Vault-13

ITEOS THERAPEUTICS INC ITOS

COM · Common Stock · CUSIP 46565G104 · ISIN US46565G1040

154 institutional holders +7 vs Q4 2022
36,260,04736.3m shares reported held*
$492.6mreported value*
25 new 46 added 56 reduced 17 sold out net bought ≈ $1.1m (+78.2k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($61.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $13.59. Options: 4 managers hold calls ($321.6k notional), 5 hold puts ($948.3k).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 144Q4 22: 147Q1 23: 154154Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022144
Q4 2022147
Q1 2023154

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 68 bought or addedQ4 22: 60 cut or sold outQ4 22Q1 23: 71 bought or addedQ1 23: 73 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20226860
Q1 20237173

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5mQ3 22 calls: $201.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $1.0mQ4 22 puts: $460.5kQ4 22P/C 0.45Q1 23 calls: $321.6kQ1 23 puts: $948.3kQ1 23P/C 2.95
Numbers
QuarterCallsPutsP/C
Q3 2022$201.0k$00.00
Q4 2022$1.0m$460.5k0.45
Q1 2023$321.6k$948.3k2.95

Biggest buyers

683 Capital Management, LLC Added +330,000+330.0k
DIMENSIONAL FUND ADVISORS LP Added +250,455+250.5k
Octagon Capital Advisors LP Added +151,000+151.0k
Saturn V Capital Management LP Added +138,582+138.6k
STATE STREET CORP Added +90,101+90.1k
CITADEL ADVISORS LLC Added +88,073+88.1k
LMR Partners LLP Added +82,700+82.7k
STRS OHIO Added +75,100+75.1k
FMR LLC Added +70,432+70.4k
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) New +69,300+69.3k

Biggest sellers

MILLENNIUM MANAGEMENT LLC Reduced -346,208-346.2k
BANK OF AMERICA CORP /DE/ Reduced -314,885-314.9k
MORGAN STANLEY Reduced -283,645-283.6k
Advisors Preferred, LLC Sold out -90,973-91.0k
Allspring Global Investments Holdings, LLC Reduced -90,960-91.0k
Integral Health Asset Management, LLC Reduced -90,000-90.0k
Man Group plc Sold out -85,756-85.8k
BRAIDWELL LP Sold out -71,585-71.6k
PFM Health Sciences, LP Sold out -70,922-70.9k
AMERICAN CENTURY COMPANIES INC Reduced -62,416-62.4k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $303.5k22.3k shares
SIMPLEX TRADING, LLC New $14.0k1.1k shares
CITADEL ADVISORS LLC Reduced $4.1k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $390.6k28.7k shares
GROUP ONE TRADING LLC New $276.3k20.3k shares
CITADEL ADVISORS LLC Added $201.4k14.8k shares
SIMPLEX TRADING, LLC Added $80.0k5.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
TANG CAPITAL MANAGEMENT LLC 13D · may seek influence +90.0 pts · filed 2025-09-03
Stated purposeItem 4 of the Schedule 13D is amended by adding the following: Closing of the Merger: As previously disclosed, each of Concentra, the Issuer and Merger Sub entered into the Merger Agreement, which provides for an Offer by Merger Sub for all of the Issuer's Common Stock. The Offer commenced on August 1, 2025. On August 29, 2025, the Offer expired and Merger Sub accepted for purchase a total of 32,226,407 shares tendered and not withdrawn, representing approximately 72.17% of the total shares of the Issuer issued and outstanding. Following the expiration of the Offer, Merger Sub merged with and into the Issuer on August 29, 2025, pursuant to Section 251(h) of the Delaware General Corporation Law, and, among other things, each share of common stock of Merger Sub issued and outstanding immed… Full filing
 100.0% +90.0 pts 10.0k 2025-09-03
EcoR1 Capital, LLC 13D · may seek influence +13.0 pts · filed 2025-05-16
Stated purposeAll of the Common Stock of the Issuer reported on this Schedule 13D was acquired in the ordinary course of business by the reporting persons for investment purposes. The reporting persons have no present plans or proposals that relate to or would result in any of the actions described in Item 4(a) through (j) of Schedule 13D. The reporting persons may evaluate on a continuing basis the investment in the Issuer and may, from time to time, acquire or dispose of Common Stock of the Issuer. Any such acquisitions or dispositions will depend upon (i) the price and availability of the Issuer's securities; (ii) subsequent developments concerning the Issuer's business and prospects and the industry in which the Issuer operates; (iii) investment policies of the reporting persons; (iv) other invest… Full filing
 27.9% +13.0 pts 10.7m 2025-05-16
BlackRock Portfolio Management LLC 13G · institution new · filed 2025-04-15 6.1% new 2.3m 2025-04-15
BlackRock, Inc. 13G · institution filed 2025-04-23 5.7% 2.2m 2025-04-23

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.00% of their portfolio New York, NY 4,463,3064.5m $60.7m $60.7m 0.00% Reduced -16.1k -16,115
2 RA CAPITAL MANAGEMENT, L.P. 1.36% of their portfolio BOSTON, MA 4,417,2594.4m $60.1m $60.1m 1.36% Unchanged
3 MPM ASSET MANAGEMENT LLC 15.53% of their portfolio BOSTON, MA 2,738,7852.7m $37.3m $37.3m 15.53% Unchanged
4 Boxer Capital, LLC 1.44% of their portfolio San Diego, CA 2,154,0582.2m $29.3m $29.3m 1.44% Unchanged
5 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,827,3911.8m $24.9m $24.9m 0.00% Added +90.1k +90,101
6 BVF INC/IL 0.90% of their portfolio San Francisco, CA 1,810,8351.8m $24.6m $24.6m 0.90% Unchanged
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,772,9891.8m $24.1m $24.1m 0.00% Reduced -46.0k -46,041
8 MPM BIOIMPACT LLC 6.17% of their portfolio BOSTON, MA 1,745,9431.7m $23.8m $23.8m 6.17% Unchanged
9 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 1,443,5001.4m $19.6m $19.6m 0.02% Added +88.1k +88,073
10 Candriam S.C.A. 0.06% of their portfolio STRASSEN, N4 739,517739.5k $9.3m $9.3m 0.06% Unchanged
11 Octagon Capital Advisors LP 1.17% of their portfolio NEW YORK, NY 596,000596.0k $8.1m $8.1m 1.17% Added +151.0k +151,000
12 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 588,561588.6k $8.0m $8.0m 0.00% Reduced -20.0k -20,039
13 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 563,214563.2k $7.7m $7.7m 0.00% Reduced -283.6k -283,645
14 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 528,272528.3k $7.2m $7.2m 0.01% Reduced -346.2k -346,208
15 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 526,157526.2k $7.2m $7.2m 0.00% Reduced -57.8k -57,801
16 JACOBS LEVY EQUITY MANAGEMENT, INC 0.04% of their portfolio FLORHAM PARK, NJ 514,925514.9k $7.0m $7.0m 0.04% Added +11.4k +11,395
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 481,239481.2k $6.5m $6.5m 0.00% Added +9.7k +9,731
18 Saturn V Capital Management LP 4.89% of their portfolio AUSTIN, TX 480,653480.7k $6.5m $6.5m 4.89% Added +138.6k +138,582
19 683 Capital Management, LLC 0.58% of their portfolio NEW YORK, NY 480,000480.0k $6.5m $6.5m 0.58% Added +330.0k +330,000
20 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 438,109438.1k $6.0m $6.0m 0.00% Added +11.6k +11,598
21 FMR LLC 0.00% of their portfolio BOSTON, MA 425,430425.4k $5.8m $5.8m 0.00% Added +70.4k +70,432
22 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 415,606415.6k $5.7m $5.7m 0.00% Added +250.5k +250,455
23 Artal Group S.A. 0.32% of their portfolio LUXEMBOURG, N4 400,000400.0k $5.4m $5.4m 0.32% Unchanged
24 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 329,900329.9k $4.5m $4.5m 0.01% Added +12.8k +12,800
25 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 288,885288.9k $3.9m $3.9m 0.01% Added +54.6k +54,589
26 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.10% of their portfolio HOUSTON, TX 266,945266.9k $3.6m $3.6m 0.10% Added +23.4k +23,445
27 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 261,955262.0k $3.6m $3.6m 0.00% Reduced -12.4k -12,418
28 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 256,956257.0k $3.5m $3.5m 0.00% Added +2.0k +1,995
29 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 252,019252.0k $3.4m $3.4m 0.00% Reduced -1.7k -1,668
30 AXA S.A. 0.01% of their portfolio PARIS, I0 218,600218.6k $3.0m $3.0m 0.01% Reduced -496 -496
31 TANG CAPITAL MANAGEMENT LLC 0.44% of their portfolio SAN DIEGO, CA 216,700216.7k $2.9m $2.9m 0.44% Unchanged
32 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 182,966183.0k $2.5m $2.5m 0.00% Added +477 +477
33 Integral Health Asset Management, LLC 0.51% of their portfolio New York, NY 180,000180.0k $2.4m $2.4m 0.51% Reduced -90.0k -90,000
34 AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio Greenwich, CT 176,822176.8k $2.4m $2.4m 0.01% Reduced -25.5k -25,521
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 157,630157.6k $2.1m $2.1m 0.00% Reduced -314.9k -314,885
36 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 157,361157.4k $2.1m $2.1m 0.00% Added +11.3k +11,300
37 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 155,157155.2k $2.1m $2.1m 0.00% Reduced -3.3k -3,331
38 BAKER BROS. ADVISORS LP 0.01% of their portfolio NEW YORK, NY 150,346150.3k $2.0m $2.0m 0.01% Unchanged
39 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 148,594148.6k $2.0m $2.0m 0.00% Reduced -2.0k -1,953
40 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 138,640138.6k $1.9m $1.9m 0.00% Added +16.7k +16,653
41 PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio BOSTON, MA 116,734116.7k $1.6m $1.6m 0.01% Added +66.3k +66,303
42 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 114,050114.0k $1.6m $1.6m 0.01% Added +11.4k +11,384
43 LMR Partners LLP 0.03% of their portfolio LONDON, X0 112,919112.9k $1.5m $1.5m 0.03% Added +82.7k +82,700
44 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 110,290110.3k $1.5m $1.5m 0.00% Reduced -62.4k -62,416
45 LOS ANGELES CAPITAL MANAGEMENT LLC 0.01% of their portfolio LOS ANGELES, CA 107,222107.2k $1.5m $1.5m 0.01% Added +19.0k +19,024
46 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 104,100104.1k $1.4m $1.4m 0.00% Added +75.1k +75,100
47 DAFNA Capital Management LLC 0.40% of their portfolio LOS ANGELES, CA 98,56098.6k $1.3m $1.3m 0.40% Unchanged
48 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 97,28297.3k $1.3m $1.3m 0.00% Added +7.9k +7,854
49 SECTORAL ASSET MANAGEMENT INC 0.23% of their portfolio MONTREAL, A8 88,37388.4k $1.2m $1.2m 0.23% Added +30.6k +30,611
50 Vontobel Holding Ltd. 0.01% of their portfolio ZURICH, V8 88,37388.4k $1.2m $1.2m 0.01% Added +30.6k +30,611
51 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 84,44984.4k $1.1m $1.1m 0.00% Added +20.9k +20,857
52 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio Boston, MA 83,15483.2k $1.1m $1.1m 0.00% Reduced -40.7k -40,708
53 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 81,22181.2k $1.1m $1.1m 0.00% Added +7.2k +7,216
54 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 72,66672.7k $989.0k $989.0k 0.00% Added +5.7k +5,653
55 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 72,24672.2k $983.0k $983.0k 0.00% Added +27.6k +27,586
56 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 69,30069.3k $943.2k $943.2k 0.02% New
57 AlphaCentric Advisors LLC 0.59% of their portfolio SAN JUAN, PR 63,00063.0k $857.4k $857.4k 0.59% New
58 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 61,24761.2k $834.0k $834.0k 0.00% Added +3.0k +3,025
59 Legal & General Group Plc 0.00% of their portfolio London, X0 58,12558.1k $791.1k $791.1k 0.00% Reduced -940 -940
60 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 55,00955.0k $748.7k $748.7k 0.00% New
61 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 54,11554.1k $736.5k $736.5k 0.01% New
62 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 51,24351.2k $697.4k $697.4k 0.00% Added +11.0k +10,996
63 JUPITER ASSET MANAGEMENT LTD 0.01% of their portfolio London, X0 48,92148.9k $663.9k $663.9k 0.01% Reduced -9.3k -9,318
64 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 46,44846.4k $632.2k $632.2k 0.01% New
65 Tekla Capital Management LLC 0.02% of their portfolio Boston, MA 45,73545.7k $622.5k $622.5k 0.02% New
66 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 43,76943.8k $595.7k $595.7k 0.00% Added +25.1k +25,128
67 UBS Group AG 0.00% of their portfolio ZURICH, V8 43,64743.6k $594.0k $594.0k 0.00% Reduced -47.2k -47,218
68 Public Sector Pension Investment Board 0.00% of their portfolio MONTREAL, A8 43,17243.2k $587.6k $587.6k 0.00% Reduced -1.8k -1,822
