LEXEO THERAPEUTICS INC LXEO
COM · Common Stock · CUSIP 52886X107
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersNew York, NY
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.0k this quarter). Holder counts are more reliable. Shares outstanding: 33.2m as of 2025-03-21, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.57. Options: 3 managers hold calls ($111.3k notional), 4 hold puts ($87.1k).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 32 |
| Q1 2024 | 55 |
| Q2 2024 | 61 |
| Q3 2024 | 70 |
| Q4 2024 | 91 |
| Q1 2025 | 89 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 45 | 10 |
| Q2 2024 | 40 | 22 |
| Q3 2024 | 49 | 15 |
| Q4 2024 | 54 | 20 |
| Q1 2025 | 40 | 41 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $0 | $0 | — |
| Q3 2024 | $0 | $0 | — |
| Q4 2024 | $0 | $0 | — |
| Q1 2025 | $111.3k | $87.1k | 0.78 |
Biggest buyers
| Affinity Asset Advisors, LLC | New | +1.5m |
| MILLENNIUM MANAGEMENT LLC | Added | +929.5k |
| Avidity Partners Management LP | New | +645.0k |
| Point72 Asset Management, L.P. | Added | +347.9k |
| JANUS HENDERSON GROUP PLC | Added | +218.7k |
| TWO SIGMA ADVISERS, LP | New | +96.1k |
| MARSHALL WACE, LLP | Added | +63.2k |
| Ikarian Capital, LLC | Added | +50.7k |
| Shay Capital LLC | New | +43.3k |
| AQR CAPITAL MANAGEMENT LLC | Added | +39.6k |
Biggest sellers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -2.0m |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -1.2m |
| D1 Capital Partners L.P. | Reduced | -1.2m |
| Altium Capital Management LLC | Sold out | -405.0k |
| Verition Fund Management LLC | Reduced | -295.0k |
| Opaleye Management Inc. | Sold out | -130.0k |
| WELLINGTON MANAGEMENT GROUP LLP | Sold out | -77.0k |
| Vestal Point Capital, LP | Reduced | -63.8k |
| Walleye Capital LLC | Sold out | -61.9k |
| SUPERSTRING CAPITAL MANAGEMENT LP | Sold out | -52.6k |
Biggest calls
| SIMPLEX TRADING, LLC | New | $111.0k32.1k shares |
| CITADEL ADVISORS LLC | New | $347100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $44.4k12.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $42.7k12.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | New | $0100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution +0.3 pts · filed 2026-08-14 | 10.0% |
| JANUS HENDERSON GROUP PLC 13G · institution -1.3 pts · filed 2025-12-08 | 10.0% |
| Affinity Asset Advisors, LLC 13G · institution +1.3 pts · filed 2026-08-13 | 8.4% |
| SUVRETTA CAPITAL MANAGEMENT, LLC 13G · passive investor new · filed 2026-04-13 | 7.7% |
| Vestal Point Capital, LP 13G · institution +1.5 pts · filed 2025-11-14 | 7.5% |
| CITADEL ADVISORS LLC 13G · passive investor -2.2 pts · filed 2026-02-17 | 7.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2025-10-27 | 6.9% |
| BlackRock, Inc. 13G · institution +2.7 pts · filed 2026-01-21 | 6.7% |
| MIZUHO FINANCIAL GROUP INC 13G · institution +0.8 pts · filed 2025-05-13 | 6.6% |
| JPMORGAN CHASE & CO 13G · institution new · filed 2026-10-13 | 5.5% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor -3.0 pts · filed 2026-08-14 | 5.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -0.6 pts · filed 2026-02-13 | 5.1% |
Fell to 5% or below in the last year: ORBIMED ADVISORS LLC (4.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27), Longitude Capital Partners IV, LLC (3.8%, 2025-11-14)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 1 | $154.4k | $154.4k |
| Q3 2024 | 0 | — | 1 | $1.0m | $1.0m |
| Q4 2024 | 1 | $104.8k | 1 | $80.5k | $80.5k |
| Q1 2025 | 0 | — | 4 | $45.3k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-02-19 | Townsend Richard Nolan Chief Executive Officer, director | Sold | $19.1k4.3k shares |
| 2025-02-19 | Adler Eric Chief Medical Officer | Sold | $10.4k2.4k shares |
| 2025-02-19 | Robertson Jenny Chief Legal Officer | Sold | $9.3k2.1k shares |
| 2025-02-19 | See Tai Sandi Chief Development Officer | Sold | $6.6k1.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 4.6m $18.6m | Added +218.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 2.7m $9.5m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 1.8m $6.4m | Added +20.3k |
| Affinity Asset Advisors, LLC 0.80% of their portfolio | 1.5m $5.1m | New |
| Omega Fund Management, LLC 2.43% of their portfolio | 1.2m $4.1m | Unchanged |
| Blackstone Inc. 0.02% of their portfolio | 1.2m $4.0m | Unchanged |
| Vestal Point Capital, LP 0.28% of their portfolio | 1.1m $3.9m | Reduced -63.8k |
| NOVO HOLDINGS A/S 0.30% of their portfolio | 1.1m $3.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.1m $3.8m | Reduced -19.6k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 1.1m $3.8m | Added +347.9k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.1m $3.7m | Added +929.5k |
| D1 Capital Partners L.P. 0.05% of their portfolio | 978.7k $3.4m | Reduced -1.2m |
| Frazier Life Sciences Management, L.P. 0.15% of their portfolio | 955.5k $3.3m | Unchanged |
| Woodline Partners LP 0.02% of their portfolio | 837.0k $2.9m | Reduced -21.7k |
| Avidity Partners Management LP 0.46% of their portfolio | 645.0k $2.2m | New |
| Siren, L.L.C. 0.12% of their portfolio | 603.4k $2.1m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 586.5k $2.0m | Added +19.1k |
| Ikarian Capital, LLC 0.62% of their portfolio | 550.0k $1.9m | Added +50.7k |
| RA CAPITAL MANAGEMENT, L.P. 0.03% of their portfolio | 546.6k $1.9m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 469.7k $1.6m | Added +12.3k |
| Verition Fund Management LLC 0.01% of their portfolio | 414.9k $1.4m | Reduced -295.0k |
| DAFNA Capital Management LLC 0.37% of their portfolio | 378.1k $1.3m | Reduced -15.0k |
| Laurion Capital Management LP 0.07% of their portfolio | 260.2k $903.0k | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 238.0k $825.7k | Reduced -2.0m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 206.1k $715.1k | Reduced -8.2k |
| ADAR1 Capital Management, LLC 0.11% of their portfolio | 170.4k $591.5k | Added +943 |
| BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio | 163.2k $566.2k | Added +15.4k |
| Privium Fund Management B.V. 0.14% of their portfolio | 160.2k $555.9k | Added +22.1k |
| PERCEPTIVE ADVISORS LLC 0.02% of their portfolio | 139.8k $485.2k | Unchanged |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 96.1k $333.5k | New |
| MORGAN STANLEY 0.00% of their portfolio | 84.3k $292.6k | Added +9.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 81.0k $281.1k | Added +63.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 79.1k $274.5k | Reduced -11.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 56.2k $194.9k | Reduced -7.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 50.6k $175.7k | Reduced -16 |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 50.3k $174.7k | Added +39.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 50.1k $174.0k | Added +39.0k |
| BARCLAYS PLC 0.00% of their portfolio | 46.7k $161.9k | Reduced -8.5k |
| Shay Capital LLC 0.04% of their portfolio | 43.3k $150.2k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 40.2k $139.5k | First filing |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 38.4k $133.2k | Reduced -26.6k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 36.6k $127.1k | New |
| Nuveen, LLC 0.00% of their portfolio | 36.0k $125.1k | First filing |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 34.7k $120.6k | New |
| UBS Group AG 0.00% of their portfolio | 32.1k $111.3k | Reduced -19.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 30.2k $104.8k | Added +5.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 24.6k $85.0k | New |
| CITIGROUP INC 0.00% of their portfolio | 23.3k $80.9k | Reduced -1.6k |
| Ground Swell Capital, LLC 0.18% of their portfolio | 23.1k $80.2k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 21.8k $75.5k | Reduced -8.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 20.3k $70.4k | New |
| Soltis Investment Advisors LLC 0.01% of their portfolio | 20.0k $69.4k | New |
| Pale Fire Capital SE 0.01% of their portfolio | 18.9k $65.6k | Added +2.8k |
| CAXTON CORP 1.22% of their portfolio | 17.9k $61.9k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 16.0k $55.4k | Unchanged |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 14.1k $48.9k | Added +624 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 13.8k $47.8k | Added +409 |
| Corton Capital Inc. 0.15% of their portfolio | 12.7k $44.1k | Reduced -1.1k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 11.5k $40.1k | Reduced -171 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 11.4k $39.6k | Added +253 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 11.4k $39.5k | Reduced -1.9k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 11.3k $39.4k | Reduced -225 |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 10.4k $37.0k | Unchanged |
| FMR LLC 0.00% of their portfolio | 9.9k $34.2k | Added +7.9k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 6.6k $23.0k | Reduced -379 |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 6.0k $21.0k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5.9k $20.4k | Added +4.2k |
| Allostery Investments LP 0.03% of their portfolio | 5.1k $17.5k | Unchanged |
| FNY Investment Advisers, LLC 0.01% of their portfolio | 5.0k $17.0k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 4.2k $14.5k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 4.1k $14.0k | Added +3.4k |
| Legal & General Group Plc 0.00% of their portfolio | 2.5k $8.8k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.4k $8.3k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.8k $6.0k | Added +868 |
| COMERICA BANK 0.00% of their portfolio | 1.8k $6.1k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.7k $6.0k | Unchanged |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 979 $4.0k | Reduced -123 |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 820 $2.8k | Added +126 |
| AMALGAMATED BANK 0.00% of their portfolio | 623 $2.0k | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 376 $1.3k | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 339 $1.2k | Reduced -57 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 197 $684 | Unchanged |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 100 $347 | Unchanged |
| COLDSTREAM CAPITAL MANAGEMENT INC 0.00% of their portfolio | 93 $323 | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 27 $94 | Unchanged |
| True Wealth Design, LLC 0.00% of their portfolio | 19 $66 | New |
| IFP Advisors, Inc 0.00% of their portfolio | 6 $21 | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $3 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |