MBX BIOSCIENCES INC MBX
COM · Common Stock · CUSIP 55287L101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarmel, IN
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($24.5k this quarter). Holder counts are more reliable. Shares outstanding: 33.6m as of 2025-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $11.41. Options: 4 managers hold calls ($848.2k notional), 4 hold puts ($1.6m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 46 |
| Q4 2024 | 64 |
| Q1 2025 | 80 |
| Q2 2025 | 89 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 42 | 21 |
| Q1 2025 | 49 | 23 |
| Q2 2025 | 60 | 26 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $0 | $0 | — |
| Q4 2024 | $0 | $0 | — |
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $848.2k | $1.6m | 1.92 |
Biggest buyers
| Point72 Asset Management, L.P. | Added | +863.3k |
| MILLENNIUM MANAGEMENT LLC | Added | +596.4k |
| Parkman Healthcare Partners LLC | Added | +543.6k |
| Schonfeld Strategic Advisors LLC | Added | +430.8k |
| VANGUARD GROUP INC | Added | +378.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +246.0k |
| Sio Capital Management, LLC | New | +241.0k |
| BlackRock, Inc. | Added | +228.5k |
| SECTORAL ASSET MANAGEMENT INC | New | +191.8k |
| MPM BIOIMPACT LLC | Added | +161.5k |
Biggest sellers
| RA CAPITAL MANAGEMENT, L.P. | Reduced | -1.1m |
| Deep Track Capital, LP | Reduced | -830.3k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -371.9k |
| JPMORGAN CHASE & CO | Reduced | -193.1k |
| Affinity Asset Advisors, LLC | Sold out | -175.0k |
| MARSHALL WACE, LLP | Sold out | -111.2k |
| EcoR1 Capital, LLC | Reduced | -109.5k |
| CITIGROUP INC | Reduced | -91.6k |
| MORGAN STANLEY | Reduced | -90.6k |
| PLATINUM INVESTMENT MANAGEMENT LTD | Reduced | -73.2k |
Biggest calls
| MILLENNIUM MANAGEMENT LLC | New | $585.3k51.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $257.9k22.6k shares |
| SIMPLEX TRADING, LLC | New | $5.0k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | New | $745.0k65.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $645.8k56.6k shares |
| CITADEL ADVISORS LLC | New | $236.2k20.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Frazier Life Sciences Public Fund, L.P.
13D · may seek influence
no change · filed 2026-08-10
Stated purposeItem 4 is hereby amended to remove references to "FLSPOF" and the "FLSPOF Shares" from the first paragraph. Full filing |
11.7% |
| FMR LLC 13G · institution +5.0 pts · filed 2026-07-08 | 11.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution +3.0 pts · filed 2026-07-08 | 10.5% |
New Enterprise Associates 17, L.P.
13D · may seek influence
filed 2025-11-10
Stated purposeNEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of dire… Full filing |
8.1% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.3 pts · filed 2026-08-10
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
6.4% |
| BlackRock, Inc. 13G · institution +0.7 pts · filed 2026-07-29 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-06-24 | 5.2% |
Fell to 5% or below in the last year: Deep Track Capital, LP (3.6%, 2026-08-14), Hawryluk P. Kent (4.3%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 5 | $34.0m | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 3 | $2.6m | 0 | — | — |
| Q2 2025 | 1 | $45.3k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-04-08 | Pescovitz Ora H. Director | Bought | $45.3k7.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 2.73% of their portfolio | 6.0m $68.3m | Unchanged |
| ORBIMED ADVISORS LLC 1.15% of their portfolio | 4.0m $45.7m | Unchanged |
| NEA Management Company, LLC 3.10% of their portfolio | 3.6m $41.2m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 2.3m $25.9m | Reduced -371.9k |
| Deep Track Capital, LP 0.80% of their portfolio | 2.2m $25.0m | Reduced -830.3k |
| NVP ASSOCIATES, LLC 13.24% of their portfolio | 2.1m $24.4m | Unchanged |
| Driehaus Capital Management LLC 0.14% of their portfolio | 1.6m $17.9m | Reduced -7.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.3m $15.4m | Added +246.0k |
| MPM BIOIMPACT LLC 2.56% of their portfolio | 1.3m $14.8m | Added +161.5k |
| EcoR1 Capital, LLC 0.78% of their portfolio | 1.1m $13.1m | Reduced -109.5k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.0m $11.9m | Added +378.1k |
| BlackRock, Inc. 0.00% of their portfolio | 1.0m $11.5m | Added +228.5k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 973.8k $11.1m | Added +863.3k |
| Woodline Partners LP 0.05% of their portfolio | 901.1k $10.3m | Added +23.6k |
| Parkman Healthcare Partners LLC 1.15% of their portfolio | 871.9k $9.9m | Added +543.6k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 766.8k $8.7m | Added +596.4k |
| Cormorant Asset Management, LP 0.59% of their portfolio | 700.0k $8.0m | Unchanged |
| TCG Crossover Management, LLC 0.85% of their portfolio | 650.0k $7.4m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.05% of their portfolio | 631.4k $7.2m | Added +430.8k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 494.9k $5.6m | Added +125.5k |
