Vault-13

MBX BIOSCIENCES INC MBX

COM · Common Stock · CUSIP 55287L101

80 institutional holders +16 vs Q4 2024
35,666,44935.7m shares reported held*
106.7% of all shares outstanding*
$263.2mreported value*
26 new 23 added 15 reduced 8 sold out net bought ≈ $20.1m (+2.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 33.4m as of 2025-03-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.38.

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

050100Q3 24: 46Q4 24: 64Q1 25: 8080Q3 24Q4 24Q1 25
Numbers
QuarterHolders
Q3 202446
Q4 202464
Q1 202580

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q4 24: 42 bought or addedQ4 24: 21 cut or sold outQ4 24Q1 25: 49 bought or addedQ1 25: 23 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q4 20244221
Q1 20254923

Biggest buyers

MPM BIOIMPACT LLC New +1,132,950+1.1m
Woodline Partners LP Added +268,740+268.7k
Opaleye Management Inc. New +250,000+250.0k
JPMORGAN CHASE & CO Added +192,129+192.1k
ORBIMED ADVISORS LLC Added +190,672+190.7k
Affinity Asset Advisors, LLC New +175,000+175.0k
Parkman Healthcare Partners LLC Added +158,323+158.3k
Exome Asset Management LLC New +133,113+133.1k
Schonfeld Strategic Advisors LLC Added +129,142+129.1k
TD Asset Management Inc Added +114,904+114.9k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -271,118-271.1k
CITADEL ADVISORS LLC Sold out -220,330-220.3k
Alyeska Investment Group, L.P. Sold out -174,700-174.7k
MILLENNIUM MANAGEMENT LLC Reduced -163,202-163.2k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -60,611-60.6k
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY Sold out -26,708-26.7k
GOLDMAN SACHS GROUP INC Reduced -19,659-19.7k
UBS Group AG Reduced -18,402-18.4k
Saturn V Capital Management LP Sold out -18,000-18.0k
BIT Capital GmbH Sold out -12,743-12.7k

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Frazier Life Sciences Public Fund, L.P. 13D · may seek influence no change · filed 2026-08-10
Stated purposeItem 4 is hereby amended to remove references to "FLSPOF" and the "FLSPOF Shares" from the first paragraph. Full filing
11.7% no change 5.2m≈ $289.4m 2026-08-10
FMR LLC 13G · institution +5.0 pts · filed 2026-07-08 11.2% +5.0 pts 5.3m≈ $293.8m 2026-07-08
WELLINGTON MANAGEMENT GROUP LLP 13G · institution +3.0 pts · filed 2026-07-08 10.5% +3.0 pts 5.0m≈ $274.8m 2026-07-08
New Enterprise Associates 17, L.P. 13D · may seek influence filed 2025-11-10
Stated purposeNEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of dire… Full filing
8.1% 3.6m≈ $199.8m 2025-11-10
ORBIMED ADVISORS LLC 13D · may seek influence -1.3 pts · filed 2026-08-10
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing
6.4% -1.3 pts 3.1m≈ $169.7m 2026-08-10
BlackRock, Inc. 13G · institution +0.7 pts · filed 2026-07-29 5.5% +0.7 pts 2.6m≈ $145.1m 2026-07-29
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-06-24 5.2% new 2.5m≈ $137.6m 2026-06-24

Fell to 5% or below in the last year: Deep Track Capital, LP (3.6%, 2026-08-14), Hawryluk P. Kent (4.3%, 2025-11-14)

