FULCRUM THERAPEUTICS INC FULC
COM · Common Stock · CUSIP 359616109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded2016
- Websitefulcrumtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.2m this quarter). Holder counts are more reliable. Shares outstanding: 62.4m as of 2024-07-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.20. Options: 15 managers hold calls ($36.6m notional), 6 hold puts ($1.9m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 106 |
| Q4 2022 | 111 |
| Q1 2023 | 117 |
| Q2 2023 | 89 |
| Q3 2023 | 82 |
| Q4 2023 | 102 |
| Q1 2024 | 127 |
| Q2 2024 | 122 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 65 | 43 |
| Q1 2023 | 79 | 43 |
| Q2 2023 | 41 | 72 |
| Q3 2023 | 32 | 47 |
| Q4 2023 | 49 | 32 |
| Q1 2024 | 69 | 39 |
| Q2 2024 | 75 | 62 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $3.1m | $1.2m | 0.40 |
| Q4 2023 | $4.6m | $811.4k | 0.18 |
| Q1 2024 | $30.4m | $1.2m | 0.04 |
| Q2 2024 | $36.6m | $1.9m | 0.05 |
Biggest buyers
| BlackRock Inc. | Added | +3.3m |
| STATE STREET CORP | Added | +784.4k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +743.9k |
| VANGUARD GROUP INC | Added | +532.5k |
| Woodline Partners LP | New | +501.3k |
| Assenagon Asset Management S.A. | New | +497.5k |
| Vestal Point Capital, LP | Added | +465.0k |
| CITADEL ADVISORS LLC | Added | +451.7k |
| TWO SIGMA INVESTMENTS, LP | Added | +334.5k |
| MPM BIOIMPACT LLC | Added | +307.7k |
Biggest sellers
| MORGAN STANLEY | Reduced | -2.2m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -806.4k |
| COWEN AND COMPANY, LLC | Reduced | -749.8k |
| Affinity Asset Advisors, LLC | Sold out | -550.3k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -494.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -479.4k |
| Invesco Ltd. | Reduced | -465.6k |
| JANE STREET GROUP, LLC | Reduced | -366.8k |
| MONTANOVA CAPITAL, LLC | Reduced | -307.4k |
| JPMORGAN CHASE & CO | Reduced | -251.8k |
Biggest calls
| Logos Global Management LP | Added | $18.6m3.0m shares |
| Caption Management, LLC | Added | $12.9m2.1m shares |
| Affinity Asset Advisors, LLC | Reduced | $1.6m250.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $814.1k131.3k shares |
| Squarepoint Ops LLC | Added | $753.3k121.5k shares |
| CITADEL ADVISORS LLC | Added | $717.3k115.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $569.0k91.8k shares |
| WOLVERINE TRADING, LLC | Added | $235.6k38.0k shares |
| ADAR1 Capital Management, LLC | New | $124.0k20.0k shares |
| JPMORGAN CHASE & CO | New | $109.1k17.6k shares |
Biggest puts
| Caption Management, LLC | Added | $1.3m210.0k shares |
| SPHERA FUNDS MANAGEMENT LTD. | New | $365.8k59.0k shares |
| CITADEL ADVISORS LLC | Added | $155.6k25.1k shares |
| WOLVERINE TRADING, LLC | New | $78.7k12.7k shares |
| SIMPLEX TRADING, LLC | Added | $21.0k3.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| TANG CAPITAL MANAGEMENT LLC 13G · passive investor +2.2 pts · filed 2026-07-15 | 10.4% |
| EcoR1 Capital, LLC 13G · institution no change · filed 2026-06-25 | 9.0% |
| Nantahala Capital Management, LLC 13G · institution +3.6 pts · filed 2026-08-14 | 8.2% |
| BlackRock Portfolio Management LLC 13G · institution +2.1 pts · filed 2026-10-27 | 8.1% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-28 | 7.2% |
| MONTANOVA CAPITAL, LLC 13G · institution -3.9 pts · filed 2026-08-14 | 5.5% |
Fell to 5% or below in the last year: BANK OF AMERICA CORP /DE/ (1.5%, 2026-10-28), RA CAPITAL MANAGEMENT, L.P. (0.0%, 2026-08-14), TCG Crossover GP II, LLC (0.0%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-26), Adage Capital Management, L.P. (4.5%, 2025-11-13)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 1 | $101.5k | — |
| Q2 2023 | 0 | — | 1 | $695 | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 1 | $492.1k | 1 | $57.2k | — |
