.0k $4.8m | Unchanged |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 198.9k $4.8m | Reduced -57.8k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 191.9k $4.6m | Reduced -17.9k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 188.8k $4.6m | Reduced -10.9k |
| Casdin Capital, LLC 0.23% of their portfolio | 186.0k $4.5m | Unchanged |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 172.1k $4.2m | Added +105.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 168.5k $4.1m | Added +13.9k |
| Nuveen, LLC 0.00% of their portfolio | 166.8k $4.0m | Added +45.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 163.6k $4.0m | Reduced -90.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 156.6k $3.8m | Added +74.3k |
| STEMPOINT CAPITAL LP 0.64% of their portfolio | 153.5k $3.7m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 140.9k $3.4m | Added +121.6k |
| Exome Asset Management LLC 2.05% of their portfolio | 137.1k $3.3m | Reduced -42.4k |
| CITIGROUP INC 0.00% of their portfolio | 129.5k $3.1m | Added +114.9k |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 121.1k $2.9m | New |
| Trexquant Investment LP 0.02% of their portfolio | 115.4k $2.8m | Added +66.2k |
| Caption Management, LLC 0.10% of their portfolio | 112.3k $2.7m | New |
| Atom Investors LP 0.24% of their portfolio | 111.0k $2.7m | Reduced -83.5k |
| Jain Global LLC 0.03% of their portfolio | 110.6k $2.7m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 102.5k $2.5m | Reduced -276.6k |
| Invesco Ltd. 0.00% of their portfolio | 97.0k $2.3m | Reduced -5.2k |
| Swiss National Bank 0.00% of their portfolio | 96.3k $2.3m | Added +35.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 94.6k $2.3m | Added +18.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 87.4k $1.4m | Added +31.7k |
| Squarepoint Ops LLC 0.00% of their portfolio | 83.0k $2.0m | Added +45.8k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 79.1k $1.9m | Added +63.9k |
| DIADEMA PARTNERS LP 0.67% of their portfolio | 78.4k $1.9m | Reduced -108.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 76.8k $1.8m | Added +9.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 75.1k $1.8m | Added +27.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 68.7k $1.7m | Added +45.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 66.7k $1.6m | Reduced -7.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 65.5k $1.6m | Added +46.2k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 58.8k $1.4m | Reduced -45.9k |
| Tetragon Partners GP Ltd 0.22% of their portfolio | 56.1k $1.4m | New |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 54.3k $1.3m | Reduced -2.2k |
| Quantinno Capital Management LP 0.00% of their portfolio | 54.2k $1.3m | Added +196 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 54.2k $1.3m | Added +50.9k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 50.0k $1.2m | Reduced -27.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 49.0k $1.2m | Added +6.6k |
| SEVEN GRAND MANAGERS, LLC 0.04% of their portfolio | 45.0k $1.1m | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 43.5k $1.1m | Added +10.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 40.9k $988.3k | Added +5.1k |
| Legal & General Group Plc 0.00% of their portfolio | 40.4k $977.1k | Added +16.1k |
| XTX Topco Ltd 0.01% of their portfolio | 39.9k $965.0k | Reduced -17.9k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 38.8k $938.3k | Added +31.4k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 38.6k $935.0k | Added +2.6k |
| Round Rock Advisors LLC 0.12% of their portfolio | 37.2k $900.9k | Unchanged |