| RA CAPITAL MANAGEMENT, L.P. 0.07% of their portfolio | 377.8k $4.3m | Reduced -1.1m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 348.4k $4.0m | Added +74.0k |
| STATE STREET CORP 0.00% of their portfolio | 265.1k $3.0m | Added +87.9k |
| Sio Capital Management, LLC 1.10% of their portfolio | 241.0k $2.7m | New |
| Opaleye Management Inc. 0.55% of their portfolio | 239.3k $2.7m | Reduced -10.7k |
| SECTORAL ASSET MANAGEMENT INC 1.45% of their portfolio | 191.8k $2.2m | New |
| TD Asset Management Inc 0.00% of their portfolio | 171.3k $2.0m | Added +19.8k |
| STEMPOINT CAPITAL LP 0.52% of their portfolio | 141.0k $1.6m | Added +44.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 115.6k $1.3m | Added +19.1k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.09% of their portfolio | 112.7k $1.3m | Reduced -73.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 107.5k $1.2m | Added +12.9k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 87.1k $993.8k | Added +37.0k |
| Walleye Capital LLC 0.01% of their portfolio | 70.3k $802.5k | Added +37.8k |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 68.3k $779.0k | New |
| Exome Asset Management LLC 0.61% of their portfolio | 63.1k $719.7k | Reduced -70.0k |
| FMR LLC 0.00% of their portfolio | 61.3k $699.8k | Added +17.1k |
| BARCLAYS PLC 0.00% of their portfolio | 58.5k $668.0k | Added +46.7k |
| Aaron Wealth Advisors LLC 0.06% of their portfolio | 50.0k $570.5k | Unchanged |
| Resolute Capital Asset Partners LLC 0.30% of their portfolio | 49.7k $566.7k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 42.4k $483.6k | Added +14.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 38.0k $433.9k | Added +14.1k |
| Koa Wealth Management, LLC 0.29% of their portfolio | 31.8k $362.3k | Added +12.4k |
| UBS Group AG 0.00% of their portfolio | 31.0k $353.3k | Added +3.5k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 29.2k $333.2k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 27.6k $315.3k | Added +14.0k |
| MORGAN STANLEY 0.00% of their portfolio | 24.0k $273.9k | Reduced -90.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 23.7k $270.0k | Added +14.9k |
| Nuveen, LLC 0.00% of their portfolio | 22.1k $252.7k | Added +7.7k |
| ALPS ADVISORS INC 0.00% of their portfolio | 18.0k $205.9k | Reduced -8.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 18.0k $205.4k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 15.6k $178.2k | Reduced -24.6k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 14.3k $162.8k | Added +3.5k |
| XTX Topco Ltd 0.01% of their portfolio | 11.9k $135.3k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 11.0k $125.7k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 10.9k $124.9k | Added +5.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 10.5k $119.8k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 9.3k $106.4k | Added +2.7k |
| Virtus Investment Advisers, LLC 0.03% of their portfolio | 8.8k $100.1k | Added +766 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.8k $100.0k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 8.2k $93.4k | Reduced -193.1k |
| Quarry LP 0.02% of their portfolio | 8.0k $91.3k | New |
| CITIGROUP INC 0.00% of their portfolio | 5.7k $65.3k | Reduced -91.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 4.3k $49.1k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2.6k $30.0k | Added +2.0k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 2.1k $24.5k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.1k $24.1k | Added +745 |
| CWM, LLC 0.00% of their portfolio | 1.8k $21.0k | Added +1.7k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.6k $18.2k | New |
| Legal & General Group Plc 0.00% of their portfolio | 1.6k $17.7k | Added +444 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 1.3k $15.2k | Reduced -29.6k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 1.2k $13.4k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.1k $12.1k | Added +232 |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 761 $8.7k | New |
| STRS OHIO 0.00% of their portfolio | 700 $8.0k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 460 $5.2k | Added +369 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 411 $4.0k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 384 $4.0k | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 337 $3.8k | Added +7 |
| GAMMA Investing LLC 0.00% of their portfolio | 299 $3.4k | Added +279 |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 109 $1.2k | New |
| Parallel Advisors, LLC 0.00% of their portfolio | 108 $1.2k | New |
| SIGNATUREFD, LLC 0.00% of their portfolio | 101 $1.2k | New |
| Rise Advisors, LLC 0.00% of their portfolio | 68 $776 | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 35 $399 | New |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 29 $331 | Added +20 |
| Allworth Financial LP 0.00% of their portfolio | 25 $286 | New |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 20 $228 | New |
| Essential Partners LLC 0.00% of their portfolio | 2 $23 | First filing |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |