LEXICON PHARMACEUTICALS INC LXRX
COM NEW · Common Stock · CUSIP 528872302 · ISIN US5288723027
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersThe Woodlands, TX
- Founded1995
- Websitelexpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($117.3k this quarter). Holder counts are more reliable. Shares outstanding: 445.0m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.40. Options: 5 managers hold calls ($5.1m notional), 4 hold puts ($165.6k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 105 |
| Q1 2023 | 105 |
| Q2 2023 | 124 |
| Q3 2023 | 113 |
| Q4 2023 | 108 |
| Q1 2024 | 119 |
| Q2 2024 | 128 |
| Q3 2024 | 138 |
| Q4 2024 | 128 |
| Q1 2025 | 128 |
| Q2 2025 | 125 |
| Q3 2025 | 124 |
| Q4 2025 | 126 |
| Q1 2026 | 137 |
| Q2 2026 | 149 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 69 | 35 |
| Q4 2024 | 64 | 58 |
| Q1 2025 | 64 | 60 |
| Q2 2025 | 57 | 69 |
| Q3 2025 | 44 | 59 |
| Q4 2025 | 49 | 58 |
| Q1 2026 | 66 | 41 |
| Q2 2026 | 80 | 66 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $3.8m | $449.9k | 0.12 |
| Q4 2025 | $1.1m | $288.8k | 0.25 |
| Q1 2026 | $3.3m | $242.3k | 0.07 |
| Q2 2026 | $5.1m | $165.6k | 0.03 |
Biggest buyers
| Artal Group S.A. | Added | +20.4m |
| BlackRock, Inc. | Added | +14.0m |
| FMR LLC | Added | +6.7m |
| STATE STREET CORP | Added | +4.0m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +3.1m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +1.8m |
| NORTHERN TRUST CORP | Added | +1.5m |
| Sessa Capital IM, L.P. | Added | +1.0m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Added | +645.5k |
| Nuveen, LLC | New | +586.7k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -3.8m |
| JANE STREET GROUP, LLC | Sold out | -2.7m |
| MARSHALL WACE, LLP | Sold out | -2.4m |
| UBS Group AG | Reduced | -1.8m |
| CIBC Bancorp USA Inc. | Reduced | -1.8m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -1.4m |
| Hennion & Walsh Asset Management, Inc. | Sold out | -848.1k |
| GOLDMAN SACHS GROUP INC | Reduced | -585.0k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -556.2k |
| GSA CAPITAL PARTNERS LLP | Reduced | -532.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.6m668.5k shares |
| JANE STREET GROUP, LLC | Added | $1.4m582.9k shares |
| GROUP ONE TRADING LLC | Added | $1.1m461.4k shares |
| CITADEL ADVISORS LLC | Reduced | $886.3k369.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $150.2k62.6k shares |
Biggest puts
| GROUP ONE TRADING LLC | Added | $51.1k21.3k shares |
| CITADEL ADVISORS LLC | Reduced | $43.0k17.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $43.0k17.9k shares |
| SIMPLEX TRADING, LLC | Added | $28.6k11.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Invus Global Management, LLC
13D · may seek influence
+3.2 pts · filed 2026-05-08
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: As previously disclosed in Amendment No. 25, on February 2, 2026, Artal Participations S.a.r.l. acquired 367,145.12 shares of Preferred Stock, and on February 17, 2026 Artal Participations S.a r.l. purchased an additional 41,289.58 shares of Preferred Stock, in each case, pursuant to the terms of the Preferred Purchase Agreement. Each share of Preferred Stock would automatically convert into 50 shares (subject to adjustments) of Issuer Common Stock immediately following the satisfaction of all of the following conditions: (i) the approval of the New Charter by the shareholders of the Issuer at the Annual Meeting; (ii) the adoption of the New Charter by the Issuer's board of directors; and (iii) the filing and acceptan… Full filing |
39.4% |
| FMR LLC 13G · institution +1.2 pts · filed 2026-08-06 | 11.7% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 2 | $2.7m | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Artal Group S.A. 45.15% of their portfolio | 175.2m $420.4m | Added +20.4m |
| FMR LLC 0.01% of their portfolio | 51.8m $124.3m | Added +6.7m |
| Siren, L.L.C. 2.16% of their portfolio | 44.3m $106.3m | Unchanged |
| Sessa Capital IM, L.P. 0.79% of their portfolio | 19.0m $45.5m | Added +1.0m |
| BlackRock, Inc. 0.00% of their portfolio | 17.3m $41.6m | Added +14.0m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 9.9m $23.8m | Added +382.0k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 8.3m $19.8m | Added +436.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 6.2m $15.0m | Added +3.1m |
| STATE STREET CORP 0.00% of their portfolio | 4.9m $11.8m | Added +4.0m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 2.4m $5.7m | Added +1.8m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.0m $4.7m | Added +1.5m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.0m $4.7m | Added +645.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.6m $3.9m | Added +302.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.6m $3.8m | Added +506.3k |
| Ishara Investments LP 2.24% of their portfolio | 1.3m $3.1m | Added +369.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.1m $2.7m | Reduced -3.8m |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 1.1m $2.7m | Reduced -473.5k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 963.4k $2.3m | Added +190.7k |
| ADAR1 Capital Management, LLC 0.08% of their portfolio | 750.0k $1.8m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 696.8k $1.7m | Reduced -1.4m |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 696.6k $1.7m | Added +251.3k |
| UBS Group AG 0.00% of their portfolio | 684.7k $1.6m | Reduced -1.8m |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 643.4k $1.5m | Reduced -556.2k |
| Nuveen, LLC 0.00% of their portfolio | 586.7k $1.4m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 568.7k $1.4m | Added +541.2k |
