MBX BIOSCIENCES INC MBX
COM · Common Stock · CUSIP 55287L101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarmel, IN
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($80.0k this quarter). Holder counts are more reliable. Shares outstanding: 47.5m as of 2026-03-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $29.85. Options: 4 managers hold calls ($3.7m notional), 4 hold puts ($1.5m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 46 |
| Q4 2024 | 64 |
| Q1 2025 | 80 |
| Q2 2025 | 89 |
| Q3 2025 | 118 |
| Q4 2025 | 138 |
| Q1 2026 | 157 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 42 | 21 |
| Q1 2025 | 49 | 23 |
| Q2 2025 | 60 | 26 |
| Q3 2025 | 68 | 38 |
| Q4 2025 | 92 | 49 |
| Q1 2026 | 76 | 65 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $848.2k | $1.6m | 1.92 |
| Q3 2025 | $15.3m | $29.0m | 1.89 |
| Q4 2025 | $4.1m | $14.0m | 3.42 |
| Q1 2026 | $3.7m | $1.5m | 0.40 |
Biggest buyers
| FMR LLC | Added | +2.9m |
| Polar Capital Holdings Plc | New | +1.6m |
| Aaron Wealth Advisors LLC | Added | +1.1m |
| STEMPOINT CAPITAL LP | Added | +920.4k |
| Caligan Partners LP | New | +848.6k |
| BRAIDWELL LP | Added | +473.9k |
| Candriam S.C.A. | New | +294.4k |
| BOOTHBAY FUND MANAGEMENT, LLC | New | +208.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +188.5k |
| JPMORGAN CHASE & CO | Added | +132.4k |
Biggest sellers
| EcoR1 Capital, LLC | Reduced | -1.3m |
| Point72 Asset Management, L.P. | Sold out | -680.6k |
| Deep Track Capital, LP | Reduced | -492.2k |
| Driehaus Capital Management LLC | Reduced | -389.9k |
| D. E. Shaw & Co., Inc. | Reduced | -382.9k |
| Trails Edge Capital Partners, LP | Sold out | -315.2k |
| ORBIMED ADVISORS LLC | Reduced | -297.3k |
| Soleus Capital Management, L.P. | Reduced | -230.0k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -158.1k |
| Balyasny Asset Management L.P. | Sold out | -119.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.8m92.9k shares |
| JANE STREET GROUP, LLC | Added | $597.0k20.0k shares |
| CITADEL ADVISORS LLC | Reduced | $295.5k9.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $14.9k500 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $755.2k25.3k shares |
| JANE STREET GROUP, LLC | New | $650.7k21.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $44.8k1.5k shares |
| GROUP ONE TRADING LLC | Reduced | $6.0k200 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Frazier Life Sciences Public Fund, L.P.
13D · may seek influence
no change · filed 2026-08-10
Stated purposeItem 4 is hereby amended to remove references to "FLSPOF" and the "FLSPOF Shares" from the first paragraph. Full filing |
11.7% |
| FMR LLC 13G · institution +5.0 pts · filed 2026-07-08 | 11.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution +3.0 pts · filed 2026-07-08 | 10.5% |
New Enterprise Associates 17, L.P.
