Vault-13

IONIS PHARMACEUTICALS INC IONS

COM · Common Stock · CUSIP 462222100 · ISIN US4622221004

American pharmaceutical company

513 institutional holders +16 vs Q1 2026
179,044,090179.0m shares reported held*
107.7% of all shares outstanding*
$14.2bnreported value*
61 new 202 added 159 reduced 46 sold out net bought ≈ $548.6m (+7.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($56.2m this quarter). Holder counts are more reliable. Shares outstanding: 166.2m as of 2026-07-23, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $79.38. Options: 29 managers hold calls ($395.4m notional), 19 hold puts ($250.1m).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 350Q4 22: 339Q1 23: 316Q2 23: 307Q3 23: 313Q4 23: 366Q1 24: 362Q2 24: 358Q3 24: 357Q4 24: 359Q1 25: 348Q2 25: 366Q3 25: 439Q4 25: 494Q1 26: 497Q2 26: 513513Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 2022350
Q4 2022339
Q1 2023316
Q2 2023307
Q3 2023313
Q4 2023366
Q1 2024362
Q2 2024358
Q3 2024357
Q4 2024359
Q1 2025348
Q2 2025366
Q3 2025439
Q4 2025494
Q1 2026497
Q2 2026513

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q3 24: 176 bought or addedQ3 24: 159 cut or sold outQ4 24: 160 bought or addedQ4 24: 169 cut or sold outQ4 24Q1 25: 150 bought or addedQ1 25: 184 cut or sold outQ2 25: 197 bought or addedQ2 25: 169 cut or sold outQ2 25Q3 25: 245 bought or addedQ3 25: 152 cut or sold outQ4 25: 261 bought or addedQ4 25: 186 cut or sold outQ4 25Q1 26: 241 bought or addedQ1 26: 223 cut or sold outQ2 26: 263 bought or addedQ2 26: 205 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 2024176159
Q4 2024160169
Q1 2025150184
Q2 2025197169
Q3 2025245152
Q4 2025261186
Q1 2026241223
Q2 2026263205

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300m$400mQ3 25 calls: $171.8mQ3 25 puts: $74.8mQ3 25P/C 0.44Q4 25 calls: $149.5mQ4 25 puts: $102.3mQ4 25P/C 0.68Q1 26 calls: $141.4mQ1 26 puts: $144.3mQ1 26P/C 1.02Q2 26 calls: $395.4mQ2 26 puts: $250.1mQ2 26P/C 0.63
Numbers
QuarterCallsPutsP/C
Q3 2025$171.8m$74.8m0.44
Q4 2025$149.5m$102.3m0.68
Q1 2026$141.4m$144.3m1.02
Q2 2026$395.4m$250.1m0.63

Biggest buyers

ROYAL BANK OF CANADA Added +2,380,664+2.4m
BARCLAYS PLC Added +1,313,262+1.3m
WELLINGTON MANAGEMENT GROUP LLP Added +1,259,599+1.3m
Alyeska Investment Group, L.P. Added +944,766+944.8k
Capital International Investors New +823,764+823.8k
Polar Capital Holdings Plc Added +624,510+624.5k
Artisan Partners Limited Partnership Added +581,716+581.7k
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. Added +515,111+515.1k
Capital World Investors Added +482,857+482.9k
Davern Capital Partners, LP Added +411,806+411.8k