Insider purchases and sales in Q1 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
505Q2 23: 0 buyingQ2 23: 0 sellingQ3 23: 0 buyingQ3 23: 0 sellingQ3 23Q4 23: 0 buyingQ4 23: 0 sellingQ1 24: 0 buyingQ1 24: 0 sellingQ1 24Q2 24: 0 buyingQ2 24: 0 sellingQ3 24: 5 buyingQ3 24: 0 sellingQ3 24Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 3 buyingQ1 25: 0 sellingQ1 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20230—0——
Q3 20230—0——
Q4 20230—0——
Q1 20240—0——
Q2 20240—0——
Q3 20245$34.0m0——
Q4 20240—0——
Q1 20253$2.6m0——
DateInsiderTradeSharesPrice ValueTheir holding
2025-02-18 ORBIMED ADVISORS LLC +2 Director · See footnotes Bought 143,170 $10.84 $1.6m143.2k shares +24%
2025-02-18 GORDON CARL L Director · See footnotes Bought 143,170 $10.84 $1.6m143.2k shares +24%
2025-02-14 ORBIMED ADVISORS LLC +2 Director · See footnotes Bought 47,502 $9.87 $468.8k47.5k shares +2%
2025-02-14 GORDON CARL L Director · See footnotes Bought 47,502 $9.87 $468.8k47.5k shares +2%
2025-02-04 Hawryluk P. Kent President & CEO, director · By Trust Bought 50,000 $10.69 $534.5k50.0k shares +13%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Frazier Life Sciences Management, L.P. 2.02% of their portfolio PALO ALTO, CA 5,985,3476.0m $44.2m $44.2m 2.02% Unchanged
2 ORBIMED ADVISORS LLC 0.71% of their portfolio New York, NY 4,002,8874.0m $29.5m $29.5m 0.71% Added +190.7k +190,672
3 NEA Management Company, LLC 2.05% of their portfolio TIMONIUM, MD 3,614,4863.6m $26.7m $26.7m 2.05% Unchanged
4 Deep Track Capital, LP 0.72% of their portfolio GREENWICH, CT 3,018,9353.0m $22.3m $22.3m 0.72% Unchanged
5 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 2,638,5212.6m $19.5m $19.5m 0.00% Reduced -271.1k -271,118
6 NVP ASSOCIATES, LLC 14.05% of their portfolio MENLO PARK, CA 2,136,3352.1m $15.8m $15.8m 14.05% Unchanged
7 Driehaus Capital Management LLC 0.11% of their portfolio Chicago, IL 1,579,2071.6m $11.7m $11.7m 0.11% Reduced -2.6k -2,553
8 RA CAPITAL MANAGEMENT, L.P. 0.19% of their portfolio BOSTON, MA 1,511,3341.5m $11.2m $11.2m 0.19% Unchanged
9 EcoR1 Capital, LLC 0.55% of their portfolio San Francisco, CA 1,259,2731.3m $9.3m $9.3m 0.55% Unchanged
10 MPM BIOIMPACT LLC 1.44% of their portfolio BOSTON, MA 1,132,9501.1m $8.4m $8.4m 1.44% New
11 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,100,9161.1m $8.1m $8.1m 0.00% Reduced -60.6k -60,611
12 Woodline Partners LP 0.04% of their portfolio San Francisco, CA 877,461877.5k $6.5m $6.5m 0.04% Added +268.7k +268,740
13 BlackRock, Inc. 0.00% of their portfolio New York, NY 783,042783.0k $5.8m $5.8m 0.00% Added +55.1k +55,090
14 Cormorant Asset Management, LP 0.39% of their portfolio BOSTON, MA 700,000700.0k $5.2m $5.2m 0.39% Unchanged
15 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 665,563665.6k $4.9m $4.9m 0.00% Reduced -5.4k -5,385
16 TCG Crossover Management, LLC 0.65% of their portfolio PALO ALTO, CA 650,000650.0k $4.8m $4.8m 0.65% Unchanged
17 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 369,315369.3k $2.7m $2.7m 0.00% Added +15 +15
18 Parkman Healthcare Partners LLC 0.29% of their portfolio STAMFORD, CT 328,323328.3k $2.4m $2.4m 0.29% Added +158.3k +158,323
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 274,458274.5k $2.0m $2.0m 0.00% Added +8.8k +8,755
20 Opaleye Management Inc. 0.41% of their portfolio BOSTON, MA 250,000250.0k $1.8m $1.8m 0.41% New
21 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 201,235201.2k $1.5m $1.5m 0.00% Added +192.1k +192,129
22 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 200,642200.6k $1.5m $1.5m 0.01% Added +129.1k +129,142
23 PLATINUM INVESTMENT MANAGEMENT LTD 0.08% of their portfolio SYDNEY AUSTRALIA 2000, C3 185,932185.9k $1.4m $1.4m 0.08% Added +23.8k +23,842
24 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 177,220177.2k $1.3m $1.3m 0.00% Added +34.6k +34,571
25 Affinity Asset Advisors, LLC 0.20% of their portfolio NEW YORK, NY 175,000175.0k $1.3m $1.3m 0.20% New
26 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 170,440170.4k $1.3m $1.3m 0.00% Reduced -163.2k -163,202
27 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 151,504151.5k $1.1m $1.1m 0.00% Added +114.9k +114,904
28 Exome Asset Management LLC 0.88% of their portfolio NEW YORK, NY 133,113133.1k $982.4k $982.4k 0.88% New
29 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 114,610114.6k $845.8k $845.8k 0.00% Added +90.8k +90,775
30 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 111,211111.2k $820.7k $820.7k 0.00% Added +85.3k +85,311
31 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 110,482110.5k $815.4k $815.4k 0.00% New
32 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 97,32897.3k $718.3k $718.3k 0.00% Added +88.5k +88,464
