KYMERA THERAPEUTICS INC KYMR
COM · Common Stock · CUSIP 501575104 · ISIN US5015751044
Biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWatertown, MA
- Websitekymeratx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.5m this quarter). Holder counts are more reliable. Shares outstanding: 71.5m as of 2025-08-08, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $43.64. Options: 7 managers hold calls ($10.1m notional), 7 hold puts ($3.2m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 129 |
| Q4 2022 | 121 |
| Q1 2023 | 128 |
| Q2 2023 | 130 |
| Q3 2023 | 123 |
| Q4 2023 | 138 |
| Q1 2024 | 165 |
| Q2 2024 | 158 |
| Q3 2024 | 177 |
| Q4 2024 | 182 |
| Q1 2025 | 175 |
| Q2 2025 | 211 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 61 | 56 |
| Q4 2023 | 66 | 70 |
| Q1 2024 | 101 | 57 |
| Q2 2024 | 81 | 80 |
| Q3 2024 | 87 | 81 |
| Q4 2024 | 82 | 88 |
| Q1 2025 | 86 | 85 |
| Q2 2025 | 130 | 78 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $2.8m | $3.9m | 1.38 |
| Q4 2024 | $3.0m | $704.0k | 0.23 |
| Q1 2025 | $7.8m | $6.6m | 0.84 |
| Q2 2025 | $10.1m | $3.2m | 0.31 |
Biggest buyers
| FMR LLC | Added | +1.0m |
| Capital Research Global Investors | Added | +897.0k |
| Commodore Capital LP | New | +750.0k |
| BAKER BROS. ADVISORS LP | Added | +655.5k |
| CITADEL ADVISORS LLC | Added | +516.4k |
| VANGUARD GROUP INC | Added | +388.5k |
| FRONTIER CAPITAL MANAGEMENT CO LLC | Added | +359.8k |
| BVF INC/IL | Added | +340.9k |
| Nextech Invest Ltd. | New | +340.9k |
| ROYAL BANK OF CANADA | Added | +310.4k |
Biggest sellers
| JANUS HENDERSON GROUP PLC | Reduced | -751.3k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -624.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -453.9k |
| Rock Springs Capital Management LP | Reduced | -344.1k |
| Driehaus Capital Management LLC | Reduced | -234.9k |
| STATE STREET CORP | Reduced | -206.3k |
| Redmile Group, LLC | Reduced | -180.1k |
| Aquilo Capital Management, LLC | Sold out | -138.5k |
| BlackRock, Inc. | Reduced | -134.6k |
| Affinity Asset Advisors, LLC | Sold out | -100.0k |
Biggest calls
| Caption Management, LLC | Added | $2.8m64.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.4m55.2k shares |
| CITADEL ADVISORS LLC | Added | $1.5m33.5k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m30.1k shares |
| JANE STREET GROUP, LLC | Added | $1.1m24.4k shares |
| GROUP ONE TRADING LLC | Reduced | $1.0m23.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | New | $1.1m25.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $650.2k14.9k shares |
| Caption Management, LLC | New | $632.8k14.5k shares |
| Ikarian Capital, LLC | Reduced | $436.4k10.0k shares |
| SIMPLEX TRADING, LLC | New | $244.0k5.6k shares |
| GROUP ONE TRADING LLC | New | $96.0k2.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.1 pts · filed 2026-05-06 | 14.3% |
BAKER BROS. ADVISORS LP
13D · may seek influence
+1.4 pts · filed 2025-12-11
Stated purposeItem 4 of Amendment No. 3 is supplemented and amended, as the case may be, as follows: The disclosure in Item 3 and in Item 6 below is incorporated herein by reference. On December 9, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with Morgan Stanley & Co. LLC, J.P. Morgan Securities LLC, Jefferies LLC, Stifel, Nicolaus & Company, Incorporated, Guggenheim Securities, LLC and Wells Fargo Securities, LLC (the "Underwriters"), related to the public offering (the "Offering") of 7,000,000 shares of common stock of the Issuer ("Common Stock") at a price to the public of $86.00 per share. In addition, the Issuer granted the Underwriters an option exercisable for 30 days from the date of the Underwriting Agreement to purchase, at the public offering price … Full filing |
10.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution +2.1 pts · filed 2026-09-08 | 10.7% |
| T. Rowe Price Investment Management, Inc. 13G · institution new · filed 2026-05-15 | 6.7% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-10-27 | 6.6% |
| BIOTECHNOLOGY VALUE FUND L P 13D · may seek influence -2.2 pts · filed 2026-06-26 | 6.3% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.9%, 2026-08-13), WELLINGTON MANAGEMENT GROUP LLP (4.8%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 1 | $5.3m | 0 | — | — |
| Q1 2024 | 0 | — | 5 | $22.6m | $22.2m |
| Q2 2024 | 0 | — | 3 | $1.3m | $1.2m |
| Q3 2024 | 1 | $46 | 4 | $20.0m | $20.0m |