Biggest sellers

T. Rowe Price Investment Management, Inc. Reduced -2,199,655-2.2m
Bellevue Group AG Reduced -846,407-846.4k
MILLENNIUM MANAGEMENT LLC Reduced -762,634-762.6k
CITADEL ADVISORS LLC Reduced -706,250-706.2k
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Reduced -616,770-616.8k
AMERIPRISE FINANCIAL INC Reduced -592,439-592.4k
Squarepoint Ops LLC Reduced -585,897-585.9k
GEODE CAPITAL MANAGEMENT, LLC Reduced -400,308-400.3k
Zurich Insurance Group Ltd/FI Sold out -239,645-239.6k
J. Goldman & Co LP Reduced -194,894-194.9k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $103.1m1.3m shares
Caption Management, LLC New $50.0m630.0k shares
JANE STREET GROUP, LLC Added $44.0m555.5k shares
Ikarian Capital, LLC Added $31.7m400.0k shares
Integral Health Asset Management, LLC New $23.8m300.0k shares
MILLENNIUM MANAGEMENT LLC New $20.4m257.5k shares
CITADEL ADVISORS LLC Added $18.4m232.5k shares
JPMORGAN CHASE & CO Unchanged $13.3m165.0k shares
CITIGROUP INC Added $12.0m151.3k shares
IMC-Chicago, LLC Added $10.1m127.8k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $65.2m822.1k shares
JANE STREET GROUP, LLC Added $43.1m543.2k shares
CITADEL ADVISORS LLC Added $30.6m386.5k shares
Caption Management, LLC New $27.4m345.9k shares
Ikarian Capital, LLC New $23.8m300.0k shares
JPMORGAN CHASE & CO Unchanged $13.3m165.0k shares
IMC-Chicago, LLC Added $9.9m124.9k shares
BOOTHBAY FUND MANAGEMENT, LLC New $7.3m92.1k shares
SIG BROKERAGE, LP Added $6.5m82.5k shares
SIMPLEX TRADING, LLC Added $5.1m64.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Capital World Investors 13G · institution +1.7 pts · filed 2026-05-14 12.8% +1.7 pts 21.2m≈ $1.7bn 2026-05-14
BlackRock, Inc. 13G · institution filed 2025-04-17 5.7% 9.1m≈ $718.9m 2025-04-17
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.0% new 8.3m≈ $661.7m 2026-04-30

Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (3.7%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
20020Q4 24: 1 buyingQ4 24: 3 sellingQ1 25: 0 buyingQ1 25: 10 sellingQ1 25Q2 25: 1 buyingQ2 25: 3 sellingQ3 25: 0 buyingQ3 25: 14 sellingQ3 25Q4 25: 0 buyingQ4 25: 12 sellingQ1 26: 0 buyingQ1 26: 15 sellingQ1 26Q2 26: 0 buyingQ2 26: 13 sellingQ3 26: 1 buyingQ3 26: 4 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20241$181.1k3$811.0k$809.0k
Q1 20250—10$5.2m$1.5m
Q2 20251$477.9k3$216.4k—
Q3 20250—14$42.6m$29.3m
Q4 20250—12$26.8m$23.7m
Q1 20260—15$75.8m$57.6m
Q2 20260—13$26.5m$25.7m
Q3 20261$1.1m4$3.5m$3.5m
DateInsiderTradeSharesPrice ValueTheir holding
2026-07-31 Hayden Michael R Director · by Spouse Bought 5,000 $51.60 $258.0k5.0k shares +26%
2026-07-30 Hayden Michael R Director · by Spouse Bought 15,000 $53.38 $800.7k15.0k shares +375%
2026-07-07 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 15,000 $85.46 $1.3m15.0k shares -100%
2026-07-07 Diaz Allene M. Director Sold plan 10,111 $85.42 $863.7k10.1k shares -73%
2026-07-07 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 5,536 $83.58 $462.7k5.5k shares -7%
2026-07-07 Kordasiewicz Holly B. EVP, Chief Development Officer Sold plan 362 $84.30 $30.5k362 shares -2%
2026-07-01 KLEIN JOSEPH III Director Sold plan 11,518 $79.04 $910.4k11.5k shares -51%
2026-06-26 Monia Brett P Chief Executive Officer, director Sold plan 50,000 $80.59 $4.0m50.0k shares -17%
2026-06-26 Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold plan 26,000 $81.05 $2.1m26.0k shares -25%
2026-06-26 Baroldi Joseph EVP, Chief Business Officer · by Spouse Sold plan 5,635 $80.16 $451.7k5.6k shares -55%
2026-06-26 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 3,069 $80.00 $245.5k3.1k shares -5%
2026-06-25 Monia Brett P Chief Executive Officer, director Sold plan 21,072 $78.49 $1.7m21.1k shares -8%
2026-06-25 Swayze Eric EVP Research Sold plan 10,602 $79.18 $839.5k10.6k shares -33%
2026-06-24 Monia Brett P Chief Executive Officer, director Sold plan 14,565 $78.41 $1.1m14.6k shares -6%
2026-06-15 BERTHELSEN SPENCER R Director Sold plan 8,000 $73.49 $587.9k8.0k shares -5%
2026-06-12 Kordasiewicz Holly B. EVP, Chief Development Officer Sold plan 60,846 $73.40 $4.5m60.8k shares -73%
2026-06-01 BERTHELSEN SPENCER R Director Sold plan 8,000 $75.67 $605.4k8.0k shares -5%
2026-05-14 Monia Brett P Chief Executive Officer, director Sold plan 3,220 $78.68 $253.3k3.2k shares -1%
2026-05-13 Monia Brett P Chief Executive Officer, director Sold plan 1,316 $78.01 $102.7k1.3k shares -0%
2026-05-04 LOSCALZO JOSEPH Director Sold plan 77,289 $75.06 $5.8m77.3k shares -68%
2026-05-01 KLEIN JOSEPH III Director Sold plan 10,111 $73.51 $743.2k10.1k shares -48%
2026-04-28 Baroldi Joseph EVP, Chief Business Officer Sold plan 1,626 $71.79 $116.7k1.6k shares -4%
2026-04-16 Baroldi Joseph EVP, Chief Business Officer Sold 5,619 $74.56 $419.0k5.6k shares -11%
2026-04-16 Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sold 4,902 $75.17 $368.5k4.9k shares -17%
2026-04-16 Birchler Brian EVP, Corp and Development Ops Sold 973 $75.04 $73.0k973 shares -1%
2026-04-15 PARSHALL B LYNNE Director Sold plan 5,000 $76.27 $381.4k5.0k shares -9%
2026-04-02 Devers Shannon L. EVP, Chief Human Resources Ofc Sold plan 6,193 $74.05 $458.6k6.2k shares -28%
2026-04-01 KLEIN JOSEPH III Director Sold plan 22,321 $75.54 $1.7m22.3k shares -67%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.08% of their portfolio BOSTON, MA 24,631,95624.6m $2.0bn $2.0bn 0.08% Added +75.3k +75,319
2 Capital World Investors 0.20% of their portfolio LOS ANGELES, CA 21,669,22621.7m $1.7bn $1.7bn 0.20% Added +482.9k +482,857
3 BlackRock, Inc. 0.01% of their portfolio New York, NY 10,704,66010.7m $848.8m $848.8m 0.01% Added +262.2k +262,184
4 VANGUARD PORTFOLIO MANAGEMENT LLC 0.03% of their portfolio MALVERN, PA 7,859,5297.9m $623.2m $623.2m 0.03% Added +50.6k +50,627
5 WELLINGTON MANAGEMENT GROUP LLP 0.10% of their portfolio Boston, MA 7,651,4157.7m $606.7m $606.7m 0.10% Added +1.3m +1,259,599
6 VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 7,211,4977.2m $571.8m $571.8m 0.01% Added +93.2k +93,167
7 TWO SIGMA INVESTMENTS, LP 0.37% of their portfolio NEW YORK, NY 6,252,3426.3m $495.7m $495.7m 0.37% Added +394.7k +394,713
8 ROYAL BANK OF CANADA 0.08% of their portfolio TORONTO, A6 6,182,4796.2m $490.2m $490.2m 0.08% Added +2.4m +2,380,664
9 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 4,334,8484.3m $343.7m $343.7m 0.01% Added +339.3k +339,284
10 T. Rowe Price Investment Management, Inc. 0.21% of their portfolio BALTIMORE, MD 3,959,3724.0m $313.9m $313.9m 0.21% Reduced -2.2m -2,199,655
11 GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio BOSTON, MA 3,584,0243.6m $294.8m $294.8m 0.02% Reduced -400.3k -400,308
12 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 3,184,5003.2m $252.5m $252.5m 0.03% Added +159.2k +159,249
13 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 2,671,7172.7m $216.2m $216.2m 0.01% Added +308.1k +308,150
14 Artisan Partners Limited Partnership 0.34% of their portfolio Milwaukee, WI 2,640,0242.6m $209.3m $209.3m 0.34% Added +581.7k +581,716
15 Tweedy, Browne Co LLC 13.70% of their portfolio Stamford, CT 2,280,3112.3m $180.8m $180.8m 13.70% Added +4.7k +4,686
16 Deep Track Capital, LP 2.57% of their portfolio GREENWICH, CT 2,200,0002.2m $174.4m $174.4m 2.57% Added +250.0k +250,000
17 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 2,109,9452.1m $167.3m $167.3m 0.02% Added +410.1k +410,098
18 BAKER BROS. ADVISORS LP 0.81% of their portfolio NEW YORK, NY 2,047,7272.0m $162.4m $162.4m 0.81% Unchanged
19 DEERFIELD MANAGEMENT COMPANY, L.P. 1.64% of their portfolio New York, NY 1,979,6692.0m $157.0m $157.0m 1.64% Unchanged
20 AMERICAN CENTURY COMPANIES INC 0.07% of their portfolio KANSAS CITY, MO 1,947,0761.9m $154.4m $154.4m 0.07% Added +283.3k +283,273
21 FRANKLIN RESOURCES INC 0.03% of their portfolio San Mateo, CA 1,623,3771.6m $128.7m $128.7m 0.03% Added +48.4k +48,354
22 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 1,605,0541.6m $127.3m $127.3m 0.02% Added +21.8k +21,788
23 BARCLAYS PLC 0.04% of their portfolio LONDON, X0 1,603,1361.6m $127.1m $127.1m 0.04% Added +1.3m +1,313,262
24 Pictet Asset Management Holding SA 0.12% of their portfolio CAROUGE, V8 1,596,9981.6m $127.0m $127.0m 0.12% Added +162.0k +162,003
25 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio NEW YORK, NY 1,454,6721.5m $115.3m $115.3m 0.02% Reduced -21.0k -20,960
26 Polar Capital Holdings Plc 0.33% of their portfolio London, X0 1,454,0211.5m $115.3m $115.3m 0.33% Added +624.5k +624,510
27 Alyeska Investment Group, L.P. 0.29% of their portfolio CHICAGO, IL 1,417,9161.4m $112.4m $112.4m 0.29% Added +944.8k +944,766
28 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.15% of their portfolio PHILADELPHIA, PA 1,300,3921.3m $103.1m $103.1m 0.15% Added +515.1k +515,111
29 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,281,4441.3m $101.6m $101.6m 0.01% Added +254.9k +254,935
30 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 1,120,7071.1m $88.9m $88.9m 0.01% Reduced -156.7k -156,651
31 VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio MALVERN, PA 1,060,8451.1m $84.1m $84.1m 0.02% Added +36.5k +36,468
32 Bellevue Group AG 1.62% of their portfolio ZURICH, V8 972,258972.3k $77.1m $77.1m 1.62% Reduced -846.4k -846,407
33 GROUPAMA ASSET MANAGMENT 0.95% of their portfolio PARIS, I0 937,083937.1k $75.2m $75.2m 0.95% Added +112.5k +112,543
34 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 913,610913.6k $72.4m $72.4m 0.01% Added +45.4k +45,431
35 Capital International Investors 0.01% of their portfolio Los Angeles, CA 823,764823.8k $65.3m $65.3m 0.01% New
36 Davern Capital Partners, LP 10.80% of their portfolio NY, NY 798,709798.7k $63.3m $63.3m 10.80% Added +411.8k +411,806
37 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 790,990791.0k $62.7m $62.7m 0.00% Reduced -49.6k -49,608
38 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.62% of their portfolio Boston, MA 787,263787.3k $62.4m $62.4m 1.62% Reduced -616.8k -616,770
39 GW&K Investment Management, LLC 0.46% of their portfolio BOSTON, MA 746,966747.0k $59.2m $59.2m 0.46% Reduced -32.4k -32,383
40 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio Paris, I0 734,219734.2k $58.2m $58.2m 0.06% Reduced -173.3k -173,314
41 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 726,282726.3k $57.6m $57.6m 0.01% Added +77.8k +77,786
42 Connor, Clark & Lunn Investment Management Ltd. 0.10% of their portfolio VANCOUVER, A1 684,236684.2k $54.3m $54.3m 0.10% Reduced -189.9k -189,853
43 Eversept Partners, LP 2.87% of their portfolio NEW YORK, NY 664,684664.7k $52.7m $52.7m 2.87% Added +32.6k +32,584
44 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.22% of their portfolio JUPITER, FL 655,454655.5k $52.0m $52.0m 0.22% Reduced -17.4k -17,404
45 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.02% of their portfolio Boston, MA 651,816651.8k $51.7m $51.7m 0.02% Reduced -14.3k -14,300
46 NEUBERGER BERMAN GROUP LLC 0.03% of their portfolio NEW YORK, NY 633,533633.5k $50.2m $50.2m 0.03% Added +190.3k +190,261
47 ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio BOSTON, MA 632,028632.0k $50.1m $50.1m 0.02% Reduced -105.8k -105,831
48 UBS Group AG 0.01% of their portfolio ZURICH, V8 624,874624.9k $49.5m $49.5m 0.01% Reduced -183.6k -183,569
49 TimesSquare Capital Management, LLC 0.72% of their portfolio NEW YORK, NY 614,070614.1k $48.7m $48.7m 0.72% Added +338.4k +338,396
50 EVENTIDE ASSET MANAGEMENT, LLC 0.61% of their portfolio Boston, MA 575,000575.0k $45.6m $45.6m 0.61% Unchanged
51 PERCEPTIVE ADVISORS LLC 0.70% of their portfolio NEW YORK, NY 566,000566.0k $44.9m $44.9m 0.70% Added +62.0k +62,000
52 RENAISSANCE TECHNOLOGIES LLC 0.06% of their portfolio NEW YORK, NY 559,414559.4k $44.4m $44.4m 0.06% Added +253.9k +253,865
53 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 542,454542.5k $43.0m $43.0m 0.01% Added +27.8k +27,837
54 TEACHER RETIREMENT SYSTEM OF TEXAS 0.11% of their portfolio AUSTIN, TX 522,317522.3k $41.4m $41.4m 0.11% Reduced -1.6k -1,615
55 BOONE CAPITAL MANAGEMENT LLC 9.64% of their portfolio ATLANTA, GA 519,977520.0k $41.2m $41.2m 9.64% Added +19.5k +19,455
56 JANE STREET GROUP, LLC 0.03% of their portfolio NEW YORK, NY 503,647503.6k $39.9m $39.9m 0.03% Added +311.8k +311,829
57 NEW YORK STATE COMMON RETIREMENT FUND 0.05% of their portfolio ALBANY, NY 500,050500.1k $39.6m $39.6m 0.05% Added +149.6k +149,636
58 BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio PARIS, I0 454,649454.6k $36.0m $36.0m 0.02% Reduced -24.8k -24,811
59 Candriam S.C.A. 0.16% of their portfolio STRASSEN, N4 445,019445.0k $35.3m $35.3m 0.16% Reduced -39.0k -39,034
60 FIRST TRUST ADVISORS LP 0.02% of their portfolio Wheaton, IL 427,197427.2k $33.9m $33.9m 0.02% Reduced -41.2k -41,166
61 PINNACLE ASSOCIATES LTD 0.36% of their portfolio NEW YORK, NY 419,752419.8k $33.3m $33.3m 0.36% Reduced -16.7k -16,705
62 NOMURA HOLDINGS INC 0.13% of their portfolio TOKYO, M0 402,192402.2k $31.9m $31.9m 0.13% Added +288.1k +288,112
63 Handelsbanken Fonder AB 0.09% of their portfolio STOCKHOLM, V7 383,211383.2k $30.4m $30.4m 0.09% Added +169.3k +169,300
64 C WorldWide Group Holding A/S 0.70% of their portfolio COPENHAGEN, G7 366,000366.0k $29.0m $29.0m 0.70% Unchanged
65 TD Asset Management Inc 0.02% of their portfolio Toronto, A6 340,548340.5k $27.0m $27.0m 0.02% Reduced -189.4k -189,406
66 ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio NASHVILLE, TN 340,450340.4k $25.6m $25.6m 0.01% Reduced -60.2k -60,219
67 Freestone Grove Partners LP 0.18% of their portfolio San Francisco, CA 339,967340.0k $27.0m $27.0m 0.18% New