13D · may seek influence
filed 2025-11-10
Stated purposeNEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of dire… Full filing |
8.1% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.3 pts · filed 2026-08-10
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
6.4% |
| BlackRock, Inc. 13G · institution +0.7 pts · filed 2026-07-29 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-06-24 | 5.2% |
Fell to 5% or below in the last year: Deep Track Capital, LP (3.6%, 2026-08-14), Hawryluk P. Kent (4.3%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 5 | $34.0m | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 3 | $2.6m | 0 | — | — |
| Q2 2025 | 1 | $45.3k | 0 | — | — |
| Q3 2025 | 1 | $12.0m | 0 | — | — |
| Q4 2025 | 2 | $537.8k | 0 | — | — |
| Q1 2026 | 1 | $525.6k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-13 | Hawryluk P. Kent President & CEO, director · By Trust | Bought | $525.6k18.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 5.11% of their portfolio | 6.7m $198.6m | Unchanged |
| ORBIMED ADVISORS LLC 2.37% of their portfolio | 3.6m $108.6m | Reduced -297.3k |
| NEA Management Company, LLC 6.13% of their portfolio | 3.6m $107.9m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 3.2m $95.3m | Reduced -158.1k |
| BlackRock, Inc. 0.00% of their portfolio | 2.9m $87.8m | Added +21.6k |
| FMR LLC 0.00% of their portfolio | 2.9m $87.7m | Added +2.9m |
| Deep Track Capital, LP 1.70% of their portfolio | 2.8m $82.3m | Reduced -492.2k |
| NVP ASSOCIATES, LLC 36.20% of their portfolio | 2.1m $63.8m | Unchanged |
| Polar Capital Holdings Plc 0.21% of their portfolio | 1.6m $48.4m | New |
| BRAIDWELL LP 1.49% of their portfolio | 1.5m $44.6m | Added +473.9k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.5m $44.1m | First filing |
| Aaron Wealth Advisors LLC 2.01% of their portfolio | 1.2m $34.9m | Added +1.1m |
| Cormorant Asset Management, LP 1.69% of their portfolio | 1.1m $33.4m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.0m $30.7m | Added +188.5k |
| Driehaus Capital Management LLC 0.22% of their portfolio | 1.0m $30.4m | Reduced -389.9k |
| STEMPOINT CAPITAL LP 2.89% of their portfolio | 998.9k $29.8m | Added +920.4k |
| Kynam Capital Management, LP 1.77% of their portfolio | 934.8k $27.9m | Unchanged |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 932.8k $27.8m | Added +123.0k |
| Woodline Partners LP 0.10% of their portfolio | 900.1k $26.9m | Reduced -100.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.44% of their portfolio | 890.0k $26.6m | Unchanged |
| Caligan Partners LP 1.79% of their portfolio | 848.6k $25.3m | New |
| Parkman Healthcare Partners LLC 2.48% of their portfolio | 800.0k $23.9m | Reduced -85.6k |
| STATE STREET CORP 0.00% of their portfolio | 787.2k $23.5m | Added +114.5k |
| EcoR1 Capital, LLC 0.99% of their portfolio | 777.0k $23.2m | Reduced -1.3m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 670.4k $20.0m | Added +21.0k |
| TCG Crossover Management, LLC 0.56% of their portfolio | 650.0k $19.4m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 564.4k $16.8m | Added +102.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 457.9k $13.7m | Added +126.0k |
| UBS Group AG 0.00% of their portfolio | 346.9k $10.4m | Added +65.7k |
| Candriam S.C.A. 0.05% of their portfolio | 294.4k $8.8m | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 293.3k $8.8m | First filing |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 288.9k $8.6m | Reduced -382.9k |
| Rock Springs Capital Management LP 0.51% of their portfolio | 288.0k $8.6m | Added +5.3k |
| Opaleye Management Inc. 1.02% of their portfolio | 260.0k $7.8m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 214.9k $6.4m | Reduced -7.3k |
| Elmind Capital, LP 1.79% of their portfolio | 211.0k $6.3m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 210.6k $6.3m | Added +19.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.14% of their portfolio | 208.0k $6.2m | New |
| Soleus Capital Management, L.P. 0.22% of their portfolio | 178.9k $5.3m | Reduced -230.0k |
| DAFNA Capital Management LLC 1.19% of their portfolio | 175.5k $5.2m | Added +10.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 170.2k $5.1m | First filing |
| Goelzer Investment Management, Inc. 0.24% of their portfolio | 164.2k $4.9m | Reduced -57.5k |
| Affinity Asset Advisors, LLC 0.26% of their portfolio | 150.0k $4.5m | Reduced -100.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 147.1k $4.0m | Added +132.4k |
| Tetragon Partners GP Ltd 0.85% of their portfolio | 145.5k $4.3m | Added +2.2k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 123.8k $3.7m | Reduced -43.3k |
| KVP Capital Advisors, LP 2.71% of their portfolio | 121.5k $3.6m | Unchanged |
| TD Asset Management Inc 0.00% of their portfolio | 116.0k $3.5m | Added +14.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 115.1k $3.4m | Reduced -23.5k |
| Burkehill Global Management, LP 0.15% of their portfolio | 100.0k $3.0m | Unchanged |
| Squarepoint Ops LLC 0.01% of their portfolio | 97.2k $2.9m | Added +50.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 90.6k $2.7m | Added +21.1k |
| Nuveen, LLC 0.00% of their portfolio | 81.8k $2.4m | Added +6.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 80.2k $2.4m | Added +5.0k |
| PFM Health Sciences, LP 0.23% of their portfolio | 71.9k $2.1m | Reduced -7.4k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 71.0k $2.1m | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 62.7k $1.9m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 57.3k $1.5m | Reduced -16.4k |
| XTX Topco Ltd 0.03% of their portfolio | 53.2k $1.6m | Added +33.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 46.8k $1.4m | New |
| Swiss National Bank 0.00% of their portfolio | 44.4k $1.3m | New |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.33% of their portfolio | 43.6k $1.3m | Unchanged |
| ALPS ADVISORS INC 0.01% of their portfolio | 36.5k $1.1m | Reduced -322 |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 36.0k $1.1m | New |
| Creative Planning 0.00% of their portfolio | 36.0k $1.1m | Added +2.3k |
| EXCHANGE TRADED CONCEPTS, LLC 0.01% of their portfolio | 34.3k $1.0m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 33.9k $1.0m | Added +451 |
| MORGAN STANLEY 0.00% of their portfolio | 31.6k $942.1k | Reduced -27.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 30.5k $962.0k | Added +2.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 28.8k $858.2k | Reduced -9.1k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 28.1k $838.4k | Reduced -28.9k |
| Invesco Ltd. 0.00% of their portfolio | 27.5k $821.6k | Added +6.3k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.4k $817.5k | Reduced -4.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 22.9k $685.1k | Added +2.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 22.8k $679.5k | Added +21.0k |
| Cerity Partners LLC 0.00% of their portfolio | 21.2k $631.7k | Reduced -160 |
| Legal & General Group Plc 0.00% of their portfolio | 19.4k $577.8k | Added +16.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 19.3k $575.0k | New |
| Koa Wealth Management, LLC 0.39% of their portfolio | 17.9k $534.7k | Reduced -500 |
| Engineers Gate Manager LP 0.01% of their portfolio | 17.4k $518.8k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 17.2k $513.0k | Reduced -6.0k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 16.0k $478.4k | First filing |
| MetLife Investment Management, LLC 0.00% of their portfolio | 16.0k $478.1k | Unchanged |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 14.8k $440.3k | First filing |
| OPTIMIZE FINANCIAL INC. 0.21% of their portfolio | 14.5k $433.1k | New |
| CITIGROUP INC 0.00% of their portfolio | 13.5k $402.9k | Reduced -2.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 13.3k $397.8k | Added +67 |
| Jump Financial, LLC 0.01% of their portfolio | 12.7k $379.1k | New |
| Swiss Life Asset Management Ltd 0.00% of their portfolio | 12.1k $657.2k | New |
| BARCLAYS PLC 0.00% of their portfolio | 11.8k $353.4k | Reduced -40.9k |
| HighVista Strategies LLC 0.09% of their portfolio | 11.5k $342.4k | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 10.9k $325.4k | Reduced -700 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 10.8k $321.2k | Reduced -21.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 10.4k $310.0k | Added +3.6k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 10.3k $308.2k | New |
| Verition Fund Management LLC 0.00% of their portfolio | 10.2k $305.1k | Reduced -47.4k |
| Aquatic Capital Management LLC 0.01% of their portfolio | 10.2k $303.1k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 9.5k $283.2k | Reduced -67.0k |
| Virtus Investment Advisers, LLC 0.08% of their portfolio | 9.1k $272.6k | Added +221 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 9.0k $268.6k | Added +4.7k |