MBX BIOSCIENCES INC MBX
COM · Common Stock · CUSIP 55287L101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarmel, IN
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($72.0k this quarter). Holder counts are more reliable. Shares outstanding: 44.9m as of 2025-11-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $31.54. Options: 6 managers hold calls ($4.1m notional), 5 hold puts ($14.0m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 46 |
| Q4 2024 | 64 |
| Q1 2025 | 80 |
| Q2 2025 | 89 |
| Q3 2025 | 118 |
| Q4 2025 | 138 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 42 | 21 |
| Q1 2025 | 49 | 23 |
| Q2 2025 | 60 | 26 |
| Q3 2025 | 68 | 38 |
| Q4 2025 | 92 | 49 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $848.2k | $1.6m | 1.92 |
| Q3 2025 | $15.3m | $29.0m | 1.89 |
| Q4 2025 | $4.1m | $14.0m | 3.42 |
Biggest buyers
| BRAIDWELL LP | New | +1.0m |
| BlackRock, Inc. | Added | +962.3k |
| EVENTIDE ASSET MANAGEMENT, LLC | New | +890.0k |
| D. E. Shaw & Co., Inc. | New | +671.8k |
| STATE STREET CORP | Added | +353.5k |
| Goelzer Investment Management, Inc. | New | +221.7k |
| UBS Group AG | Added | +220.5k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +175.5k |
| VANGUARD GROUP INC | Added | +140.4k |
| Soleus Capital Management, L.P. | Added | +133.9k |
Biggest sellers
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -1.5m |
| FRANKLIN RESOURCES INC | Sold out | -1.3m |
| Kynam Capital Management, LP | Reduced | -1.1m |
| BAKER BROS. ADVISORS LP | Sold out | -277.8k |
| Longaeva Partners L.P. | Sold out | -224.4k |
| Woodline Partners LP | Reduced | -201.1k |
| SECTORAL ASSET MANAGEMENT INC | Sold out | -194.9k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -193.4k |
| CITADEL ADVISORS LLC | Reduced | -186.2k |
| PFM Health Sciences, LP | Reduced | -142.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.6m49.9k shares |
| Caption Management, LLC | Reduced | $791.7k25.1k shares |
| CITADEL ADVISORS LLC | Reduced | $533.0k16.9k shares |
| JANE STREET GROUP, LLC | New | $520.4k16.5k shares |
| GROUP ONE TRADING LLC | Reduced | $507.8k16.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $167.2k5.3k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $7.2m228.0k shares |
| 683 Capital Management, LLC | Reduced | $5.0m158.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.4m44.7k shares |
| CITADEL ADVISORS LLC | Reduced | $271.2k8.6k shares |
| GROUP ONE TRADING LLC | Reduced | $113.5k3.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Frazier Life Sciences Public Fund, L.P.
13D · may seek influence
no change · filed 2026-08-10
Stated purposeItem 4 is hereby amended to remove references to "FLSPOF" and the "FLSPOF Shares" from the first paragraph. Full filing |
11.7% |
| FMR LLC 13G · institution +5.0 pts · filed 2026-07-08 | 11.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution +3.0 pts · filed 2026-07-08 | 10.5% |
New Enterprise Associates 17, L.P.