| Invesco Ltd. 0.00% of their portfolio | 508.1k $1.2m | Reduced -4.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 485.5k $1.2m | Reduced -585.0k |
| Compagnie Lombard Odier SCmA 0.01% of their portfolio | 480.0k $1.2m | Reduced -30.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 421.3k $1.0m | Reduced -104.8k |
| GSA CAPITAL PARTNERS LLP 0.06% of their portfolio | 397.2k $953.0k | Reduced -532.9k |
| BARCLAYS PLC 0.00% of their portfolio | 387.5k $930.0k | Added +282.0k |
| XTX Topco Ltd 0.01% of their portfolio | 357.9k $858.9k | Added +43.3k |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 295.5k $709.0k | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 257.9k $619.0k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 256.9k $616.5k | Added +256.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 247.5k $594.1k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 230.5k $553.1k | Added +222.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 204.4k $491.0k | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 179.7k $431.3k | New |
| CITIGROUP INC 0.00% of their portfolio | 175.2k $420.5k | Added +8.8k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 175.0k $420.0k | Reduced -10.0k |
| Virtus Investment Advisers, LLC 0.10% of their portfolio | 170.4k $409.0k | New |
| Headlands Technologies LLC 0.04% of their portfolio | 167.2k $401.3k | Reduced -24.1k |
| Ikarian Capital, LLC 0.06% of their portfolio | 164.7k $395.2k | Unchanged |
| Quarry LP 0.06% of their portfolio | 156.2k $374.8k | Added +46.2k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 146.4k $351.4k | New |
| MORGAN STANLEY 0.00% of their portfolio | 132.9k $319.0k | Reduced -87.0k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 132.0k $316.9k | New |
| State of Wyoming 0.03% of their portfolio | 119.1k $285.8k | Added +108.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 114.1k $273.9k | New |
| Cornerstone Investment Partners, LLC 0.01% of their portfolio | 113.7k $273.0k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 109.8k $290.0k | New |
| Cerity Partners LLC 0.00% of their portfolio | 98.4k $236.2k | Reduced -12.1k |
| ALGERT GLOBAL LLC 0.00% of their portfolio | 92.2k $221.2k | New |
| BANK OF NOVA SCOTIA 0.00% of their portfolio | 86.6k $207.9k | Added +12.9k |
| LPL Financial LLC 0.00% of their portfolio | 84.9k $203.8k | Added +15.1k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 77.9k $187.1k | Reduced -15.7k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 75.2k $180.6k | Reduced -21.0k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 73.4k $176.2k | New |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 0.02% of their portfolio | 71.4k $171.4k | Added +35.7k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 71.3k $171.2k | Added +37.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 69.7k $167.4k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 68.4k $164.2k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 67.8k $105.8k | New |
| TWO SIGMA SECURITIES, LLC 0.01% of their portfolio | 66.4k $159.3k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 63.9k $153.4k | New |
| Straight Path Wealth Management 0.04% of their portfolio | 62.7k $150.4k | Unchanged |
| R Squared Ltd 0.07% of their portfolio | 55.0k $132.0k | Reduced -12.5k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 54.3k $130.4k | Reduced -631 |
| Fortis Group Advisors, LLC 0.02% of their portfolio | 50.0k $120.0k | Unchanged |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 49.4k $118.6k | Reduced -25.7k |
| SCOTIA CAPITAL INC. 0.00% of their portfolio | 48.9k $117.3k | Reduced -111.0k |
| PROFUND ADVISORS LLC 0.00% of their portfolio | 48.6k $116.6k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 47.8k $114.7k | New |
| AXQ CAPITAL, LP 0.01% of their portfolio | 45.7k $109.7k | Added +25.6k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio | 44.3k $106.4k | Unchanged |
| WINTON GROUP Ltd 0.00% of their portfolio | 43.2k $103.7k | Added +17.7k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 42.5k $102.0k | New |
| LMR Partners LLP 0.00% of their portfolio | 41.1k $98.6k | Added +17.8k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 40.0k $96.0k | Reduced -30.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 37.8k $90.7k | Added +20.2k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 34.1k $81.8k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 32.6k $78.2k | New |
| Leonteq Securities AG 0.00% of their portfolio | 30.0k $72.0k | Unchanged |
| Pathstone Holdings, LLC 0.00% of their portfolio | 30.0k $71.9k | Added +195 |
| PINNACLE ASSOCIATES LTD 0.00% of their portfolio | 29.0k $69.6k | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 24.2k $58.1k | Added +1.5k |
| Legal & General Group Plc 0.00% of their portfolio | 24.2k $58.0k | New |
| XPONANCE LLC 0.00% of their portfolio | 23.8k $57.0k | New |
| Graham Capital Management, L.P. 0.00% of their portfolio | 23.5k $56.5k | Reduced -10.5k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 23.0k $55.2k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 22.2k $53.3k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 22.0k $52.8k | Reduced -88.4k |
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC 0.00% of their portfolio | 20.0k $48.0k | Unchanged |
| WEDBUSH SECURITIES INC 0.00% of their portfolio | 20.0k $48.0k | Reduced -20.9k |
| DIKER MANAGEMENT LLC 0.04% of their portfolio | 20.0k $48.0k | Unchanged |
| Invera Wealth Advisors, LLC 0.03% of their portfolio | 20.0k $48.0k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 19.9k $47.8k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 19.5k $46.8k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 19.2k $46.1k | Added +15.1k |