Vault-13

IVERIC BIO INC OPHT

COM · Common Stock · CUSIP 46583P102 · ISIN US46583P1021

225 institutional holders +0 vs Q4 2022
148,084,331148.1m shares reported held*
$3.6bnreported value*
37 new 86 added 77 reduced 33 sold out net bought ≈ $29.3m (+1.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($727.9k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $24.35. Options: 23 managers hold calls ($59.3m notional), 15 hold puts ($49.2m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 213Q4 22: 225Q1 23: 225225Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022213
Q4 2022225
Q1 2023225

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 137 bought or addedQ4 22: 98 cut or sold outQ4 22Q1 23: 123 bought or addedQ1 23: 110 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 202213798
Q1 2023123110

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ3 22 calls: $186.0mQ3 22 puts: $70.9mQ3 22P/C 0.38Q4 22 calls: $35.2mQ4 22 puts: $25.6mQ4 22P/C 0.73Q1 23 calls: $59.3mQ1 23 puts: $49.2mQ1 23P/C 0.83
Numbers
QuarterCallsPutsP/C
Q3 2022$186.0m$70.9m0.38
Q4 2022$35.2m$25.6m0.73
Q1 2023$59.3m$49.2m0.83

Biggest buyers

VANGUARD GROUP INC Added +3,509,386+3.5m
AMERICAN CENTURY COMPANIES INC Added +2,713,544+2.7m
PICTET ASSET MANAGEMENT SA Added +2,302,337+2.3m
Holocene Advisors, LP New +1,996,476+2.0m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,968,987+2.0m
Avidity Partners Management LP Added +1,030,793+1.0m
Invesco Ltd. Added +616,275+616.3k
PFM Health Sciences, LP Added +547,926+547.9k
Hudson Bay Capital Management LP New +512,252+512.3k
BARCLAYS PLC Added +483,518+483.5k

Biggest sellers

Point72 Asset Management, L.P. Sold out -2,967,729-3.0m
DEERFIELD MANAGEMENT COMPANY, L.P. Reduced -1,920,274-1.9m
Yiheng Capital Management, L.P. Reduced -1,469,757-1.5m
Deep Track Capital, LP Reduced -1,378,119-1.4m
Octagon Capital Advisors LP Sold out -1,278,000-1.3m
PURA VIDA INVESTMENTS, LLC Sold out -1,182,975-1.2m
DEUTSCHE BANK AG\ Reduced -1,148,521-1.1m
Artal Group S.A. Sold out -1,000,000-1.0m
FARALLON CAPITAL MANAGEMENT, L.L.C. Reduced -977,201-977.2k
MILLENNIUM MANAGEMENT LLC Reduced -931,236-931.2k

Biggest calls

BOOTHBAY FUND MANAGEMENT, LLC Added $15.6m642.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.4m387.8k shares
CITADEL ADVISORS LLC Reduced $5.6m232.2k shares
BANK OF AMERICA CORP /DE/ New $4.3m175.0k shares
JANE STREET GROUP, LLC Reduced $4.1m167.4k shares
Balyasny Asset Management L.P. New $3.2m130.0k shares
Parallax Volatility Advisers, L.P. New $2.6m105.9k shares
Precept Management LLC New $2.4m100.0k shares
GROUP ONE TRADING LLC Reduced $2.3m92.7k shares
SIMPLEX TRADING, LLC Reduced $2.2m89.2k shares

Biggest puts

BARCLAYS PLC New $19.8m813.8k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $8.6m353.6k shares
BANK OF AMERICA CORP /DE/ New $4.8m199.2k shares
JANE STREET GROUP, LLC Added $4.1m168.6k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $3.5m142.4k shares
SIMPLEX TRADING, LLC Added $2.7m111.9k shares
CITADEL ADVISORS LLC Reduced $2.3m93.9k shares
GROUP ONE TRADING LLC Reduced $1.9m78.7k shares
WOLVERINE TRADING, LLC New $547.0k23.0k shares
Walleye Capital LLC Added $481.7k19.8k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 13,661,38913.7m $332.4m $332.4m 0.01% Added +3.5m +3,509,386
2 BlackRock Inc. 0.01% of their portfolio New York, NY 10,128,47510.1m $246.4m $246.4m 0.01% Added +377.3k +377,320
3 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 6,812,6466.8m $165.8m $165.8m 0.02% Added +2.0m +1,968,987
4 Avoro Capital Advisors LLC 2.45% of their portfolio NEW YORK, NY 6,800,0006.8m $165.4m $165.4m 2.45% Added +50.0k +50,000
5 Deep Track Capital, LP 6.72% of their portfolio GREENWICH, CT 6,500,0006.5m $158.1m $158.1m 6.72% Reduced -1.4m -1,378,119
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 5,624,1785.6m $136.8m $136.8m 0.01% Reduced -712.7k -712,658
7 TCG Crossover Management, LLC 24.38% of their portfolio PALO ALTO, CA 5,141,1185.1m $125.1m $125.1m 24.38% Unchanged
8 JANUS HENDERSON GROUP PLC 0.08% of their portfolio LONDON, X0 4,687,2094.7m $114.0m $114.0m 0.08% Added +133.3k +133,305
9 Redmile Group, LLC 4.44% of their portfolio LARKSPUR, CA 4,205,2064.2m $102.3m $102.3m 4.44% Reduced -296.9k -296,905
10 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 4,067,0354.1m $99.0m $99.0m 0.04% Reduced -164.9k -164,882
11 AMERICAN CENTURY COMPANIES INC 0.08% of their portfolio KANSAS CITY, MO 4,044,9184.0m $98.4m $98.4m 0.08% Added +2.7m +2,713,544
12 BRAIDWELL LP 2.98% of their portfolio STAMFORD, CT 3,714,6723.7m $90.4m $90.4m 2.98% Added +373.4k +373,372
13 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,587,8572.6m $63.0m $63.0m 0.01% Added +172.0k +172,028
14 PICTET ASSET MANAGEMENT SA 0.07% of their portfolio GENEVA 73, V8 2,316,3002.3m $56.4m $56.4m 0.07% Added +2.3m +2,302,337
15 Capital International Investors 0.01% of their portfolio Los Angeles, CA 2,164,0992.2m $52.7m $52.7m 0.01% Unchanged
16 Yiheng Capital Management, L.P. 4.07% of their portfolio SAN FRANCISCO, CA 2,143,4972.1m $52.2m $52.2m 4.07% Reduced -1.5m -1,469,757
17 Soleus Capital Management, L.P. 6.41% of their portfolio GREENWICH, CT 2,127,0432.1m $51.8m $51.8m 6.41% Added +12.3k +12,315
18 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 2,028,6112.0m $49.4m $49.4m 0.01% Added +616.3k +616,275
19 Holocene Advisors, LP 0.24% of their portfolio New York, NY 1,996,4762.0m $48.6m $48.6m 0.24% New
20 Avidity Partners Management LP 1.51% of their portfolio DALLAS, TX 1,869,2001.9m $45.5m $45.5m 1.51% Added +1.0m +1,030,793
21 ARMISTICE CAPITAL, LLC 1.04% of their portfolio NEW YORK, NY 1,836,0001.8m $44.7m $44.7m 1.04% Added +44.0k +44,000
22 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 1,721,7981.7m $41.9m $41.9m 0.02% Added +10.9k +10,895
23 Logos Global Management LP 5.29% of their portfolio San Francisco, CA 1,520,0001.5m $37.0m $37.0m 5.29% Added +20.0k +20,000
24 SAMLYN CAPITAL, LLC 0.68% of their portfolio New York, NY 1,517,7831.5m $36.9m $36.9m 0.68% Added +15.9k +15,908
25 DEERFIELD MANAGEMENT COMPANY, L.P. 0.82% of their portfolio New York, NY 1,504,5781.5m $36.6m $36.6m 0.82% Reduced -1.9m -1,920,274
26 PFM Health Sciences, LP 1.64% of their portfolio SAN FRANCISCO, CA 1,465,4831.5m $35.7m $35.7m 1.64% Added +547.9k +547,926
27 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 1,386,5331.4m $33.7m $33.7m 0.01% Reduced -47.7k -47,742
28 Polar Capital Holdings Plc 0.24% of their portfolio London, X0 1,362,0011.4m $33.1m $33.1m 0.24% Reduced -506.6k -506,627
29 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 1,302,7221.3m $31.7m $31.7m 0.01% Added +38.9k +38,920
30 DEUTSCHE BANK AG\ 0.02% of their portfolio FRANKFURT AM MAIN, 2M 1,281,9281.3m $31.2m $31.2m 0.02% Reduced -1.1m -1,148,521
31 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 1,243,1991.2m $30.2m $30.2m 0.01% Added +150.0k +150,021
32 MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio NEW YORK, NY 1,240,2971.2m $30.2m $30.2m 0.04% Reduced -931.2k -931,236
33 Balyasny Asset Management L.P. 0.10% of their portfolio Chicago, IL 1,202,7331.2m $29.3m $29.3m 0.10% Added +359.4k +359,422
34 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 1,187,3381.2m $28.9m $28.9m 0.01% Reduced -370.0k -369,955
35 KINGDON CAPITAL MANAGEMENT, L.L.C. 6.01% of their portfolio NEW YORK, NY 1,053,0001.1m $25.6m $25.6m 6.01% Added +200.0k +200,000
36 MPM BIOIMPACT LLC 6.61% of their portfolio BOSTON, MA 1,045,6911.0m $25.4m $25.4m 6.61% Reduced -14.0k -13,997
37 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 996,462996.5k $24.2m $24.2m 0.01% Reduced -281.0k -280,962
38 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 977,454977.5k $23.8m $23.8m 0.01% Added +13.1k +13,093
39 Candriam S.C.A. 0.14% of their portfolio STRASSEN, N4 930,930930.9k $20.8m $20.8m 0.14% Reduced -204.9k -204,902
40 Sofinnova Investments, Inc. 1.49% of their portfolio Menlo Park, CA 905,982906.0k $22.0m $22.0m 1.49% Added +267.6k +267,584
41 FMR LLC 0.00% of their portfolio BOSTON, MA 843,226843.2k $20.5m $20.5m 0.00% Added +367.7k +367,702
42 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 830,963831.0k $20.2m $20.2m 0.00% Added +398.1k +398,083
43 Boxer Capital, LLC 0.99% of their portfolio San Diego, CA 825,000825.0k $20.1m $20.1m 0.99% Unchanged
44 Skandinaviska Enskilda Banken AB (publ) 0.13% of their portfolio STOCKHOLM, V7 784,542784.5k $19.1m $19.1m 0.13% Reduced -6.3k -6,260
45 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 782,096782.1k $19.0m $19.0m 0.00% Added +83.0k +83,003
46 EMERALD ADVISERS, LLC 0.88% of their portfolio LEOLA, PA 754,032754.0k $18.3m $18.3m 0.88% Reduced -6.0k -6,012
47 Finepoint Capital LP 6.72% of their portfolio BOSTON, MA 723,600723.6k $17.6m $17.6m 6.72% Added +16.0k +16,000
48 TimesSquare Capital Management, LLC 0.26% of their portfolio NEW YORK, NY 719,825719.8k $17.5m $17.5m 0.26% Reduced -291.8k -291,815
49 BARCLAYS PLC 0.02% of their portfolio LONDON, X0 717,670717.7k $17.5m $17.5m 0.02% Added +483.5k +483,518
50 GREAT POINT PARTNERS LLC 3.34% of their portfolio Greenwich, CT 694,009694.0k $16.9m $16.9m 3.34% Reduced -131.0k -130,991
51 SAMSARA BIOCAPITAL, LLC 3.45% of their portfolio PALO ALTO, CA 686,835686.8k $16.7m $16.7m 3.45% Reduced -121.2k -121,206
52 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 613,355613.4k $14.9m $14.9m 0.00% Added +102.9k +102,915
53 DAFNA Capital Management LLC 4.47% of their portfolio LOS ANGELES, CA 612,975613.0k $14.9m $14.9m 4.47% Added +7.0k +7,000
54 EMERALD MUTUAL FUND ADVISERS TRUST 0.86% of their portfolio LEOLA, PA 599,181599.2k $14.6m $14.6m 0.86% Unchanged
55 PUTNAM INVESTMENTS LLC 0.02% of their portfolio BOSTON, MA 557,794557.8k $13.6m $13.6m 0.02% Added +180.9k +180,885
56 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 548,935548.9k $13.4m $13.4m 0.00% Reduced -30.7k -30,741
57 Driehaus Capital Management LLC 0.18% of their portfolio Chicago, IL 533,818533.8k $13.0m $13.0m 0.18% Reduced -248.9k -248,904
58 Hudson Bay Capital Management LP 0.07% of their portfolio STAMFORD, CT 512,252512.3k $12.5m $12.5m 0.07% New
59 Ensign Peak Advisors, Inc 0.03% of their portfolio SALT LAKE CITY, UT 512,215512.2k $12.5m $12.5m 0.03% Added +6.0k +6,050
60 PERCEPTIVE ADVISORS LLC 0.36% of their portfolio NEW YORK, NY 500,000500.0k $12.2m $12.2m 0.36% Reduced -87.4k -87,400
61 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 499,048499.0k $12.1m $12.1m 0.01% Added +379.7k +379,651
62 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.07% of their portfolio SAN FRANCISCO, CA 484,799484.8k $11.8m $11.8m 0.07% Reduced -977.2k -977,201
63 WESTFIELD CAPITAL MANAGEMENT CO LP 0.08% of their portfolio BOSTON, MA 476,721476.7k $11.6m $11.6m 0.08% New
64 FEDERATED HERMES, INC. 0.03% of their portfolio PITTSBURGH, PA 470,000470.0k $11.4m $11.4m 0.03% New
65 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 442,355442.4k $10.8m $10.8m 0.00% Added +374.8k +374,774
66 Lombard Odier Asset Management (Switzerland) SA 0.88% of their portfolio PETIT-LANCY, V8 413,115413.1k $10.1m $10.1m 0.88% Added +177.6k +177,556
67 Artia Global Partners LP 3.96% of their portfolio MIAMI, FL 404,615404.6k $9.8m $9.8m 3.96% Reduced -100.0k -100,000
68 Duquesne Family Office LLC 0.42% of their portfolio New York, NY 400,000400.0k $9.7m $9.7m 0.42% New
69 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 377,747377.7k $9.2m $9.2m 0.01% Added +336.0k +335,989
70 JANE STREET GROUP, LLC 0.02% of their portfolio NEW YORK, NY 368,096368.1k $9.0m $9.0m 0.02% Added +329.7k +329,654
71 Schonfeld Strategic Advisors LLC 0.08% of their portfolio NEW YORK, NY 341,075341.1k $8.3m $8.3m 0.08% Added +75.5k +75,541
72 LORD, ABBETT & CO. LLC 0.01% of their portfolio JERSEY CITY, NJ 339,420339.4k $8.3m $8.3m 0.01% Added +12.8k +12,754
73 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 327,677327.7k $8.0m $8.0m 0.01% Added +98.4k +98,392