13D · may seek influence
filed 2025-11-10
Stated purposeNEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of dire… Full filing |
8.1% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.3 pts · filed 2026-08-10
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
6.4% |
| BlackRock, Inc. 13G · institution +0.7 pts · filed 2026-07-29 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-06-24 | 5.2% |
Fell to 5% or below in the last year: Deep Track Capital, LP (3.6%, 2026-08-14), Hawryluk P. Kent (4.3%, 2025-11-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 5 | $34.0m | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 3 | $2.6m | 0 | — | — |
| Q2 2025 | 1 | $45.3k | 0 | — | — |
| Q3 2025 | 1 | $12.0m | 0 | — | — |
| Q4 2025 | 2 | $537.8k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-10-20 | Hawryluk P. Kent President & CEO, director · By Trust | Bought | $272.8k20.0k shares |
| 2025-10-17 | Hoerter Steven L. Director · By Trust | Bought | $265.0k20.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 5.64% of their portfolio | 6.7m $209.8m | Unchanged |
| ORBIMED ADVISORS LLC 2.54% of their portfolio | 3.9m $124.1m | Reduced -67.7k |
| NEA Management Company, LLC 5.81% of their portfolio | 3.6m $114.0m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 3.3m $105.7m | Reduced -1.5m |
| Deep Track Capital, LP 2.34% of their portfolio | 3.2m $102.5m | Added +99.8k |
| BlackRock, Inc. 0.00% of their portfolio | 2.9m $92.1m | Added +962.3k |
| NVP ASSOCIATES, LLC 26.40% of their portfolio | 2.1m $67.4m | Unchanged |
| EcoR1 Capital, LLC 3.06% of their portfolio | 2.1m $67.0m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.8m $57.3m | Added +140.4k |
| Driehaus Capital Management LLC 0.30% of their portfolio | 1.4m $44.4m | Reduced -131.5k |
| Cormorant Asset Management, LP 2.00% of their portfolio | 1.1m $35.3m | Reduced -105.0k |
| BRAIDWELL LP 1.03% of their portfolio | 1.0m $32.1m | New |
| Woodline Partners LP 0.12% of their portfolio | 1.0m $31.5m | Reduced -201.1k |
| Kynam Capital Management, LP 1.92% of their portfolio | 934.8k $29.5m | Reduced -1.1m |
| EVENTIDE ASSET MANAGEMENT, LLC 0.44% of their portfolio | 890.0k $28.1m | New |
| Parkman Healthcare Partners LLC 2.66% of their portfolio | 885.6k $27.9m | Added +112.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 840.5k $26.5m | Reduced -114.2k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 809.9k $25.5m | Reduced -186.2k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 680.6k $21.5m | Added +52.9k |
| STATE STREET CORP 0.00% of their portfolio | 672.7k $21.2m | Added +353.5k |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 671.8k $21.2m | New |
| TCG Crossover Management, LLC 0.68% of their portfolio | 650.0k $20.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 649.4k $20.5m | Added +175.5k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 462.0k $14.6m | Reduced -193.4k |
| Soleus Capital Management, L.P. 0.55% of their portfolio | 408.9k $12.9m | Added +133.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 331.9k $10.5m | Reduced -26.2k |
| Trails Edge Capital Partners, LP 2.46% of their portfolio | 315.2k $9.9m | First filing |
| Rock Springs Capital Management LP 0.46% of their portfolio | 282.6k $8.9m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 281.2k $8.9m | Added +220.5k |
| Opaleye Management Inc. 1.08% of their portfolio | 260.0k $8.2m | Added +7.0k |
| Affinity Asset Advisors, LLC 0.57% of their portfolio | 250.0k $7.9m | Added +85.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 222.2k $7.0m | Added +52.2k |
| Goelzer Investment Management, Inc. 0.32% of their portfolio | 221.7k $7.0m | New |
| Elmind Capital, LP 1.96% of their portfolio | 211.0k $6.7m | First filing |
| NORTHERN TRUST CORP 0.00% of their portfolio | 190.9k $6.0m | Added +57.6k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 167.1k $5.3m | Reduced -115.6k |
| DAFNA Capital Management LLC 1.21% of their portfolio | 165.3k $5.2m | Added +80.3k |
| Tetragon Partners GP Ltd 0.95% of their portfolio | 143.3k $4.5m | Reduced -34.5k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 138.6k $4.4m | Added +125.0k |
| KVP Capital Advisors, LP 3.96% of their portfolio | 121.5k $3.8m | First filing |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 119.7k $3.8m | Added +94.1k |
| TD Asset Management Inc 0.00% of their portfolio | 101.5k $3.2m | Reduced -17.3k |