33 STEMPOINT CAPITAL LP 0.23% of their portfolio NEW YORK, NY 96,61596.6k $713.0k $713.0k 0.23% New
34 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 96,50796.5k $712.2k $712.2k 0.00% Added +5.8k +5,825
35 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 94,54694.5k $697.7k $697.7k 0.00% Added +1.2k +1,235
36 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 50,11050.1k $369.8k $369.8k 0.00% Added +435 +435
37 Aaron Wealth Advisors LLC 0.04% of their portfolio Chicago, IL 50,00050.0k $369.0k $369.0k 0.04% New
38 Shay Capital LLC 0.11% of their portfolio NEW YORK, NY 49,13349.1k $362.6k $362.6k 0.11% New
39 FMR LLC 0.00% of their portfolio BOSTON, MA 44,24044.2k $326.5k $326.5k 0.00% Added +19.7k +19,667
40 PRELUDE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 40,22540.2k $296.9k $296.9k 0.03% New
41 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 33,83333.8k $249.7k $249.7k 0.00% New
42 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 32,49032.5k $239.8k $239.8k 0.00% New
43 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 30,91630.9k $228.2k $228.2k 0.00% First filing
44 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 28,99629.0k $214.0k $214.0k 0.00% New
45 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 28,09028.1k $207.3k $207.3k 0.00% Added +12.0k +12,031
46 UBS Group AG 0.00% of their portfolio ZURICH, V8 27,49927.5k $202.9k $202.9k 0.00% Reduced -18.4k -18,402
47 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 26,03426.0k $192.1k $192.1k 0.00% Reduced -986 -986
48 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 23,91023.9k $176.5k $176.5k 0.00% Reduced -4 -4
49 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 20,09820.1k $148.3k $148.3k 0.00% New
50 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 19,81519.8k $146.2k $146.2k 0.00% New
51 Koa Wealth Management, LLC 0.12% of their portfolio Encinitas, CA 19,39619.4k $143.1k $143.1k 0.12% New
52 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 15,16815.2k $111.9k $111.9k 0.00% Reduced -19.7k -19,659
53 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 14,47114.5k $106.8k $106.8k 0.00% First filing
54 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 13,66013.7k $100.8k $100.8k 0.00% New
55 GSA CAPITAL PARTNERS LLP 0.01% of their portfolio LONDON, X0 12,36912.4k $91.0k $91.0k 0.01% New
56 WEALTHEDGE INVESTMENT ADVISORS, LLC 0.04% of their portfolio NEW YORK, NY 11,86411.9k $87.6k $87.6k 0.04% New
57 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 11,81811.8k $87.2k $87.2k 0.00% Reduced -5.6k -5,615
58 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 10,72810.7k $79.2k $79.2k 0.00% New
59 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 8,7628.8k $64.7k $64.7k 0.00% Added +4.4k +4,424
60 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 8,7128.7k $64.3k $64.3k 0.00% Reduced -760 -760
61 Virtus Investment Advisers, LLC 0.02% of their portfolio HARTFORD, CT 8,0068.0k $59.1k $59.1k 0.02% New
62 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 6,6476.6k $49.1k $49.1k 0.00% Added +312 +312
63 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 5,9776.0k $44.1k $44.1k 0.00% Added +133 +133
64 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 5,5115.5k $40.7k $40.7k 0.00% Reduced -82 -82
65 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 4,3004.3k $31.7k $31.7k 0.00% New
66 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 2,1432.1k $15.8k $15.8k 0.00% Unchanged
67 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,3651.4k $10.1k $10.1k 0.00% Added +562 +562
68 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 1,1771.2k $8.7k $8.7k 0.00% Unchanged
69 Legal & General Group Plc 0.00% of their portfolio London, X0 1,1071.1k $8.2k $8.2k 0.00% Unchanged
70 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 832832 $6.1k $6.1k 0.00% Unchanged
71 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 700700 $5.2k $5.2k 0.00% Reduced -1.4k -1,400
72 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 635635 $4.0k $4.0k 0.00% Reduced -198 -198
73 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 384384 $3.0k $3.0k 0.00% Unchanged
74 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 330330 $2.4k $2.4k 0.00% New
75 CWM, LLC 0.00% of their portfolio OMAHA, NE 137137 $1.0k $1.0k 0.00% New
76 Sterling Capital Management LLC 0.00% of their portfolio CHARLOTTE, NC 9191 $672 $672 0.00% Reduced -70 -70
77 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 2020 $148 $148 0.00% New
78 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 99 $66 $66 0.00% New
79 True Wealth Design, LLC 0.00% of their portfolio AKRON, OH 33 $23 $23 0.00% New
80 CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio BIRMINGHAM, AL 00 $0 $0 — Unchanged