68 Qube Research & Technologies Ltd 0.03% of their portfolio LONDON, X0 333,952334.0k $26.5m $26.5m 0.03% Added +291.1k +291,096
69 Capital Research Global Investors 0.00% of their portfolio Los Angeles, CA 331,936331.9k $26.3m $26.3m 0.00% Added +8.9k +8,921
70 CAPITAL FUND MANAGEMENT S.A. 0.19% of their portfolio PARIS, I0 329,554329.6k $26.1m $26.1m 0.19% Added +187.4k +187,353
71 Carmignac Gestion 0.33% of their portfolio PARIS, I0 321,000321.0k $25.5m $25.5m 0.33% Added +268.0k +268,000
72 Privium Fund Management B.V. 4.66% of their portfolio AMSTERDAM, P7 319,924319.9k $25.4m $25.4m 4.66% Added +29.9k +29,900
73 Swiss National Bank 0.01% of their portfolio ZURICH, V8 315,000315.0k $25.0m $25.0m 0.01% Added +10.5k +10,500
74 Jump Financial, LLC 0.22% of their portfolio Chicago, IL 306,330306.3k $24.3m $24.3m 0.22% Added +99.7k +99,655
75 ARK Investment Management LLC 0.15% of their portfolio ST. PETERSBURG, FL 300,770300.8k $23.8m $23.8m 0.15% Added +12.1k +12,054
76 Legal & General Group Plc 0.00% of their portfolio London, X0 299,184299.2k $23.7m $23.7m 0.00% Added +4.5k +4,505
77 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 297,041297.0k $23.6m $23.6m 0.01% Reduced -132.6k -132,558
78 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 288,872288.9k $22.9m $22.9m 0.02% Reduced -762.6k -762,634
79 DAVENPORT & Co LLC 0.11% of their portfolio RICHMOND, VA 283,960284.0k $22.5m $22.5m 0.11% Added +45.7k +45,722
80 Aberdeen Group plc 0.03% of their portfolio EDINBURGH, X0 277,400277.4k $22.0m $22.0m 0.03% Added +163.6k +163,557
81 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 270,843270.8k $21.5m $21.5m 0.01% Added +15.4k +15,358
82 TOCQUEVILLE ASSET MANAGEMENT L.P. 0.26% of their portfolio New York, NY 251,215251.2k $19.9m $19.9m 0.26% Added +32.0k +31,995
83 RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio ST. PETERSBURG, FL 237,348237.3k $18.8m $18.8m 0.01% Added +2.2k +2,227
84 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 236,284236.3k $18.7m $18.7m 0.01% Reduced -706.2k -706,250
85 Universal- Beteiligungs- und Servicegesellschaft mbH 0.03% of their portfolio FRANKFURT AM MAIN, 2M 233,499233.5k $18.5m $18.5m 0.03% Added +13.8k +13,847
86 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 226,213226.2k $17.9m $17.9m 0.00% Added +36.4k +36,360
87 Empowered Funds, LLC 0.09% of their portfolio NEWTOWN SQUARE, PA 223,142223.1k $17.7m $17.7m 0.09% Added +120.0k +120,001
88 Orion Investment Co 5.10% of their portfolio ST. LOUIS, MO 220,335220.3k $17.5m $17.5m 5.10% Reduced -4.7k -4,680
89 Life Cycle Investment Partners Ltd 0.08% of their portfolio LONDON, X0 219,896219.9k $17.4m $17.4m 0.08% New
90 ALGERT GLOBAL LLC 0.19% of their portfolio SAN FRANCISCO, CA 206,853206.9k $16.4m $16.4m 0.19% Added +90.3k +90,290
91 STIFEL FINANCIAL CORP 0.01% of their portfolio ST. LOUIS, MO 202,983203.0k $16.1m $16.1m 0.01% Added +6.3k +6,280
92 Corient Private Wealth LP 0.02% of their portfolio MIAMI, FL 196,661196.7k $15.6m $15.6m 0.02% Added +62 +62
93 Eagle Health Investments LP 2.56% of their portfolio Greenwich, CT 194,577194.6k $15.4m $15.4m 2.56% New
94 SECTOR GAMMA AS 3.26% of their portfolio OSLO, Q8 189,468189.5k $15.0m $15.0m 3.26% Added +20.0k +20,000
95 HSBC HOLDINGS PLC 0.01% of their portfolio LONDON, X0 188,402188.4k $15.0m $15.0m 0.01% Added +2.4k +2,435
96 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 180,949180.9k $14.3m $14.3m 0.01% Added +4.5k +4,464
97 Polymer Capital Management (HK) LTD 1.43% of their portfolio HONG KONG, K3 177,897177.9k $14.1m $14.1m 1.43% Added +116.7k +116,697
98 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 169,614169.6k $13.4m $13.4m 0.00% Added +9.7k +9,723
99 ADAR1 Capital Management, LLC 0.62% of their portfolio AUSTIN, TX 166,286166.3k $13.2m $13.2m 0.62% Added +5.9k +5,948
100 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 164,911164.9k $13.1m $13.1m 0.01% Reduced -8.5k -8,529