| Q4 2024 | 0 | — | 1 | $122.5k | $122.5k |
| Q1 2025 | 0 | — | 4 | $630.0k | — |
| Q2 2025 | 2 | $42.8m | 5 | $2.9m | $2.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-30 | BAKER JULIAN +5 Director · See Footnotes | Bought | $28.8m655.5k shares |
| 2025-06-30 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Bought | $14.0m317.2k shares |
| 2025-06-11 | Ridloff Elena Director | Sold plan | $225.0k4.5k shares |
| 2025-06-03 | Mainolfi Nello Chief Executive Officer, director | Sold plan | $1.5m30.0k shares |
| 2025-06-03 | Ridloff Elena Director | Sold plan | $553.2k12.0k shares |
| 2025-06-03 | Albers Jeffrey W. Director | Sold plan | $311.1k6.3k shares |
| 2025-06-03 | Esposito Pamela Director | Sold plan | $245.2k5.0k shares |
| 2025-05-23 | Chadwick Jeremy G Chief Operating Officer | Sold | $75.4k2.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio | 6.9m $299.3m | Added +156.8k |
| BAKER BROS. ADVISORS LP 2.82% of their portfolio | 6.7m $290.3m | Added +655.5k |
| Avoro Capital Advisors LLC 5.01% of their portfolio | 6.6m $286.1m | Added +95.6k |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.6m $245.3m | Added +388.5k |
| BVF INC/IL 8.58% of their portfolio | 5.5m $240.1m | Added +340.9k |
| FMR LLC 0.01% of their portfolio | 5.4m $237.1m | Added +1.0m |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 5.4m $234.4m | Reduced -624.8k |
| Atlas Venture Life Science Advisors, LLC 32.26% of their portfolio | 4.9m $213.7m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 4.1m $181.0m | Reduced -134.6k |
| Siren, L.L.C. 7.74% of their portfolio | 3.4m $149.6m | Added +187.8k |
| STATE STREET CORP 0.00% of their portfolio | 1.6m $67.8m | Reduced -206.3k |
| Capital Research Global Investors 0.01% of their portfolio | 1.3m $55.1m | Added +897.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.2m $52.1m | Added +59.3k |
| Driehaus Capital Management LLC 0.33% of their portfolio | 933.9k $40.8m | Reduced -234.9k |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 825.0k $36.0m | Added +272.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 818.9k $35.7m | Reduced -77.5k |
| Redmile Group, LLC 3.73% of their portfolio | 803.3k $35.1m | Reduced -180.1k |
| Merck & Co., Inc. 16.53% of their portfolio | 772.2k $33.7m | Unchanged |
| Commodore Capital LP 2.31% of their portfolio | 750.0k $32.7m | New |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.52% of their portfolio | 653.0k $28.5m | Added +60.0k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 563.4k $24.6m | Added +167.9k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.43% of their portfolio | 563.0k $24.6m | Added +37.9k |
| UBS Group AG 0.01% of their portfolio | 557.7k $24.3m | Reduced -35.9k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 518.9k $22.6m | Added +516.4k |
| Woodline Partners LP 0.11% of their portfolio | 498.1k $21.7m | Reduced -27.1k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.20% of their portfolio | 491.8k $21.5m | Added +359.8k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 488.0k $21.3m | Added +67.9k |
| AJU IB Investment Co., Ltd. 21.71% of their portfolio | 457.1k $19.9m | Unchanged |
| Rock Springs Capital Management LP 1.22% of their portfolio | 450.4k $19.7m | Reduced -344.1k |
| Boxer Capital Management, LLC 9.49% of their portfolio | 432.0k $18.9m | Added +107.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 429.3k $18.7m | Added +47.6k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 409.4k $17.9m | Reduced -12.3k |
| Nextech Invest Ltd. 2.82% of their portfolio | 340.9k $14.9m | New |
| GILDER GAGNON HOWE & CO LLC 0.15% of their portfolio | 329.0k $14.4m | Added +10.6k |
| Deer Management Co. LLC 1.13% of their portfolio | 325.9k $14.2m | Reduced -90.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 312.5k $13.6m | Added +310.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 304.2k $13.3m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 278.7k $12.2m | Reduced -65.5k |
| MONTANOVA CAPITAL, LLC 0.45% of their portfolio | 275.0k $12.0m | New |
| MARSHALL WACE, LLP 0.01% of their portfolio | 269.3k $11.8m | Added +67.4k |
| Octagon Capital Advisors LP 2.55% of their portfolio | 266.0k $11.6m | New |
| Polar Capital Holdings Plc 0.06% of their portfolio | 250.0k $10.9m | New |
| MORGAN STANLEY 0.00% of their portfolio | 237.6k $10.4m | Added +65.5k |
| TD Asset Management Inc 0.01% of their portfolio | 235.0k $10.3m | Added +32.9k |
| TWO SIGMA ADVISERS, LP 0.02% of their portfolio | 224.3k $9.8m | Added +41.0k |
| PERCEPTIVE ADVISORS LLC 0.34% of their portfolio | 210.1k $9.2m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 207.7k $9.1m | Added +160.8k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 184.5k $8.1m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 162.3k $7.1m | Added +18.1k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 159.2k $6.9m | Added +11.5k |
| Candriam S.C.A. 0.04% of their portfolio | 154.1k $6.7m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 152.2k $6.6m | Added +9.6k |
| Atika Capital Management LLC 0.67% of their portfolio | 146.6k $6.4m | New |
| Foresite Capital Management VI LLC 3.59% of their portfolio | 146.3k $6.4m | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 143.2k $6.2m | Added +58.0k |
| Patient Square Capital LP 2.20% of their portfolio | 140.0k $6.1m | Reduced -2.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 134.9k $5.9m | Added +38.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 130.7k $5.7m | Added +3.8k |
| Yiheng Capital Management, L.P. 1.94% of their portfolio | 122.6k $5.4m | Unchanged |
| Cubist Systematic Strategies, LLC 0.06% of their portfolio | 118.8k $5.2m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 110.2k $4.8m | Reduced -48.1k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio | 107.4k $4.7m | Added +22.4k |
| Checkpoint Capital L.P. 2.18% of their portfolio | 107.0k $4.7m | Reduced -29.6k |
| ExodusPoint Capital Management, LP 0.05% of their portfolio | 101.0k $4.4m | Added +71.5k |
| Nuveen, LLC 0.00% of their portfolio | 100.4k $4.4m | Reduced -42.8k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 91.9k $4.0m | New |
| AXA S.A. 0.01% of their portfolio | 91.0k $4.0m | Reduced -18.0k |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 90.6k $4.0m | New |
| Monashee Investment Management LLC 1.96% of their portfolio | 85.0k $3.7m | New |
| Burkehill Global Management, LP 0.24% of their portfolio | 75.0k $3.3m | New |
| Swiss National Bank 0.00% of their portfolio | 74.4k $3.2m | Reduced -900 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 71.1k $3.1m | Added +1.1k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 64.2k $2.8m | Reduced -31.3k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 58.9k $2.6m | Added +10.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 57.5k $2.5m | Reduced -6.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 56.5k $2.5m | Reduced -453.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 50.9k $2.2m | Reduced -3.1k |
| Weiss Asset Management LP 0.04% of their portfolio | 50.8k $2.2m | Not comparable |
| Trexquant Investment LP 0.02% of their portfolio | 50.7k $2.2m | New |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 50.0k $2.2m | New |
| Maven Securities LTD 0.57% of their portfolio | 50.0k $2.2m | New |
| COMERICA BANK 0.01% of their portfolio | 49.1k $2.1m | Added +27.7k |
| Invesco Ltd. 0.00% of their portfolio | 47.9k $2.1m | Added +5.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 47.0k $2.1m | Added +2.0k |
| Legal & General Group Plc 0.00% of their portfolio | 41.5k $1.8m | Added +1.5k |
| NORGES BANK 0.00% of their portfolio | 41.4k $1.8m | Reduced -8.3k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 40.1k $1.8m | Reduced -18.8k |
| Jain Global LLC 0.03% of their portfolio | 38.7k $1.7m | New |
| Skandinaviska Enskilda Banken AB (publ) 0.01% of their portfolio | 38.1k $1.7m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 36.3k $1.6m | Reduced -521 |
| Moody Aldrich Partners LLC 0.29% of their portfolio | 34.8k $1.5m | New |
| ROYCE & ASSOCIATES LP 0.02% of their portfolio | 33.8k $1.5m | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 33.6k $1.5m | Added +822 |
| HARBOR CAPITAL ADVISORS, INC. 0.06% of their portfolio | 33.5k $1.5m | Added +2.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 33.3k $1.5m | Reduced -15.9k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 32.8k $1.4m | Reduced -24.4k |
| Nan Fung Group Holdings Ltd 2.12% of their portfolio | 30.9k $1.3m | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 29.8k $1.3m | Reduced -47.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 29.6k $1.3m | Added +16.6k |
| HRT FINANCIAL LP 0.01% of their portfolio | 28.9k $1.3m | New |