| Burkehill Global Management, LP 0.21% of their portfolio | 100.0k $3.2m | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 86.6k $2.7m | New |
| PFM Health Sciences, LP 0.25% of their portfolio | 79.3k $2.5m | Reduced -142.2k |
| STEMPOINT CAPITAL LP 0.43% of their portfolio | 78.6k $2.5m | Added +3.6k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 77.6k $2.4m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 76.5k $2.4m | New |
| Nuveen, LLC 0.00% of their portfolio | 75.6k $2.4m | Added +53.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 75.3k $2.4m | Added +27.5k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 73.7k $2.3m | Reduced -10.0k |
| Aaron Wealth Advisors LLC 0.12% of their portfolio | 70.0k $2.2m | Added +20.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 69.6k $2.2m | Added +1.2k |
| MORGAN STANLEY 0.00% of their portfolio | 59.0k $1.9m | Added +14.2k |
| Verition Fund Management LLC 0.01% of their portfolio | 57.6k $1.8m | New |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 57.0k $1.8m | Reduced -43.0k |
| BARCLAYS PLC 0.00% of their portfolio | 52.7k $1.7m | Added +31.1k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 48.6k $1.5m | Added +43.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 46.7k $1.5m | New |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.32% of their portfolio | 43.6k $1.4m | Reduced -25.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 37.9k $1.2m | Added +11.3k |
| ALPS ADVISORS INC 0.01% of their portfolio | 36.9k $1.2m | Added +20.0k |
| Creative Planning 0.00% of their portfolio | 33.7k $1.1m | Added +4.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 33.4k $1.1m | Added +11.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 32.6k $1.0m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 31.9k $1.0m | Added +20.2k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 31.4k $990.6k | Added +15.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 27.9k $880.0k | Added +17.4k |
| Brevan Howard Capital Management LP 0.02% of their portfolio | 25.7k $809.4k | New |
| Trexquant Investment LP 0.01% of their portfolio | 24.3k $765.4k | New |
| FOX RUN MANAGEMENT, L.L.C. 0.12% of their portfolio | 23.8k $751.3k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 23.2k $732.1k | New |
| Cerity Partners LLC 0.00% of their portfolio | 21.3k $672.5k | New |
| Invesco Ltd. 0.00% of their portfolio | 21.2k $668.7k | Added +9.4k |
| XTX Topco Ltd 0.02% of their portfolio | 20.1k $635.2k | Reduced -18.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 20.0k $631.7k | Added +9.1k |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 19.3k $609.0k | New |
| Koa Wealth Management, LLC 0.40% of their portfolio | 18.4k $580.7k | Reduced -8.3k |
| Seven Fleet Capital Management LP 0.39% of their portfolio | 18.2k $574.0k | First filing |
| CITIGROUP INC 0.00% of their portfolio | 16.4k $517.0k | Added +16.2k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 16.0k $505.2k | Added +5.0k |
| FMR LLC 0.00% of their portfolio | 15.7k $496.6k | Reduced -53.2k |
| China Universal Asset Management Co., Ltd. 0.04% of their portfolio | 15.3k $483.1k | Added +10.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 14.6k $461.9k | Added +2.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 13.3k $418.2k | Added +6.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 12.2k $385.9k | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 11.6k $365.9k | New |
| Graham Capital Management, L.P. 0.01% of their portfolio | 11.3k $355.0k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 10.4k $225.7k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 10.0k $315.4k | Reduced -4.2k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 9.4k $297.4k | New |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 9.2k $290.6k | New |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 8.9k $281.5k | New |
| Virtus Investment Advisers, LLC 0.08% of their portfolio | 8.9k $281.0k | Reduced -1.7k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 8.1k $255.9k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 7.7k $241.5k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 7.5k $237.2k | Added +3.0k |
| ProShare Advisors LLC 0.00% of their portfolio | 7.2k $226.7k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 6.9k $216.3k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 6.8k $214.0k | Added +3.9k |