ZEVRA THERAPEUTICS INC ZVRA
COM NEW · Common Stock · CUSIP 488445206
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Shares outstanding: 59.4m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.32. Options: 8 managers hold calls ($23.9m notional), 8 hold puts ($31.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 69 |
| Q4 2022 | 71 |
| Q1 2023 | 62 |
| Q2 2023 | 72 |
| Q3 2023 | 78 |
| Q4 2023 | 85 |
| Q1 2024 | 90 |
| Q2 2024 | 94 |
| Q3 2024 | 109 |
| Q4 2024 | 111 |
| Q1 2025 | 112 |
| Q2 2025 | 122 |
| Q3 2025 | 166 |
| Q4 2025 | 159 |
| Q1 2026 | 148 |
| Q2 2026 | 157 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 62 | 32 |
| Q4 2024 | 61 | 42 |
| Q1 2025 | 58 | 39 |
| Q2 2025 | 68 | 43 |
| Q3 2025 | 108 | 46 |
| Q4 2025 | 80 | 82 |
| Q1 2026 | 67 | 79 |
| Q2 2026 | 93 | 57 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $24.8m | $12.8m | 0.51 |
| Q4 2025 | $28.0m | $11.4m | 0.41 |
| Q1 2026 | $14.2m | $20.7m | 1.47 |
| Q2 2026 | $23.9m | $31.6m | 1.32 |
Biggest buyers
| FMR LLC | Added | +1.7m |
| Woodline Partners LP | Added | +1.3m |
| Nantahala Capital Management, LLC | Added | +1.1m |
| BlackRock, Inc. | Added | +652.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +597.2k |
| D. E. Shaw & Co., Inc. | Added | +460.5k |
| Swedbank AB | New | +439.4k |
| DIMENSIONAL FUND ADVISORS LP | Added | +404.0k |
| Qube Research & Technologies Ltd | Added | +399.0k |
| Invesco Ltd. | Added | +231.5k |
Biggest sellers
| AIGH Capital Management LLC | Sold out | -1.2m |
| Point72 Asset Management, L.P. | Sold out | -1.2m |
| CITADEL ADVISORS LLC | Reduced | -614.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -499.8k |
| MARSHALL WACE, LLP | Reduced | -369.7k |
| UBS Group AG | Reduced | -277.2k |
| Stonepine Capital Management, LLC | Reduced | -221.3k |
| JANE STREET GROUP, LLC | Reduced | -199.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -197.6k |
| Squarepoint Ops LLC | Sold out | -182.9k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $5.4m379.8k shares |
| JANE STREET GROUP, LLC | Added | $4.7m327.8k shares |
| SIMPLEX TRADING, LLC | Added | $4.7m324.5k shares |
| GROUP ONE TRADING LLC | Reduced | $2.9m201.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.3m157.1k shares |
| Caption Management, LLC | Added | $1.4m100.0k shares |
| TUDOR INVESTMENT CORP ET AL | Reduced | $1.3m90.8k shares |
| IMC-Chicago, LLC | New | $1.2m85.2k shares |
Biggest puts
| Caption Management, LLC | Unchanged | $28.7m2.0m shares |
| JANE STREET GROUP, LLC | Added | $830.3k57.9k shares |
| SABBY MANAGEMENT, LLC | Added | $612.3k427 shares |
| CITADEL ADVISORS LLC | Reduced | $493.3k34.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $319.8k22.3k shares |
| GROUP ONE TRADING LLC | Added | $305.4k21.3k shares |
| IMC-Chicago, LLC | New | $177.8k12.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $156.3k10.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +2.8 pts · filed 2026-08-06 | 8.3% |
| Woodline Partners LP 13G · institution +1.9 pts · filed 2026-08-14 | 8.1% |
| BlackRock, Inc. 13G · institution filed 2025-02-05 | 7.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Adage Capital Management, L.P. (4.0%, 2025-11-13)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $4.0k | 0 | — | — |
| Q1 2025 | 2 | $82.0k | 4 | $920.1k | $920.1k |
| Q2 2025 | 0 | — | 1 | $221.0k | $221.0k |
| Q3 2025 | 3 | $228.4k | 0 | — | — |
| Q4 2025 | 0 | — | 1 | $211.0k | $211.0k |
| Q1 2026 | 0 | — | 5 | $1.2m | $1.2m |
| Q2 2026 | 0 | — | 1 | $458.5k | $458.5k |
| Q3 2026 | 0 | — | 2 | $613.2k | $474.9k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-14 | Thompson Rahsaan Chief Legal & Compliance | Sold plan | $474.9k42.7k shares |
| 2026-08-10 | Watton Corey Michael Director | Sold | $138.4k12.3k shares |
| 2026-06-22 | Thompson Rahsaan Chief Legal & Compliance | Sold plan | $438.2k34.6k shares |
| 2026-05-11 | Thompson Rahsaan Chief Legal & Compliance | Sold plan | $20.3k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 5.1m $73.3m | Added +652.4k |
| FMR LLC 0.00% of their portfolio | 4.9m $70.5m | Added +1.7m |
| Woodline Partners LP 0.21% of their portfolio | 4.8m $68.6m | Added +1.3m |
| Nantahala Capital Management, LLC 1.56% of their portfolio | 3.6m $51.6m | Added +1.1m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.6m $37.8m | Added +169.6k |
| STATE STREET CORP 0.00% of their portfolio | 1.7m $24.1m | Added +120.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.5m $22.1m | Added +169.1k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 1.3m $18.7m | Added +460.5k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 1.2m $17.8m | Added +399.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $17.3m | Added +11.6k |
| Legal & General Group Plc 0.00% of their portfolio | 1.2m $17.2m | Added +38.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 958.8k $13.7m | Added +404.0k |
| ROYCE & ASSOCIATES LP 0.10% of their portfolio | 882.7k $12.7m | Reduced -106.0k |
| 683 Capital Management, LLC 1.13% of their portfolio | 855.0k $12.3m | Reduced -120.0k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 1.50% of their portfolio | 775.0k $11.1m | Unchanged |
| Retirement Planning Co of New England, Inc. 3.27% of their portfolio | 634.4k $9.1m | Reduced -16.7k |
| Jupiter Topco LLC 0.00% of their portfolio | 613.4k $8.8m | First filing |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 597.2k $8.6m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 545.6k $7.8m | Reduced -197.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 541.1k $7.8m | Added +74.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 486.5k $7.0m | Added +49.5k |
| Swedbank AB 0.01% of their portfolio | 439.4k $6.3m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 439.3k $6.2m | Reduced -66.7k |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 415.1k $6.0m | Reduced -28.1k |
| Stratos Wealth Partners, LTD. 0.06% of their portfolio | 408.0k $5.9m | Unchanged |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 400.2k $5.7m | Added +4.3k |
| Hennion & Walsh Asset Management, Inc. 0.16% of their portfolio | 383.7k $5.5m | Added +206.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 360.9k $5.1m | Reduced -18.0k |
| Mystic Asset Management, Inc. 1.08% of their portfolio | 352.1k $5.0m | Reduced -9.2k |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.06% of their portfolio | 348.8k $5.0m | Reduced -1.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 310.0k $4.4m | Added +123.4k |
| Phocas Financial Corp. 0.59% of their portfolio | 295.9k $4.2m | Added +136.5k |
| Janney Montgomery Scott LLC 0.01% of their portfolio | 272.2k $3.9m | Added +35.4k |
| Invesco Ltd. 0.00% of their portfolio | 264.4k $3.8m | Added +231.5k |
| Stonepine Capital Management, LLC 2.82% of their portfolio | 258.7k $3.7m | Reduced -221.3k |
| Propel Bio Management, LLC 1.90% of their portfolio | 253.5k $3.6m | Reduced -28.9k |
| Diametric Capital, LP 0.35% of their portfolio | 231.5k $3.3m | Added +123.4k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 216.9k $3.0m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 200.0k $2.9m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 198.4k $2.8m | Added +26.0k |
| GLOBEFLEX CAPITAL L P 0.35% of their portfolio | 191.9k $2.8m | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 191.0k $2.7m | Added +111.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 184.8k $2.7m | Added +22.8k |
| Inspire Investing, LLC 0.10% of their portfolio | 173.0k $2.5m | New |
| Kovack Advisors, Inc. 0.11% of their portfolio | 171.2k $2.4m | Reduced -4.1k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 168.0k $2.4m | Added +22.8k |
| Nuveen, LLC 0.00% of their portfolio | 166.2k $2.4m | Reduced -26.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 164.5k $2.4m | Added +8.1k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 154.4k $2.2m | New |