| Q2 2024 | 0 | — | 1 | $1.8k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-05-07 | Tourangeau Greg Principal Accounting Officer | Sold | $1.8k236 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.95% of their portfolio | 11.6m $72.0m | Unchanged |
| RTW INVESTMENTS, LP 0.56% of their portfolio | 5.8m $36.2m | Unchanged |
| FMR LLC 0.00% of their portfolio | 5.3m $33.0m | Reduced -34.7k |
| BlackRock Inc. 0.00% of their portfolio | 4.8m $29.8m | Added +3.3m |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.1m $19.0m | Added +532.5k |
| COWEN AND COMPANY, LLC 0.51% of their portfolio | 3.0m $18.4m | Reduced -749.8k |
| MONTANOVA CAPITAL, LLC 0.64% of their portfolio | 2.5m $15.8m | Reduced -307.4k |
| TRV GP IV, LLC 7.18% of their portfolio | 2.3m $14.5m | Unchanged |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.8m $11.0m | Added +451.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.5m $9.2m | Added +176.1k |
| MPM BIOIMPACT LLC 1.39% of their portfolio | 1.4m $9.0m | Added +307.7k |
| Jefferies Financial Group Inc. 0.17% of their portfolio | 1.4m $8.9m | Added +281.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $8.1m | Added +743.9k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $7.7m | Reduced -2.2m |
| Vestal Point Capital, LP 0.54% of their portfolio | 1.2m $7.2m | Added +465.0k |
| STATE STREET CORP 0.00% of their portfolio | 1.0m $6.5m | Added +784.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 849.2k $5.3m | Added +26.1k |
| Propel Bio Management, LLC 3.02% of their portfolio | 750.0k $4.7m | Unchanged |
| Rock Springs Capital Management LP 0.14% of their portfolio | 727.7k $4.5m | Unchanged |
| STEMPOINT CAPITAL LP 1.27% of their portfolio | 696.5k $4.3m | Added +289.4k |
| Simplify Asset Management Inc. 0.37% of their portfolio | 674.8k $4.2m | Reduced -1.2k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 591.8k $3.7m | Reduced -33.4k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 563.5k $3.5m | Added +143.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 560.5k $3.5m | Reduced -249.8k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 553.3k $3.4m | Reduced -169.9k |
| Caption Management, LLC 0.35% of their portfolio | 525.3k $3.3m | Added +209.8k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 509.7k $3.2m | Added +334.5k |
| Woodline Partners LP 0.03% of their portfolio | 501.3k $3.1m | New |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 497.5k $3.1m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 402.7k $2.5m | Reduced -494.7k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.61% of their portfolio | 398.4k $2.5m | Unchanged |
| ADAR1 Capital Management, LLC 0.46% of their portfolio | 368.4k $2.3m | Added +28.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 333.2k $2.1m | Added +107.6k |
| Exome Asset Management LLC 1.67% of their portfolio | 302.7k $1.9m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 300.0k $1.9m | Reduced -806.4k |
| BESSEMER GROUP INC 0.00% of their portfolio | 287.0k $1.8m | Unchanged |
| Opaleye Management Inc. 0.40% of their portfolio | 285.0k $1.8m | Added +155.0k |
| Aberdeen Group plc 0.00% of their portfolio | 256.9k $1.6m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 223.0k $1.4m | Added +36.0k |
| Mass General Brigham, Inc 6.20% of their portfolio | 205.4k $1.3m | Unchanged |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 202.1k $1.3m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 190.6k $1.2m | Added +117.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 186.7k $1.2m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 182.7k $1.1m | Added +10.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 176.0k $1.1m | Added +151.5k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 169.5k $1.1m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 168.2k $1.0m | Reduced -366.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 166.9k $1.0m | Added +30.5k |
| Eversept Partners, LP 0.07% of their portfolio | 153.0k $948.4k | New |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 150.5k $933.0k | Added +129.1k |
| Fiduciary Trust Co 0.01% of their portfolio | 136.6k $846.6k | Unchanged |
| GSA CAPITAL PARTNERS LLP 0.06% of their portfolio | 135.2k $838.0k | Added +120.1k |
| RBF Capital, LLC 0.05% of their portfolio | 125.0k $775.0k | Reduced -15.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 104.4k $647.1k | Added +12.2k |
| Jump Financial, LLC 0.01% of their portfolio | 94.2k $583.9k | Added +63.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 91.4k $566.9k | Added +89.8k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 87.6k $543.2k | Added +2.6k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 84.4k $523.0k | Added +1.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 81.6k $505.9k | Reduced -479.4k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 81.2k $503.5k | Reduced -87.6k |
| Trexquant Investment LP 0.01% of their portfolio | 70.5k $437.1k | Added +23.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 69.9k $433.3k | Added +8.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 66.1k $409.7k | Reduced -251.8k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $568.0k | Unchanged |
| Alpine Global Management, LLC 0.06% of their portfolio | 60.0k $371.9k | New |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 59.4k $368.2k | Added +38.5k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 57.1k $354.0k | Added +26.4k |
| ALPS ADVISORS INC 0.00% of their portfolio | 48.5k $300.6k | Added +4.8k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 41.3k $256.1k | Added +27.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 35.7k $222.0k | Added +19.8k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 33.4k $207.3k | First filing |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 32.3k $204.3k | New |
| Invesco Ltd. 0.00% of their portfolio | 31.0k $192.5k | Reduced -465.6k |
| COUNTRY TRUST BANK 0.00% of their portfolio | 30.2k $187.2k | Unchanged |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 28.1k $174.2k | New |
| Semanteon Capital Management, LP 0.12% of their portfolio | 26.7k $165.3k | New |
| BARCLAYS PLC 0.00% of their portfolio | 26.6k $164.8k | Reduced -44.9k |
| Corton Capital Inc. 0.09% of their portfolio | 26.2k $162.3k | Added +13.7k |
| AlphaQuest LLC 0.02% of their portfolio | 26.2k $162.2k | New |
| BRANDYWINE MANAGERS, LLC 0.17% of their portfolio | 26.1k $162.0k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 26.1k $162.0k | Added +13.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 25.1k $155.7k | Added +24.7k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 25.1k $155.6k | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 24.8k $153.9k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 24.5k $152.0k | Reduced -30.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 24.5k $151.8k | New |
| CITIGROUP INC 0.00% of their portfolio | 22.8k $141.3k | Reduced -155.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.2k $131.2k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 21.0k $130.4k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 19.9k $123.1k | New |
| Aigen Investment Management, LP 0.02% of their portfolio | 19.3k $119.7k | New |
| CAXTON ASSOCIATES LP 0.00% of their portfolio | 18.9k $117.0k | New |
| Aquatic Capital Management LLC 0.00% of their portfolio | 17.3k $107.3k | Added +8.3k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 16.3k $101.2k | Added +6.5k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 15.9k $98.6k | New |
| Alphabet Inc. 0.00% of their portfolio | 14.3k $88.4k | Unchanged |
| Quantbot Technologies LP 0.00% of their portfolio | 14.0k $87.0k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 13.3k $82.2k | New |
| VIRTUS ADVISERS, LLC 0.04% of their portfolio | 11.6k $72.0k | New |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 11.4k $70.5k | Reduced -4.3k |