74 Polar Asset Management Partners Inc. 0.14% of their portfolio TORONTO, A6 317,315317.3k $7.7m $7.7m 0.14% Reduced -277.3k -277,300
75 Rafferty Asset Management, LLC 0.05% of their portfolio New York, NY 315,468315.5k $7.7m $7.7m 0.05% Reduced -82.9k -82,888
76 Artisan Partners Limited Partnership 0.01% of their portfolio Milwaukee, WI 311,121311.1k $7.6m $7.6m 0.01% New
77 THORNBURG INVESTMENT MANAGEMENT INC 0.12% of their portfolio SANTA FE, NM 291,337291.3k $7.1m $7.1m 0.12% Reduced -3.5k -3,504
78 Woodline Partners LP 0.10% of their portfolio San Francisco, CA 289,458289.5k $7.0m $7.0m 0.10% New
79 5AM Venture Management, LLC 1.77% of their portfolio SAN FRANCISCO, CA 284,626284.6k $6.9m $6.9m 1.77% Reduced -100.0k -100,000
80 ACUTA CAPITAL PARTNERS, LLC 5.31% of their portfolio REDWOOD CITY, CA 280,500280.5k $6.8m $6.8m 5.31% Reduced -80.0k -80,000
81 Rhenman & Partners Asset Management AB 0.73% of their portfolio Stockholm, V7 280,000280.0k $6.7m $6.7m 0.73% Reduced -150.0k -150,000
82 NORGES BANK 0.00% of their portfolio OSLO, Q8 268,586268.6k $6.5m $6.5m 0.00% Added +129.2k +129,246
83 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 264,037264.0k $6.4m $6.4m 0.01% Reduced -109.5k -109,494
84 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 263,965264.0k $6.4m $6.4m 0.01% Added +84.6k +84,617
85 Ally Bridge Group (NY) LLC 8.14% of their portfolio NEW YORK, NY 255,310255.3k $6.2m $6.2m 8.14% New
86 Swiss National Bank 0.00% of their portfolio ZURICH, V8 246,000246.0k $6.0m $6.0m 0.00% Reduced -29.2k -29,200
87 SPHERA FUNDS MANAGEMENT LTD. 1.22% of their portfolio TEL AVIV, L3 231,591231.6k $5.6m $5.6m 1.22% Added +36.0k +36,000
88 Pier Capital, LLC 0.85% of their portfolio STAMFORD, CT 231,162231.2k $5.6m $5.6m 0.85% Added +2.4k +2,410
89 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 223,218223.2k $5.4m $5.4m 0.01% Added +60.8k +60,800
90 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 216,059216.1k $5.3m $5.3m 0.00% Added +51.1k +51,054
91 Ikarian Capital, LLC 2.16% of their portfolio DALLAS, TX 213,521213.5k $5.2m $5.2m 2.16% Reduced -163.5k -163,500
92 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 206,336206.3k $5.0m $5.0m 0.01% Reduced -606.6k -606,631
93 TWINBEECH CAPITAL LP 0.10% of their portfolio PURCHASE, NY 204,435204.4k $5.0m $5.0m 0.10% Added +89.3k +89,313
94 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 189,700189.7k $4.6m $4.6m 0.01% Added +176.1k +176,100
95 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 187,878187.9k $4.6m $4.6m 0.01% Added +6.1k +6,083
96 Global IMC LLC 1.22% of their portfolio SOLANA BEACH, CA 178,456178.5k $4.3m $4.3m 1.22% Added +16.4k +16,352
97 J. Goldman & Co LP 0.25% of their portfolio NEW YORK, NY 176,543176.5k $4.3m $4.3m 0.25% Reduced -128.8k -128,835
98 Ghost Tree Capital, LLC 1.61% of their portfolio NEW YORK, NY 175,000175.0k $4.3m $4.3m 1.61% Reduced -275.0k -275,000
99 MOORE CAPITAL MANAGEMENT, LP 0.13% of their portfolio NEW YORK, NY 171,241171.2k $4.2m $4.2m 0.13% Reduced -38.8k -38,759
100 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 150,927150.9k $3.7m $3.7m 0.01% Reduced -2.0k -1,952