HERON THERAPEUTICS INC HRTX
COM · Common Stock · CUSIP 427746102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.4k this quarter). Holder counts are more reliable. Shares outstanding: 189.9m as of 2026-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.43. Options: 5 managers hold calls ($1.6m notional), 5 hold puts ($914.2k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 185 |
| Q4 2022 | 176 |
| Q1 2023 | 162 |
| Q2 2023 | 149 |
| Q3 2023 | 141 |
| Q4 2023 | 152 |
| Q1 2024 | 161 |
| Q2 2024 | 190 |
| Q3 2024 | 173 |
| Q4 2024 | 161 |
| Q1 2025 | 166 |
| Q2 2025 | 172 |
| Q3 2025 | 172 |
| Q4 2025 | 170 |
| Q1 2026 | 167 |
| Q2 2026 | 162 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 86 | 77 |
| Q4 2024 | 62 | 86 |
| Q1 2025 | 75 | 62 |
| Q2 2025 | 85 | 49 |
| Q3 2025 | 75 | 68 |
| Q4 2025 | 78 | 68 |
| Q1 2026 | 78 | 73 |
| Q2 2026 | 78 | 62 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $44.3k | $2.7m | 60.55 |
| Q4 2025 | $520.3k | $30.3k | 0.06 |
| Q1 2026 | $903.8k | $1.7m | 1.89 |
| Q2 2026 | $1.6m | $914.2k | 0.58 |
Biggest buyers
| MARSHALL WACE, LLP | New | +2.4m |
| Qube Research & Technologies Ltd | Added | +990.7k |
| GSA CAPITAL PARTNERS LLP | Added | +937.8k |
| AQR CAPITAL MANAGEMENT LLC | Added | +912.3k |
| UBS Group AG | Added | +711.2k |
| Caption Management, LLC | Added | +686.3k |
| DIADEMA PARTNERS LP | New | +458.7k |
| BlackRock, Inc. | Added | +444.3k |
| Richmond Brothers, Inc. | Added | +355.6k |
| PANAGORA ASSET MANAGEMENT INC | Added | +319.3k |
Biggest sellers
| ORBIMED ADVISORS LLC | Sold out | -9.8m |
| PALISADE CAPITAL MANAGEMENT, LP | Sold out | -6.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -3.6m |
| D. E. Shaw & Co., Inc. | Reduced | -2.5m |
| Congress Park Capital LLC | Reduced | -2.0m |
| NEW YORK STATE COMMON RETIREMENT FUND | Reduced | -1.9m |
| Stonepine Capital Management, LLC | Reduced | -911.4k |
| Monaco Asset Management SAM | Sold out | -858.1k |
| Clearline Capital LP | Reduced | -851.3k |
| CITADEL ADVISORS LLC | Sold out | -759.3k |
Biggest calls
| Stonepine Capital Management, LLC | Unchanged | $1.5m1.0m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $48.3k112.3k shares |
| CITADEL ADVISORS LLC | Reduced | $11.1k26.1k shares |
| GROUP ONE TRADING LLC | Added | $2.1k5.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.8k4.2k shares |
Biggest puts
| Caption Management, LLC | Unchanged | $896.3k2.1m shares |
| CITADEL ADVISORS LLC | Unchanged | $9.0k21.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $4.6k10.8k shares |
| GROUP ONE TRADING LLC | New | $4.3k10.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $85200 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Rubric Capital Management LP
13D · may seek influence
-1.6 pts · filed 2025-10-17
Stated purposeOn October 15, 2025, the Issuer filed a Current Report on Form 8-K with the SEC disclosing that it obtained Stockholder Approval, as a result of which, the 94,610 shares of Preferred Stock beneficially owned by the Reporting Persons automatically converted, without any action on the part of the holders thereof, into 946,100 Shares. Additionally, as previously disclosed, on August 8, 2025, a certain Rubric Fund entered into the Note Purchase Agreement with the Issuer, pursuant to which the Issuer issued and sold to such Rubric Fund $35,000,000 aggregate principal amount of Notes for an aggregate purchase price of $33,250,000. The Convertible Note Issuance provided for the issuance of Notes with (i) a maturity date of March 1, 2031, (ii) a 5% original issuance discount, (iii) 5% per annum i… Full filing |
15.9% |
| Clearline Capital LP 13G · institution +1.4 pts · filed 2026-02-17 | 6.7% |
Fell to 5% or below in the last year: Adage Capital Management, L.P. (0.0%, 2026-05-13), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 1 | $2.6m | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Rubric Capital Management LP 0.12% of their portfolio | 30.0m $12.8m | Unchanged |
| Clearline Capital LP 0.31% of their portfolio | 11.4m $4.9m | Reduced -851.3k |
| BlackRock, Inc. 0.00% of their portfolio | 10.6m $4.5m | Added +444.3k |
| Velan Capital Investment Management LP 2.29% of their portfolio | 8.8m $3.7m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 7.8m $3.3m | Reduced -27.6k |
| Tejara Capital Ltd 1.14% of their portfolio | 6.5m $2.8m | Added +174.0k |
| TANG CAPITAL MANAGEMENT LLC 0.12% of their portfolio | 6.2m $2.7m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.3m $1.8m | Added +260.9k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 4.1m $1.7m | Reduced -3.6m |
| JW Asset Management, LLC 0.50% of their portfolio | 3.8m $1.6m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 3.2m $1.4m | Reduced -615.1k |
| UBS Group AG 0.00% of their portfolio | 3.0m $1.3m | Added +711.2k |
| Pale Fire Capital SE 0.08% of their portfolio | 2.5m $1.1m | Reduced -204.8k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 2.4m $1.0m | New |
| Congress Park Capital LLC 0.23% of their portfolio | 2.0m $860.6k | Reduced -2.0m |
| Richmond Brothers, Inc. 0.40% of their portfolio | 1.8m $765.0k | Added +355.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.6m $674.9k | Added +271.2k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.6m $663.2k | Added +912.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 1.5m $643.1k | Reduced -211.4k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.4m $582.9k | Added +212.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.3m $567.5k | Added +272.8k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 1.3m $547.1k | Added +319.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $522.2k | Added +51.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.2m $519.6k | Reduced -158.9k |
| GSA CAPITAL PARTNERS LLP 0.03% of their portfolio | 1.0m $445.0k | Added +937.8k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 1.0m $435.8k | Added +990.7k |
| Caption Management, LLC 0.02% of their portfolio | 1.0m $426.8k | Added +686.3k |
| CM Management, LLC 0.27% of their portfolio | 1.0m $426.8k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 694.2k $296.3k | Reduced -1.9m |
| Stonepine Capital Management, LLC 0.16% of their portfolio | 490.8k $209.5k | Reduced -911.4k |
| NEXPOINT ASSET MANAGEMENT, L.P. 0.01% of their portfolio | 475.8k $203.1k | Unchanged |
| DIADEMA PARTNERS LP 0.07% of their portfolio | 458.7k $195.8k | New |
| Invesco Ltd. 0.00% of their portfolio | 406.7k $173.6k | Added +80.2k |
| Xcelsior Advisor Partners LLC 0.02% of their portfolio | 405.8k $173.2k | Added +120.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 395.8k $168.9k | Reduced -11.0k |
| Apeiron RIA LLC 0.04% of their portfolio | 370.6k $158.2k | Added +64.9k |
| Squarepoint Ops LLC 0.00% of their portfolio | 321.2k $137.1k | Reduced -538.8k |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 318.9k $136.1k | Added +223.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 299.9k $240.0k | Added +101.4k |
| Virtu Financial LLC 0.00% of their portfolio | 283.2k $121.0k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 266.3k $113.7k | Reduced -51.1k |
| FMR LLC 0.00% of their portfolio | 226.8k $96.8k | Added +168.6k |
| Nuveen, LLC 0.00% of their portfolio | 221.8k $94.7k | Reduced -304.5k |
| Abel Hall, LLC 0.02% of their portfolio | 213.2k $91.0k | Added +196.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 195.5k $83.5k | Added +11.0k |
| Quinn Opportunity Partners LLC 0.00% of their portfolio | 175.3k $74.8k | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 158.2k $67.5k | Added +20.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 153.0k $65.0k | Reduced -360.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 152.9k $65.3k | Added +86.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 137.1k $58.5k | Reduced -151.2k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 120.4k $51.4k | Reduced -2.5m |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 120.3k $51.3k | Reduced -122.7k |