| UBS Group AG 0.00% of their portfolio | 144.8k $2.1m | Reduced -277.2k |
| XTX Topco Ltd 0.02% of their portfolio | 134.1k $1.9m | New |
| Caption Management, LLC 0.06% of their portfolio | 120.0k $1.7m | Reduced -135.2k |
| CREDIT AGRICOLE S A 0.00% of their portfolio | 106.0k $1.5m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 90.5k $1.3m | Reduced -499.8k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 85.3k $1.2m | Added +31.1k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 78.9k $1.1m | Added +72.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 77.1k $1.1m | Added +9.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 74.7k $1.1m | Added +36.4k |
| HighTower Advisors, LLC 0.00% of their portfolio | 72.3k $1.0m | New |
| Simplify Asset Management Inc. 0.01% of their portfolio | 70.8k $1.0m | Reduced -29.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 70.6k $657.9k | Added +5.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 70.3k $1.0m | Reduced -369.7k |
| CAXTON ASSOCIATES LLP 0.02% of their portfolio | 70.0k $1.0m | New |
| Campbell & CO Investment Adviser LLC 0.05% of their portfolio | 68.9k $987.6k | Added +45.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 66.3k $950.3k | Added +1.4k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 65.2k $935.1k | Added +12.8k |
| Arete Wealth Advisors, LLC 0.06% of their portfolio | 64.2k $920.7k | Reduced -2.2k |
| IFG Advisors, LLC 0.12% of their portfolio | 61.8k $886.8k | Unchanged |
| CARRET ASSET MANAGEMENT, LLC 0.07% of their portfolio | 58.3k $836.0k | Reduced -1.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 57.8k $829.0k | Added +6.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 57.0k $817.0k | Added +30.8k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 54.1k $776.0k | Added +11.9k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 52.9k $758.6k | New |
| Quantinno Capital Management LP 0.00% of their portfolio | 49.6k $711.8k | Added +17.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 48.4k $694.0k | Added +4.8k |
| Element Squared LLC 0.33% of their portfolio | 46.3k $664.5k | New |
| CITIGROUP INC 0.00% of their portfolio | 44.9k $644.2k | Added +23.0k |
| EntryPoint Capital, LLC 0.14% of their portfolio | 39.2k $561.8k | Reduced -3.7k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 38.7k $554.8k | Added +1.9k |
| BARCLAYS PLC 0.00% of their portfolio | 36.9k $529.0k | Added +21.4k |
| AVIVA PLC 0.00% of their portfolio | 35.9k $514.2k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 35.0k $502.2k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 34.5k $495.1k | Added +8.3k |
| STRS OHIO 0.00% of their portfolio | 31.5k $451.7k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 27.0k $387.3k | Added +913 |
| WINTON GROUP Ltd 0.01% of their portfolio | 24.3k $349.0k | Added +8.0k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 23.6k $339.0k | Reduced -2.3k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 23.1k $331.0k | New |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 21.7k $311.6k | Reduced -1.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 21.6k $309.8k | Reduced -199.5k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 20.2k $290.3k | Reduced -4.0k |
| Quaker Wealth Management, LLC 0.08% of their portfolio | 19.4k $277.7k | Added +19.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 19.0k $273.0k | Reduced -4.2k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 18.4k $263.7k | Added +3.4k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 16.4k $235.1k | Added +11.3k |
| Creative Planning 0.00% of their portfolio | 16.3k $234.4k | Added +4.7k |
| LPL Financial LLC 0.00% of their portfolio | 15.7k $224.9k | Added +2.2k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 15.5k $222.6k | Added +1.8k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 15.4k $220.3k | Added +226 |
| Sanctuary Advisors, LLC 0.00% of their portfolio | 15.0k $215.5k | Reduced -3.5k |