LEXEO THERAPEUTICS INC LXEO
COM · Common Stock · CUSIP 52886X107
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersNew York, NY
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($29.4k this quarter). Holder counts are more reliable. Shares outstanding: 54.0m as of 2025-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.02. Options: 3 managers hold calls ($7.6k notional), 2 hold puts ($8.0k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 32 |
| Q1 2024 | 55 |
| Q2 2024 | 61 |
| Q3 2024 | 70 |
| Q4 2024 | 91 |
| Q1 2025 | 89 |
| Q2 2025 | 91 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 45 | 10 |
| Q2 2024 | 40 | 22 |
| Q3 2024 | 49 | 15 |
| Q4 2024 | 54 | 20 |
| Q1 2025 | 40 | 41 |
| Q2 2025 | 52 | 32 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $0 | $0 | — |
| Q4 2024 | $0 | $0 | — |
| Q1 2025 | $111.3k | $87.1k | 0.78 |
| Q2 2025 | $7.6k | $8.0k | 1.05 |
Biggest buyers
| Balyasny Asset Management L.P. | New | +4.0m |
| Frazier Life Sciences Management, L.P. | Added | +3.5m |
| Affinity Asset Advisors, LLC | Added | +2.1m |
| Vestal Point Capital, LP | Added | +2.1m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.8m |
| Woodline Partners LP | Added | +1.7m |
| VANGUARD GROUP INC | Added | +903.6k |
| CITADEL ADVISORS LLC | Added | +884.6k |
| Ally Bridge Group (NY) LLC | New | +867.3k |
| UBS Group AG | Added | +239.8k |
Biggest sellers
| NOVO HOLDINGS A/S | Sold out | -1.1m |
| JANUS HENDERSON GROUP PLC | Reduced | -873.5k |
| Avidity Partners Management LP | Sold out | -645.0k |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -546.6k |
| Point72 Asset Management, L.P. | Reduced | -450.3k |
| Laurion Capital Management LP | Sold out | -260.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -238.0k |
| TWO SIGMA ADVISERS, LP | Sold out | -96.1k |
| MARSHALL WACE, LLP | Sold out | -81.0k |
| Shay Capital LLC | Sold out | -43.3k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $4.0k1.1k shares |
| GROUP ONE TRADING LLC | New | $3.6k900 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $8.0k2.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution +0.3 pts · filed 2026-08-14 | 10.0% |
| JANUS HENDERSON GROUP PLC 13G · institution -1.3 pts · filed 2025-12-08 | 10.0% |
| Affinity Asset Advisors, LLC 13G · institution +1.3 pts · filed 2026-08-13 | 8.4% |
| SUVRETTA CAPITAL MANAGEMENT, LLC 13G · passive investor new · filed 2026-04-13 | 7.7% |
| Vestal Point Capital, LP 13G · institution +1.5 pts · filed 2025-11-14 | 7.5% |
| CITADEL ADVISORS LLC 13G · passive investor -2.2 pts · filed 2026-02-17 | 7.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2025-10-27 | 6.9% |
| BlackRock, Inc. 13G · institution +2.7 pts · filed 2026-01-21 | 6.7% |
| MIZUHO FINANCIAL GROUP INC 13G · institution +0.8 pts · filed 2025-05-13 | 6.6% |
| JPMORGAN CHASE & CO 13G · institution new · filed 2026-10-13 | 5.5% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor -3.0 pts · filed 2026-08-14 | 5.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -0.6 pts · filed 2026-02-13 | 5.1% |
Fell to 5% or below in the last year: ORBIMED ADVISORS LLC (4.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 1 | $154.4k | $154.4k |
| Q3 2024 | 0 | — | 1 | $1.0m | $1.0m |
| Q4 2024 | 1 | $104.8k | 1 | $80.5k | $80.5k |
| Q1 2025 | 0 | — | 4 | $45.3k | — |
| Q2 2025 | 0 | — | 4 | $7.1k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-16 | Townsend Richard Nolan Chief Executive Officer, director | Sold | $3.0k1.1k shares |
| 2025-05-16 | Adler Eric Chief Medical Officer | Sold | $1.6k585 shares |
| 2025-05-16 | Robertson Jenny Chief Legal Officer | Sold | $1.4k521 shares |
| 2025-05-16 | See Tai Sandi Chief Development Officer | Sold | $1.0k367 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 0.71% of their portfolio | 4.4m $17.8m | Added +3.5m |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 4.0m $16.1m | New |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 3.7m $14.8m | Reduced -873.5k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 3.6m $14.5m | Added +884.6k |
| Affinity Asset Advisors, LLC 2.13% of their portfolio | 3.6m $14.4m | Added +2.1m |
| Vestal Point Capital, LP 0.68% of their portfolio | 3.2m $13.0m | Added +2.1m |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 2.8m $11.4m | Added +1.8m |
| Woodline Partners LP 0.05% of their portfolio | 2.6m $10.3m | Added +1.7m |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.0m $8.1m | Added +903.6k |
| BlackRock, Inc. 0.00% of their portfolio | 1.8m $7.3m | Reduced -14.3k |
| Omega Fund Management, LLC 3.08% of their portfolio | 1.2m $4.8m | Unchanged |
| Blackstone Inc. 0.02% of their portfolio | 1.1m $4.5m | Reduced -33.7k |
| D1 Capital Partners L.P. 0.05% of their portfolio | 978.7k $3.9m | Unchanged |
| Ally Bridge Group (NY) LLC 3.05% of their portfolio | 867.3k $3.5m | New |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 647.9k $2.6m | Reduced -450.3k |
| Siren, L.L.C. 0.13% of their portfolio | 603.4k $2.4m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 578.1k $2.3m | Reduced -8.4k |
| Ikarian Capital, LLC 0.73% of their portfolio | 550.0k $2.2m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 513.0k $2.1m | Added +43.3k |
| Verition Fund Management LLC 0.01% of their portfolio | 414.9k $1.7m | Unchanged |