| Persistent Asset Partners Ltd 0.02% of their portfolio | 117.1k $50.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 111.7k $47.7k | Reduced -401.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 111.5k $48.0k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 108.4k $46.2k | Reduced -52.6k |
| Redwood Family Wealth LLC 0.04% of their portfolio | 105.5k $45.0k | Added +41.0k |
| Biltmore Family Office, LLC 0.01% of their portfolio | 100.0k $42.7k | Unchanged |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 96.6k $41.2k | Added +29.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 96.3k $41.4k | Added +3.2k |
| BARCLAYS PLC 0.00% of their portfolio | 91.0k $38.8k | Reduced -372 |
| SEARLE & CO. 0.01% of their portfolio | 86.2k $36.8k | Unchanged |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 83.8k $35.8k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 81.2k $34.7k | Added +68.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 75.7k $33.0k | Added +10.6k |
| CITIGROUP INC 0.00% of their portfolio | 74.9k $32.0k | Added +67.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 73.6k $31.4k | Added +460 |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 68.3k $29.1k | Added +27.3k |
| LPL Financial LLC 0.00% of their portfolio | 61.1k $26.1k | Reduced -17.6k |
| Cerity Partners LLC 0.00% of their portfolio | 60.3k $25.8k | Added +43.1k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 59.2k $25.3k | Reduced -550 |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 56.0k $24.0k | Added +33.7k |
| Mariner, LLC 0.00% of their portfolio | 56.0k $23.9k | Added +20.6k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 51.5k $22.0k | Added +4.3k |
| Chicago Partners Investment Group LLC 0.00% of their portfolio | 51.3k $23.5k | Added +24.5k |
| R Squared Ltd 0.01% of their portfolio | 46.7k $19.9k | Added +13.1k |
| Centiva Capital, LP 0.00% of their portfolio | 45.5k $19.4k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 42.1k $18.0k | Unchanged |
| HORAN Wealth, LLC 0.00% of their portfolio | 41.6k $17.8k | Unchanged |
| Prospera Financial Services Inc 0.00% of their portfolio | 40.6k $17.3k | Unchanged |
| Cornerstone Select Advisors, LLC 0.01% of their portfolio | 40.0k $17.1k | Reduced -19.4k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 39.0k $16.6k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 38.4k $16.4k | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 37.9k $16.2k | Reduced -48.9k |
| Creative Planning 0.00% of their portfolio | 35.9k $15.3k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 35.6k $15.2k | Added +4.1k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 33.4k $14.5k | Unchanged |
| DDFG, Inc 0.00% of their portfolio | 32.9k $14.0k | New |
| King Wealth Management Group 0.00% of their portfolio | 32.8k $14.0k | Unchanged |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 32.4k $13.4k | Added +15.8k |
| Concurrent Investment Advisors, LLC 0.00% of their portfolio | 31.9k $13.6k | Unchanged |
| CoreCap Advisors, LLC 0.00% of their portfolio | 28.4k $12.1k | Unchanged |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 27.3k $11.6k | Added +13.8k |
| HRT FINANCIAL LP 0.00% of their portfolio | 27.0k $11.0k | New |
| DIVERSIFIED TRUST CO 0.00% of their portfolio | 26.5k $11.3k | Unchanged |
| Pallas Capital Advisors LLC 0.00% of their portfolio | 25.7k $11.0k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 25.7k $11.0k | New |
| TopTier Wealth Management, LLC 0.01% of their portfolio | 25.4k $10.8k | Reduced -12.0k |
| Parkway Wealth Management Group, LLC 0.00% of their portfolio | 25.0k $10.7k | Unchanged |
| HighTower Advisors, LLC 0.00% of their portfolio | 24.6k $10.5k | Added +7.0k |