69 Swiss National Bank 0.00% of their portfolio ZURICH, V8 42,20042.2k $574.3k $574.3k 0.00% Reduced -5.0k -5,000
70 VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% of their portfolio RICHMOND, VA 39,90039.9k $543.0k $543.0k 0.01% Reduced -4.1k -4,100
71 BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 35,65235.7k $485.2k $485.2k 0.01% New
72 Vident Investment Advisory, LLC 0.01% of their portfolio Alpharetta, GA 32,88732.9k $447.6k $447.6k 0.01% Reduced -1.1k -1,134
73 Prairiewood Capital, LLC 0.30% of their portfolio FARGO, ND 32,26932.3k $439.2k $439.2k 0.30% Unchanged
74 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 31,31931.3k $426.3k $426.3k 0.00% Reduced -16.1k -16,083
75 CAXTON ASSOCIATES LP 0.07% of their portfolio NEW YORK, NY 30,69530.7k $417.8k $417.8k 0.07% New
76 Allianz Asset Management GmbH 0.00% of their portfolio MUNICH, 2M 30,17930.2k $410.7k $410.7k 0.00% New
77 NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio ALBANY, NY 29,41729.4k $400.0k $400.0k 0.00% Added +300 +300
78 COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 0.00% of their portfolio HARRISBURG, PA 25,99126.0k $353.7k $353.7k 0.00% Reduced -280 -280
79 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 25,93725.9k $353.0k $353.0k 0.00% Reduced -455 -455
80 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 25,30025.3k $344.3k $344.3k 0.00% Reduced -3.6k -3,622
81 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 25,16125.2k $342.4k $342.4k 0.00% Added +4.0k +4,024
82 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 24,91124.9k $339.0k $339.0k 0.00% Reduced -281 -281
83 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 24,56824.6k $334.4k $334.4k 0.00% Added +23.9k +23,855
84 Thrivent Financial for Lutherans 0.00% of their portfolio Minneapolis, MN 24,32624.3k $331.0k $331.0k 0.00% Reduced -853 -853
85 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio COLUMBUS, OH 23,97924.0k $326.0k $326.0k 0.00% Unchanged
86 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 23,46623.5k $319.0k $319.0k 0.00% Reduced -1.8k -1,812
87 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 23,43523.4k $318.9k $318.9k 0.00% Reduced -16.3k -16,262
88 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 22,86422.9k $311.2k $311.2k 0.00% Added +1.6k +1,608
89 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 22,17022.2k $301.7k $301.7k 0.02% New
90 YOUSIF CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BLOOMFIELD HILLS, MI 22,07222.1k $300.4k $300.4k 0.00% Reduced -2.1k -2,130
91 TEXAS PERMANENT SCHOOL FUND CORP 0.00% of their portfolio AUSTIN, TX 21,73421.7k $295.8k $295.8k 0.00% Added +5.2k +5,232
92 Ziegler Capital Management, LLC 0.01% of their portfolio CHICAGO, IL 21,70421.7k $295.4k $295.4k 0.01% Added +214 +214
93 NinePointTwo Capital LLC 0.10% of their portfolio LOS ANGELES, CA 19,51019.5k $265.0k $265.0k 0.10% New
94 ClariVest Asset Management LLC 0.01% of their portfolio SAN DIEGO, CA 18,63218.6k $254.0k $254.0k 0.01% Reduced -68 -68
95 WINTON GROUP Ltd 0.02% of their portfolio LONDON, X0 18,43018.4k $250.8k $250.8k 0.02% Reduced -1.1k -1,097
96 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 17,71017.7k $241.0k $241.0k 0.00% Reduced -91.0k -90,960
97 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 17,67217.7k $241.0k $241.0k 0.00% Reduced -58 -58
98 State of Alaska, Department of Revenue 0.00% of their portfolio JUNEAU, AK 16,80916.8k $228.0k $228.0k 0.00% Reduced -283 -283
99 J.P. Morgan Private Wealth Advisors LLC 0.00% of their portfolio SAN FRANCISCO, CA 15,97916.0k $217.5k $217.5k 0.00% Reduced -4.8k -4,825
100 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 15,43715.4k $210.1k $210.1k 0.00% Added +4.3k +4,301