| DAFNA Capital Management LLC 0.42% of their portfolio | 378.1k $1.5m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 271.9k $1.1m | Added +239.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 200.8k $807.2k | Reduced -5.3k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 188.6k $758.3k | Added +138.3k |
| Privium Fund Management B.V. 0.16% of their portfolio | 178.4k $752.7k | Added +18.2k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio | 163.2k $656.0k | Unchanged |
| ADAR1 Capital Management, LLC 0.09% of their portfolio | 145.1k $583.3k | Reduced -25.3k |
| PERCEPTIVE ADVISORS LLC 0.02% of their portfolio | 139.8k $562.1k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 116.1k $466.9k | Added +69.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 106.2k $426.9k | Added +85.9k |
| MORGAN STANLEY 0.00% of their portfolio | 84.8k $340.8k | Added +465 |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 69.2k $278.4k | Added +32.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 65.2k $261.9k | Added +14.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 64.2k $258.2k | Added +8.0k |
| Palumbo Wealth Management LLC 0.07% of their portfolio | 56.3k $226.3k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 53.4k $214.7k | Added +15.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 48.4k $194.7k | Added +8.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 48.0k $193.0k | Reduced -2.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 47.0k $189.0k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 36.4k $146.2k | Reduced -42.7k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 34.7k $139.7k | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 33.1k $133.1k | Reduced -2.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 32.0k $128.6k | Added +1.8k |
| Quadrature Capital Ltd 0.00% of their portfolio | 29.8k $120.3k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 29.4k $118.1k | Added +13.4k |
| Pale Fire Capital SE 0.01% of their portfolio | 27.6k $111.2k | Added +8.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 26.7k $107.1k | Added +4.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 23.9k $96.2k | Added +12.6k |
| Susquehanna Portfolio Strategies, LLC 0.00% of their portfolio | 22.3k $89.5k | New |
| Soltis Investment Advisors LLC 0.01% of their portfolio | 20.0k $80.4k | Unchanged |
| CAXTON CORP 0.71% of their portfolio | 17.3k $69.7k | Reduced -519 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 15.3k $61.6k | Added +3.9k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 15.0k $60.3k | New |
| CITIGROUP INC 0.00% of their portfolio | 14.7k $59.3k | Reduced -8.6k |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 14.5k $58.0k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 13.8k $55.3k | Reduced -30 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.7k $55.0k | Added +2.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 13.5k $54.2k | Reduced -624 |
| AXQ CAPITAL, LP 0.02% of their portfolio | 12.5k $50.1k | New |
| Cerity Partners LLC 0.00% of their portfolio | 12.4k $50.0k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 11.9k $47.6k | New |
| FMR LLC 0.00% of their portfolio | 11.8k $47.2k | Added +1.9k |
| Ethic Inc. 0.00% of their portfolio | 10.7k $44.2k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 10.4k $42.0k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 10.4k $42.0k | Added +6.2k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 10.2k $41.0k | New |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 6.7k $26.8k | Added +35 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.3k $24.0k | Added +4.4k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 6.0k $24.3k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5.1k $20.5k | Reduced -771 |
| FNY Investment Advisers, LLC 0.01% of their portfolio | 5.0k $20.0k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 4.2k $16.8k | Unchanged |
| Brooklyn Investment Group 0.00% of their portfolio | 3.9k $15.5k | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 2.8k $11.1k | Added +2.4k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.4k $9.6k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 2.0k $8.2k | Reduced -495 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.7k $7.0k | Unchanged |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 1.3k $5.2k | Added +303 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 1.2k $4.8k | Added +1.0k |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 820 $3.3k | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 657 $2.6k | Added +281 |
| Sterling Capital Management LLC 0.00% of their portfolio | 645 $2.6k | Added +618 |
| AMALGAMATED BANK 0.00% of their portfolio | 623 $3.0k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 219 $880 | New |
| Essential Partners LLC 0.00% of their portfolio | 174 $699 | First filing |
| IFP Advisors, Inc 0.00% of their portfolio | 107 $430 | Added +101 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 105 $364 | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 100 $402 | Unchanged |
| True Wealth Design, LLC 0.00% of their portfolio | 3 $13 | Reduced -16 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $4 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |